Santa Cruz Vacation Packages
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Your Santa Cruz Vacation
With one of our vacation packages to Santa Cruz, you'll find countless opportunities for adventure and relaxation. There's so much to experience, including its beaches and lively atmosphere. If taking in sights is part of the program during your trip to Santa Cruz, check out major attractions like Plaza 24 de Septiembre, Guembe Biocenter and Ventura Mall. Whoever you're heading away with and whatever the size of your budget, your dream Santa Cruz vacation is just clicks away with Expedia.
Santa Cruz Hotel Deals
Ibis Santa Cruz DE LA Sierra
AVENIDA CRISTOBAL DE MENDOZA Santa Cruz
The price is CA $75 per night from Apr 27 to Apr 28
CA $75
CA $75 total
Apr 27 - Apr 28
9.6/10 Exceptional! (106 reviews)
Excelente hotel , práctico y conveniente para ir de negocios
Reviewed on Apr 23, 2026
Sun Hotel
Av. Banzer Km 13 Santa Cruz Santa Cruz
The price is CA $133 per night from May 8 to May 9
CA $133
CA $133 total
May 8 - May 9
8.2/10 Very Good! (368 reviews)
No vip treatment! nothing special, booked a king room got a double, wc was running water all the time and the sink didn’t drain properly. Breakfast was lame. Staff was good and the bed was comfy, but that’s it.
Reviewed on Apr 18, 2026
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel
Ave. San Martin, #455 Santa Cruz
The price is CA $208 per night from May 10 to May 11
CA $208
CA $208 total
May 10 - May 11
9/10 Wonderful! (370 reviews)
Great
Reviewed on Apr 22, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Santa Cruz
Plaza 24 de Septiembre
5/5(5 reviews)
The heart of Santa Cruz lies in this public square, where locals relax and tourists sightsee in a welcoming, laid-back atmosphere.
Ventura Mall
4.5/5(3 reviews)
During your visit to Santa Cruz, you can find the perfect gifts to bring home at Ventura Mall. Make some time to visit the cathedral while you're in the area.
Guembe Biocenter
5/5(1 review)
Explore the great outdoors at Guembe Biocenter, a lovely green space in Colinas del Urubo. While in the area, you can find time to visit its shops.
What to do in Santa Cruz
Santa Cruz: 2-Day Tour of the Che Guevara Route in Bolivia
CA $968
per adult
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
