Title: Book The Best Hotels in San Cosme y Damian for 2026 from CA $80 - Fully Refundable Options - Expedia.ca [San Cosme y Damian Travel Guide](https://expedia.ca/San-Cosme-Y-Damian.dx6348319)[Hotels in San Cosme y Damian](https://expedia.ca/San-Cosme-Y-Damian-Hotels.d6348319.Travel-Guide-Hotels)[Vacation Rentals in San Cosme y Damian](https://expedia.ca/San-Cosme-Y-Damian-Vacation-Rentals.d6348319.Travel-Guide-VacationRentals)[San Cosme y Damian Car Rentals](https://expedia.ca/Car-Rentals-In-San-Cosme-Y-Damian.d6348319.Car-Rental-Guide) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/32a5a1b7-682e-4c22-a8ab-4b736795e0ea/expedia_fallback.webp?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/32a5a1b7-682e-4c22-a8ab-4b736795e0ea/expedia_fallback.webp?impolicy=fcrop&w=1200&h=500&q=medium) - ## Plan, book, travel with confidence - ### Better together Save up to CA $1,096 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Plan, book, and manage your trip all in one place ## Check prices for these dates Tonight [Feb 18 - Feb 19](https://www.expedia.ca/Hotel-Search?regionId=6348319&startDate=2026-02-18&endDate=2026-02-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel) Tomorrow [Feb 19 - Feb 20](https://www.expedia.ca/Hotel-Search?regionId=6348319&startDate=2026-02-19&endDate=2026-02-20&adults=2&rfrr=TG.LP.CheckPrices.Hotel) This weekend [Feb 20 - Feb 22](https://www.expedia.ca/Hotel-Search?regionId=6348319&startDate=2026-02-20&endDate=2026-02-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel) Next weekend [Feb 27 - Mar 1](https://www.expedia.ca/Hotel-Search?regionId=6348319&startDate=2026-02-27&endDate=2026-03-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSan-Cosme-Y-Damian.d6348319.Destination-Travel-Guides)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSan-Cosme-Y-Damian.d6348319.Destination-Travel-Guides) ## Stay near popular San Cosme y Damian attractions ### Guarani Jesuit Ruins of San Cosme and San Damián Find out about the history of San Cosme y Damian when you take a trip to Guarani Jesuit Ruins of San Cosme and San Damián. Take in the museums while you're in the area. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=812269535561961472) ### Buenaventura Suarez Planetarium You can spend time browsing the exhibits at Buenaventura Suarez Planetarium during your travels in San Cosme y Damian. Take in the museums while you're in the area. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532463875) ## Top San Cosme y Damian Hotel Reviews ## More cheap stays in San Cosme y Damian ![Puesta del Sol by Nobile](https://images.trvl-media.com/lodging/16000000/15240000/15237500/15237430/560dc4db_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Puesta del Sol by Nobile 14 de Mayo 44 Esq. Av. Francia Encarnacion Itapua CA $72 CA $80 total Mar 1 - Mar 2 includes taxes & fees 8.6/10 Excellent! (48 reviews) [](https://expedia.ca/Encarnacion-Hotels-Hotel-Puesta-Del-Sol.h15237430.Hotel-Information) ![Apartament central with river views pool](https://images.trvl-media.com/lodging/104000000/103160000/103150100/103150003/ea823cad_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Apartament central with river views pool Paraguayan Railways Encarnacion Itapúa Department CA $368 CA $473 total Mar 14 - Mar 15 includes taxes & fees [](https://expedia.ca/Encarnacion-Hotels-Apartament-Central-With-River-Views-Pool.h103150003.Hotel-Information) ![Hermosa Casa de 3 Dormitorios 🤩](https://images.trvl-media.com/lodging/106000000/105890000/105886800/105886780/c6b64097_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hermosa Casa de 3 Dormitorios 🤩 Encarnación Itapúa [Get rates](https://expedia.ca/Hotel-Search?startDate=04%2F03%2F2026&endDate=05%2F03%2F2026&selected=105886780&PinnedHotelID=105886780&HadPinnedHotel=true®ionId=6348319) [](https://expedia.ca/Encarnacion-Hotels-Hermosa-Casa-De-3-Dormitorios.h105886780.Hotel-Information) ![Terwindt Hotel](https://images.trvl-media.com/lodging/30000000/29060000/29059400/29059377/1100e8de_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Terwindt Hotel Lomas Valentinas 1152 e Wissen y corá Encarnacion [Get rates](https://expedia.ca/Hotel-Search?startDate=04%2F03%2F2026&endDate=05%2F03%2F2026&selected=29059377&PinnedHotelID=29059377&HadPinnedHotel=true®ionId=6348319) [](https://expedia.ca/Encarnacion-Hotels-Terwindt-Hotel.h29059377.Hotel-Information) ![Casa de la Y, b&b, your place in Encarnación, close to everything.](https://images.trvl-media.com/lodging/122000000/121120000/121110200/121110117/c96014ea_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Casa de la Y, b&b, your place in Encarnación, close to everything. Encarnación Itapúa [Get rates](https://expedia.ca/Hotel-Search?startDate=04%2F03%2F2026&endDate=05%2F03%2F2026&selected=121110117&PinnedHotelID=121110117&HadPinnedHotel=true®ionId=6348319) [](https://expedia.ca/Encarnacion-Hotels-Vrbo-Property.h121110117.Hotel-Information) ## Frequently asked questions ### What is the best area to stay in San Cosme Y Damian? > This area is the heart of visitor activity. It's relatively compact, with accommodations often found within a short walk or drive of the historic Jesuit mission site. You'll find a few local eateries and shops primarily suiting tourists here. > > > For couples and anyone interested in history and astronomy, staying near the Jesuit Ruins is ideal. The mission itself is a UNESCO World Heritage site, and its astronomical observatory is a unique feature. ### Can I cancel my hotel reservation on Expedia? ### How can I save on a San Cosme y Damian hotel booking with Expedia? ### How much is the nightly rate at a San Cosme y Damian hotel? ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app