Title: Visit South Main: Best of South Main, Houston Travel 2026 | Expedia Tourism - Expedia.ca [Hotels in South Main](https://expedia.ca/South-Main-Houston-Hotels.0-n553248635976386992-0.Travel-Guide-Filter-Hotels)[Flights to Houston](https://expedia.ca/Cheap-Flights-To-Houston.d178265.Travel-Guide-Flights)[Things to do in Houston](https://expedia.ca/Things-To-Do-In-Houston.d178265.Travel-Guide-Activities)[South Main Car Rentals](https://expedia.ca/Car-Rentals-In-South-Main.d553248635976386992.Car-Rental-Guide)[South Main Vacations](https://expedia.ca/South-Main.d553248635976386992.Destination-Travel-Guides) # South Main ## Houston ![Photo by Hazem Abdul](https://mediaim.expedia.com/destination/2/7fff8623dc31b090fdc6a6747a27a07c.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) [Photo by Hazem Abdul](https://mediaim.expedia.com/destination/2/7fff8623dc31b090fdc6a6747a27a07c.jpg) ## Visit South Main Things to do Hotels Where to stay [Houston travel guide](https://expedia.ca/Houston.dx178265) --- ### Popular places to visit ![George R. Brown Convention Center](https://mediaim.expedia.com/destination/2/d04fae4d31850e974d4d299ace52c216.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### George R. Brown Convention Center During your trip, find out what's happening at George R. Brown Convention Center, a top convention center in Houston. Experience the great live music and acclaimed theater scene in this vibrant area. [](https://expedia.ca/George-R-Brown-Convention-Center-Houston.d501247.Vacation-Attraction) ![NASA Johnson Space Center](https://mediaim.expedia.com/destination/1/54ef7ea440c4f30ef13fae830868d608.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### NASA Johnson Space Center After visiting NASA Johnson Space Center, make a plan to see the other sights and activities in Houston. Amble around the area's lakeside or attend a sporting event. [](https://expedia.ca/NASA-Johnson-Space-Center-Nassau-Bay.d501253.Vacation-Attraction) ![Rice University](https://mediaim.expedia.com/destination/9/e1b2db4673636b6abeace7c5db8994c8.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Rice University Enjoy the collegiate vibe around Rice University, a top university in Houston. Experience the area's acclaimed art scene and great live music. [](https://expedia.ca/Rice-University-Houston.d501268.Vacation-Attraction) ![Daikin Park](https://mediaim.expedia.com/destination/2/b967bdea9a04899a32a85434bcd258b4.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Daikin Park Catch an event at Daikin Park during your trip to Houston. Experience the acclaimed art scene and lively festivals in this vibrant area. [](https://expedia.ca/Daikin-Park-Downtown-Houston.d6034772.Vacation-Attraction) ![Space Center Houston](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/508000/508218-space-center-houston.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Space Center Houston This iconic “mission control” was immortalized for its role in the first moon landing. [](https://expedia.ca/Space-Center-Houston-Nassau-Bay.d6163111.Vacation-Attraction) ![Toyota Center](https://mediaim.expedia.com/destination/2/04a239602208954e530d98d4b190cb5c.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Toyota Center Catch an event at Toyota Center during your trip to Houston. Experience the acclaimed theater scene and entertainment choices in this vibrant area. [](https://expedia.ca/Toyota-Center-Downtown-Houston.d6082241.Vacation-Attraction) ### Things to do ![Houston Space Center](https://mediaim.expedia.com/localexpert/1341309/02135dd9-3195-40c1-a500-25efe978e608.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Space Center Houston Admission Ticket CA $45 per adult **92%** of travellers recommend [](https://expedia.ca/things-to-do/space-center-houston-admission-ticket.a1341309.activity-details) ![Houston Museum of Natural Sciences: Planetarium Ticket](https://mediaim.expedia.com/localexpert/44640654/aacb07df-d3b1-4df6-8ffe-1f57d958b987.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Houston Museum of Natural Sciences: Planetarium Ticket CA $17 per adult **84%** of travellers recommend [](https://expedia.ca/things-to-do/houston-museum-of-natural-sciences-planetarium-ticket.a44640654.activity-details) ![Houston: Houston Botanic Garden Entry Ticket](https://mediaim.expedia.com/localexpert/46150646/bfc34474-c86f-4151-a485-5cc63efe2aab.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Houston: Houston Botanic Garden Entry Ticket CA $17 per adult **80%** of travellers recommend [](https://expedia.ca/things-to-do/houston-houston-botanic-garden-entry-ticket.a46150646.activity-details) ![Houston Museum of Natural Science: Cockrell Butterfly Center](https://mediaim.expedia.com/localexpert/44625315/e99bbf3b-85e6-41ea-a18a-5443204f2aef.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Houston Museum of Natural Science: Cockrell Butterfly Center CA $21 per adult **100%** of travellers recommend [](https://expedia.ca/things-to-do/houston-museum-of-natural-science-cockrell-butterfly-center.a44625315.activity-details) ![Houston: Museum of Natural Science General Admission Ticket](https://mediaim.expedia.com/localexpert/44624726/7df2f7a9-1343-48ce-acab-88df62f142d4.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Houston Museum of Natural Science General Admission Ticket CA $34 per adult **96%** of travellers recommend [](https://expedia.ca/things-to-do/houston-museum-of-natural-science-general-admission-ticket.a44624726.activity-details) ![Houston: Children's Museum Houston Entry Ticket](https://mediaim.expedia.com/localexpert/48163948/762108e4-fa0f-48eb-a447-e33069884acf.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Houston: Children's Museum Houston Entry Ticket CA $28 per adult **100%** of travellers recommend [](https://expedia.ca/things-to-do/houston-childrens-museum-houston-entry-ticket.a48163948.activity-details) [See all activities in Houston](https://expedia.ca/Things-To-Do-In-Houston.d178265.Travel-Guide-Activities) --- ## South Main Hotel Deals ![DoubleTree by Hilton Hotel & Suites Houston by the Galleria](https://images.trvl-media.com/lodging/1000000/30000/20200/20116/555244ce_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### DoubleTree by Hilton Hotel & Suites Houston by the Galleria 5353 Westheimer Rd Houston TX CA $174 CA $205 total Dec 23 - Dec 24 includes taxes & fees Stay at this hotel in Houston. Enjoy an outdoor pool, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff and the clean rooms ... 8.2/10 Very Good! (3,062 reviews) 5 stars Reviewed on Dec 11, 2025 [](https://expedia.ca/Hotel-Search?startDate=23%2F12%2F2025&endDate=24%2F12%2F2025&selected=20116&PinnedHotelID=20116&HadPinnedHotel=true®ionId=553248635976386992) ![Hotel Zaza Houston Museum District](https://images.trvl-media.com/lodging/1000000/10000/3400/3306/47c5ade4_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hotel Zaza Houston Museum District 5701 Main Street Houston TX Book a stay at this luxury aparthotel in Houston. Enjoy free WiFi, a full-service spa, and a rooftop terrace. Our guests praise the helpful staff in our reviews. ... 8.8/10 Excellent! (1,841 reviews) Best margaritas and great bar vibe! Reviewed on Dec 12, 2025 [Get rates](https://expedia.ca/Hotel-Search?startDate=30%2F12%2F2025&endDate=31%2F12%2F2025&selected=3306&PinnedHotelID=3306&HadPinnedHotel=true®ionId=553248635976386992) [](https://expedia.ca/Hotel-Search?startDate=30%2F12%2F2025&endDate=31%2F12%2F2025&selected=3306&PinnedHotelID=3306&HadPinnedHotel=true®ionId=553248635976386992) ![Club Quarters Hotel Downtown, Houston](https://images.trvl-media.com/lodging/2000000/1160000/1157000/1156923/44a9a3fd_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Club Quarters Hotel Downtown, Houston 1085 Rusk Street Houston TX CA $95 CA $111 total Dec 20 - Dec 21 includes taxes & fees Book a stay at this business-friendly hotel in Houston. Enjoy free WiFi, breakfast (surcharge), and room service. Our guests praise the restaurant and the helpful ... 8.4/10 Very Good! (3,935 reviews) Broken elevator was a slight frustration but overall, i liked the property. Reviewed on Dec 15, 2025 [](https://expedia.ca/Hotel-Search?startDate=20%2F12%2F2025&endDate=21%2F12%2F2025&selected=1156923&PinnedHotelID=1156923&HadPinnedHotel=true®ionId=553248635976386992) ![The Whitehall Houston](https://images.trvl-media.com/lodging/1000000/700000/693700/693655/f1d85056_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### The Whitehall Houston 1700 Smith St Houston TX CA $175 CA $205 total Dec 23 - Dec 24 includes taxes & fees Book a stay at this business-friendly hotel in Houston. Enjoy free WiFi, breakfast (surcharge), and a free area shuttle. Our guests praise the helpful staff ... 8.4/10 Very Good! (1,912 reviews) Everything was great. The staff met my expectations and beyond. Reviewed on Dec 10, 2025 [](https://expedia.ca/Hotel-Search?startDate=23%2F12%2F2025&endDate=24%2F12%2F2025&selected=693655&PinnedHotelID=693655&HadPinnedHotel=true®ionId=553248635976386992) ![Blossom Hotel Houston, Curio Collection by Hilton](https://images.trvl-media.com/lodging/59000000/58990000/58985900/58985846/db7ae93f_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Blossom Hotel Houston, Curio Collection by Hilton 7118 Bertner Ave Houston TX CA $181 CA $212 total Jan 15 - Jan 16, 2026 includes taxes & fees Book a stay at this spa hotel in Houston. Enjoy free WiFi, a full-service spa, and 2 bars/lounges. Our guests praise the pool and the helpful staff in our reviews. ... 9/10 Wonderful! (3,596 reviews) The rooms are truly beautiful and the restroom is so spacious. Reviewed on Dec 12, 2025 [](https://expedia.ca/Hotel-Search?startDate=15%2F01%2F2026&endDate=16%2F01%2F2026&selected=58985846&PinnedHotelID=58985846&HadPinnedHotel=true®ionId=553248635976386992) ![The Royal Sonesta Houston Galleria](https://images.trvl-media.com/lodging/1000000/880000/878700/878652/9874e960_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### The Royal Sonesta Houston Galleria 2222 West Loop South Houston TX CA $153 CA $179 total Dec 20 - Dec 21 includes taxes & fees Book a stay at this business-friendly hotel in Houston. Enjoy breakfast (surcharge), room service, and a 24-hour health club. Our guests praise the helpful staff ... 8.4/10 Very Good! (1,449 reviews) Janel gave us the best customer service! Must go again! Reviewed on Dec 11, 2025 [](https://expedia.ca/Hotel-Search?startDate=20%2F12%2F2025&endDate=21%2F12%2F2025&selected=878652&PinnedHotelID=878652&HadPinnedHotel=true®ionId=553248635976386992) [See all 6,793 properties in South Main](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=17%2F12%2F2025&endDate=18%2F12%2F2025®ionId=553248635976386992) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Check South Main hotel availability [Tonight ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976386992&startDate=2025-12-16&endDate=2025-12-17)[Dec 16 - Dec 17](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976386992&startDate=2025-12-16&endDate=2025-12-17) [Tomorrow night ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976386992&startDate=2025-12-17&endDate=2025-12-18)[Dec 17 - Dec 18](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976386992&startDate=2025-12-17&endDate=2025-12-18) [This weekend ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976386992&startDate=19%2F12%2F2025&endDate=21%2F12%2F2025)[Dec 19 - Dec 21](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976386992&startDate=19%2F12%2F2025&endDate=21%2F12%2F2025) [Next weekend ](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976386992&startDate=26%2F12%2F2025&endDate=28%2F12%2F2025)[Dec 26 - Dec 28](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635976386992&startDate=26%2F12%2F2025&endDate=28%2F12%2F2025) --- ### Other neighbourhoods around South Main ![Default Image](https://mediaim.expedia.com/destination/2/a22124917701df6fb597653efab4baae.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Astrodome 5/5(1 area review) If you're spending time in Astrodome, check out sights like NRG Stadium or NRG Astrodome and hop on the metro to see more the city at Stadium Park/Astrodome Station or Smith Lands Station. [](https://expedia.ca/Houston-Astrodome.dx553248635976007975) ![Default Image](https://mediaim.expedia.com/destination/1/f4655cac96c82fca6c00f4ab3162178c.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Texas Medical Center 4.5/5(2 area reviews) Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience. [](https://expedia.ca/Houston-Texas-Medical-Center.dx6143504) ![Hermann Park featuring a garden and landscape views](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/23000/23515-Hermann-Park.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Museum District Known for its ample dining options and fascinating museums, there's plenty to explore in Museum District. You can visit top attractions like Children's Museum of Houston and Houston Natural Science Museum, and jump on the metro at M. D. Anderson Station or Museum District Station to see more of the city. [](https://expedia.ca/Houston-Houston-Museum-District.dx6164045) ![Hermann Park featuring a garden and landscape views](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/23000/23515-Hermann-Park.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### South Central Houston 5/5(1 area review) If you're spending time in South Central Houston, check out sights like Continental Club or Midtown Arts and Theater Center Houston and hop on the metro to see more the city at Elgin/Third Ward Station or TSU/UH Athletics District Station. [](https://expedia.ca/Houston-South-Central-Houston.dx553248635976476176) ![Menil Collection which includes interior views and art](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/23000/23619-Menil-Collection.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Montrose 3.5/5(4 area reviews) Unique features of Montrose include the theaters and museums. Make a stop by Menil Collection or Houston Center for Photography while you're exploring the area. [](https://expedia.ca/Houston-Montrose.dx3000663145) ![Default Image](https://mediaim.expedia.com/destination/2/68c44f1bf9b93b0f54471eaf2fad6ffb.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### River Oaks Gardens and monuments are just a few things travelers like about River Oaks. A stop by River Oaks Country Club is also recommended if you've got time to explore the area. [](https://expedia.ca/Houston-River-Oaks.dx553248635074842911) --- --- - [Stays](?pwaLob=wizard-hotel-pwa-v2) - [Packages](?pwaLob=wizard-package-pwa) - [Flights](?pwaLob=wizard-flight-pwa) - [Things to do](?pwaLob=wizard-lx-pwa) - [Cruises](?pwaLob=wizard-cruise-pwa) - [Cars](?pwaLob=wizard-car-pwa) # South Main ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app