Title: Murphysboro Vacation Rentals from CA $207: Short-Term Rentals for 2026 | Expedia.ca

[Hotels in Murphysboro](https://expedia.ca/Murphysboro-Hotels.d55857.Travel-Guide-Hotels)[Murphysboro Car Rentals](https://expedia.ca/Car-Rentals-In-Murphysboro.d55857.Car-Rental-Guide)[Murphysboro Vacation Packages](https://expedia.ca/Murphysboro.d55857.Destination-Travel-Guides)

![Lake Murphysboro State Park which includes autumn leaves, picnicing and forests](https://images.trvl-media.com/place/6186677/108d6e6a-45bc-4623-a9ba-f3146d9aa969.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

Photo by Southernmost Illinois Tourism Bureau

![](https://images.trvl-media.com/place/6186677/108d6e6a-45bc-4623-a9ba-f3146d9aa969.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check prices for these dates

In two weeks

[Feb 20 - Feb 22](https://www.expedia.ca/Hotel-Search?regionId=55857&startDate=2026-02-20&endDate=2026-02-22&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two months

[Apr 3 - Apr 5](https://www.expedia.ca/Hotel-Search?regionId=55857&startDate=2026-04-03&endDate=2026-04-05&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In three months

[May 1 - May 3](https://www.expedia.ca/Hotel-Search?regionId=55857&startDate=2026-05-01&endDate=2026-05-03&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In four months

[May 29 - May 31](https://www.expedia.ca/Hotel-Search?regionId=55857&startDate=2026-05-29&endDate=2026-05-31&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Murphysboro vacation rentals

![House (1 Bedroom) | Front of property](https://images.trvl-media.com/lodging/124000000/123670000/123661900/123661842/aa6e717a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/124000000/123670000/123661900/123661842/3ed90f05.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/124000000/123670000/123661900/123661842/d5f4e688.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![House (1 Bedroom) | Interior](https://images.trvl-media.com/lodging/124000000/123670000/123661900/123661842/3ac16db9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Lakefront, Pet-friendly 1BR w/ Porch & Fire Pit

[](https://www.expedia.ca/Murphysboro-Hotels-Lakefront.h123661842.Hotel-Information)

Murphysboro

CA $134

CA $327 total

includes taxes & fees

Feb 8 - Feb 9

[](https://www.expedia.ca/Murphysboro-Hotels-Lakefront.h123661842.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-21&endDate=2026-02-22&regionId=55857&adults=2&categorySearch=vacation_rentals_option&stay_options_group=vacation_rentals_option&openPlayBack=true)

## Find vacation rentals that suit your style

Cabins

[](https://www.expedia.ca/Hotel-Search?destination=Murphysboro%2C+Illinois%2C+United+States+of+America&regionId=55857&latLong=37.768705%2C-89.328771&adults=2&startDate=2026-05-07&d1=2026-05-07&endDate=2026-05-10&d2=2026-05-10&lodging=CABIN)

Cottages

[](https://www.expedia.ca/Hotel-Search?destination=Murphysboro%2C+Illinois%2C+United+States+of+America&regionId=55857&latLong=37.768705%2C-89.328771&adults=2&startDate=2026-05-07&d1=2026-05-07&endDate=2026-05-10&d2=2026-05-10&lodging=COTTAGE)

Private vacation homes

[](https://www.expedia.ca/Hotel-Search?destination=Murphysboro%2C+Illinois%2C+United+States+of+America&regionId=55857&latLong=37.768705%2C-89.328771&adults=2&startDate=2026-05-07&d1=2026-05-07&endDate=2026-05-10&d2=2026-05-10&lodging=VACATION_HOME)

Apartments

[](https://www.expedia.ca/Hotel-Search?destination=Murphysboro%2C+Illinois%2C+United+States+of+America&regionId=55857&latLong=37.768705%2C-89.328771&adults=2&startDate=2026-05-07&d1=2026-05-07&endDate=2026-05-10&d2=2026-05-10&lodging=APARTMENT)

Condos

[](https://www.expedia.ca/Hotel-Search?destination=Murphysboro%2C+Illinois%2C+United+States+of+America&regionId=55857&latLong=37.768705%2C-89.328771&adults=2&startDate=2026-05-07&d1=2026-05-07&endDate=2026-05-10&d2=2026-05-10&lodging=CONDO)

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## Top Murphysboro Hotel Reviews

![Drury Inn & Suites Marion](https://images.trvl-media.com/lodging/1000000/50000/42100/42025/a8315e37_y.jpg)

### Drury Inn & Suites Marion

10/10 Excellent

"Our room was clean and tidy. "

[](https://expedia.ca/Carbondale-Hotels-Drury-Inn-Marion.h42025.Hotel-Information)

![Walker's Bluff Casino Resort](https://images.trvl-media.com/lodging/98000000/97070000/97064800/97064786/1aec7f72_y.jpg)

### Walker's Bluff Casino Resort

10/10 Excellent

"Our room was clean, and very spacious! the establishment was very nice! We had reservations at Ruthie’s and it was amazing like always "

[](https://expedia.ca/Carterville-Hotels-Walkers-Bluff-Casino-Resort.h97064786.Hotel-Information)

![Best Western Marion Hotel](https://images.trvl-media.com/lodging/1000000/100000/98000/97975/86964c5d_y.jpg)

### Best Western Marion Hotel

10/10 Excellent

"clean room, great service, and breakfast was good (biscuits and gravy, sausage, and eggs). Night-time staff was excellent, very nice, accommodating, and made the check in process painless. Would recommend to anyone travelling to stay here. "

[](https://expedia.ca/Carbondale-Hotels-Best-Western-Marion-Hotel.h97975.Hotel-Information)

![Quality Inn And Suites](https://images.trvl-media.com/lodging/1000000/30000/27100/27086/5ddb47c0_y.jpg)

### Quality Inn And Suites

10/10 Excellent

"Everyone was nice"

[](https://expedia.ca/Carbondale-Hotels-Quality-Inn-And-Suites.h27086.Hotel-Information)

![Baymont by Wyndham Marion](https://images.trvl-media.com/lodging/1000000/20000/19300/19275/7eb84743_y.jpg)

### Baymont by Wyndham Marion

10/10 Excellent

"Room was clean and shower was excellent. "

[](https://expedia.ca/Carbondale-Hotels-Baymont-By-Wyndham-Marion.h19275.Hotel-Information)

![Holiday Inn Carbondale-Conference Center by IHG](https://images.trvl-media.com/lodging/2000000/1490000/1489300/1489254/c0186ee3_y.jpg)

### Holiday Inn Carbondale-Conference Center by IHG

10/10 Excellent

"The room was clean and modern"

[](https://expedia.ca/Carbondale-Hotels-Holiday-Inn-Carbondale-Conference-Center.h1489254.Hotel-Information)

![Holiday Inn Express & Suites Murphysboro - Carbondale by IHG](https://images.trvl-media.com/lodging/64000000/63310000/63308800/63308723/2785ae14_y.jpg)

### Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

10/10 Excellent

"Yes, very clean and service was great."

[](https://expedia.ca/Carbondale-Hotels-Holiday-Inn-Express-Suites-Murphysboro-Carbondale.h63308723.Hotel-Information)

![Best Western Saluki Inn](https://images.trvl-media.com/lodging/1000000/120000/119200/119178/3da90d9b_y.jpg)

### Best Western Saluki Inn

10/10 Excellent

"Great staff and very clean!!"

[](https://expedia.ca/Carbondale-Hotels-Best-Western-Saluki-Inn.h119178.Hotel-Information)

![Super 8 by Wyndham Carbondale](https://images.trvl-media.com/lodging/1000000/440000/439700/439693/8adbc8b5_y.jpg)

### Super 8 by Wyndham Carbondale

10/10 Excellent

"Clean room, friendly staff"

[](https://expedia.ca/Carbondale-Hotels-Super-8-By-Wyndham-Carbondale.h439693.Hotel-Information)

## Find out more about Murphysboro

You always said you would go on a dream vacation someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannon ball into the deep end. Go ahead, unplug and unwind in style. When you book one of our vacation rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment or room. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your vacation just got upgraded.  
  
As much as you love your short-term rental, it’s always good to get out and explore to soak up . Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in . Seeing all the best attractions is bound to make you fall in love with Murphysboro. Who knows, you may even be tempted to extend your vacation rental stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true.   
  
It’s your escape so why share it? You deserve your own slice of paradise. Booking your vacation rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in short-term rentals, that won’t be hard to do.   

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- [Vacation Homes in Murphysboro ](https://expedia.ca/Murphysboro-Private-Vacation-Homes.d55857-aaPrivateVacationHomes.Travel-Guide-Accommodation)
- [Cabin Rentals in Murphysboro ](https://expedia.ca/Murphysboro-Cabins.d55857-aaCabins.Travel-Guide-Accommodation)
- [RV Parks in Murphysboro ](https://expedia.ca/Murphysboro-RV-Parks.d55857-aaRVParks.Travel-Guide-Accommodation)
- [Apartments in Murphysboro ](https://expedia.ca/Murphysboro-Apartments.d55857-aaApartments.Travel-Guide-Accommodation)
- [Motels in Murphysboro ](https://expedia.ca/Murphysboro-Motels.d55857-aaMotels.Travel-Guide-Accommodation)
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- [Farmstay in Murphysboro ](https://expedia.ca/Murphysboro-Agritourism.d55857-aaAgritourism.Travel-Guide-Accommodation)
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- [Lodges in Murphysboro ](https://expedia.ca/Murphysboro-Lodges.d55857-aaLodges.Travel-Guide-Accommodation)
- [Guest Houses in Murphysboro ](https://expedia.ca/Murphysboro-Guest-Houses.d55857-aaGuestHouses.Travel-Guide-Accommodation)
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## Frequently asked questions

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