Title: Hotels by Best Western in Perryville | Expedia.ca [Perryville Travel Guide](https://expedia.ca/Perryville.dx6134448)[Hotels in Perryville](https://expedia.ca/Perryville-Hotels.d6134448.Travel-Guide-Hotels)[Vacation Rentals in Perryville](https://expedia.ca/Perryville-Vacation-Rentals.d6134448.Travel-Guide-VacationRentals)[Flights to Perryville](https://expedia.ca/Cheap-Flights-To-Perryville.d6134448.Travel-Guide-Flights)[Things to do in Perryville](https://expedia.ca/Things-To-Do-In-Perryville.d6134448.Travel-Guide-Activities)[Perryville Car Rentals](https://expedia.ca/Car-Rentals-In-Perryville.d6134448.Car-Rental-Guide)[Perryville Vacation Packages](https://expedia.ca/Perryville.d6134448.Destination-Travel-Guides) ![Arched train bridge](https://images.trvl-media.com/place/6134448/9dc94c46-c0ab-4d3f-b5fe-2d6ecd4d81c3.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Hotels by Best Western in Perryville - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Dec 21 - Dec 22](https://www.expedia.ca/Hotel-Search?regionId=6134448&startDate=2025-12-21&endDate=2025-12-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Dec 22 - Dec 23](https://www.expedia.ca/Hotel-Search?regionId=6134448&startDate=2025-12-22&endDate=2025-12-23&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=6134448&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Jan 2 - Jan 4](https://www.expedia.ca/Hotel-Search?regionId=6134448&startDate=2026-01-02&endDate=2026-01-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FPerryville-Hotels-Best-Western.0-0-d6134448--bBestWestern.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FPerryville-Hotels-Best-Western.0-0-d6134448--bBestWestern.Travel-Guide-Filter-Hotels) ## Top Perryville Hotel Reviews ![La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau](https://images.trvl-media.com/lodging/54000000/53350000/53348100/53348099/05fcda41_y.jpg) ### La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau 10/10 Excellent "Very clean premises, easy check-in, quiet, good breakfast and Wendy, the receptionist was the BEST ever in providing professional, quality and attentive customer service with a smile and warm welcome!" [](https://expedia.ca/Jackson-Hotels-La-Quinta-Inn-Suites-By-Wyndham-JacksonCape-Girardeau.h53348099.Hotel-Information) ![Drury Inn & Suites Jackson MO](https://images.trvl-media.com/lodging/1000000/50000/41100/41077/8996a36d_y.jpg) ### Drury Inn & Suites Jackson MO 10/10 Excellent "Yes" [](https://expedia.ca/Sikeston-Hotels-Drury-Inn-Suites-Jackson-MO.h41077.Hotel-Information) ![Tru By Hilton Cape Girardeau](https://images.trvl-media.com/lodging/112000000/111600000/111590900/111590879/w3837h2560x3y0-1bbb6bc9_y.jpg) ### Tru By Hilton Cape Girardeau 10/10 Excellent "Happy kind staff. Clean room. " [](https://expedia.ca/Cape-Girardeau-Hotels-Tru-By-Hilton-Cape-Girardeau.h111590879.Hotel-Information) ![Holiday Inn Express & Suites Murphysboro - Carbondale by IHG](https://images.trvl-media.com/lodging/64000000/63310000/63308800/63308723/2785ae14_y.jpg) ### Holiday Inn Express & Suites Murphysboro - Carbondale by IHG 10/10 Excellent "Everything was good " [](https://expedia.ca/Carbondale-Hotels-Holiday-Inn-Express-Suites-Murphysboro-Carbondale.h63308723.Hotel-Information) ![Holiday Inn Express Hotel & Suites Sparta by IHG](https://images.trvl-media.com/lodging/2000000/1700000/1691200/1691121/331aa35f_y.jpg) ### Holiday Inn Express Hotel & Suites Sparta by IHG 10/10 Excellent "Spotless" [](https://expedia.ca/Chester-Hotels-Holiday-Inn-Express-Hotel-Suites-Sparta.h1691121.Hotel-Information) ![Holiday Inn Express & Suites Perryville by IHG](https://images.trvl-media.com/lodging/21000000/20120000/20115400/20115319/68f46185_y.jpg) ### Holiday Inn Express & Suites Perryville by IHG 10/10 Excellent "Friendly staff, spacious rooms and excellent breakfast." [](https://expedia.ca/Perryville-Hotels-Holiday-Inn-Express-Suites-Perryville.h20115319.Hotel-Information) ![Baymont by Wyndham Chester IL](https://images.trvl-media.com/lodging/1000000/10000/1700/1699/19091438_y.jpg) ### Baymont by Wyndham Chester IL 10/10 Excellent "The hotel has been declining in recent years but the new management is working to make things better and they are doing a great job. Our room was very comfortable and clean. The staff were very friendly and helpful. It was an enjoyable experience and we will stay here again. " [](https://expedia.ca/Chester-Hotels-Baymont-By-Wyndham-Chester-IL.h1699.Hotel-Information) ![Super 8 by Wyndham Perryville](https://images.trvl-media.com/lodging/1000000/670000/664100/664059/f824aec9_y.jpg) ### Super 8 by Wyndham Perryville 10/10 Excellent "The room and common area was very clean and attractive. But breakfast was a big disapp ointment. Maybe they ran out of bacon or sausage but it wasn't refilled so all of this left and 8:30 was waffles cereal and scrambled eggs." [](https://expedia.ca/Perryville-Hotels-Super-8-By-Wyndham-Perryville.h664059.Hotel-Information) ![Microtel Inn & Suites by Wyndham Sainte Genevieve](https://images.trvl-media.com/lodging/1000000/430000/426000/425932/96e79bac_y.jpg) ### Microtel Inn & Suites by Wyndham Sainte Genevieve 10/10 Excellent "very clean" [](https://expedia.ca/Ste-Genevieve-Hotels-Microtel-Inn-Suites-By-Wyndham-Sainte-Genevieve.h425932.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - [Belgique Hotels ](https://www.expedia.ca/Belgique-Hotels.d553248635975859150.Travel-Guide-Hotels) - [Bloomsdale Hotels ](https://www.expedia.ca/Bloomsdale-Hotels.d3000444549.Travel-Guide-Hotels) - [Cabin Rentals in Brazeau Township ](https://www.expedia.ca/Brazeau-Township-Cabins.d553248635976430617-aaCabins.Travel-Guide-Accommodation) - [Rv Parks in Cape Girardeau County ](https://www.expedia.ca/Cape-Girardeau-County-RV-Parks.d553248635976430467-aaRVParks.Travel-Guide-Accommodation) - [Cottages in Clearwater ](https://www.expedia.ca/Clearwater-Cottages.d553248635975868303-aaCottages.Travel-Guide-Accommodation) - [Lodges in Clearwater ](https://www.expedia.ca/Clearwater-Lodges.d553248635975868303-aaLodges.Travel-Guide-Accommodation) - [Cobalt Hotels ](https://www.expedia.ca/Cobalt-Hotels.d553248634983153223.Travel-Guide-Hotels) - [Drury Inn & Suites Hotels in Creve Coeur ](https://www.expedia.ca/Creve-Coeur-St-Louis-Hotels-Drury-Inn-Suites.0-n7717-0--bDruryInnSuites.Travel-Guide-Filter-Hotels) - [Hilton Hotels in Cuba ](https://www.expedia.ca/Cuba-Hotels-Hilton-Hotels.0-0-d6499--bHiltonHotels.Travel-Guide-Filter-Hotels) - [Wyndham Hotels in Cuba ](https://www.expedia.ca/Cuba-Hotels-Wyndham-Hotels.0-0-d6499--bWyndhamHotels.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Ste. 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