--- title: "Book The Best Hotels in San Cosme y Damian for 2026 - Fully Refundable Options - Expedia" description: "Book the best hotels in San Cosme y Damian in 2026. Compare room rates, hotel reviews and availability. Most hotels are fully refundable." canonical: "https://www.expedia.ca/San-Cosme-Y-Damian-Hotels.d6348319.Travel-Guide-Hotels" language: en-CA market: CA currency: CAD prices_as_of: 2026-11-14T12:46:03Z --- Plan your trip - [San Cosme y Damian Travel Guide](https://www.expedia.ca/San-Cosme-Y-Damian.dx6348319) - [Flights to San Cosme y Damian](https://www.expedia.ca/Cheap-Flights-To-San-Cosme-Y-Damian.d6348319.Travel-Guide-Flights) - [Car Rentals in San Cosme y Damian](https://www.expedia.ca/Car-Rentals-In-San-Cosme-Y-Damian.d6348319.Car-Rental-Guide) - [San Cosme y Damian Vacation Packages](https://www.expedia.ca/San-Cosme-Y-Damian.d6348319.Destination-Travel-Guides) - [Vacation Rentals in San Cosme y Damian](https://www.expedia.ca/San-Cosme-Y-Damian-Vacation-Rentals.d6348319.Travel-Guide-VacationRentals) # Find hotels in San Cosme y Damian ### Change your mind Book hotels with free cancellation ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in San Cosme y Damian [Apart­ment](https://www.expedia.ca/Hotel-Search?destination=San%20Cosme%20y%20Damian,%20Itapúa%20Department,%20Paraguay®ionId=6348319&latLong=-27.315951,-56.331269&adults=2&startDate=2026-11-21&d1=2026-11-21&endDate=2026-11-23&d2=2026-11-23&lodging=APARTMENT) [Condo](https://www.expedia.ca/Hotel-Search?destination=San%20Cosme%20y%20Damian,%20Itapúa%20Department,%20Paraguay®ionId=6348319&latLong=-27.315951,-56.331269&adults=2&startDate=2026-11-21&d1=2026-11-21&endDate=2026-11-23&d2=2026-11-23&lodging=CONDO) [Waterpark](https://www.expedia.ca/Hotel-Search?destination=San%20Cosme%20y%20Damian,%20Itapúa%20Department,%20Paraguay®ionId=6348319&latLong=-27.315951,-56.331269&adults=2&startDate=2026-11-21&d1=2026-11-21&endDate=2026-11-23&d2=2026-11-23&amenities=WATER%5FPARK) ## Check prices for these dates [Check prices for these dates, December 14–15, 2026](https://www.expedia.ca/Hotel-Search?regionId=6348319&startDate=2026-12-14&endDate=2026-12-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) [View in a map](https://www.expedia.ca/Hotel-Search?regionId=6348319&stayLength=1&daysInFuture=30&pwaOverlay=map) ## Stay near popular San Cosme y Damian attractions ### Buenaventura Suarez Planetarium Rating: 9.0/10 (2 reviews) You can spend time browsing the exhibits at Buenaventura Suarez Planetarium during your travels in San Cosme y Damian. Take in the museums while you're in the area. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248621532463875) ### Guarani Jesuit Ruins of San Cosme and San Damián Find out about the history of San Cosme y Damian when you take a trip to Guarani Jesuit Ruins of San Cosme and San Damián. Take in the museums while you're in the area. [See properties](https://www.expedia.ca/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=812269535561961472) ## Frequently Asked Questions ### What is the best area to stay in San Cosme Y Damian? The best area to stay in San Cosme Y Damian is close to the Jesuit Ruins of San Cosme y Damián, as this is the main attraction and offers the most convenience. This area is the heart of visitor activity. It's relatively compact, with accommodations often found within a short walk or drive of the historic Jesuit mission site. You'll find a few local eateries and shops primarily suiting tourists here. For couples and anyone interested in history and astronomy, staying near the Jesuit Ruins is ideal. The mission itself is a UNESCO World Heritage site, and its astronomical observatory is a unique feature. ### Can I cancel my hotel reservation on Expedia? You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in San Cosme y Damian. ### How much is the nightly rate at a San Cosme y Damian hotel? Prices for hotels in San Cosme y Damian often vary, but you can find a great deal on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate. ## Explore a world of travel with Expedia - [Lodging](?equalTargetTab=tab-0) - [Flights](?equalTargetTab=tab-1) - [Packages](?equalTargetTab=tab-2) - [Things to do](?equalTargetTab=tab-3) - [Bella Vista Hotels](https://www.expedia.ca/Bella-Vista-Hotels.d6141312.Travel-Guide-Hotels) - [Encarnacion Hotels](https://www.expedia.ca/Encarnacion-Hotels.d6141802.Travel-Guide-Hotels) - [Jesús Hotels](https://www.expedia.ca/Jesus-Hotels.d6353265.Travel-Guide-Hotels) - [Trinidad Hotels](https://www.expedia.ca/Trinidad-Hotels.d6141611.Travel-Guide-Hotels) - [Flights to Bella Vista](https://www.expedia.ca/Cheap-Flights-To-Bella-Vista.d6141312.Travel-Guide-Flights) - [Flights to Encarnacion](https://www.expedia.ca/Cheap-Flights-To-Encarnacion.d6141802.Travel-Guide-Flights) - [Encarnacion Vacations](https://www.expedia.ca/Encarnacion.d6141802.Destination-Travel-Guides) - [Jesús Vacations](https://www.expedia.ca/Jesus.d6353265.Destination-Travel-Guides) - [Trinidad Vacations](https://www.expedia.ca/Trinidad.d6141611.Destination-Travel-Guides) - [Things to do in Encarnacion](https://www.expedia.ca/Things-To-Do-In-Encarnacion.d6141802.Travel-Guide-Activities) ## Other language versions ```yaml hreflang: x-default: https://www.expedia.com/ th-TH: https://www.expedia.co.th/San-Cosme-Y-Damian-Hotels.d6348319.Travel-Guide-Hotels de-AT: https://www.expedia.at/Cosme-Y-San-Damian-Hotel.d6348319.Reise-Angebote-Hotels es-ES: https://www.expedia.es/San-Cosme-Y-Damian-Hoteles.d6348319.Guia-Viajes-Hoteles ja-JP: https://www.expedia.co.jp/San-Cosme-Y-Damian-Hotels.d6348319.Travel-Guide-Hotels en-CA: https://www.expedia.ca/San-Cosme-Y-Damian-Hotels.d6348319.Travel-Guide-Hotels en-ID: https://www.expedia.co.id/en/San-Cosme-Y-Damian-Hotels.d6348319.Travel-Guide-Hotels sv-SE: https://www.expedia.se/San-Cosme-Y-Damian-Hotell.d6348319.Reseguide-Hotell en-PH: https://www.expedia.com.ph/San-Cosme-Y-Damian-Hotels.d6348319.Travel-Guide-Hotels en-IE: https://www.expedia.ie/San-Cosme-Y-Damian-Hotels.d6348319.Travel-Guide-Hotels fr-CA: https://www.expedia.ca/fr/San-Cosme-Y-Damian-Hotel.d6348319.Travel-Guide-Hotels vi-VN: https://www.expedia.com.vn/San-Cosme-Y-Damian-Hotels.d6348319.Huong-dan-du-lich-Khach-san ar: https://www.expedia.sa/San-Cosme-Y-Damian-Hotels.d6348319.Travel-Guide-Hotels id-ID: https://www.expedia.co.id/San-Cosme-Y-Damian-Hotels.d6348319.Travel-Guide-Hotels nb-NO: https://www.expedia.no/San-Cosme-Y-Damian-Hoteller.d6348319.Reise-Guide-Hoteller ko-KR: https://www.expedia.co.kr/San-Cosme-Y-Damian-Hotels.d6348319.Travel-Guide-Hotels es: https://www.expedia.com/es/San-Cosme-Y-Damian-Hoteles.d6348319.Guia-Viajes-Hoteles es-AR: https://www.expedia.com.ar/San-Cosme-Y-Damian-Hoteles.d6348319.Guia-de-Hoteles fi-FI: https://www.expedia.fi/San-Cosme-Y-Damian-Hotellit.d6348319.Matkaoppaat-hotellit en-IN: https://www.expedia.co.in/San-Cosme-Y-Damian-Hotels.d6348319.Travel-Guide-Hotels fr-FR: https://www.expedia.fr/San-Cosme-Y-Damian-Hotel.d6348319.Voyage-Guide-Hotels en-TH: https://www.expedia.co.th/en/San-Cosme-Y-Damian-Hotels.d6348319.Travel-Guide-Hotels en-AE: https://www.expedia.ae/San-Cosme-Y-Damian-Hotels.d6348319.Travel-Guide-Hotels it-IT: https://www.expedia.it/San-Cosme-Y-Damian-Hotel.d6348319.Guida-Viaggi-Hotel en-TW: https://www.expedia.com.tw/en/San-Cosme-Y-Damian-Hotels.d6348319.Travel-Guide-Hotels en-HK: https://www.expedia.com.hk/en/San-Cosme-Y-Damian-Hotels.d6348319.Travel-Guide-Hotels en-GB: https://www.expedia.co.uk/San-Cosme-Y-Damian-Hotels.d6348319.Travel-Guide-Hotels zh-CN: https://www.expedia.com/cn/San-Cosme-Y-Damian-Hotels.d6348319.Travel-Guide-Hotels es-MX: https://www.expedia.mx/San-Cosme-Y-Damian-Hoteles.d6348319.Guia-Viajes-Hoteles pt-BR: https://www.expedia.com.br/San-Cosme-Y-Damian-Hoteis.d6348319.Guia-de-Hoteis en-JP: https://www.expedia.co.jp/en/San-Cosme-Y-Damian-Hotels.d6348319.Travel-Guide-Hotels en-AU: https://www.expedia.com.au/San-Cosme-Y-Damian-Hotels.d6348319.Travel-Guide-Hotels da-DK: https://www.expedia.dk/San-Cosme-Y-Damian-Hoteller.d6348319.Rejse-Guide-Hoteller en-NZ: https://www.expedia.co.nz/San-Cosme-Y-Damian-Hotels.d6348319.Travel-Guide-Hotels en-KR: https://www.expedia.co.kr/en/San-Cosme-Y-Damian-Hotels.d6348319.Travel-Guide-Hotels de-DE: https://www.expedia.de/Cosme-Y-San-Damian-Hotel.d6348319.Reise-Angebote-Hotels de-CH: https://www.expedia.ch/Cosme-Y-San-Damian-Hotel.d6348319.Reise-Angebote-Hotels nl-NL: https://www.expedia.nl/Cosme-Y-San-Damian-Hotels.d6348319.Reisgids-Hotels zh-TW: https://www.expedia.com.tw/San-Cosme-Y-Damian-Hotels.d6348319.Travel-Guide-Hotels en-SG: https://www.expedia.com.sg/San-Cosme-Y-Damian-Hotels.d6348319.Travel-Guide-Hotels ```