Hotels in Matlacha Isles, Cape Coral from CA $83
Change your mind
Book hotels with free cancellation
Be picky
Search almost a million properties worldwide
Go beyond your typical stay in Matlacha Isles
Resort
Family friendly
Check prices for these dates
Matlacha Isles hotels and places to stay
Our top choices for Matlacha Isles hotels

Marriott Sanibel Harbour Resort & Spa
Marriott Sanibel Harbour Resort & Spa
8.4 out of 10, Very good, (1004)
The price is CA $235
CA $297 total
includes taxes & fees
Aug 25 - Aug 26

Allure Suites
Allure Suites
7.6 out of 10, Good, (1001)
The price is CA $92
CA $103 total
includes taxes & fees
Sep 22 - Sep 23

Days Inn by Wyndham Fort Myers Springs Resort
Days Inn by Wyndham Fort Myers Springs Resort
6.0 out of 10, (1001)
The price is CA $124
CA $138 total
includes taxes & fees
Aug 24 - Aug 25

Econo Lodge North
Econo Lodge North
5.6 out of 10, (291)
The price is CA $74
CA $82 total
includes taxes & fees
Aug 25 - Aug 26

Best Western Fort Myers Inn & Suites
Best Western Fort Myers Inn & Suites
8.6 out of 10, Excellent, (1019)
The price is CA $91
CA $102 total
includes taxes & fees
Aug 24 - Aug 25

Days Inn & Suites by Wyndham Fort Myers Near JetBlue Park
Days Inn & Suites by Wyndham Fort Myers Near JetBlue Park
7.8 out of 10, Good, (1415)
The price is CA $94
CA $105 total
includes taxes & fees
Aug 23 - Aug 24
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Where to stay in Matlacha Isles
Find the best Matlacha Isles areas and neighborhoods for the activities you enjoy most.

Pelican
If you're spending some time in Pelican, Tarpon Point and Harbour View Gallery are top sights worth seeing.

Caloosahatchee
If you're spending some time in Caloosahatchee, Cape Coral Yacht Club Beach and Dolphin Marina are top sights worth seeing.
Yacht Club
While there might not be top attractions in Yacht Club, you can explore the larger area and discover places like Cape Coral Yacht Club Beach and Veterans Foundation Headquarters.
Mariner
While visiting Mariner, you might make a stop by sights like Mike Greenwell's Bat-A-Ball & Family Fun Park and Yucca Pens Unit State Wildlife Management Area.

Hancock
While visiting Hancock, you might make a stop by sights like Four Mile Cove Ecological Preserve and Pine Island Shopping Center.
Top Matlacha Isles Hotel Reviews

Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
10/10 Excellent
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Hotels in top Cape Coral neighborhoods
- Hotels in Pelican
- Hotels in Caloosahatchee
- Hotels in Iona
- Hotels in Yacht Club
- Hotels in Mariner
- Hotels in Hancock
- Hotels in Punta Rassa
- Hotels in Burnt Store
- Hotels in Trafalgar
- Hotels in McGregor
- Hotels in Eight Lakes
- Hotels in Cape Harbour
- Hotels in Diplomat
- Hotels in Lochmoor Waterway Estates
- Hotels in Jacarandas
- Hotels in Matlacha Isles
- Hotels in Del Tura
- Hotels in Peninsula Point
Hotels near popular Cape Coral Attractions
- Hotels near Key West Express
- Hotels near Sanibel Island Southern Beach
- Hotels near Edison Mall
- Hotels near Lee Health Sports Complex
- Hotels near Estero Boulevard Beach
- Hotels near Boca Grande Beach
- Hotels near Captiva Beach
- Hotels near North Captiva Island Beach
- Hotels near Bowman's Beach
- Hotels near Edison and Ford Winter Estates
More Accommodation Types in Matlacha Isles
Hotels Close to Nearby Airports
Matlacha Isles Hotels by Star Rating
Matlacha Isles Hotels by Brand
Explore more hotels
- The Westin Cape Coral Resort At Marina Village
- DiamondHead Beach Resort
- La Quinta Inn & Suites by Wyndham Ft. Myers-Sanibel Gateway
- Hyatt Place Fort Myers/at The Forum
- The Lighthouse Resort Inn & Suites
- Extended Stay America Premier Suites - Fort Myers - Airport
- Holiday Inn Express & Suites Ft Myers Beach-Sanibel Gateway by IHG
- Days Inn & Suites by Wyndham Fort Myers Near JetBlue Park
- Hampton Inn & Suites Fort Myers Beach/Sanibel Gateway
- Hampton Inn Fort Myers Downtown
- Americas Best Value Inn Ft. Myers
- Comfort Inn & Suites Airport
More ways to book
Expedia's Latest Trends
Hotels
- Hotels in Brickell
- Hotels in Downtown Tampa
- Hotels in Coconut Grove
- Hotels in Doral
- Hotels in Downtown Miami
- Hotels in Downtown Orlando
- Hotels in Wynwood Art District
- South Beach Cheap Hotels
- South Beach Boutique Hotels
- Hotels in Little Havana
- 5 Star Hotels in South Beach
- Hotels in South Beach
- South Beach Beach Hotel
- Hotels in Mid Beach
- South Beach Oceanfront Hotels
Packages