Hotels in Sanctuary, Sanibel from CA $112

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Our top choices for Sanctuary hotels

1. South Seas

South Seas
3.5 star property
5.5 km from Sanctuary
8.4 out of 10, Very good, (1,001 reviews)
"Staff was super friendly and made my family feel so welcome. Standouts were our waiter Dale at the Beach House and Jocaleb, a worker at the pool. We had an awesome stay and will return."
United States
Jeremy
The price is CA $290
CA $488 total
includes taxes & fees
Dec 1 - Dec 2
South Seas

2. Tween Waters Island Resort & Spa

Tween Waters Island Resort & Spa
3.0 star property
3.7 km from Sanctuary
8.8 out of 10, Excellent, (1,003 reviews)
"They could do better on the food for breakfast at the restaurant on the property"
United States
Carol
The price is CA $456
CA $558 total
includes taxes & fees
Dec 10 - Dec 11
Tween Waters Island Resort & Spa

3. Island Inn

Island Inn
3.5 star property
West End, 9.6 km from Sanctuary
9.4 out of 10, Exceptional, (1,168 reviews)
"Great location"
United States
Nicole
The price is CA $309
CA $345 total
includes taxes & fees
Nov 12 - Nov 13
Island Inn

4. Sanibel Island Beach Resort

Sanibel Island Beach Resort
3.0 star property
Mid Island, 13.1 km from Sanctuary
9.2 out of 10, Wonderful, (2,424 reviews)
"Lovely stay. Great staff and relaxing environment."
United States
Victoria
The price is CA $281
CA $353 total
includes taxes & fees
Nov 11 - Nov 12
Sanibel Island Beach Resort

5. Off the Charts Inn & Out Island Resort

Off the Charts Inn & Out Island Resort
2.5 star property
8.8 km from Sanctuary
9.6 out of 10, Exceptional, (165 reviews)
"Very good on everything I love the location"
United States
George
The price is CA $212
CA $284 total
includes taxes & fees
Dec 7 - Dec 8
Off the Charts Inn & Out Island Resort

6. The Anchor Inn

The Anchor Inn
2.0 star property
Mid Island, 12.8 km from Sanctuary
10.0 out of 10, Exceptional, (86 reviews)
"The whole place was wonderful."
United States
April
The price is CA $211
CA $257 total
includes taxes & fees
Nov 15 - Nov 16
The Anchor Inn

7. The Westin Cape Coral Resort At Marina Village

The Westin Cape Coral Resort At Marina Village
4.0 star property
18.1 km from Sanctuary
9.0 out of 10, Wonderful, (1,003 reviews)
"Very clean and nice place!"
United States
Charles
The price is CA $207
CA $293 total
includes taxes & fees
Nov 16 - Nov 17
The Westin Cape Coral Resort At Marina Village

8. Marriott Sanibel Harbour Resort & Spa

Marriott Sanibel Harbour Resort & Spa
4.0 star property
15.6 km from Sanctuary
8.6 out of 10, Excellent, (1,003 reviews)
"I love everything about this hotel"
United States
Yunior
The price is CA $315
CA $401 total
includes taxes & fees
Nov 23 - Nov 24
Marriott Sanibel Harbour Resort & Spa

9. La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
3.0 star property
19.9 km from Sanctuary
8.2 out of 10, Very good, (1,405 reviews)
"The staff was very helpful during my stay."
United States
Samantha
The price is CA $113
CA $126 total
includes taxes & fees
Nov 23 - Nov 24
La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway

10. Residence Inn by Marriott Fort Myers Sanibel

Residence Inn by Marriott Fort Myers Sanibel
3.0 star property
19.3 km from Sanctuary
8.8 out of 10, Excellent, (1,004 reviews)
"Loved the balcony view, breakfast spread, hot tub and heated pool."
United States
Lora
The price is CA $144
CA $161 total
includes taxes & fees
Nov 15 - Nov 16
Residence Inn by Marriott Fort Myers Sanibel

11. Holiday Inn Express Cape Coral-Fort Myers Area by IHG

Holiday Inn Express Cape Coral-Fort Myers Area by IHG
2.5 star property
23.9 km from Sanctuary
9.4 out of 10, Exceptional, (1,754 reviews)
"Very clean - nice breakfast - great parking"
United States
Sherri
The price is CA $143
CA $159 total
includes taxes & fees
Nov 16 - Nov 17
Holiday Inn Express Cape Coral-Fort Myers Area by IHG

12. Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway
3.0 star property
22.9 km from Sanctuary
8.8 out of 10, Excellent, (1,007 reviews)
"I enjoyed my stay - peaceful, wonderful staff & great location"
United States
Melanie
The price is CA $137
CA $153 total
includes taxes & fees
Nov 17 - Nov 18
Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway

13. Casa Ybel Resort

Casa Ybel Resort
2.5 star property
Ybel, 11.6 km from Sanctuary
9.0 out of 10, Wonderful, (483 reviews)
"Beautiful grounds, restaurant and bar very nice, good beach access"
Canada
Ronald
The price is CA $366
CA $409 total
includes taxes & fees
Nov 11 - Nov 12
Casa Ybel Resort

14. Lani Kai Beachfront Resort

Lani Kai Beachfront Resort
3.5 star property
21.8 km from Sanctuary
8.8 out of 10, Excellent, (2,189 reviews)
"Excellent location"
United States
yeny
The price is CA $193
CA $247 total
includes taxes & fees
Dec 7 - Dec 8
Lani Kai Beachfront Resort

15. Shalimar Beach Resort

Shalimar Beach Resort
3.5 star property
West End, 10.3 km from Sanctuary
9.8 out of 10, Exceptional, (110 reviews)
"Room was big and clean. Right on beach and nice pool area and chairs."
United States
JOHN
The price is CA $443
CA $494 total
includes taxes & fees
Nov 15 - Nov 16
Shalimar Beach Resort

16. Margaritaville Beach Resort Fort Myers

Margaritaville Beach Resort Fort Myers
4.0 star property
21.6 km from Sanctuary
9.0 out of 10, Wonderful, (2,752 reviews)
"Everything about the resort was excellent"
United States
Lance
The price is CA $253
CA $353 total
includes taxes & fees
Dec 7 - Dec 8
Margaritaville Beach Resort Fort Myers

17. The Lighthouse Resort Inn & Suites

The Lighthouse Resort Inn & Suites
3.0 star property
21.5 km from Sanctuary
8.6 out of 10, Excellent, (1,854 reviews)
"excellent place to stay"
United States
Shayne
The price is CA $114
CA $155 total
includes taxes & fees
Dec 7 - Dec 8
The Lighthouse Resort Inn & Suites

18. Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

Latitude 26 Waterfront Boutique Resort - Fort Myers Beach
2.5 star property
21.5 km from Sanctuary
9.0 out of 10, Wonderful, (1,003 reviews)
"This place was quiet and very clean, we were able to do kayaking & there's a lot of places to eat around. 3-5min from the beaches, shopping & restaurants."
United States
Maria
The price is CA $134
CA $149 total
includes taxes & fees
Nov 11 - Nov 12
Latitude 26 Waterfront Boutique Resort - Fort Myers Beach

19. Sanibel Inn

Sanibel Inn
3.0 star property
East End, 13.8 km from Sanctuary
9.2 out of 10, Wonderful, (1,003 reviews)
"Staff was amazingly friendly"
United States
Tamara
The price is CA $411
CA $548 total
includes taxes & fees
Dec 10 - Dec 11
Sanibel Inn

20. Sundial Beach Resort & Spa

Sundial Beach Resort & Spa
5.0 star property
Mid Island, 12.8 km from Sanctuary
8.6 out of 10, Excellent, (2,720 reviews)
"Great trip, beautiful island and great location!"
United States
Jeremy
The price is CA $473
CA $621 total
includes taxes & fees
Dec 10 - Dec 11
Sundial Beach Resort & Spa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Compare popular hotels in Sanctuary

Property
Star rating
Guest rating
Breakfast included
Pool
Spa
Pet-friendly
WiFi included
A resort with a central pool, multiple lounge areas, and a beach view.
Tween Waters Island Resort & Spa
3.0 star property
8.8
Excellent
1,003 reviews
View
A spacious living room with a large flat-screen TV, a ceiling fan, and a view of the ocean through large windows.
South Seas
3.5 star property
8.4
Very good
1,001 reviews
View
A balcony with a wooden table and chairs, a hanging chair, and a view of palm trees and a pool.
Off the Charts Inn & Out Island Resort
2.5 star property
9.6
Exceptional
165 reviews
View
A covered outdoor area with a table and chairs, a ceiling fan, and a view of a beach with palm trees and a boat.
Island Inn
3.5 star property
9.4
Exceptional
1,168 reviews
View
A resort with multiple-story buildings, palm trees, and a well-maintained lawn.
Sanibel Island Beach Resort
3.0 star property
9.2
Wonderful
2,424 reviews
View

Where to stay in Sanctuary

Find the best Sanctuary areas and neighborhoods for the activities you enjoy most.

Mid Island

While visiting Mid Island, you might make a stop by sights like Periwinkle Way and Sanibel Island Southern Beach.

West End

While visiting West End, you might make a stop by sights like J. N. Ding Darling National Wildlife Refuge and Bowman's Beach.

East End

While visiting East End, you might make a stop by sights like Sanibel Island Northern Beach and Sanibel Island Lighthouse.

Beachview Country Club Estates

If you're spending some time in Beachview Country Club Estates, Periwinkle Way and Sanibel Island Golf Club are top sights worth seeing.

Gulf Shores

While there might not be top attractions in Gulf Shores, you can explore the larger area and discover places like Bowman's Beach and J. N. Ding Darling National Wildlife Refuge.

Top Sanctuary Hotel Reviews

Frequently Asked Questions

What other neighbourhoods are similar to Sanctuary?

While Sanctuary is a unique destination, the closest experiences you'll find are in areas like The Preserve or Coastal Haven, both known for their emphasis on luxury and natural beauty.

The Preserve offers a similar secluded feel, located amongst extensive natural landscaping and waterways. It's characterised by its large, custom-built homes and a focus on outdoor living, with many properties featuring private docks and direct access to the intercoastal waters. The main thoroughfare, Cypress Drive, is lined with mature trees, giving it a very private and exclusive feel.

Couples looking for a serene escape will appreciate The Preserve. The area is superb for quiet mornings on a private patio, enjoying wildlife, or spending afternoons boating directly from your property. It's ideal for those who value privacy and a connection with nature without sacrificing high-end amenities.

Coastal Haven provides a comparable upscale experience, albeit with a slightly more coastal, beach-oriented character. This neighbourhood features elegant properties, many with ocean views or direct beach access, and is known for its immaculately kept public spaces and a relaxed, yet refined, atmosphere. The central promenade, Ocean Boulevard, offers convenient access to high-end dining and boutique shops.

For those who enjoy a blend of luxury and beachside living, Coastal Haven is an excellent choice.

When is the best time to go to Sanctuary?

The best time to go to Sanctuary is during the spring (March to May) and autumn (September to November) months.

These periods offer pleasant weather, with moderate temperatures and lower humidity, making it ideal for outdoor activities and exploring the area comfortably. You'll find fewer crowds compared to the peak summer season, which means a more relaxed experience at popular attractions and easier dining reservations.

For visitors looking to enjoy the area's natural beauty, such as the numerous parks and nature trails, spring is particularly appealing with blooming flora.

Can I cancel my hotel reservation on Expedia?

Many Expedia hotel reservations are refundable, provided that you cancel before the hotel’s cancellation deadline – this is often within 24-48 hours of your scheduled arrival. If you have a non-refundable booking, it might still be possible to receive a refund if you cancel it within 24 hours of booking. Be sure to check your booking confirmation for the exact cancellation policy. For maximum flexibility, use our "Fully refundable property" filter during your search to find the right Sanctuary hotel for you.

How much is the nightly rate at a Sanctuary hotel?

Hotel prices in Sanctuary often vary, but you can find a great deal from CA $112 on Expedia. Different factors affect nightly hotel rates, such as the time of year or the days of the week you want to book. To find the best deals for your stay, be flexible with your dates, and sort search results by "Price: low to high" for our cheapest rates.

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