An aerial view of a coastal landscape with a dam, farmland, and dense forests.

Search Santee Villa Rentals from CA $89

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
Sep 18 - Sep 20
In two months
Oct 30 - Nov 1
In three months
Nov 27 - Nov 29
In four months
Dec 25 - Dec 27
No exact matches found, but these alternatives could be just right

Recommended hotels in Santee

Exterior

1. Hampton Inn Santee-I-95

Hampton Inn Santee-I-95
2.5 star property
Santee
9.6 out of 10, Exceptional, (1,002 reviews)
"I’ve stayed there many times before always happy with it ."
United States
Janice
The price is CA $172
CA $191 total
includes taxes & fees
Sep 13 - Sep 14
Hampton Inn Santee-I-95
Exterior

2. Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee
3.0 star property
Santee
9.8 out of 10, Exceptional, (1,001 reviews)
"Property was clean and the breakfast was delicious would stay there again."
United States
Melissa
The price is CA $179
CA $199 total
includes taxes & fees
Sep 15 - Sep 16
Fairfield Inn & Suites by Marriott Santee
Exterior

3. Tru By Hilton Santee

Tru By Hilton Santee
2.5 star property
Santee
9.2 out of 10, Wonderful, (943 reviews)
"Quick stay, hotel was clean and safe. Staff was super helpful and friendly."
United States
Vicky L
The price is CA $135
CA $150 total
includes taxes & fees
Sep 13 - Sep 14
Tru By Hilton Santee
Exterior

4. Baymont by Wyndham Santee

Baymont by Wyndham Santee
2.5 star property
Santee
8.0 out of 10, Very good, (1,487 reviews)
"Very quiet, dog friendly, clean, breakfast included."
United States
Yomerys
The price is CA $111
CA $123 total
includes taxes & fees
Sep 7 - Sep 8
Baymont by Wyndham Santee
Exterior

5. Best Western Plus Santee Inn

Best Western Plus Santee Inn
2.5 star property
Santee
8.8 out of 10, Excellent, (1,000 reviews)
"Breakfast was good, staff very helpful."
United States
Bonnie
The price is CA $153
CA $170 total
includes taxes & fees
Sep 20 - Sep 21
Best Western Plus Santee Inn
Exterior

6. Holiday Inn Santee by IHG

Holiday Inn Santee by IHG
3.0 star property
Santee
8.2 out of 10, Very good, (1,000 reviews)
"I stay here all the time when traveling with my dog. This place is super clean and the staff is excellent."
United States
Dennis
The price is CA $145
CA $161 total
includes taxes & fees
Sep 13 - Sep 14
Holiday Inn Santee by IHG
Exterior

7. Comfort Inn & Suites Santee

Comfort Inn & Suites Santee
2.5 star property
Santee
8.0 out of 10, Very good, (1,002 reviews)
"Was a good place to stay"
United States
santa
The price is CA $141
CA $156 total
includes taxes & fees
Sep 27 - Sep 28
Comfort Inn & Suites Santee
Exterior

8. Travelodge by Wyndham Santee

Travelodge by Wyndham Santee
2.0 star property
Santee
7.2 out of 10, Good, (773 reviews)
"The staff was very helpful and respectful."
United States
Mark
The price is CA $89
CA $98 total
includes taxes & fees
Sep 7 - Sep 8
Travelodge by Wyndham Santee
Exterior

9. Super 8 by Wyndham Santee/I-95

Super 8 by Wyndham Santee/I-95
2.0 star property
Santee
6.8 out of 10, (475 reviews)
"An older fecility but certainly well maintained. Loved Mr. Patel!"
United States
William
The price is CA $88
CA $98 total
includes taxes & fees
Sep 13 - Sep 14
Super 8 by Wyndham Santee/I-95
Exterior

10. Econo Lodge Santee

Econo Lodge Santee
2.0 star property
Santee
6.4 out of 10, (316 reviews)
"The shops and restaurants are all within walking distance & it is only 4.2 miles to the Palmetto Resort where my sister & I met up with my nephew& his wife."
United States
Dorothy
The price is CA $80
CA $89 total
includes taxes & fees
Sep 27 - Sep 28
Econo Lodge Santee
Exterior

11. Quality Inn & Suites Santee I-95

Quality Inn & Suites Santee I-95
2.5 star property
Santee
6.0 out of 10, (586 reviews)
"It was very clean-might need a few updates to the bathroom tho."
United States
Clara
The price is CA $75
CA $91 total
includes taxes & fees
Sep 27 - Sep 28
Quality Inn & Suites Santee I-95
Exterior

12. Red Roof Inn Santee

Red Roof Inn Santee
2.0 star property
Santee
6.6 out of 10, (663 reviews)
"Clean rooms and staff was great"
United States
Tiffany
The price is CA $87
CA $97 total
includes taxes & fees
Sep 9 - Sep 10
Red Roof Inn Santee
Outdoor dining

13. Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!

Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!
Santee
10.0 out of 10, Exceptional, (46 reviews)
"This was our first long trip with our dog and she loved the place! Fenced in yard and home was cozy and dog friendly. Loved the farmhouse style and large bedrooms and baths. "
United States
Lori B.
The price is CA $187
CA $518 total
includes taxes & fees
Sep 13 - Sep 14
Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95!
Terrace/patio

14. LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks

LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks
Santee
8.8 out of 10, Excellent, (6 reviews)
"Great stay no complaints. "
United States
Quantrel P.
The price is CA $224
CA $634 total
includes taxes & fees
Sep 19 - Sep 20
LuxuryGrndFloorCornerLakeViewPoolGolfFishBoatParks
Property grounds

15. Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!

Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!
Santee
10.0 out of 10, Exceptional, (15 reviews)
"This is an amazing place to stay! Wake up in a beautiful place with stunning views and huge kitchen! Multiple boat docks that you can see turtles, alligators, fish from! Highly recommend "
United States
Hope M.
The price is CA $221
CA $588 total
includes taxes & fees
Sep 20 - Sep 21
Peaceful Condo on Lake Marion in Santee, SC. Time to play golf and go fishing!
Exterior

16. Lake Marion Condo, Boat Slip Included, Pet Friendly

Lake Marion Condo, Boat Slip Included, Pet Friendly
Santee
The price is CA $228
CA $484 total
includes taxes & fees
Sep 9 - Sep 10
Lake Marion Condo, Boat Slip Included, Pet Friendly
Exterior

17. Ramada by Wyndham Santee I-95

Ramada by Wyndham Santee I-95
2.0 star property
Santee
6.4 out of 10, (591 reviews)
"The price rate was great"
United States
Stevenson
The price is CA $99
CA $110 total
includes taxes & fees
Sep 27 - Sep 28
Ramada by Wyndham Santee I-95
Exterior

18. Red Roof Inn Orangeburg

Red Roof Inn Orangeburg
2.0 star property
Orangeburg
5.8 out of 10, (739 reviews)
"The only thing about the property is that there are still some renovations going on. But the room is self was very clean, the remodeling is very nice and there are no bugs. The staff is also very pleasant and friendly! I would definitely stay there again in the future."
United States
Amanda
The price is CA $81
CA $90 total
includes taxes & fees
Sep 13 - Sep 14
Red Roof Inn Orangeburg
Front of property

19. Fairfield Inn by Marriott Orangeburg

Fairfield Inn by Marriott Orangeburg
3.0 star property
Orangeburg
8.4 out of 10, Very good, (824 reviews)
"Amazing hotel. Always my go to whenever I am staying in Orangeburg. Highly recommended!"
United States
Percy
The price is CA $140
CA $155 total
includes taxes & fees
Sep 10 - Sep 11
Fairfield Inn by Marriott Orangeburg
Terrace/patio

20. Tru by Hilton Orangeburg

Tru by Hilton Orangeburg
2.5 star property
Orangeburg
9.2 out of 10, Wonderful, (1,003 reviews)
"great hotel"
Canada
Andrew
The price is CA $158
CA $175 total
includes taxes & fees
Sep 20 - Sep 21
Tru by Hilton Orangeburg
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Santee Hotel Reviews

Comfort Inn & Suites Santee

Comfort Inn & Suites Santee

10/10 Excellent
"GOOD"
Lisette 1-night trip
Posted 2 days ago
Comfort Inn & Suites Santee

Find out more about Santee

Santee Villas information

Number of reviews
9,155
Accommodation
0 Villas
Lowest Price
CA $89
Highest Price
CA $208

Frequently asked questions

Why book your villa in Santee with Expedia?
Reserving a villa in Santee is as simple as entering your travel dates and choosing the option that suits your style. Looking for something upscale or budget friendly, or a property that also comes with WiFi and a hot tub? Use Expedia's search filters to narrow your results and find your perfect match.
How can I find cheap villas in Santee?
A fantastic way to get cheap villas in Santee is with Expedia's helpful filter tool. Narrow your search results by star rating, budget and amenities to secure unbeatable deals in just a couple of clicks.
What is there to do near my villa in Santee?
After you've unpacked your suitcases, venture out and discover the fun things Santee has on offer. Santee State Park is a popular attraction to add to your must-do list.

Explore a world of travel with Expedia