South Main Vacation Packages
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Top Holiday Package Deals in South Main
Price found within the past 48 hours. Click for updated prices.
Experience a First Class Stay - 2 BDRM
CA $913
per person
Oct 22 - Oct 25
found 16 hours ago
Roundtrip non-stop flight included
Toronto (YTO) to Houston (IAH)
8/10 Very good! (5 reviews)
This people have water that smells like poop. Sewage water is what they use for water. Remnants of trash, sticky nastiness in drawers, air vents falling off ceilings. Random kids belts found? Candy stuck to floor? Trash wasn’t even taken out. Mind you I have kids that found these things as well.
Oh and don’t even try and ask for them to refund you for their disgusting rental. They will give you the run around and then IGNORE YOU. Awful establishment and these people NEED TO BE SHUTDOWN.
Reviewed on Mar 11, 2022
Where to stay in South Main
Find the best South Main areas and neighborhoods for the activities you enjoy most. Learn more about South Main
Downtown Houston
3 out of top 10 points of interest in this area
Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.
The Galleria
Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Gerald D. Hines Waterwall Park.
Texas Medical Center
1 out of top 10 points of interest in this area
Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.
Montrose
Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.
South Main Hotel Deals
Wyndham Houston at Reliant Park & Medical Center
8686 Kirby Drive Houston TX
Fully refundableReserve now, pay when you stay
CA $115
CA $134 total
Sep 27 - Sep 28
includes taxes & fees
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
5353 Westheimer Rd Houston TX
Fully refundableReserve now, pay when you stay
CA $166
CA $195 total
Sep 22 - Sep 23
includes taxes & fees
8.4/10 Very good! (4,518 reviews)
"The breakfast buffet was amazing, the best I've had ever."
Reviewed on Sep 20, 2026
Hotel Zaza Houston Museum District
5701 Main Street Houston TX
Fully refundableReserve now, pay when you stay
CA $333
CA $455 total
Sep 25 - Sep 26
includes taxes & fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
How much does a South Main vacation package cost?
Get set to book, because a getaway to South Main starts from an enticing CA $604. When you combine your flights, hotels and more into a travel package, you'll walk away with the best bargains.
How do I get a cheap travel package to South Main?
You'll save tons of cash if you bundle your car rentals, hotels and flights into a South Main vacation package. Sometimes cheap means fewer options. But that's not the case with Expedia. We offer over 550 airlines and 1,000,000 hotels across the globe, which means you'll always have plenty of variety to choose from. Like to save even more? Add some interesting activities to your package deal to unlock even bigger bargains! After all, travel is about more than just getting to your destination.
Where should I stay in South Main?
Book a hotel within walking distance of Houston Zoo, one of this neighborhood's most popular attractions. It's the perfect spot if you're an eager sightseer.
What are the top hotels in South Main?
Get your trip off to a fantastic start by booking a stay at Travelers Dream 1bd 1 Bath Getaway. It's one of most popular hotels in South Main. Another welcoming option is Luxury King And Queen 1bedroom Suite | Nrg Stadium | Medical Ctr | Galleria | Downtown.
How far in advance should I book my South Main vacation?
It all depends on the air carrier, but you can usually browse through international airfares on Expedia nearly a year in advance. While it's a good idea to book ahead of time, lucky customers occasionally find a cheaper seat just weeks before the date of departure.
What does an Expedia South Main travel package include?
Flights, car rentals and hotels — we bring you all the best deals. All you have to do is figure out your favorite combination. Once you've made your booking, you can add on the exciting stuff like sightseeing activities. Our travel packages make it easy to customize an unforgettable South Main vacation.
What should I know before booking a South Main travel package?
You can save big by bundling your hotels, airfares and rental cars. Once you've made your booking, you can add on things like sightseeing tours or experiences. Your next unforgettable adventure is only a couple of clicks away.
Can I choose my airline with a South Main Expedia vacation package?
You certainly can. Expedia has access to more than 550 airline partners around the world, so fly with the carrier that best suits your needs.
If I'm not able to travel, can I cancel my South Main vacation package?
It's hard to predict what the future holds, so it's comforting to know that you can change or cancel your South Main vacation package. If you made your booking in the last 24 hours, you may be entitled to a refund. If it's an older booking, your airline, hotel or car rental company may charge a fee. Visit our Customer Service Portal to learn more.
Things to do
Houston: Space Center Houston Admission Ticket
CA $41
per adult
92% of travellers recommend
NASA's Space Center & Official Houston City Tour with tickets
CA $137
per adult
92% of travellers recommend
Houston: Guided City Tour by an Open-Top Double Decker Bus
CA $55
per adult
98% of travellers recommend
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.