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Check prices for these dates

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Nov 20 - Nov 22
In two weeks
Nov 27 - Nov 29
In one month
Dec 11 - Dec 13
In two months
Jan 8 - Jan 10

Our top choices for San Ysidro aparthotels

A narrow, enclosed walkway with wooden railings and a metal grid barrier, leading to a building entrance.

1. City24 Hotel Little Italy Mission Hills

City24 Hotel Little Italy Mission Hills
4.5 star property
Middletown
9.6 out of 10, Exceptional, (243 reviews)
"Location is great because it is so close to the airport and you won’t even be able to hear the planes. The room is so roomy and has every utility you need !"
United States
Stephanie
The price is CA $165
CA $234 total
includes taxes & fees
Dec 2 - Dec 3
City24 Hotel Little Italy Mission Hills
A spacious lounge area with a sofa, a coffee table, and a bar with stools.

2. Marriott Vacation Club®, San Diego

Marriott Vacation Club®, San Diego
3.5 star property
Downtown San Diego
9.4 out of 10, Exceptional, (1,265 reviews)
"Amazing stay! Would definitely come back!"
United States
Dirosia
The price is CA $204
CA $237 total
includes taxes & fees
Nov 30 - Dec 1
Marriott Vacation Club®, San Diego
A spacious lobby with a sofa, chairs, a bookshelf, and a large window with a view of greenery.

3. Uptown Inn by Vantaggio - Limited Service Apart-Hotel

Uptown Inn by Vantaggio - Limited Service Apart-Hotel
2.5 star property
Hillcrest
8.4 out of 10, Very good, (522 reviews)
"Front desk service was amazing and love the central location to all the LGBTQ bars and restaurants."
United States
Victor
The price is CA $128
CA $144 total
includes taxes & fees
Nov 19 - Nov 20
Uptown Inn by Vantaggio - Limited Service Apart-Hotel
A modern lobby with a green sofa, a wooden accent wall, and a large plant.

4. Little Italy Inn - Limited Service Apart Hotel

Little Italy Inn - Limited Service Apart Hotel
2.5 star property
Downtown San Diego
8.4 out of 10, Very good, (413 reviews)
"clean, affordable, safe, such a great stay!"
United States
Beatriz
The price is CA $139
CA $161 total
includes taxes & fees
Nov 17 - Nov 18
Little Italy Inn - Limited Service Apart Hotel
A neatly made bed with white and gold bedding, two bedside tables with lamps, and three wall-mounted mirrors.

5. Kasa Gaslamp Quarter San Diego

Kasa Gaslamp Quarter San Diego
3.5 star property
Downtown San Diego
7.8 out of 10, Good, (241 reviews)
"Wonderful place!"
Canada
Eric
The price is CA $139
CA $158 total
includes taxes & fees
Nov 17 - Nov 18
Kasa Gaslamp Quarter San Diego
A modern bedroom with a bed, bedside table, lamp, and a mirror.

6. The Penn Hotel - Queen Bed, AC & Walk to Gaslamp!!

The Penn Hotel - Queen Bed, AC & Walk to Gaslamp!!
Downtown San Diego
The price is CA $91
CA $307 total
includes taxes & fees
Nov 16 - Nov 17
The Penn Hotel - Queen Bed, AC & Walk to Gaslamp!!
A modern hotel room with a bed, a sofa, a coffee table, and a TV displaying the Netflix logo.

7. The Penn Hotel - Walk to Attractions & Sleeps 5!!

The Penn Hotel - Walk to Attractions & Sleeps 5!!
Downtown San Diego
The price is CA $102
CA $469 total
includes taxes & fees
Nov 15 - Nov 16
The Penn Hotel - Walk to Attractions & Sleeps 5!!
🏙 Bright open-concept living residence—bathed in natural light with views overlooking the vibrant Gaslamp Quarter.

8. The Penn Hotel - Designer 2BR Near Gaslamp & Park

The Penn Hotel - Designer 2BR Near Gaslamp & Park
Downtown San Diego
The price is CA $102
CA $465 total
includes taxes & fees
Nov 15 - Nov 16
The Penn Hotel - Designer 2BR Near Gaslamp & Park
A modern living room with a dining area, a flat-screen TV mounted on the wall, a sofa, and a bed.

9. The Penn Hotel - Smart TV, AC & Downtown Location!

The Penn Hotel - Smart TV, AC & Downtown Location!
Downtown San Diego
The price is CA $102
CA $452 total
includes taxes & fees
Nov 16 - Nov 17
The Penn Hotel - Smart TV, AC & Downtown Location!
A modern bedroom with a large bed, a city view through the window, and a round nightstand with a plant.

10. The Penn Hotel - Smart TV, King Bed & Walkability!

The Penn Hotel - Smart TV, King Bed & Walkability!
Downtown San Diego
The price is CA $98
CA $462 total
includes taxes & fees
Nov 12 - Nov 13
The Penn Hotel - Smart TV, King Bed & Walkability!
A dining table set with white bowls, wine glasses, and a vase with flowers.

11. The Penn Hotel - Smart TV, AC & Walk to Gaslamp!!!

The Penn Hotel - Smart TV, AC & Walk to Gaslamp!!!
Downtown San Diego
The price is CA $102
CA $468 total
includes taxes & fees
Nov 17 - Nov 18
The Penn Hotel - Smart TV, AC & Walk to Gaslamp!!!
☕ Gourmet kitchen detail—featuring sleek cabinetry, stainless microwave, and under-cabinet lighting.

12. The Penn Hotel - King & Queen Bed | Gaslamp Life

The Penn Hotel - King & Queen Bed | Gaslamp Life
Downtown San Diego
The price is CA $102
CA $452 total
includes taxes & fees
Nov 16 - Nov 17
The Penn Hotel - King & Queen Bed | Gaslamp Life
A modern kitchen with a central island, stainless steel appliances, and a view of a cityscape through the window.

13. The Penn Hotel - Smart TV, AC & Gaslamp Steps Away

The Penn Hotel - Smart TV, AC & Gaslamp Steps Away
Downtown San Diego
The price is CA $102
CA $452 total
includes taxes & fees
Nov 16 - Nov 17
The Penn Hotel - Smart TV, AC & Gaslamp Steps Away
🛋 Sunlit lounge area—thoughtfully arranged with armchairs and large windows for relaxing or taking in city views.

14. The Penn Hotel - Sleeps 5 & Nightlife Above Clubs!

The Penn Hotel - Sleeps 5 & Nightlife Above Clubs!
Downtown San Diego
The price is CA $102
CA $468 total
includes taxes & fees
Nov 17 - Nov 18
The Penn Hotel - Sleeps 5 & Nightlife Above Clubs!
A rooftop pool with lounge chairs and a city skyline in the background.

15. Kasa Little Italy San Diego

Kasa Little Italy San Diego
4.5 star property
Downtown San Diego
9.6 out of 10, Exceptional, (564 reviews)
"Super nice amenities - would stay again. Great location"
United States
Nirmeen
The price is CA $255
CA $399 total
includes taxes & fees
Nov 15 - Nov 16
Kasa Little Italy San Diego
A modern kitchen with a central island, bar stools, a sofa, and a dining area with blue chairs.

16. The Penn Hotel -Live Above Gaslamp Nightlife &AC

The Penn Hotel -Live Above Gaslamp Nightlife &AC
Downtown San Diego
The price is CA $102
CA $468 total
includes taxes & fees
Nov 17 - Nov 18
The Penn Hotel -Live Above Gaslamp Nightlife &AC
A modern hotel room with a bed, seating area, TV, and a dining table.

17. The Penn Hotel - Sleeps 5 & Gaslamp Nightlife Now!

The Penn Hotel - Sleeps 5 & Gaslamp Nightlife Now!
Downtown San Diego
The price is CA $102
CA $452 total
includes taxes & fees
Nov 16 - Nov 17
The Penn Hotel - Sleeps 5 & Gaslamp Nightlife Now!
A modern apartment with a kitchen island, seating area, and a bedroom with a large bed and a round mirror.

18. The Penn Hotel - Premium Beds & Gaslamp Nightlife!

The Penn Hotel - Premium Beds & Gaslamp Nightlife!
Downtown San Diego
The price is CA $102
CA $452 total
includes taxes & fees
Nov 16 - Nov 17
The Penn Hotel - Premium Beds & Gaslamp Nightlife!
A dining area with a round table set for four, surrounded by dark chairs.

19. The Penn Hotel - Steps to Gaslamp & Petco Park, AC

The Penn Hotel - Steps to Gaslamp & Petco Park, AC
Downtown San Diego
The price is CA $102
CA $470 total
includes taxes & fees
Nov 18 - Nov 19
The Penn Hotel - Steps to Gaslamp & Petco Park, AC
A modern hotel room with a bed, a sofa, a dining table, and a large window offering a city view.

20. The Penn Hotel - King Bed, AC & Gaslamp Nightlife!

The Penn Hotel - King Bed, AC & Gaslamp Nightlife!
Downtown San Diego
The price is CA $102
CA $468 total
includes taxes & fees
Nov 17 - Nov 18
The Penn Hotel - King Bed, AC & Gaslamp Nightlife!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about San Ysidro

The world's busiest land border crossing transforms into a shopper's paradise at Las Americas Premium Outlets. Visit Border Field State Park for coastal trails where you can glimpse both San Diego and Tijuana from one stunning viewpoint.

See all hotels in San Ysidro
A beach with seagulls and a large metal fence.

Top reviews in San Ysidro

A spacious lounge area with a sofa, a coffee table, and a bar with stools.
Marriott Vacation Club®, San Diego

Marriott Vacation Club®, San Diego

Marriott Vacation Club®, San Diego
Downtown San Diego

10/10 Excellent

We stayed here for two nights while visiting San Diego with our child, and our whole family really loved this hotel! The room was clean and comfortable, the location was very convenient, and having self-parking was a huge plus. We had a great stay and would definitely come back next time we’re in San Diego!
Canada
Min
Reviewed September 5, 2026
Marriott Vacation Club®, San Diego

Frequently Asked Questions

What can I look forward to during my San Ysidro aparthotel stay?

When you choose an aparthotel or serviced apartment in San Ysidro, expect to be more centrally situated. Take time to enjoy the array of shops and top-notch restaurants in this relaxing area. San Ysidro is also known for its beaches and live music.

What are the favorite aparthotels for my stay in San Ysidro?

Located 13.3 mi (21.4 km) from San Ysidro, Marriott Vacation Club®, San Diego is a favorite aparthotel featuring 264 apartments with free WiFi and comfy beds as well as hotel amenities like a restaurant. In the area, a couple of other top aparthotels to consider are Little Italy Inn - Limited Service Apart Hotel and Uptown Inn by Vantaggio - Limited Service Apart-Hotel.

How many aparthotels will I find in San Ysidro?

Bookable on Expedia, there are 14 hotels and other accommodations in San Ysidro. Though you won't find many aparthotels, we can help you find places to stay that are similar such as a condo or apartment.

What are the must-see places to visit in San Ysidro?

Favorite sights to visit while in town include San Ysidro Border Crossing. Explore the area and family-friendly sights such as San Diego Zoo, or get out into nature at a spot like Mission Bay. In the larger area, you’ll find popular places like Petco Park and Port of San Diego.

What is an aparthotel?

An aparthotel is both a hotel and an apartment, with amenities you might expect at a traditional hotel, and the space and privacy of an apartment. Feel like a local in an apartment-like space, often situated in the center of San Ysidro. Enjoy making home-cooked meals in a fully-equipped kitchen and having some extra space to relax after a long day of sightseeing.

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