Title: Book The Best Hotels in San Cosme y Damian for 2026 from CA $79 - Fully Refundable Options - Expedia.ca [San Cosme y Damian Travel Guide](https://expedia.ca/San-Cosme-Y-Damian.dx6348319)[Vacation Rentals in San Cosme y Damian](https://expedia.ca/San-Cosme-Y-Damian-Vacation-Rentals.d6348319.Travel-Guide-VacationRentals)[San Cosme y Damian Car Rentals](https://expedia.ca/Car-Rentals-In-San-Cosme-Y-Damian.d6348319.Car-Rental-Guide)[San Cosme y Damian Vacation Packages](https://expedia.ca/San-Cosme-Y-Damian.d6348319.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Mar 11 - Mar 12](https://www.expedia.ca/Hotel-Search?regionId=6348319&startDate=2026-03-11&endDate=2026-03-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Mar 12 - Mar 13](https://www.expedia.ca/Hotel-Search?regionId=6348319&startDate=2026-03-12&endDate=2026-03-13&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Mar 13 - Mar 15](https://www.expedia.ca/Hotel-Search?regionId=6348319&startDate=2026-03-13&endDate=2026-03-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Mar 20 - Mar 22](https://www.expedia.ca/Hotel-Search?regionId=6348319&startDate=2026-03-20&endDate=2026-03-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.ca/deals?rfrr=HTG_SPRING_PROMO_6348319) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSan-Cosme-Y-Damian-Hotels.d6348319.Travel-Guide-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSan-Cosme-Y-Damian-Hotels.d6348319.Travel-Guide-Hotels) ## Stay near popular San Cosme y Damian attractions ### Buenaventura Suarez Planetarium You can spend time browsing the exhibits at Buenaventura Suarez Planetarium during your travels in San Cosme y Damian. Take in the museums while you're in the area. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532463875) ### Guarani Jesuit Ruins of San Cosme and San Damián Find out about the history of San Cosme y Damian when you take a trip to Guarani Jesuit Ruins of San Cosme and San Damián. Take in the museums while you're in the area. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=812269535561961472) ## Top San Cosme y Damian Hotel Reviews ## More cheap stays in San Cosme y Damian ![Puesta del Sol by Nobile](https://images.trvl-media.com/lodging/16000000/15240000/15237500/15237430/560dc4db_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Puesta del Sol by Nobile 14 de Mayo 44 Esq. Av. Francia Encarnacion Itapua CA $72 CA $79 total Mar 12 - Mar 13 includes taxes & fees [](https://expedia.ca/Encarnacion-Hotels-Hotel-Puesta-Del-Sol.h15237430.Hotel-Information) ![Terwindt Hotel](https://images.trvl-media.com/lodging/30000000/29060000/29059400/29059377/628f6de2_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Terwindt Hotel Lomas Valentinas 1152 e Wissen y corá Encarnacion [Get rates](https://expedia.ca/Hotel-Search?startDate=25%2F03%2F2026&endDate=26%2F03%2F2026&selected=29059377&PinnedHotelID=29059377&HadPinnedHotel=true®ionId=6348319) 4.8/10 (3 reviews) [](https://expedia.ca/Encarnacion-Hotels-Terwindt-Hotel.h29059377.Hotel-Information) ## Frequently asked questions ### What is the best area to stay in San Cosme Y Damian? > This area is the heart of visitor activity. It's relatively compact, with accommodations often found within a short walk or drive of the historic Jesuit mission site. You'll find a few local eateries and shops primarily suiting tourists here. > > > For couples and anyone interested in history and astronomy, staying near the Jesuit Ruins is ideal. The mission itself is a UNESCO World Heritage site, and its astronomical observatory is a unique feature. ### Can I cancel my hotel reservation on Expedia? ### How can I save on a San Cosme y Damian hotel booking with Expedia? ### How much is the nightly rate at a San Cosme y Damian hotel? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Other - [Bella Vista Hotels ](https://www.expedia.ca/Bella-Vista-Hotels.d6141312.Travel-Guide-Hotels) - [Encarnacion Hotels ](https://www.expedia.ca/Encarnacion-Hotels.d6141802.Travel-Guide-Hotels) - [Jesús Hotels ](https://www.expedia.ca/Jesus-Hotels.d6353265.Travel-Guide-Hotels) - [Trinidad Hotels ](https://www.expedia.ca/Trinidad-Hotels.d6141611.Travel-Guide-Hotels) - [Flights to Bella Vista ](https://www.expedia.ca/Cheap-Flights-To-Bella-Vista.d6141312.Travel-Guide-Flights) - [Flights to Encarnacion ](https://www.expedia.ca/Cheap-Flights-To-Encarnacion.d6141802.Travel-Guide-Flights) - [Encarnacion Vacations ](https://www.expedia.ca/Encarnacion.d6141802.Destination-Travel-Guides) - [Jesús Vacations ](https://www.expedia.ca/Jesus.d6353265.Destination-Travel-Guides) - [Trinidad Vacations ](https://www.expedia.ca/Trinidad.d6141611.Destination-Travel-Guides) - [Things to do in Encarnacion ](https://www.expedia.ca/Things-To-Do-In-Encarnacion.d6141802.Travel-Guide-Activities) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels and earn double points when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. 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