
Hotels in South Main, Houston
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Our top choices for South Main hotels

1. DoubleTree by Hilton Hotel & Suites Houston by the Galleria
DoubleTree by Hilton Hotel & Suites Houston by the Galleria8.9 km from South Main
8.4 out of 10, Very good, (4,712 reviews)
The price is CA $162
CA $191 total
includes taxes & fees
Nov 27 - Nov 28

2. Blossom Hotel Houston, Curio Collection by Hilton
Blossom Hotel Houston, Curio Collection by HiltonTexas Medical Center, 3.5 km from South Main
9.0 out of 10, Wonderful, (3,782 reviews)
The price is CA $209
CA $246 total
includes taxes & fees
Nov 22 - Nov 23

3. Kozy Houston North
Kozy Houston North39.3 km from South Main
8.6 out of 10, Excellent, (2,668 reviews)
The price is CA $49
CA $75 total
includes taxes & fees
Dec 10 - Dec 11

4. Club Quarters Hotel Downtown, Houston
Club Quarters Hotel Downtown, HoustonHouston Central Business District, 10.9 km from South Main
8.6 out of 10, Excellent, (4,592 reviews)
The price is CA $124
CA $145 total
includes taxes & fees
Nov 18 - Nov 19

5. Marriott Marquis Houston
Marriott Marquis Houston10.8 km from South Main
9.0 out of 10, Wonderful, (1,346 reviews)
The price is CA $383
CA $496 total
includes taxes & fees
Nov 26 - Nov 27

6. The Whitehall Houston
The Whitehall HoustonHouston Central Business District, 10 km from South Main
8.6 out of 10, Excellent, (2,524 reviews)
The price is CA $142
CA $167 total
includes taxes & fees
Dec 12 - Dec 13

7. Hyatt Place Houston Medical Center
Hyatt Place Houston Medical CenterTexas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (2,739 reviews)
The price is CA $177
CA $209 total
includes taxes & fees
Nov 15 - Nov 16

8. DoubleTree by Hilton Hotel Houston - Greenway Plaza
DoubleTree by Hilton Hotel Houston - Greenway PlazaGreenway Plaza-Upper Kirby, 6.6 km from South Main
8.4 out of 10, Very good, (1,978 reviews)
The price is CA $119
CA $140 total
includes taxes & fees
Dec 6 - Dec 7

9. Hilton Houston Plaza/Medical Center
Hilton Houston Plaza/Medical CenterTexas Medical Center, 4.4 km from South Main
8.6 out of 10, Excellent, (2,254 reviews)
The price is CA $140
CA $165 total
includes taxes & fees
Nov 29 - Nov 30

10. The Royal Sonesta Houston Galleria
The Royal Sonesta Houston GalleriaThe Galleria, 8.8 km from South Main
8.8 out of 10, Excellent, (2,449 reviews)
The price is CA $170
CA $198 total
includes taxes & fees
Nov 23 - Nov 24

11. Crowne Plaza Houston Med Ctr-Galleria Area by IHG
Crowne Plaza Houston Med Ctr-Galleria Area by IHGGreenway Plaza-Upper Kirby, 6.5 km from South Main
7.8 out of 10, Good, (1,753 reviews)
The price is CA $95
CA $112 total
includes taxes & fees
Nov 22 - Nov 23

12. Home2 Suites by Hilton at the Galleria
Home2 Suites by Hilton at the GalleriaGreater Uptown, 8 km from South Main
9.0 out of 10, Wonderful, (1,097 reviews)
The price is CA $150
CA $176 total
includes taxes & fees
Dec 1 - Dec 2

13. Hotel Ylem
Hotel Ylem2.3 km from South Main
8.2 out of 10, Very good, (1,599 reviews)
The price is CA $101
CA $125 total
includes taxes & fees
Dec 2 - Dec 3

14. Hilton Americas-Houston
Hilton Americas-Houston10.4 km from South Main
9.4 out of 10, Exceptional, (1,899 reviews)
The price is CA $221
CA $261 total
includes taxes & fees
Nov 22 - Nov 23

15. Hyatt House Houston Medical Center
Hyatt House Houston Medical CenterTexas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (1,292 reviews)
The price is CA $177
CA $209 total
includes taxes & fees
Nov 21 - Nov 22

16. Hyatt Regency Houston/Galleria
Hyatt Regency Houston/Galleria8.7 km from South Main
9.2 out of 10, Wonderful, (1,574 reviews)
The price is CA $180
CA $213 total
includes taxes & fees
Nov 22 - Nov 23

17. Hotel Zaza Houston Museum District
Hotel Zaza Houston Museum District6.3 km from South Main
9.2 out of 10, Wonderful, (1,015 reviews)
The price is CA $274
CA $387 total
includes taxes & fees
Dec 2 - Dec 3

18. Magnolia Hotel Houston, A Tribute Portfolio Hotel
Magnolia Hotel Houston, A Tribute Portfolio HotelHouston Central Business District, 11 km from South Main
9.2 out of 10, Wonderful, (1,727 reviews)
The price is CA $165
CA $198 total
includes taxes & fees
Nov 23 - Nov 24

19. The Westin Houston Medical Center/Museum District
The Westin Houston Medical Center/Museum DistrictTexas Medical Center, 4.4 km from South Main
9.2 out of 10, Wonderful, (1,283 reviews)
The price is CA $170
CA $211 total
includes taxes & fees
Nov 22 - Nov 23

20. Grand Tuscany Hotel
Grand Tuscany Hotel20.3 km from South Main
8.4 out of 10, Very good, (460 reviews)
The price is CA $139
CA $163 total
includes taxes & fees
Nov 15 - Nov 16
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Compare top hotels in South Main
![]() DoubleTree by Hilton Hotel & Suites Houston by the Galleria8.9 km from South Main | ![]() Blossom Hotel Houston, Curio Collection by HiltonTexas Medical Center, 3.5 km from South Main | ![]() Kozy Houston North39.3 km from South Main | ![]() Club Quarters Hotel Downtown, HoustonHouston Central Business District, 10.9 km from South Main | ![]() Marriott Marquis Houston10.8 km from South Main |
|---|---|---|---|---|
8.4 Very good 4,712 reviews | 9.0 Wonderful 3,782 reviews | 8.6 Excellent 2,668 reviews | 8.6 Excellent 4,592 reviews | 9.0 Wonderful 1,346 reviews |
The price is CA $162 CA $191 total includes taxes & fees Nov 27 - Nov 28 | The price is CA $209 CA $246 total includes taxes & fees Nov 22 - Nov 23 | The price is CA $49 CA $75 total includes taxes & fees Dec 10 - Dec 11 | The price is CA $124 CA $145 total includes taxes & fees Nov 18 - Nov 19 | The price is CA $383 CA $496 total includes taxes & fees Nov 26 - Nov 27 |
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Where to stay in South Main
Find the best South Main areas and neighborhoods for the activities you enjoy most.

Downtown Houston
Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

The Galleria
Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

Texas Medical Center
Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

Montrose
Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

Photo by George Zimzores
Open Photo by George Zimzores
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.
Top South Main Hotel Reviews

Courtyard by Marriott Houston Intercontinental Airport
10/10 Excellent
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