Title: Hotels by Motel 6 in Upstate South Carolina from CA $86 | Expedia.ca [Upstate South Carolina Travel Guide](https://expedia.ca/Upstate-South-Carolina.dx6057939)[Hotels in Upstate South Carolina](https://expedia.ca/Upstate-South-Carolina-Hotels.d6057939.Travel-Guide-Hotels)[Vacation Rentals in Upstate South Carolina](https://expedia.ca/Upstate-South-Carolina-Vacation-Rentals.d6057939.Travel-Guide-VacationRentals)[Flights to Upstate South Carolina](https://expedia.ca/Cheap-Flights-To-Upstate-South-Carolina.d6057939.Travel-Guide-Flights)[Things to do in Upstate South Carolina](https://expedia.ca/Things-To-Do-In-Upstate-South-Carolina.d6057939.Travel-Guide-Activities)[Upstate South Carolina Car Rentals](https://expedia.ca/Car-Rentals-In-Upstate-South-Carolina.d6057939.Car-Rental-Guide)[Upstate South Carolina Vacation Packages](https://expedia.ca/Upstate-South-Carolina.d6057939.Destination-Travel-Guides) ![Greenville - Spartanburg featuring mountains, views and a sunset](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/63000/63748-Greenville-Spartanburg.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Hotels by Motel 6 in Upstate South Carolina from CA $86 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Oct 10 - Oct 11](https://www.expedia.ca/Hotel-Search?regionId=6057939&startDate=2025-10-10&endDate=2025-10-11&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 11 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=6057939&startDate=2025-10-11&endDate=2025-10-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=6057939&startDate=2025-10-10&endDate=2025-10-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=6057939&startDate=2025-10-17&endDate=2025-10-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Upstate South Carolina Motel 6 Hotels ![Exterior](https://images.trvl-media.com/lodging/37000000/36830000/36824600/36824597/6f7f191d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee service](https://images.trvl-media.com/lodging/37000000/36830000/36824600/36824597/4b514a45.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/37000000/36830000/36824600/36824597/60a1e95b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, free WiFi](https://images.trvl-media.com/lodging/37000000/36830000/36824600/36824597/c95d1422.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 Greenville, SC - I-85 Near Downtown Greenville 6.8/10 (305) "Good service fairly clean good price close to our places of interest friendly " CA $79 CA $86 total includes taxes & fees Oct 14 - Oct 15 [](https://www.expedia.ca/Greenville-Spartanburg-Hotels-Motel-6-Greenville.h36824597.Hotel-Information) ![Desk, laptop workspace, blackout drapes, free WiFi](https://images.trvl-media.com/lodging/104000000/103060000/103059200/103059155/38900136.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/104000000/103060000/103059200/103059155/b09ac693.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/104000000/103060000/103059200/103059155/de407ae3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Combined shower/tub, towels, soap, toilet paper](https://images.trvl-media.com/lodging/104000000/103060000/103059200/103059155/e0b4a48f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 Spartanburg, Sc – Northwest / Business 85 Spartanburg 7.4/10 Good (68) "It’s a quiet laid back hotel with clean rooms!" CA $102 CA $114 total includes taxes & fees Oct 12 - Oct 13 [](https://www.expedia.ca/Spartanburg-Hotels-Motel-6-Spartanburg.h103059155.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/330000/328900/328810/085635e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/1000000/330000/328900/328810/837914fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Flat-screen TV](https://images.trvl-media.com/lodging/1000000/330000/328900/328810/c5cb4bb2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/1000000/330000/328900/328810/0200d1b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 Simpsonville, SC - Greenville Simpsonville 7.2/10 Good (340) "Checkin and Checkout procedures were very straightforward, especially with advanced booking through Expedia." CA $98 CA $108 total includes taxes & fees Oct 12 - Oct 13 [](https://www.expedia.ca/Simpsonville-Hotels-Motel-6-Simpsonville.h328810.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-24&endDate=2025-10-25®ionId=6057939&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FUpstate-South-Carolina-Hotels-Motel-6.0-0-d6057939--bMotel6.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FUpstate-South-Carolina-Hotels-Motel-6.0-0-d6057939--bMotel6.Travel-Guide-Filter-Hotels) ## Top Upstate South Carolina Hotel Reviews ![Grand Bohemian Lodge Greenville, Autograph Collection](//images.trvl-media.com/lodging/72000000/71770000/71762700/71762652/6a375dd3_y.jpg) ### Grand Bohemian Lodge Greenville, Autograph Collection 10/10 Excellent "We celebrated our 36th anniversary; we did not share that with the hotel. We had a wonderful day, enjoyed a welcome complimentary fall drink before heading over the bridge to Jianna's for a wonderful meal. Came back to a comfy bed with a fluffy comforter. We did not stay for coffee, which would have been nice, but we had a nice stay." [](https://expedia.ca/Greenville-Hotels-Grand-Bohemian-Lodge-Greenville.h71762652.Hotel-Information) ![Drury Inn & Suites Greenville](//images.trvl-media.com/lodging/2000000/1540000/1533500/1533439/6d7853ae_y.jpg) ### Drury Inn & Suites Greenville 10/10 Excellent "Stayed for a quick stop but everything was good " [](https://expedia.ca/Greenville-Hotels-Drury-Inn-Suites-Greenville.h1533439.Hotel-Information) ![Best Western Plus Clemson Hotel & Conference Center](//images.trvl-media.com/lodging/1000000/10000/1400/1370/w3840h2557x0y4-16ef7416_y.jpg) ### Best Western Plus Clemson Hotel & Conference Center 10/10 Excellent "Great value and great hotel. We would stay there again. " [](https://expedia.ca/Anderson-Hotels-Best-Western-Plus-University-Inn-Conference-Center.h1370.Hotel-Information) ![Hyatt Place Greenville Downtown](//images.trvl-media.com/lodging/28000000/27050000/27043000/27042919/dac522c0_y.jpg) ### Hyatt Place Greenville Downtown 10/10 Excellent "Great location " [](https://expedia.ca/Greenville-Hotels-Hyatt-Place-GreenvilleDowntown.h27042919.Hotel-Information) ![The Shepherd Hotel Downtown Clemson](//images.trvl-media.com/lodging/88000000/87690000/87688200/87688155/8f34da45_y.jpg) ### The Shepherd Hotel Downtown Clemson 10/10 Excellent "The staff was very accommodating, the decor was beautiful and the room was comfortable. The roof deck was a great spot to relax during the day. It was a little loud at night, especially being on the 2nd floor directly below the bar. But overall it was a great stay." [](https://expedia.ca/Clemson-Hotels-The-Shepherd-Hotel-Downtown-Clemson.h87688155.Hotel-Information) ![Baymont by Wyndham Greenville Woodruff Rd](//images.trvl-media.com/lodging/1000000/20000/12300/12266/e0489212_y.jpg) ### Baymont by Wyndham Greenville Woodruff Rd 10/10 Excellent "Yes!" [](https://expedia.ca/Greenville-Hotels-Baymont-By-Wyndham-Greenville-Woodruff-Rd.h12266.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Greenville Haywood](//images.trvl-media.com/lodging/1000000/170000/165800/165759/89ed0b3d_y.jpg) ### La Quinta Inn & Suites by Wyndham Greenville Haywood 10/10 Excellent "I enjoyed my stay here. It was very clean and cozy. I will make another stay here, if available for my next travel. Thank you! " [](https://expedia.ca/Greenville-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Greenville-Haywood.h165759.Hotel-Information) ![Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG](//images.trvl-media.com/lodging/1000000/10000/1400/1379/91409d5a_y.jpg) ### Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG 10/10 Excellent "Very nice property. I would stay there again." [](https://expedia.ca/Greenville-Hotels-Crowne-Plaza-Hotel-Greenville-I-385-Roper-Mtn-Rd.h1379.Hotel-Information) ![Best Western Plus Greenville I-385 Inn & Suites](//images.trvl-media.com/lodging/1000000/30000/23100/23003/20a0c66a_y.jpg) ### Best Western Plus Greenville I-385 Inn & Suites 10/10 Excellent "Very friendly. Great coffee and breakfast. Hotel was clean and convenient " [](https://expedia.ca/Greenville-Hotels-Best-Western-Plus-Greenville-I-385-Inn-Suites.h23003.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - More ways to book - [Best Western Hotels in Aiken](https://www.expedia.ca/Aiken-Hotels-Best-Western.0-0-d6058112--bBestWestern.Travel-Guide-Filter-Hotels) - [Motel 6 Hotels in Brookhaven](https://www.expedia.ca/Brookhaven-Hotels-Motel-6.0-0-d553248635975852330--bMotel6.Travel-Guide-Filter-Hotels) - [Starwood Capital Hotels in Central](https://www.expedia.ca/Central-Hotels-Starwood-Capital.0-0-d10503--bStarwoodCapital.Travel-Guide-Filter-Hotels) - [Motel 6 Hotels in Clover](https://www.expedia.ca/Clover-Hotels-Motel-6.0-0-d3000455892--bMotel6.Travel-Guide-Filter-Hotels) - [Hotels near Donaldson Center](https://www.expedia.ca/Donaldson-Center-Airport-Hotels.0-aGDC-0.Travel-Guide-Filter-Hotels) - [Motel 6 Hotels in Duncan](https://www.expedia.ca/Duncan-Hotels-Motel-6.0-0-d6761--bMotel6.Travel-Guide-Filter-Hotels) - 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[Flights from Savannah (SAV) to Greenville (GMU)](https://www.expedia.ca/lp/flights/sav/gmu/savannah-to-greenville) - [Flights from Schenectady (SCH) to Greenville (GMU)](https://www.expedia.ca/lp/flights/sch/gmu/schenectady-to-greenville) - [Flights from Louisville (SDF) to Greenville (GMU)](https://www.expedia.ca/lp/flights/sdf/gmu/louisville-to-greenville) - [Flights from Sanford (SFM) to Greenville (GMU)](https://www.expedia.ca/lp/flights/sfm/gmu/sanford-to-greenville) - [Flights from Newburgh (SWF) to Greenville (GMU)](https://www.expedia.ca/lp/flights/swf/gmu/newburgh-to-greenville) - [Flights from Montreal (YUL) to Greenville (GMU)](https://www.expedia.ca/lp/flights/yul/gmu/montreal-to-greenville) - [Flights from Vancouver (YVR) to Greenville (GMU)](https://www.expedia.ca/lp/flights/yvr/gmu/vancouver-to-greenville) - [Flights from Toronto (YYZ) to Greenville (GDC)](https://www.expedia.ca/lp/flights/yyz/gdc/toronto-to-greenville) - [Flights from Toronto (YYZ) to Greenville (GMU)](https://www.expedia.ca/lp/flights/yyz/gmu/toronto-to-greenville) - [7th Inning Splash Waterpark](https://www.expedia.ca/7th-Inning-Splash-Waterpark-Piedmont.d553248621532656702.Vacation-Attraction) - [Central Vacations](https://www.expedia.ca/Central.d10503.Destination-Travel-Guides) - [Discovery Island Water Park](https://www.expedia.ca/Discovery-Island-Water-Park-Greenville.d553248621532656705.Vacation-Attraction) - [Frankie's Fun Park](https://www.expedia.ca/Frankies-Fun-Park-Greenville.d553248621532656780.Vacation-Attraction) - [Mauldin Vacations](https://www.expedia.ca/Mauldin.d183944.Destination-Travel-Guides) - [Prisma Health Greenville Memorial Hospital](https://www.expedia.ca/Prisma-Health-Greenville-Memorial-Hospital-Greenville.d553248635941390934.Vacation-Attraction) - [Terrace Shopping Center](https://www.expedia.ca/Terrace-Shopping-Center-Greenville.d553248621563220413.Vacation-Attraction) - [Car rentals near Prisma Health Greenville Memorial Hospital](https://www.expedia.ca/Car-Rentals-In-Prisma-Health-Greenville-Memorial-Hospital.d553248635941390934.Car-Rental-Guide) - [Book Motel 6 in Upstate South Carolina on Expedia.com](https://www.expedia.com/Upstate-South-Carolina-Hotels-Motel-6.0-0-d6057939--bMotel6.Travel-Guide-Filter-Hotels)