Title: Hotels by Best Western in Perryville | Expedia.ca [Perryville Travel Guide](https://expedia.ca/Perryville.dx6134448)[Hotels in Perryville](https://expedia.ca/Perryville-Hotels.d6134448.Travel-Guide-Hotels)[Vacation Rentals in Perryville](https://expedia.ca/Perryville-Vacation-Rentals.d6134448.Travel-Guide-VacationRentals)[Flights to Perryville](https://expedia.ca/Cheap-Flights-To-Perryville.d6134448.Travel-Guide-Flights)[Things to do in Perryville](https://expedia.ca/Things-To-Do-In-Perryville.d6134448.Travel-Guide-Activities)[Perryville Car Rentals](https://expedia.ca/Car-Rentals-In-Perryville.d6134448.Car-Rental-Guide)[Perryville Vacation Packages](https://expedia.ca/Perryville.d6134448.Destination-Travel-Guides) ![Default HTG hotel image](https://media.expedia.com/media/content/shared/images/travelguides/sem-hotels-tablet.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Hotels by Best Western in Perryville ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Oct 24 - Oct 25](https://www.expedia.ca/Hotel-Search?regionId=6134448&startDate=2025-10-24&endDate=2025-10-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 25 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=6134448&startDate=2025-10-25&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=6134448&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=6134448&startDate=2025-10-31&endDate=2025-11-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Perryville Best Western Hotels ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FPerryville-Hotels-Best-Western.0-0-d6134448--bBestWestern.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FPerryville-Hotels-Best-Western.0-0-d6134448--bBestWestern.Travel-Guide-Filter-Hotels) ## Top Perryville Hotel Reviews ![Tru By Hilton Cape Girardeau](//images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/w3837h2560x3y0-1bbb6bc9_y.jpg) ### Tru By Hilton Cape Girardeau 10/10 Excellent "The staff was very kind and welcoming!" [](https://expedia.ca/Cape-Girardeau-Hotels-Tru-By-Hilton-Cape-Girardeau.h111590879.Hotel-Information) ![Holiday Inn Express & Suites Murphysboro - Carbondale by IHG](//images.trvl-media.com/lodging/64000000/63310000/63308800/63308723/2785ae14_y.jpg) ### Holiday Inn Express & Suites Murphysboro - Carbondale by IHG 10/10 Excellent "We enjoyed our two night stay. Even being four years old the property appeared new. Our 4th floor room was clean and comfortable. The breakfast was good. The pancake machine worked very well & fast. Their coffee machine ground the coffee beans and brewed fresh coffee with every cup. We will gladly return to this hotel when we are in the area." [](https://expedia.ca/Carbondale-Hotels-Holiday-Inn-Express-Suites-Murphysboro-Carbondale.h63308723.Hotel-Information) ![Drury Inn & Suites Jackson MO](//images.trvl-media.com/lodging/1000000/50000/41100/41077/8996a36d_y.jpg) ### Drury Inn & Suites Jackson MO 10/10 Excellent "This place is everything you would want for the price. " [](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau](//images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/05fcda41_y.jpg) ### La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau 10/10 Excellent "Wonderful facility- top to bottom " [](https://expedia.ca/Jackson-Hotels-La-Quinta-Inn-Suites-By-Wyndham-JacksonCape-Girardeau.h53348099.Hotel-Information) ![Holiday Inn Express & Suites Perryville by IHG](//images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/68f46185_y.jpg) ### Holiday Inn Express & Suites Perryville by IHG 10/10 Excellent "I like the large bathroom and very comfortable bed.However I do not know the price we paid for the room because the hotel w/n tell me the price..! Because I booked through Expedia." [](https://expedia.ca/Perryville-Hotels-Holiday-Inn-Express-Suites-Perryville.h20115319.Hotel-Information) ![Days Inn by Wyndham Perryville](//images.trvl-media.com/lodging/1000000/20000/10400/10352/f6ab26a4_y.jpg) ### Days Inn by Wyndham Perryville 10/10 Excellent "Clean " [](https://expedia.ca/Perryville-Hotels-Days-Inn-By-Wyndham-Perryville.h10352.Hotel-Information) ![Comfort Suites Jackson-Cape Girardeau](//images.trvl-media.com/lodging/3000000/2560000/2555900/2555896/70460e25_y.jpg) ### Comfort Suites Jackson-Cape Girardeau 10/10 Excellent "Clean and comfortable every time. This is a “go to” hotel " [](https://expedia.ca/Sikeston-Hotels-Comfort-Suites-Jackson-Cape-Girardeau.h2555896.Hotel-Information) ![Super 8 by Wyndham Perryville](//images.trvl-media.com/lodging/1000000/670000/664100/664059/f824aec9_y.jpg) ### Super 8 by Wyndham Perryville 10/10 Excellent "Room was clean. Customer service was good. Safe area to walk around outside and in the general area. The one thing I was disappointed in was the breakfast. " [](https://expedia.ca/Perryville-Hotels-Super-8-By-Wyndham-Perryville.h664059.Hotel-Information) ![Hot Tub & Creek Views: Secluded Perryville Cabin](//images.trvl-media.com/lodging/116000000/115020000/115013900/115013833/762b23c1_y.jpg) ### Hot Tub & Creek Views: Secluded Perryville Cabin 10/10 Excellent "This property and secluded location is exactly what we were looking for in our getaway. It felt as if we were in the middle of nowhere however, we were still only about 15 minutes from the heart of downtown Perryville, where there are multiple restaurants, stores and other attractions. The hot tub was a nice touch to this property and the weather was a little bit cool outside, so it was perfect for the late evening setting. If we are in the area, we will definitely try to stay at this property in the future. It was exactly what we needed to get away from the day to day busyness and could actually relax and take a breath. After this visit, we both felt refreshed and rejuvenated. It was also really nice for us to spend some quality time together. " [](https://expedia.ca/Perryville-Hotels-Hot-Tub-Creek-Views-Secluded-Perryville-Cabin.h115013833.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - [Belgique Hotels](https://www.expedia.ca/Belgique-Hotels.d553248635975859150.Travel-Guide-Hotels) - [Bloomsdale Hotels](https://www.expedia.ca/Bloomsdale-Hotels.d3000444549.Travel-Guide-Hotels) - [Cabin Rentals in Brazeau Township](https://www.expedia.ca/Brazeau-Township-Cabins.d553248635976430617-aaCabins.Travel-Guide-Accommodation) - [Rv Parks in Cape Girardeau County](https://www.expedia.ca/Cape-Girardeau-County-RV-Parks.d553248635976430467-aaRVParks.Travel-Guide-Accommodation) - [Cottages in Clearwater](https://www.expedia.ca/Clearwater-Cottages.d553248635975868303-aaCottages.Travel-Guide-Accommodation) - [Lodges in Clearwater](https://www.expedia.ca/Clearwater-Lodges.d553248635975868303-aaLodges.Travel-Guide-Accommodation) - [Cobalt Hotels](https://www.expedia.ca/Cobalt-Hotels.d553248634983153223.Travel-Guide-Hotels) - [Drury Inn & Suites Hotels in Creve Coeur](https://www.expedia.ca/Creve-Coeur-St-Louis-Hotels-Drury-Inn-Suites.0-n7717-0--bDruryInnSuites.Travel-Guide-Filter-Hotels) - [Hilton Hotels in Cuba](https://www.expedia.ca/Cuba-Hotels-Hilton-Hotels.0-0-d6499--bHiltonHotels.Travel-Guide-Filter-Hotels) - [Wyndham Hotels in Cuba](https://www.expedia.ca/Cuba-Hotels-Wyndham-Hotels.0-0-d6499--bWyndhamHotels.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Ste. 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