Title: Hotels by Motel 6 in Upstate South Carolina from CA $78 | Expedia.ca [Upstate South Carolina Travel Guide](https://expedia.ca/Upstate-South-Carolina.dx6057939)[Hotels in Upstate South Carolina](https://expedia.ca/Upstate-South-Carolina-Hotels.d6057939.Travel-Guide-Hotels)[Vacation Rentals in Upstate South Carolina](https://expedia.ca/Upstate-South-Carolina-Vacation-Rentals.d6057939.Travel-Guide-VacationRentals)[Flights to Upstate South Carolina](https://expedia.ca/Cheap-Flights-To-Upstate-South-Carolina.d6057939.Travel-Guide-Flights)[Things to do in Upstate South Carolina](https://expedia.ca/Things-To-Do-In-Upstate-South-Carolina.d6057939.Travel-Guide-Activities)[Upstate South Carolina Car Rentals](https://expedia.ca/Car-Rentals-In-Upstate-South-Carolina.d6057939.Car-Rental-Guide)[Upstate South Carolina Vacation Packages](https://expedia.ca/Upstate-South-Carolina.d6057939.Destination-Travel-Guides) ![Greenville - Spartanburg featuring mountains, views and a sunset](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/63000/63748-Greenville-Spartanburg.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Hotels by Motel 6 in Upstate South Carolina from CA $78 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Oct 23 - Oct 24](https://www.expedia.ca/Hotel-Search?regionId=6057939&startDate=2025-10-23&endDate=2025-10-24&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 24 - Oct 25](https://www.expedia.ca/Hotel-Search?regionId=6057939&startDate=2025-10-24&endDate=2025-10-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=6057939&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=6057939&startDate=2025-10-31&endDate=2025-11-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Upstate South Carolina Motel 6 Hotels ![Fridge, microwave, freezer](https://images.trvl-media.com/lodging/2000000/1110000/1107500/1107497/af5363f6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1110000/1107500/1107497/4afc3716.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/2000000/1110000/1107500/1107497/6b163cf5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/2000000/1110000/1107500/1107497/5937e004.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 Greenville, SC Greenville 5.0/10 (654) "Very clean rooms wonderful staff, lot of nearby shops and restaurants to chose from " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Natalie CA $68 CA $78 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Greenville-Hotels-Motel-6-Greenville.h1107497.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/37000000/36830000/36824600/36824597/6f7f191d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, free WiFi](https://images.trvl-media.com/lodging/37000000/36830000/36824600/36824597/c95d1422.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee service](https://images.trvl-media.com/lodging/37000000/36830000/36824600/36824597/4b514a45.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/37000000/36830000/36824600/36824597/450de68d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 Greenville, SC - I-85 Near Downtown Greenville 6.8/10 (310) "The staff at the front desk was irnjoyable and fun to talk to! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Heidy CA $78 CA $86 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Greenville-Spartanburg-Hotels-Motel-6-Greenville.h36824597.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/330000/328900/328810/085635e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/1000000/330000/328900/328810/837914fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/1000000/330000/328900/328810/0200d1b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Flat-screen TV](https://images.trvl-media.com/lodging/1000000/330000/328900/328810/c5cb4bb2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 Simpsonville, SC - Greenville Simpsonville 7.2/10 Good (341) "Checkin and Checkout procedures were very straightforward, especially with advanced booking through Expedia." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) David CA $98 CA $108 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Simpsonville-Hotels-Motel-6-Simpsonville.h328810.Hotel-Information) ![Desk, laptop workspace, blackout drapes, free WiFi](https://images.trvl-media.com/lodging/104000000/103060000/103059200/103059155/38900136.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Laundry room](https://images.trvl-media.com/lodging/104000000/103060000/103059200/103059155/dca35443.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/104000000/103060000/103059200/103059155/b09ac693.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Combined shower/tub, towels, soap, toilet paper](https://images.trvl-media.com/lodging/104000000/103060000/103059200/103059155/e0b4a48f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 Spartanburg, Sc – Northwest / Business 85 Spartanburg 7.4/10 Good (68) "It’s a quiet laid back hotel with clean rooms!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Terrence CA $102 CA $113 total includes taxes & fees Oct 26 - Oct 27 [](https://www.expedia.ca/Spartanburg-Hotels-Motel-6-Spartanburg.h103059155.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-06&endDate=2025-11-07®ionId=6057939&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FUpstate-South-Carolina-Hotels-Motel-6.0-0-d6057939--bMotel6.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FUpstate-South-Carolina-Hotels-Motel-6.0-0-d6057939--bMotel6.Travel-Guide-Filter-Hotels) ## Top Upstate South Carolina Hotel Reviews ![Comfort Suites Greenville Airport](//images.trvl-media.com/lodging/47000000/46120000/46116400/46116309/9d9a99c3_y.jpg) ### Comfort Suites Greenville Airport 10/10 Excellent "Great stay! Clean rooms, very nice and quiet. We were on the top floor and a few planes flying over were loud in the evening and late morning, but it lasted only a few seconds and there were minimal planes. Would stay here again for sure! (Love having a sofa to sit on!)" [](https://expedia.ca/Greenville-Spartanburg-Hotels-Comfort-Suites.h46116309.Hotel-Information) ![Drury Inn & Suites Greenville](//images.trvl-media.com/lodging/2000000/1540000/1533500/1533439/6d7853ae_y.jpg) ### Drury Inn & Suites Greenville 10/10 Excellent "kickback - clean - convenient - safe" [](https://expedia.ca/Greenville-Hotels-Drury-Inn-Suites-Greenville.h1533439.Hotel-Information) ![Wingate by Wyndham - Greenville-Airport](//images.trvl-media.com/lodging/1000000/50000/43500/43464/a55a98c9_y.jpg) ### Wingate by Wyndham - Greenville-Airport 10/10 Excellent "Very clean very quiet nice staff " [](https://expedia.ca/Greenville-Hotels-Wingate-By-Wyndham-Greenville-Airport.h43464.Hotel-Information) ![Embassy Suites Greenville Golf Resort & Conference Center](//images.trvl-media.com/lodging/1000000/10000/3300/3223/31b0d05e_y.jpg) ### Embassy Suites Greenville Golf Resort & Conference Center 10/10 Excellent "I feel safe. " [](https://expedia.ca/Greenville-Hotels-Embassy-Suites-Greenville-Golf-Resort-Conference-Center.h3223.Hotel-Information) ![Hyatt Regency Greenville](//images.trvl-media.com/lodging/1000000/30000/22300/22252/fa37e256_y.jpg) ### Hyatt Regency Greenville 10/10 Excellent "Everything was awesome." [](https://expedia.ca/Greenville-Hotels-Hyatt-Regency-Greenville.h22252.Hotel-Information) ![Comfort Inn Greenville - Haywood Mall](//images.trvl-media.com/lodging/1000000/30000/25000/24994/6e5638cc_y.jpg) ### Comfort Inn Greenville - Haywood Mall 10/10 Excellent "Good condition. Nice room. Good breakfast. Nice lobby. Descent gym." [](https://expedia.ca/Greenville-Hotels-Comfort-Inn-Greenville-Haywood-Mall.h24994.Hotel-Information) ![Hilton Greenville](//images.trvl-media.com/lodging/1000000/30000/23200/23172/401b294d_y.jpg) ### Hilton Greenville 10/10 Excellent "Clean rooms, friendly staff, no room service contact, no TV internet, comfortable bed, nice big bathroom. I wish room service would answer their phone." [](https://expedia.ca/Greenville-Hotels-Hilton-Greenville.h23172.Hotel-Information) ![Urban Boutique Hotel, BW Signature Collection](//images.trvl-media.com/lodging/1000000/30000/24400/24334/f974826b_y.jpg) ### Urban Boutique Hotel, BW Signature Collection 10/10 Excellent "Location and affordability describe this hotel best. Located within a 5 minute drive to downtown Greenville makes this a great place to stay. Great rate makes it the hotel to choose. It was clean and had a nice breakfast. The only con for me was that the mattress was like a marshmallow. I did sleep well though. I will return here when visiting Greenville again." [](https://expedia.ca/Greenville-Hotels-Urban-Boutique-Hotel.h24334.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Greenville Haywood](//images.trvl-media.com/lodging/1000000/170000/165800/165759/89ed0b3d_y.jpg) ### La Quinta Inn & Suites by Wyndham Greenville Haywood 10/10 Excellent "Was ok,I could come back again" [](https://expedia.ca/Greenville-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Greenville-Haywood.h165759.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - More ways to book - [Best Western Hotels in Aiken](https://www.expedia.ca/Aiken-Hotels-Best-Western.0-0-d6058112--bBestWestern.Travel-Guide-Filter-Hotels) - [Motel 6 Hotels in Brookhaven](https://www.expedia.ca/Brookhaven-Hotels-Motel-6.0-0-d553248635975852330--bMotel6.Travel-Guide-Filter-Hotels) - [Starwood Capital Hotels in Central](https://www.expedia.ca/Central-Hotels-Starwood-Capital.0-0-d10503--bStarwoodCapital.Travel-Guide-Filter-Hotels) - [Motel 6 Hotels in Clover](https://www.expedia.ca/Clover-Hotels-Motel-6.0-0-d3000455892--bMotel6.Travel-Guide-Filter-Hotels) - 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[Flights from New Orleans (MSY) to Greenville (GMU)](https://www.expedia.ca/lp/flights/msy/gmu/new-orleans-to-greenville) - [Flights from Chicago (ORD) to Greenville (GDC)](https://www.expedia.ca/lp/flights/ord/gdc/chicago-to-greenville) - [Flights from Norfolk (ORF) to Greenville (GMU)](https://www.expedia.ca/lp/flights/orf/gmu/norfolk-to-greenville) - [Flights from West Palm Beach (PBI) to Greenville (GMU)](https://www.expedia.ca/lp/flights/pbi/gmu/west-palm-beach-to-greenville) - [Flights from Philadelphia (PHL) to Greenville (GMU)](https://www.expedia.ca/lp/flights/phl/gmu/philadelphia-to-greenville) - [Flights from Portland (PWM) to Greenville (GMU)](https://www.expedia.ca/lp/flights/pwm/gmu/portland-to-greenville) - [Flights from Raleigh (RDU) to Greenville (GMU)](https://www.expedia.ca/lp/flights/rdu/gmu/raleigh-to-greenville) - [Flights from Rocky Mount (RWI) to Greenville (GMU)](https://www.expedia.ca/lp/flights/rwi/gmu/rocky-mount-to-greenville) - [Flights from San Antonio (SAT) to Greenville (GDC)](https://www.expedia.ca/lp/flights/sat/gdc/san-antonio-to-greenville) - [Flights from Savannah (SAV) to Greenville (GMU)](https://www.expedia.ca/lp/flights/sav/gmu/savannah-to-greenville) - [Flights from Schenectady (SCH) to Greenville (GMU)](https://www.expedia.ca/lp/flights/sch/gmu/schenectady-to-greenville) - [Flights from Louisville (SDF) to Greenville (GMU)](https://www.expedia.ca/lp/flights/sdf/gmu/louisville-to-greenville) - [Flights from Sanford (SFM) to Greenville (GMU)](https://www.expedia.ca/lp/flights/sfm/gmu/sanford-to-greenville) - [Flights from Newburgh (SWF) to Greenville (GMU)](https://www.expedia.ca/lp/flights/swf/gmu/newburgh-to-greenville) - [Flights from Montreal (YUL) to Greenville (GMU)](https://www.expedia.ca/lp/flights/yul/gmu/montreal-to-greenville) - [Flights from Vancouver (YVR) to Greenville (GMU)](https://www.expedia.ca/lp/flights/yvr/gmu/vancouver-to-greenville) - [Flights from Toronto (YYZ) to Greenville (GDC)](https://www.expedia.ca/lp/flights/yyz/gdc/toronto-to-greenville) - [Flights from Toronto (YYZ) to Greenville (GMU)](https://www.expedia.ca/lp/flights/yyz/gmu/toronto-to-greenville) - [7th Inning Splash Waterpark](https://www.expedia.ca/7th-Inning-Splash-Waterpark-Piedmont.d553248621532656702.Vacation-Attraction) - [Central Vacations](https://www.expedia.ca/Central.d10503.Destination-Travel-Guides) - [Discovery Island Water Park](https://www.expedia.ca/Discovery-Island-Water-Park-Greenville.d553248621532656705.Vacation-Attraction) - [Frankie's Fun Park](https://www.expedia.ca/Frankies-Fun-Park-Greenville.d553248621532656780.Vacation-Attraction) - [Mauldin Vacations](https://www.expedia.ca/Mauldin.d183944.Destination-Travel-Guides) - [Prisma Health Greenville Memorial Hospital](https://www.expedia.ca/Prisma-Health-Greenville-Memorial-Hospital-Greenville.d553248635941390934.Vacation-Attraction) - [Terrace Shopping Center](https://www.expedia.ca/Terrace-Shopping-Center-Greenville.d553248621563220413.Vacation-Attraction) - [Car rentals near Prisma Health Greenville Memorial Hospital](https://www.expedia.ca/Car-Rentals-In-Prisma-Health-Greenville-Memorial-Hospital.d553248635941390934.Car-Rental-Guide) - [Book Motel 6 in Upstate South Carolina on Expedia.com](https://www.expedia.com/Upstate-South-Carolina-Hotels-Motel-6.0-0-d6057939--bMotel6.Travel-Guide-Filter-Hotels)