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Check prices for these dates

Next weekend
Nov 13 - Nov 15
In two weeks
Nov 20 - Nov 22
In one month
Dec 4 - Dec 6
In two months
Jan 1 - Jan 3
No exact matches found, but these alternatives could be just right

Recommended hotels in St. Charles

A red building with a sign reading "FEED MILL Stone Mill Hotel & Suites" and a "VACANCY" sign.

1. Stone Mill Hotel & Suites

Stone Mill Hotel & Suites
3.0 star property
Lanesboro
9.6 out of 10, Exceptional, (730 reviews)
"It was a very quaint small town Inn. It reminded me of a Bed and Breakfast. Very comfortable room and nice Restraunts walking distance from the hotel."
United States
Shari
The price is CA $147
CA $158 total
includes taxes & fees
Nov 15 - Nov 16
Stone Mill Hotel & Suites
A hotel with a covered entrance, multiple floors, and a parking lot.

2. Spark by Hilton Rochester South

Spark by Hilton Rochester South
3.0 star property
Rochester
9.2 out of 10, Wonderful, (605 reviews)
"Clean room Staff very accommodating Hot coffee and breakfast."
United States
Stanton
The price is CA $95
CA $109 total
includes taxes & fees
Nov 22 - Nov 23
Spark by Hilton Rochester South
A Comfort Inn & Suites hotel with a modern design, featuring a prominent signage and a parking lot.

3. Comfort Inn & Suites Rochester South Mayo Clinic

Comfort Inn & Suites Rochester South Mayo Clinic
2.0 star property
Rochester
8.8 out of 10, Excellent, (1,008 reviews)
"Great place to stay."
United States
LeeAnn
The price is CA $107
CA $123 total
includes taxes & fees
Dec 6 - Dec 7
Comfort Inn & Suites Rochester South Mayo Clinic
A Holiday Inn Express building with a stone facade and illuminated signage.

4. Holiday Inn Express Rochester South - Mayo Area by IHG

Holiday Inn Express Rochester South - Mayo Area by IHG
2.5 star property
Rochester
8.8 out of 10, Excellent, (1,000 reviews)
"Nice location, easy access and good breakfast."
United States
Rick
The price is CA $121
CA $139 total
includes taxes & fees
Nov 14 - Nov 15
Holiday Inn Express Rochester South - Mayo Area by IHG
A Conoco Lodge building with a beige facade, red trim, and a prominent red logo.

5. Econo Lodge Mayo Clinic Area

Econo Lodge Mayo Clinic Area
2.0 star property
Rochester
9.0 out of 10, Wonderful, (1,005 reviews)
"This was a very nice place to stay. It felt cozy, warm.... walking distance to a Perkins. Loved it."
United States
Lorraine
The price is CA $97
CA $112 total
includes taxes & fees
Dec 4 - Dec 5
Econo Lodge Mayo Clinic Area
A La Quinta Inn & Suites hotel with a well-lit entrance, a parking area, and a clear view of the building's facade.

6. La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
3.0 star property
Rochester
7.6 out of 10, Good, (1,059 reviews)
"The property was very reasonable in price. It was also very clean and staff very helpful."
United States
Lavon
The price is CA $101
CA $116 total
includes taxes & fees
Nov 15 - Nov 16
La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S
A hotel with a large sign for American Inn by Wyndham, a parking lot, and a building with a modern design.

7. AmericInn by Wyndham Rochester Near Mayo Clinic

AmericInn by Wyndham Rochester Near Mayo Clinic
3.0 star property
Rochester
8.2 out of 10, Very good, (1,600 reviews)
"Was a quick and comfortable stay."
United States
Tammy
The price is CA $102
CA $118 total
includes taxes & fees
Dec 7 - Dec 8
AmericInn by Wyndham Rochester Near Mayo Clinic
A two-story house with a porch and a covered entryway.

8. The Wen Inn formerly Andor Wenneson

The Wen Inn formerly Andor Wenneson
3.0 star property
Peterson
9.6 out of 10, Exceptional, (101 reviews)
"Very nice stay! I look forward to staying at your place again."
United States
Daniel
The price is CA $148
CA $161 total
includes taxes & fees
Nov 11 - Nov 12
The Wen Inn formerly Andor Wenneson
A brick building with a covered entrance, a wheelchair-accessible ramp, and a parking lot.

9. Quality Inn & Suites Mayo Clinic Area

Quality Inn & Suites Mayo Clinic Area
2.5 star property
Rochester
8.8 out of 10, Excellent, (971 reviews)
"Nice location, staff very helpful and friendly, and nice big room"
United States
Mark
The price is CA $93
CA $109 total
includes taxes & fees
Nov 28 - Nov 29
Quality Inn & Suites Mayo Clinic Area
A multi-story hotel with a grey and orange facade, a covered entrance, and a parking lot with marked spaces.

10. Super 8 by Wyndham Rochester Mayo Clinic Area

Super 8 by Wyndham Rochester Mayo Clinic Area
2.0 star property
Rochester
7.8 out of 10, Good, (1,001 reviews)
"The staff was very friendly and helpful, I will definitely stay there again. The room was very clean."
United States
Rick
The price is CA $71
CA $82 total
includes taxes & fees
Nov 29 - Nov 30
Super 8 by Wyndham Rochester Mayo Clinic Area
A modern hotel building with a prominent sign for 'Hotel Indigo.'

11. Hotel Indigo Rochester – Mayo Clinic Area by IHG

Hotel Indigo Rochester – Mayo Clinic Area by IHG
3.5 star property
Downtown Rochester
8.8 out of 10, Excellent, (1,000 reviews)
"This was a nice hotel with a great location. There were several bars and restaurants within walking distance."
United States
Kathleen
The price is CA $137
CA $158 total
includes taxes & fees
Nov 28 - Nov 29
Hotel Indigo Rochester – Mayo Clinic Area by IHG
A hotel with a parking lot, several cars, and a large building with a Days Inn sign.

12. Days Inn by Wyndham Winona

Days Inn by Wyndham Winona
2.0 star property
Winona
7.6 out of 10, Good, (1,001 reviews)
"clean rooms and nice breakfast"
United States
William
The price is CA $92
CA $102 total
includes taxes & fees
Dec 7 - Dec 8
Days Inn by Wyndham Winona
A Comfort Inn hotel with a stone facade, a covered entrance, and a parking area.

13. Comfort Inn & Suites West - Medical Center

Comfort Inn & Suites West - Medical Center
3.0 star property
Rochester
8.8 out of 10, Excellent, (668 reviews)
"The room was very clean and the beds were comfortable. Breakfast was good with lots of options."
United States
Tammy
The price is CA $113
CA $131 total
includes taxes & fees
Nov 28 - Nov 29
Comfort Inn & Suites West - Medical Center
A multi-story hotel with a covered entrance and outdoor seating area.

14. Country Trails Inn & Suites

Country Trails Inn & Suites
2.0 star property
Preston
9.4 out of 10, Exceptional, (164 reviews)
"Very nice place to stay."
United States
Jeannie
The price is CA $177
CA $196 total
includes taxes & fees
Dec 6 - Dec 7
Country Trails Inn & Suites
Front of property

15. Birch Hill Suite Rochester – Med City

Birch Hill Suite Rochester – Med City
2.5 star property
Rochester
7.6 out of 10, Good, (100 reviews)
"Room was clean and a functional kitchen with 2 burners and a full size fridge. Staff was exceptional and accommodating. Very helpful staff."
United States
Chuck
The price is CA $81
CA $94 total
includes taxes & fees
Nov 12 - Nov 13
Birch Hill Suite Rochester – Med City
A wooden cabin with a porch, two chairs, and a door.

16. Tiny Treehouse Cabin | Bluff Woodlands #2

Tiny Treehouse Cabin | Bluff Woodlands #2
Elba
9.8 out of 10, Exceptional, (17 reviews)
"Beautiful area enjoyed our stay immensely"
United Kingdom
I.M l.
The price is CA $173
CA $267 total
includes taxes & fees
Nov 19 - Nov 20
Tiny Treehouse Cabin | Bluff Woodlands #2
A Sleep Inn hotel with a covered entrance, stone pillars, and a clear blue sky.

17. Sleep Inn & Suites West-Near Medical Center

Sleep Inn & Suites West-Near Medical Center
2.5 star property
Rochester
9.0 out of 10, Wonderful, (726 reviews)
"Just a pleasant hotel a few hours from NYC"
United States
Christopher
The price is CA $108
CA $124 total
includes taxes & fees
Nov 28 - Nov 29
Sleep Inn & Suites West-Near Medical Center
A two-story building with a flat roof, large windows, and balconies.

18. Baymont by Wyndham Rochester Mayo Clinic Area

Baymont by Wyndham Rochester Mayo Clinic Area
2.5 star property
Rochester
7.0 out of 10, Good, (846 reviews)
"Basic place"
United States
Scottie
The price is CA $86
CA $100 total
includes taxes & fees
Nov 22 - Nov 23
Baymont by Wyndham Rochester Mayo Clinic Area
A modern Hyatt House hotel with a prominent 'Hyatt House' sign, multiple floors, and a parking garage.

19. Hyatt House Rochester/Mayo Clinic Area

Hyatt House Rochester/Mayo Clinic Area
3.0 star property
Downtown Rochester
9.0 out of 10, Wonderful, (1,002 reviews)
"Nice stay"
United States
Arlan
The price is CA $157
CA $181 total
includes taxes & fees
Nov 28 - Nov 29
Hyatt House Rochester/Mayo Clinic Area
A Hampton Inn hotel with a clear entrance, parking lot, and American flag.

20. Hampton Inn Rochester-South

Hampton Inn Rochester-South
2.5 star property
Rochester
9.0 out of 10, Wonderful, (1,000 reviews)
"Great stay"
United States
Susan
The price is CA $137
CA $158 total
includes taxes & fees
Nov 29 - Nov 30
Hampton Inn Rochester-South
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about St. Charles

St. Charles awaits: its natural setting and more!

See all hotels in St. Charles
An aerial view of a town with industrial buildings, roads, and green areas.

Top reviews in St. Charles

A hotel with a covered entrance, multiple floors, and a parking lot.
Spark by Hilton Rochester South

Spark by Hilton Rochester South

Spark by Hilton Rochester South
Rochester

10/10 Excellent

Clean, new hotel within walking distance of restaurants, stores and a theatre.
Canada
Kimberly
Reviewed August 16, 2026
Spark by Hilton Rochester South

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