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Hotels in Sanctuary, Sanibel

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Our top choices for Sanctuary hotels

1. Tween Waters Island Resort & Spa

Tween Waters Island Resort & Spa
3.0 star property
3.7 km from Sanctuary
8.6 out of 10, Excellent, (1,002 reviews)
"Great place to relax and enjoy some R&R"
United States
Kelly
The price is CA $392
CA $486 total
includes taxes & fees
Sep 28 - Sep 29
Tween Waters Island Resort & Spa

2. Residence Inn by Marriott Fort Myers Sanibel

Residence Inn by Marriott Fort Myers Sanibel
3.0 star property
19.3 km from Sanctuary
8.8 out of 10, Excellent, (1,006 reviews)
"The hotel was in a great location, very clean and had great breakfast options."
United States
jennifer
The price is CA $120
CA $134 total
includes taxes & fees
Sep 23 - Sep 24
Residence Inn by Marriott Fort Myers Sanibel

3. Off the Charts Inn & Out Island Resort

Off the Charts Inn & Out Island Resort
2.5 star property
8.8 km from Sanctuary
9.6 out of 10, Exceptional, (164 reviews)
"Very comfortable and convenient location!"
United States
Lisa
The price is CA $179
CA $246 total
includes taxes & fees
Oct 1 - Oct 2
Off the Charts Inn & Out Island Resort

4. Sanibel Island Beach Resort

Sanibel Island Beach Resort
3.0 star property
Mid Island, 13.1 km from Sanctuary
9.2 out of 10, Wonderful, (2,313 reviews)
"We had a great time, location was perfect"
United States
Jill
The price is CA $250
CA $318 total
includes taxes & fees
Oct 4 - Oct 5
Sanibel Island Beach Resort

5. Island Inn

Island Inn
3.5 star property
West End, 9.6 km from Sanctuary
9.4 out of 10, Exceptional, (1,156 reviews)
"Great location"
United States
Nicole
The price is CA $284
CA $316 total
includes taxes & fees
Sep 29 - Sep 30
Island Inn

6. La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
3.0 star property
19.9 km from Sanctuary
8.2 out of 10, Very good, (1,356 reviews)
"Perfect stay"
United States
Jorge
The price is CA $100
CA $111 total
includes taxes & fees
Sep 28 - Sep 29
La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

7. South Seas

South Seas
3.5 star property
5.5 km from Sanctuary
8.4 out of 10, Very good, (1,002 reviews)
"Staff was super friendly and made my family feel so welcome. Standouts were our waiter Dale at the Beach House and Jocaleb, a worker at the pool. We had an awesome stay and will return."
United States
Jeremy
The price is CA $310
CA $511 total
includes taxes & fees
Oct 8 - Oct 9
South Seas

8. Shalimar Beach Resort

Shalimar Beach Resort
3.5 star property
West End, 10.3 km from Sanctuary
9.8 out of 10, Exceptional, (98 reviews)
"This hotel was absolutely wonderful. I will book here again."
United States
PATRICIA
The price is CA $313
CA $349 total
includes taxes & fees
Sep 23 - Sep 24
Shalimar Beach Resort

9. Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
2.5 star property
23.1 km from Sanctuary
9.2 out of 10, Wonderful, (1,003 reviews)
"Very clean and comfortable hotel! Great breakfast too!"
United States
Gigette
The price is CA $133
CA $148 total
includes taxes & fees
Oct 20 - Oct 21
Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG

10. Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway
3.0 star property
22.9 km from Sanctuary
8.8 out of 10, Excellent, (1,009 reviews)
"Room was clean, breakfast was really good as well. We'll definitely stay here again next year."
United States
Jason
The price is CA $108
CA $121 total
includes taxes & fees
Sep 28 - Sep 29
Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

11. Casa Ybel Resort

Casa Ybel Resort
2.5 star property
Ybel, 11.6 km from Sanctuary
8.8 out of 10, Excellent, (432 reviews)
"Loved the large, condo-size rooms. Loved our ocean view and wait staff at pool was great. I would definitely stay there again."
United States
Karen Elizabeth
The price is CA $356
CA $397 total
includes taxes & fees
Sep 27 - Sep 28
Casa Ybel Resort

12. Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach
2.5 star property
21.5 km from Sanctuary
9.0 out of 10, Wonderful, (1,002 reviews)
"Perfect hotel"
United States
Ana
The price is CA $116
CA $129 total
includes taxes & fees
Sep 23 - Sep 24
Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

13. The Anchor Inn

The Anchor Inn
2.0 star property
Mid Island, 12.8 km from Sanctuary
9.8 out of 10, Exceptional, (72 reviews)
"10/10would stay here again"
United States
Jamie
The price is CA $212
CA $257 total
includes taxes & fees
Sep 27 - Sep 28
The Anchor Inn

14. Matlacha on Shoreview

Matlacha on Shoreview
2.0 star property
20.2 km from Sanctuary
9.6 out of 10, Exceptional, (292 reviews)
"Great location very well kept clean will be back soon."
United States
Robby
The price is CA $88
CA $192 total
includes taxes & fees
Oct 22 - Oct 23
Matlacha on Shoreview

15. Latitude 26 Waterfront Resort & Marina

Latitude 26 Waterfront Resort & Marina
3.0 star property
22 km from Sanctuary
8.6 out of 10, Excellent, (1,001 reviews)
"Definitely would stay again"
United States
Sebastian
The price is CA $130
CA $145 total
includes taxes & fees
Sep 23 - Sep 24
Latitude 26 Waterfront Resort & Marina

16. The Westin Cape Coral Resort At Marina Village

The Westin Cape Coral Resort At Marina Village
4.0 star property
18.1 km from Sanctuary
9.0 out of 10, Wonderful, (1,003 reviews)
"The hotel was very nice and great views of the water."
United States
Eric
The price is CA $205
CA $291 total
includes taxes & fees
Oct 14 - Oct 15
The Westin Cape Coral Resort At Marina Village

17. Best Western Plus Beach Resort

Best Western Plus Beach Resort
2.5 star property
20.9 km from Sanctuary
9.4 out of 10, Exceptional, (1,006 reviews)
"Very nice place for short stay. If you like a quiet environment, this is your best choice."
United States
selma
The price is CA $278
CA $310 total
includes taxes & fees
Sep 23 - Sep 24
Best Western Plus Beach Resort

18. Kona Kai Motel

Kona Kai Motel
2.5 star property
Mid Island, 12.2 km from Sanctuary
9.0 out of 10, Wonderful, (1,001 reviews)
"Good location"
United States
Presley
The price is CA $225
CA $259 total
includes taxes & fees
Sep 23 - Sep 24
Kona Kai Motel

19. Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Holiday Inn Express Cape Coral-Fort Myers Area by IHG
2.5 star property
23.9 km from Sanctuary
9.4 out of 10, Exceptional, (1,670 reviews)
"great hotel"
United States
john
The price is CA $144
CA $161 total
includes taxes & fees
Oct 4 - Oct 5
Holiday Inn Express Cape Coral-Fort Myers Area by IHG

20. Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL

Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL
2.5 star property
22.6 km from Sanctuary
8.8 out of 10, Excellent, (1,001 reviews)
"The staff was fantastic and very friendly to work with. Breakfast was wonderful and the hotel room was well kept."
United States
Taylor
The price is CA $132
CA $147 total
includes taxes & fees
Oct 11 - Oct 12
Hampton Inn & Suites - Cape Coral/Fort Myers Area, FL
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Sanctuary

Find the best Sanctuary areas and neighborhoods for the activities you enjoy most.

Mid Island

While visiting Mid Island, you might make a stop by sights like Periwinkle Way and Sanibel Island Golf Club.

West End

While visiting West End, you might make a stop by sights like J. N. Ding Darling National Wildlife Refuge and Bowman's Beach.

East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.

Beachview Country Club Estates

If you're spending some time in Beachview Country Club Estates, Sanibel Island Golf Club and Periwinkle Way are top sights worth seeing.

Gulf Shores

While there might not be top attractions in Gulf Shores, you can explore the larger area and discover places like Bowman's Beach and J. N. Ding Darling National Wildlife Refuge.

Top Sanctuary Hotel Reviews

Frequently asked questions

What other neighbourhoods are similar to Sanctuary?
While Sanctuary is a unique destination, the closest experiences you'll find are in areas like The Preserve or Coastal Haven, both known for their emphasis on luxury and natural beauty.

The Preserve offers a similar secluded feel, located amongst extensive natural landscaping and waterways. It's characterised by its large, custom-built homes and a focus on outdoor living, with many properties featuring private docks and direct access to the intercoastal waters. The main thoroughfare, Cypress Drive, is lined with mature trees, giving it a very private and exclusive feel.

Couples looking for a serene escape will appreciate The Preserve. The area is superb for quiet mornings on a private patio, enjoying wildlife, or spending afternoons boating directly from your property. It's ideal for those who value privacy and a connection with nature without sacrificing high-end amenities.

Coastal Haven provides a comparable upscale experience, albeit with a slightly more coastal, beach-oriented character. This neighbourhood features elegant properties, many with ocean views or direct beach access, and is known for its immaculately kept public spaces and a relaxed, yet refined, atmosphere. The central promenade, Ocean Boulevard, offers convenient access to high-end dining and boutique shops.

For those who enjoy a blend of luxury and beachside living, Coastal Haven is an excellent choice.
When is the best time to go to Sanctuary?
The best time to go to Sanctuary is during the spring (March to May) and autumn (September to November) months.

These periods offer pleasant weather, with moderate temperatures and lower humidity, making it ideal for outdoor activities and exploring the area comfortably. You'll find fewer crowds compared to the peak summer season, which means a more relaxed experience at popular attractions and easier dining reservations.

For visitors looking to enjoy the area's natural beauty, such as the numerous parks and nature trails, spring is particularly appealing with blooming flora.
Can I cancel my hotel reservation on Expedia?
Many Expedia hotel reservations are refundable, provided that you cancel before the hotel's cancellation deadline – this is often within 24-48 hours of your scheduled arrival. If you have a non-refundable booking, it might still be possible to receive a refund if you cancel it within 24 hours of booking. Be sure to check your booking confirmation for the exact cancellation policy. For maximum flexibility, use our "Fully refundable property" filter during your search to find the right Sanctuary hotel for you.
How much is the nightly rate at a Sanctuary hotel?
Hotel prices in Sanctuary often vary, but you can find a great deal on Expedia. Different factors affect nightly hotel rates, such as the time of year or the days of the week you want to book. To find the best deals for your stay, be flexible with your dates, and sort search results by "Price: low to high" for our cheapest rates.

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