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Hotels in South Main, Houston

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Our top choices for South Main hotels

1. DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria
4.0 star property
8.9 km from South Main
8.4 out of 10, Very good, (4,712 reviews)
"Great stay"
United States
Hernando
The price is CA $162
CA $191 total
includes taxes & fees
Nov 27 - Nov 28
DoubleTree by Hilton Hotel & Suites Houston by the Galleria

2. Blossom Hotel Houston, Curio Collection by Hilton

Blossom Hotel Houston, Curio Collection by Hilton
4.0 star property
Texas Medical Center, 3.5 km from South Main
9.0 out of 10, Wonderful, (3,782 reviews)
"Great hotel definitely would stay again."
United States
Michael
The price is CA $209
CA $246 total
includes taxes & fees
Nov 22 - Nov 23
Blossom Hotel Houston, Curio Collection by Hilton

3. Kozy Houston North

Kozy Houston North
4.0 star property
39.3 km from South Main
8.6 out of 10, Excellent, (2,668 reviews)
"Enjoyed my stay!"
United States
Derrell
The price is CA $49
CA $75 total
includes taxes & fees
Dec 10 - Dec 11
Kozy Houston North

4. Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston
4.0 star property
Houston Central Business District, 10.9 km from South Main
8.6 out of 10, Excellent, (4,592 reviews)
"Great stay!"
United States
paige
The price is CA $124
CA $145 total
includes taxes & fees
Nov 18 - Nov 19
Club Quarters Hotel Downtown, Houston

5. Marriott Marquis Houston

Marriott Marquis Houston
4.0 star property
10.8 km from South Main
9.0 out of 10, Wonderful, (1,346 reviews)
"Great room great service great experience"
United States
Jason
The price is CA $383
CA $496 total
includes taxes & fees
Nov 26 - Nov 27
Marriott Marquis Houston

6. The Whitehall Houston

The Whitehall Houston
4.0 star property
Houston Central Business District, 10 km from South Main
8.6 out of 10, Excellent, (2,524 reviews)
"Good service of the staff, good breakfast"
United States
Yocheved
The price is CA $142
CA $167 total
includes taxes & fees
Dec 12 - Dec 13
The Whitehall Houston

7. Hyatt Place Houston Medical Center

Hyatt Place Houston Medical Center
3.0 star property
Texas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (2,739 reviews)
"Great place to stay"
United States
Joel
The price is CA $177
CA $209 total
includes taxes & fees
Nov 15 - Nov 16
Hyatt Place Houston Medical Center

8. DoubleTree by Hilton Hotel Houston - Greenway Plaza

DoubleTree by Hilton Hotel Houston - Greenway Plaza
4.0 star property
Greenway Plaza-Upper Kirby, 6.6 km from South Main
8.4 out of 10, Very good, (1,978 reviews)
"Was clean and staff was very friendly"
United States
Scott
The price is CA $119
CA $140 total
includes taxes & fees
Dec 6 - Dec 7
DoubleTree by Hilton Hotel Houston - Greenway Plaza

9. Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
4.5 star property
Texas Medical Center, 4.4 km from South Main
8.6 out of 10, Excellent, (2,254 reviews)
"Very nice, would stay again!"
United States
Amanda
The price is CA $140
CA $165 total
includes taxes & fees
Nov 29 - Nov 30
Hilton Houston Plaza/Medical Center

10. The Royal Sonesta Houston Galleria

The Royal Sonesta Houston Galleria
4.0 star property
The Galleria, 8.8 km from South Main
8.8 out of 10, Excellent, (2,449 reviews)
"Great place to stay Would definitely come back"
United States
Bruce
The price is CA $170
CA $198 total
includes taxes & fees
Nov 23 - Nov 24
The Royal Sonesta Houston Galleria

11. Crowne Plaza Houston Med Ctr-Galleria Area by IHG

Crowne Plaza Houston Med Ctr-Galleria Area by IHG
3.5 star property
Greenway Plaza-Upper Kirby, 6.5 km from South Main
7.8 out of 10, Good, (1,753 reviews)
"Great stay"
United States
Lorenzo
The price is CA $95
CA $112 total
includes taxes & fees
Nov 22 - Nov 23
Crowne Plaza Houston Med Ctr-Galleria Area by IHG

12. Home2 Suites by Hilton at the Galleria

Home2 Suites by Hilton at the Galleria
3.0 star property
Greater Uptown, 8 km from South Main
9.0 out of 10, Wonderful, (1,097 reviews)
"Great place to stay."
United States
Jeffrey
The price is CA $150
CA $176 total
includes taxes & fees
Dec 1 - Dec 2
Home2 Suites by Hilton at the Galleria

13. Hotel Ylem

Hotel Ylem
3.5 star property
2.3 km from South Main
8.2 out of 10, Very good, (1,599 reviews)
"Clean rooms, nice staff. Will definitely again."
United States
Angela
The price is CA $101
CA $125 total
includes taxes & fees
Dec 2 - Dec 3
Hotel Ylem

14. Hilton Americas-Houston

Hilton Americas-Houston
4.0 star property
10.4 km from South Main
9.4 out of 10, Exceptional, (1,899 reviews)
"Delicious breakfast and very clean hotel."
United States
Kalynn
The price is CA $221
CA $261 total
includes taxes & fees
Nov 22 - Nov 23
Hilton Americas-Houston

15. Hyatt House Houston Medical Center

Hyatt House Houston Medical Center
3.0 star property
Texas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (1,292 reviews)
"Clean rooms, helpful staff, and great breakfast."
United States
Nikki
The price is CA $177
CA $209 total
includes taxes & fees
Nov 21 - Nov 22
Hyatt House Houston Medical Center

16. Hyatt Regency Houston/Galleria

Hyatt Regency Houston/Galleria
4.0 star property
8.7 km from South Main
9.2 out of 10, Wonderful, (1,574 reviews)
"Great location and very nice rooms"
United Kingdom
Nicholas
The price is CA $180
CA $213 total
includes taxes & fees
Nov 22 - Nov 23
Hyatt Regency Houston/Galleria

17. Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District
4.5 star property
6.3 km from South Main
9.2 out of 10, Wonderful, (1,015 reviews)
"Courteous staff, conveniently located. Very good amenities."
United States
David
The price is CA $274
CA $387 total
includes taxes & fees
Dec 2 - Dec 3
Hotel Zaza Houston Museum District

18. Magnolia Hotel Houston, A Tribute Portfolio Hotel

Magnolia Hotel Houston, A Tribute Portfolio Hotel
4.0 star property
Houston Central Business District, 11 km from South Main
9.2 out of 10, Wonderful, (1,727 reviews)
"I always love staying here when in town."
United States
Migdia
The price is CA $165
CA $198 total
includes taxes & fees
Nov 23 - Nov 24
Magnolia Hotel Houston, A Tribute Portfolio Hotel

19. The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District
4.0 star property
Texas Medical Center, 4.4 km from South Main
9.2 out of 10, Wonderful, (1,283 reviews)
"Good hotel. Clean and nice staff."
United States
Ariane
The price is CA $170
CA $211 total
includes taxes & fees
Nov 22 - Nov 23
The Westin Houston Medical Center/Museum District

20. Grand Tuscany Hotel

Grand Tuscany Hotel
4.0 star property
20.3 km from South Main
8.4 out of 10, Very good, (460 reviews)
"I was great staying there"
United States
Fahim
The price is CA $139
CA $163 total
includes taxes & fees
Nov 15 - Nov 16
Grand Tuscany Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Compare top hotels in South Main

4.0 star property
8.9 km from South Main
4.0 star property
Texas Medical Center, 3.5 km from South Main
4.0 star property
39.3 km from South Main
4.0 star property
Houston Central Business District, 10.9 km from South Main
4.0 star property
10.8 km from South Main
8.4
Very good
4,712 reviews
9.0
Wonderful
3,782 reviews
8.6
Excellent
2,668 reviews
8.6
Excellent
4,592 reviews
9.0
Wonderful
1,346 reviews
The price is CA $162
CA $191 total
includes taxes & fees
Nov 27 - Nov 28
The price is CA $209
CA $246 total
includes taxes & fees
Nov 22 - Nov 23
The price is CA $49
CA $75 total
includes taxes & fees
Dec 10 - Dec 11
The price is CA $124
CA $145 total
includes taxes & fees
Nov 18 - Nov 19
The price is CA $383
CA $496 total
includes taxes & fees
Nov 26 - Nov 27
  • No Breakfast included
  • Yes, Pool
  • No Spa
  • Yes, Pet-friendly
  • No WiFi included
  • Yes, Parking
  • No Breakfast included
  • Yes, Pool
  • Yes, Spa
  • Yes, Pet-friendly
  • No WiFi included
  • Yes, Parking
  • No Breakfast included
  • Yes, Pool
  • No Spa
  • Yes, Pet-friendly
  • Yes, WiFi included
  • Yes, Parking
  • No Breakfast included
  • No Pool
  • No Spa
  • Yes, Pet-friendly
  • Yes, WiFi included
  • Yes, Parking
  • No Breakfast included
  • Yes, Pool
  • Yes, Spa
  • No Pet-friendly
  • No WiFi included
  • Yes, Parking

Where to stay in South Main

Find the best South Main areas and neighborhoods for the activities you enjoy most.

Downtown Houston

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

Texas Medical Center

Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

Montrose

Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.

Top South Main Hotel Reviews

Frequently asked questions

What are the best hotels in South Main that travellers recommend?
For highly recommended hotels in South Main, consider the Wyndham Houston near NRG Park/Medical Center, Wingate Houston near NRG Park/Medical Center, Quality Inn & Suites NRG Park - Medical Center, and Comfort Suites Houston near Medical Centre- NRG Stadium.

The 3.5-star Wyndham Houston near NRG Park/Medical Center, with a 7.2 rating, is often praised by guests for its amazing staff, comfortable beds, and clean, big rooms. It also features an outdoor pool with sun loungers and is conveniently located close to NRG Astrodome (0.9 km), NRG Park (0.7 km), and NRG Arena (0.8 km).

The 3-star Wingate Houston near NRG Park/Medical Center is another great option. Guests frequently highlight the friendly and extremely polite staff, the free continental breakfast, and the comfortable, clean rooms. It is very close to NRG Astrodome (0.7 km), NRG Park (0.5 km), and NRG Arena (0.7 km).

The Quality Inn & Suites NRG Park - Medical Center is top for its excellent customer service and hospitality, along with clean rooms and a convenient location. This hotel offers free to-go breakfast and some rooms feature a balcony. It is situated near NRG Astrodome (1.0 km), NRG Park (0.8 km), and NRG Arena (0.9 km).

Finally, the Comfort Suites Houston near Medical Centre- NRG Stadium, with an excellent 8.6 rating, is known for its friendly and helpful staff, comfortable and clean rooms, and a great complimentary full breakfast. It also provides fitness facilities and is conveniently located near NRG Astrodome (1.0 km), NRG Park (0.8 km), and NRG Arena (1.4 km).
What are the best family hotels in South Main?
For family hotels in South Main, consider the Wingate Houston near NRG Park/Medical Center, the Wyndham Houston near NRG Park/Medical Center, and the Comfort Suites Houston near Medical Centre- NRG Stadium.

The 3-star Wingate Houston near NRG Park/Medical Center is a great option, located just 0.5 km from NRG Park. Guests appreciate the friendly and extremely polite staff, as well as the free and good breakfast. The comfortable and clean rooms with good beds contribute to a pleasant stay, and it also features a pool for family enjoyment.

Another excellent choice is the 3.5-star Wyndham Houston near NRG Park/Medical Center, rated 7.2. Situated only 0.7 km from NRG Park, this hotel offers child-friendly window design and free cribs, making it suitable for families with young children. Guests frequently mention the great and amazing staff, the superb location, and the clean, big rooms with comfortable beds.

The Comfort Suites Houston near Medical Centre- NRG Stadium, with an 8.6 rating, is also highly recommended. This hotel is conveniently located 0.8 km from NRG Park and features child-friendly window design. Guests consistently praise the comfortable and clean rooms, the friendly and helpful staff, and the great breakfast.
What are the top pet-friendly hotels in South Main?
For highly-rated pet-friendly hotels in South Main, consider the Wingate Houston near NRG Park/Medical Center, the Wyndham Houston near NRG Park/Medical Center, Candlewood Suites Houston Medical Center by IHG, and the Quality Inn & Suites NRG Park - Medical Center.

The 3-star Wingate Houston near NRG Park/Medical Center is a great option, allowing dogs and other pets. Guests frequently highlight the friendly and polite staff, the comfortable and clean rooms, and the good complimentary breakfast. It is conveniently located near NRG Park, NRG Astrodome, and NRG Arena.

Another excellent choice is the 3.5-star Wyndham Houston near NRG Park/Medical Center, which permits pets. This hotel, rated 7.2, is praised for its great and amazing staff, superb location, and clean, big rooms with comfortable beds. It offers free WiFi and is also close to NRG Park, NRG Astrodome, and NRG Arena.

The Candlewood Suites Houston Medical Center by IHG also permits pets and has a review rating of 7.4. This hotel provides free WiFi and free self-parking. It is situated near NRG Park, NRG Astrodome, and NRG Arena.

Finally, the Quality Inn & Suites NRG Park - Medical Center welcomes pets. This hotel offers free breakfast, including a to-go option, free self-parking, and a complimentary area shuttle. Guests often compliment the excellent and clean rooms, the convenient location, and the excellent customer service and hospitality. It is also very close to NRG Park, NRG Astrodome, and NRG Arena.
What are the most romantic hotels in South Main for couples?
For a romantic stay in South Main, the Quality Inn & Suites NRG Park - Medical Center is a good choice for couples.

The Quality Inn & Suites NRG Park - Medical Center offers suites that provide extra space and comfort. Guests have consistently praised the excellent and clean rooms, as well as the convenient location of the hotel. It provides complimentary breakfast and free toiletries, adding to the convenience of your stay. The hotel also offers free self-parking and a free area shuttle, making it easy to explore the surroundings. With NRG Astrodome just 1.0 km away and NRG Arena 0.9 km away, there's plenty to see and do nearby.
What are the best hotels in South Main near NRG Park?
When looking for hotels in South Main near NRG Park, the Wyndham Houston near NRG Park/Medical Center and the Wingate Houston near NRG Park/Medical Center are excellent options, particularly for families.

The 3.5-star Wyndham Houston near NRG Park/Medical Center, with a rating of 7.2, boasts a superb location, being just 0.7 km from NRG Park. Guests frequently praise the amazing staff, the clean and spacious rooms, and the comfortable beds. It also offers child-friendly window designs and free cribs, making it a great choice for those travelling with children.

Another highly-rated option is the 3-star Wingate Houston near NRG Park/Medical Center. While its rating is not provided, it is consistently praised for its good location, just 0.5 km from NRG Park. This hotel offers a pool, connecting rooms, and complimentary continental breakfast, which guests often describe as good. The staff are noted for being friendly and extremely polite, and the rooms are comfortable and clean.
When is the best time to go to South Main?
The best time to go to South Main is during the spring (March to May) and autumn (September to November) months.

These seasons offer pleasant weather, with comfortable temperatures that are ideal for exploring the area's outdoor attractions and walking around. Spring brings blooming flowers and a refreshing atmosphere, while autumn provides cooler temperatures and often clear skies, superb for enjoying the local parks and open-air markets.

For those planning a romantic getaway, spring is particularly lovely. The milder weather allows for leisurely strolls along the riverwalk and enjoying al fresco dining without the intense summer heat. The natural beauty of the area is at its peak, creating a beautiful backdrop for couples.

Families travelling with children might find autumn more appealing. The slightly cooler temperatures are more comfortable for kids, especially when visiting attractions like the local nature centres or attending outdoor festivals.
Can I cancel my hotel reservation on Expedia?
Many Expedia hotel reservations are refundable, provided that you cancel before the hotel's cancellation deadline – this is often within 24-48 hours of your scheduled arrival. If you have a non-refundable booking, it might still be possible to receive a refund if you cancel it within 24 hours of booking. Be sure to check your booking confirmation for the exact cancellation policy. For maximum flexibility, use our "Fully refundable property" filter during your search to find the right South Main hotel for you.
How much is the nightly rate at a South Main hotel?
Hotel prices in South Main often vary, but you can find a great deal on Expedia. Different factors affect nightly hotel rates, such as the time of year or the days of the week you want to book. To find the best deals for your stay, be flexible with your dates, and sort search results by "Price: low to high" for our cheapest rates.

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