Title: Hotels by Motel 6 in Upstate South Carolina from CA $86 | Expedia.ca [Upstate South Carolina Travel Guide](https://expedia.ca/Upstate-South-Carolina.dx553248635975748552)[Hotels in Upstate South Carolina](https://expedia.ca/Upstate-South-Carolina-Hotels.d553248635975748552.Travel-Guide-Hotels)[Vacation Rentals in Upstate South Carolina](https://expedia.ca/Upstate-South-Carolina-Vacation-Rentals.d553248635975748552.Travel-Guide-VacationRentals)[Flights to Upstate South Carolina](https://expedia.ca/Cheap-Flights-To-Upstate-South-Carolina.d553248635975748552.Travel-Guide-Flights)[Things to do in Upstate South Carolina](https://expedia.ca/Things-To-Do-In-Upstate-South-Carolina.d553248635975748552.Travel-Guide-Activities)[Upstate South Carolina Car Rentals](https://expedia.ca/Car-Rentals-In-Upstate-South-Carolina.d553248635975748552.Car-Rental-Guide)[Upstate South Carolina Vacation Packages](https://expedia.ca/Upstate-South-Carolina.d553248635975748552.Destination-Travel-Guides) ![Greenville - Spartanburg featuring mountains, views and a sunset](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/63000/63748-Greenville-Spartanburg.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Hotels by Motel 6 in Upstate South Carolina from CA $86 ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Sep 28 - Sep 29](https://www.expedia.ca/Hotel-Search?regionId=553248635975748552&startDate=2025-09-28&endDate=2025-09-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Sep 29 - Sep 30](https://www.expedia.ca/Hotel-Search?regionId=553248635975748552&startDate=2025-09-29&endDate=2025-09-30&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 3 - Oct 5](https://www.expedia.ca/Hotel-Search?regionId=553248635975748552&startDate=2025-10-03&endDate=2025-10-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=553248635975748552&startDate=2025-10-10&endDate=2025-10-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Upstate South Carolina Motel 6 Hotels ![Exterior](https://images.trvl-media.com/lodging/37000000/36830000/36824600/36824597/6f7f191d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee service](https://images.trvl-media.com/lodging/37000000/36830000/36824600/36824597/4b514a45.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout drapes, free WiFi](https://images.trvl-media.com/lodging/37000000/36830000/36824600/36824597/c95d1422.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/37000000/36830000/36824600/36824597/450de68d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 Greenville, SC - I-85 Near Downtown Greenville 6.8/10 (302) "Good service fairly clean good price close to our places of interest friendly " CA $78 CA $86 total includes taxes & fees Oct 1 - Oct 2 [](https://www.expedia.ca/Greenville-Spartanburg-Hotels-Motel-6-Greenville.h36824597.Hotel-Information) ![Desk, laptop workspace, blackout drapes, free WiFi](https://images.trvl-media.com/lodging/104000000/103060000/103059200/103059155/38900136.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Laundry room](https://images.trvl-media.com/lodging/104000000/103060000/103059200/103059155/dca35443.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/104000000/103060000/103059200/103059155/b09ac693.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/104000000/103060000/103059200/103059155/de407ae3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 Spartanburg, Sc – Northwest / Business 85 Spartanburg 7.4/10 Good (68) "It’s a quiet laid back hotel with clean rooms!" CA $107 CA $119 total includes taxes & fees Sep 30 - Oct 1 [](https://www.expedia.ca/Spartanburg-Hotels-Motel-6-Spartanburg.h103059155.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/330000/328900/328810/085635e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/1000000/330000/328900/328810/0200d1b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/330000/328900/328810/19e62b14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Flat-screen TV](https://images.trvl-media.com/lodging/1000000/330000/328900/328810/c5cb4bb2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 Simpsonville, SC - Greenville Simpsonville 7.2/10 Good (340) "Checkin and Checkout procedures were very straightforward, especially with advanced booking through Expedia." CA $98 CA $107 total includes taxes & fees Sep 30 - Oct 1 [](https://www.expedia.ca/Simpsonville-Hotels-Motel-6-Simpsonville.h328810.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-13&endDate=2025-10-14®ionId=553248635975748552&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FUpstate-South-Carolina-Hotels-Motel-6.0-0-d553248635975748552--bMotel6.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FUpstate-South-Carolina-Hotels-Motel-6.0-0-d553248635975748552--bMotel6.Travel-Guide-Filter-Hotels) ## Top Upstate South Carolina Hotel Reviews ![Hampton Inn & Suites Greenville Airport, SC](//images.trvl-media.com/lodging/12000000/11920000/11919200/11919192/de1bb5e2_y.jpg) ### Hampton Inn & Suites Greenville Airport, SC 10/10 Excellent "Check in was quick and easy, and the entire place was clean and tidy. The bed was very comfortable." [](https://expedia.ca/Greenville-Hotels-Hampton-Inn-Suites-Greenville-Airport.h11919192.Hotel-Information) ![Drury Inn & Suites Greenville](//images.trvl-media.com/lodging/2000000/1540000/1533500/1533439/6d7853ae_y.jpg) ### Drury Inn & Suites Greenville 10/10 Excellent "Very Clean and staff was very polite." [](https://expedia.ca/Greenville-Hotels-Drury-Inn-Suites-Greenville.h1533439.Hotel-Information) ![Comfort Suites Greenville Airport](//images.trvl-media.com/lodging/47000000/46120000/46116400/46116309/9d9a99c3_y.jpg) ### Comfort Suites Greenville Airport 10/10 Excellent "Clean comfortable room" [](https://expedia.ca/Greenville-Spartanburg-Hotels-Comfort-Suites.h46116309.Hotel-Information) ![Woodspring Suites Greenville Airport](//images.trvl-media.com/lodging/115000000/114590000/114583600/114583570/69b6f44b_y.jpg) ### Woodspring Suites Greenville Airport 10/10 Excellent "Great location and very secure property" [](https://expedia.ca/Greenville-Hotels-Woodspring-Suites-Greenville-Airport.h114583570.Hotel-Information) ![The Shepherd Hotel Downtown Clemson](//images.trvl-media.com/lodging/88000000/87690000/87688200/87688155/8f34da45_y.jpg) ### The Shepherd Hotel Downtown Clemson 10/10 Excellent "Everything! Beautiful, convenient and wonderful staff!" [](https://expedia.ca/Clemson-Hotels-The-Shepherd-Hotel-Downtown-Clemson.h87688155.Hotel-Information) ![Hyatt Regency Greenville](//images.trvl-media.com/lodging/1000000/30000/22300/22252/fa37e256_y.jpg) ### Hyatt Regency Greenville 10/10 Excellent "Nice easy walk to bon seCour center" [](https://expedia.ca/Greenville-Hotels-Hyatt-Regency-Greenville.h22252.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Greenville Haywood](//images.trvl-media.com/lodging/1000000/170000/165800/165759/89ed0b3d_y.jpg) ### La Quinta Inn & Suites by Wyndham Greenville Haywood 10/10 Excellent "Great VALUE and great room. " [](https://expedia.ca/Greenville-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Greenville-Haywood.h165759.Hotel-Information) ![Best Western Plus Greenville I-385 Inn & Suites](//images.trvl-media.com/lodging/1000000/30000/23100/23003/20a0c66a_y.jpg) ### Best Western Plus Greenville I-385 Inn & Suites 10/10 Excellent "Highly recommended Really good value for money " [](https://expedia.ca/Greenville-Hotels-Best-Western-Plus-Greenville-I-385-Inn-Suites.h23003.Hotel-Information) ![Embassy Suites Greenville Golf Resort & Conference Center](//images.trvl-media.com/lodging/1000000/10000/3300/3223/31b0d05e_y.jpg) ### Embassy Suites Greenville Golf Resort & Conference Center 10/10 Excellent "Golf Clean rooms Staff was awesome Beautiful property " [](https://expedia.ca/Greenville-Hotels-Embassy-Suites-Greenville-Golf-Resort-Conference-Center.h3223.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - More ways to book - [Anglewood Hotels](https://www.expedia.ca/Anglewood-Hotels.d553248635975857985.Travel-Guide-Hotels) - 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