Title: Book the Best Louisiana SPA Resorts from CA $145 - Spa Hotels in Louisiana, MO | Expedia.ca

 

[Hotels in Louisiana](https://expedia.ca/Louisiana-Hotels.d127811.Travel-Guide-Hotels)[Vacation Rentals in Louisiana](https://expedia.ca/Louisiana-Vacation-Rentals.d127811.Travel-Guide-VacationRentals)[Flights to Louisiana](https://expedia.ca/Cheap-Flights-To-Louisiana.d127811.Travel-Guide-Flights)[Louisiana Car Rentals](https://expedia.ca/Car-Rentals-In-Louisiana.d127811.Car-Rental-Guide)[Louisiana Vacation Packages](https://expedia.ca/Louisiana.d127811.Destination-Travel-Guides)

![Default HTG hotel image](https://media.expedia.com/media/content/shared/images/travelguides/sem-hotels-tablet.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

# Find Spa Hotels in Louisiana, MO from CA $145

-   ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg)
    
    ### 
    
    Change your mind
    
    Book hotels with free cancellation
    
-   ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg)
    
    ### 
    
    Treat yourself
    
    Sign in to save 10% or more on thousands of hotels
    
    [Sign in](https://www.expedia.ca/login)
    
-   ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg)
    
    ### 
    
    Be picky
    
    Search almost a million properties worldwide
    

## Check availability on Louisiana Spa Hotels

Tonight

[Nov 4 - Nov 5](https://www.expedia.ca/Hotel-Search?regionId=127811&startDate=2025-11-04&endDate=2025-11-05&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Nov 5 - Nov 6](https://www.expedia.ca/Hotel-Search?regionId=127811&startDate=2025-11-05&endDate=2025-11-06&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[Nov 7 - Nov 9](https://www.expedia.ca/Hotel-Search?regionId=127811&startDate=2025-11-07&endDate=2025-11-09&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Nov 14 - Nov 16](https://www.expedia.ca/Hotel-Search?regionId=127811&startDate=2025-11-14&endDate=2025-11-16&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Top Louisiana Spa Hotels

![Indoor pool, sun loungers](https://images.trvl-media.com/lodging/1000000/70000/64300/64231/e4d50f81.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/70000/64300/64231/3ec3fc7d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![In-room safe, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/1000000/70000/64300/64231/2719bcec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/70000/64300/64231/87b01476.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Comfort Inn & Suites - Hannibal

Hannibal

7.6/10

Good

(644)

"I thought the breakfast was great, the room spacious and overall experience excellent. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Rick

CA $127

CA $145 total

includes taxes & fees

Nov 16 - Nov 17

[](https://www.expedia.ca/Hannibal-Hotels-Comfort-Inn-Suites-Hannibal.h64231.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-18&endDate=2025-11-19&regionId=127811&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true)

## Top Louisiana Hotel Reviews

![Best Western On The River](//images.trvl-media.com/lodging/1000000/20000/16300/16249/b520e740_y.jpg)

### Best Western On The River

10/10 Excellent

"Very Close to Hannibal attractions."

[](https://expedia.ca/Hannibal-Hotels-Best-Western-On-The-River.h16249.Hotel-Information)

![Baymont by Wyndham Hannibal](//images.trvl-media.com/lodging/4000000/3800000/3790200/3790159/69dacd1b_y.jpg)

### Baymont by Wyndham Hannibal

10/10 Excellent

"It was nice, clean, updated facility. Breakfast was good. Close to the highway, so some truck noise but it's also easy to get to other places nearby. I would stay there again."

[](https://expedia.ca/Hannibal-Hotels-Hannibal-Inn.h3790159.Hotel-Information)

![Quality Inn & Suites Hannibal](//images.trvl-media.com/lodging/1000000/990000/983700/983646/13b9e861_y.jpg)

### Quality Inn & Suites Hannibal

10/10 Excellent

"vey nice accommodations, staff was friendly. room was clean, breakfast was very good. "

[](https://expedia.ca/Hannibal-Hotels-Quality-Inn-Suites-Hannibal.h983646.Hotel-Information)

## Frequently asked questions

### Looking for a spa hotel in Louisiana?

> Book one of our fantastic spa hotels and pamper yourself from the moment you arrive. Check out the riverfront in Louisiana - worth a picture or two! Hotels with spas are the perfect way to break out of your routine and add a layer of luxury to your vacation.

### What's there to see and do in Louisiana?

> Enjoy all that Louisiana has to offer when you visit Mississippi River, Clarksville State Game Refuge, and Clarksville Riverfront Park. If you have a bit of extra time while you're in the area, you might want to check out Ramsey Creek Church.

### What is a Louisiana spa hotel?

> Spa hotels in Louisiana provide lodging and have an on-site spa offering services such as massages as well as body treatments. Some also offer in-room treatments. Spa hotels are ideal if you are looking for some R&R during your vacation.

## Explore a world of travel with Expedia

-   Lodging
-   Flights
-   Packages
-   Cars
-   Vacation Rental
-   More ways to book

-   [4 Star Hotels in Elsberry](https://www.expedia.ca/4Star-Elsberry-Hotels.s40-0-d3000444866.Travel-Guide-Filter-Hotels)
-   [Luxury Hotels in Annada](https://www.expedia.ca/Annada-Hotels-Luxury-Hotel.0-0-d553248634983192995-tLuxuryHotel.Travel-Guide-Filter-Hotels)
-   [Aparthotels in Bowling Green](https://www.expedia.ca/Bowling-Green-Apart-Hotels.d602836-aaApartHotels.Travel-Guide-Accommodation)
-   [B&B in Bowling Green](https://www.expedia.ca/Bowling-Green-Bed-And-Breakfast.d602836-aaBedAndBreakfast.Travel-Guide-Accommodation)
-   [Cheap Hotels in Bowling Green](https://www.expedia.ca/Bowling-Green-Hotels-Cheap-Hotels.0-0-d602836-tCheapHotels.Travel-Guide-Filter-Hotels)
-   [Historic Hotels in Bowling Green](https://www.expedia.ca/Bowling-Green-Hotels-Historic-Hotel.0-0-d602836-tHistoricHotel.Travel-Guide-Filter-Hotels)
-   [Pet-Friendly Hotels in Bowling Green](https://www.expedia.ca/Bowling-Green-Hotels-Pet-Friendly-Hotel.0-0-d602836-tPetfriendlyHotel.Travel-Guide-Filter-Hotels)
-   [Bowling Green Hotels](https://www.expedia.ca/Bowling-Green-Hotels.d602836.Travel-Guide-Hotels)
-   [Lodges in Bowling Green](https://www.expedia.ca/Bowling-Green-Lodges.d602836-aaLodges.Travel-Guide-Accommodation)
-   [Farmstay in Center](https://www.expedia.ca/Center-Agritourism.d553248634983556117-aaAgritourism.Travel-Guide-Accommodation)
-   [Aparthotels in Center](https://www.expedia.ca/Center-Apart-Hotels.d553248634983556117-aaApartHotels.Travel-Guide-Accommodation)
-   [Apartments in Center](https://www.expedia.ca/Center-Apartments.d553248634983556117-aaApartments.Travel-Guide-Accommodation)
-   [Guest Houses in Center](https://www.expedia.ca/Center-Guest-Houses.d553248634983556117-aaGuestHouses.Travel-Guide-Accommodation)
-   [Aparthotels in Clarksville](https://www.expedia.ca/Clarksville-Apart-Hotels.d6085104-aaApartHotels.Travel-Guide-Accommodation)
-   [Independent Hotels in Clarksville](https://www.expedia.ca/Clarksville-Hotels-Independent.0-0-d6085104--bIndependent.Travel-Guide-Filter-Hotels)
-   [Clarksville Hotels](https://www.expedia.ca/Clarksville-Hotels.d6085104.Travel-Guide-Hotels)
-   [Farmstay in Curryville](https://www.expedia.ca/Curryville-Agritourism.d3000349338-aaAgritourism.Travel-Guide-Accommodation)
-   [B&B in Curryville](https://www.expedia.ca/Curryville-Bed-And-Breakfast.d3000349338-aaBedAndBreakfast.Travel-Guide-Accommodation)
-   [Curryville Hotels](https://www.expedia.ca/Curryville-Hotels.d3000349338.Travel-Guide-Hotels)
-   [Inns in Curryville](https://www.expedia.ca/Curryville-Inns.d3000349338-aaInns.Travel-Guide-Accommodation)
-   [Hotels with Balconies in Missouri](https://www.expedia.ca/Destinations-In-Missouri-Hotels-With-Balconies.0-0-d227-tHotelswithBalconies.Hotel-Filter-Destinations)
-   [Elsberry Hotels](https://www.expedia.ca/Elsberry-Hotels.d3000444866.Travel-Guide-Hotels)
-   [B&B in Eolia](https://www.expedia.ca/Eolia-Bed-And-Breakfast.d3000444861-aaBedAndBreakfast.Travel-Guide-Accommodation)
-   [Cheap Hotels in Eolia](https://www.expedia.ca/Eolia-Hotels-Cheap-Hotels.0-0-d3000444861-tCheapHotels.Travel-Guide-Filter-Hotels)
-   [Lodges in Eolia](https://www.expedia.ca/Eolia-Lodges.d3000444861-aaLodges.Travel-Guide-Accommodation)
-   [Hostels in Foley](https://www.expedia.ca/Foley-Hostels.d553248634983344316-aaHostels.Travel-Guide-Accommodation)
-   [Farmstay in Frankford](https://www.expedia.ca/Frankford-Agritourism.d3000444895-aaAgritourism.Travel-Guide-Accommodation)
-   [B&B in Frankford](https://www.expedia.ca/Frankford-Bed-And-Breakfast.d3000444895-aaBedAndBreakfast.Travel-Guide-Accommodation)
-   [Condo Rentals in Frankford](https://www.expedia.ca/Frankford-Condos.d3000444895-aaCondos.Travel-Guide-Accommodation)
-   [Frankford Hotels](https://www.expedia.ca/Frankford-Hotels.d3000444895.Travel-Guide-Hotels)
-   [Farmstay in Hannibal](https://www.expedia.ca/Hannibal-Agritourism.d6068-aaAgritourism.Travel-Guide-Accommodation)
-   [Aparthotels in Hannibal](https://www.expedia.ca/Hannibal-Apart-Hotels.d6068-aaApartHotels.Travel-Guide-Accommodation)
-   [B&B in Hannibal](https://www.expedia.ca/Hannibal-Bed-And-Breakfast.d6068-aaBedAndBreakfast.Travel-Guide-Accommodation)
-   [Country Houses in Hannibal](https://www.expedia.ca/Hannibal-Country-House.d6068-aaCountryHouse.Travel-Guide-Accommodation)
-   [Cheap Hotels in Hannibal](https://www.expedia.ca/Hannibal-Hotels-Cheap-Hotels.0-0-d6068-tCheapHotels.Travel-Guide-Filter-Hotels)
-   [Hotels with a Lazy River in Hannibal](https://www.expedia.ca/Hannibal-Hotels-Hotels-With-A-Lazy-River.0-0-d6068-tHotelswithaLazyRiver.Travel-Guide-Filter-Hotels)
-   [Hotels with an Indoor Pool in Hannibal](https://www.expedia.ca/Hannibal-Hotels-Hotels-With-Indoor-Pool.0-0-d6068-tHotelswithIndoorPool.Travel-Guide-Filter-Hotels)
-   [Pet-Friendly Hotels in Hannibal](https://www.expedia.ca/Hannibal-Hotels-Pet-Friendly-Hotel.0-0-d6068-tPetfriendlyHotel.Travel-Guide-Filter-Hotels)
-   [Shopping Hotels in Hannibal](https://www.expedia.ca/Hannibal-Hotels-Shopping-Hotel.0-0-d6068-tShoppingHotel.Travel-Guide-Filter-Hotels)
-   [Spa Hotels in Hannibal](https://www.expedia.ca/Hannibal-Hotels-Spa-Hotel.0-0-d6068-tSpaHotel.Travel-Guide-Filter-Hotels)
-   [Hannibal Hotels](https://www.expedia.ca/Hannibal-Hotels.d6068.Travel-Guide-Hotels)
-   [Lodges in Hannibal](https://www.expedia.ca/Hannibal-Lodges.d6068-aaLodges.Travel-Guide-Accommodation)
-   [Palaces in Hannibal](https://www.expedia.ca/Hannibal-Palaces.d6068-aaPalaces.Travel-Guide-Accommodation)
-   [Townhomes in Hannibal](https://www.expedia.ca/Hannibal-Townhomes.d6068-aaTownhomes.Travel-Guide-Accommodation)
-   [Cheap Hotels in High Hill](https://www.expedia.ca/High-Hill-Hotels-Cheap-Hotels.0-0-d6252539-tCheapHotels.Travel-Guide-Filter-Hotels)
-   [Lgbt Friendly Hotels in High Hill](https://www.expedia.ca/High-Hill-Hotels-LGBT-Friendly-Hotel.0-0-d6252539-tLGBTFriendlyHotel.Travel-Guide-Filter-Hotels)
-   [Hotel Wedding Venues Hotels in High Hill](https://www.expedia.ca/High-Hill-Hotels-Wedding-Hotels.0-0-d6252539-tWeddingHotels.Travel-Guide-Filter-Hotels)
-   [Hotels near Mark Twain Boyhood Home and Museum](https://www.expedia.ca/Mark-Twain-Boyhood-Home-And-Museum-Hotels.0-l6092645-0.Travel-Guide-Filter-Hotels)
-   [Pet-Friendly Hotels in Montgomery City](https://www.expedia.ca/Montgomery-City-Hotels-Pet-Friendly-Hotel.0-0-d6353577-tPetfriendlyHotel.Travel-Guide-Filter-Hotels)
-   [Hotels with Bar in New Florence](https://www.expedia.ca/New-Florence-Hotels-Hotels-With-Bar.0-0-d602234-tHotelswithBar.Travel-Guide-Filter-Hotels)
-   [Hotels with Free Breakfast in New Florence](https://www.expedia.ca/New-Florence-Hotels-Hotels-With-Free-Breakfast.0-0-d602234-tHotelswithFreeBreakfast.Travel-Guide-Filter-Hotels)
-   [Hotels with Free Parking in New Florence](https://www.expedia.ca/New-Florence-Hotels-Hotels-With-Free-Parking.0-0-d602234-tHotelswithFreeParking.Travel-Guide-Filter-Hotels)
-   [Aparthotels in New London](https://www.expedia.ca/New-London-Apart-Hotels.d3000445314-aaApartHotels.Travel-Guide-Accommodation)
-   [B&B in New London](https://www.expedia.ca/New-London-Bed-And-Breakfast.d3000445314-aaBedAndBreakfast.Travel-Guide-Accommodation)
-   [Guest Houses in New London](https://www.expedia.ca/New-London-Guest-Houses.d3000445314-aaGuestHouses.Travel-Guide-Accommodation)
-   [Luxury Hotels in New London](https://www.expedia.ca/New-London-Hotels-Luxury-Hotel.0-0-d3000445314-tLuxuryHotel.Travel-Guide-Filter-Hotels)
-   [New London Hotels](https://www.expedia.ca/New-London-Hotels.d3000445314.Travel-Guide-Hotels)
-   [Cheap Hotels in Palmyra](https://www.expedia.ca/Palmyra-Hotels-Cheap-Hotels.0-0-d183484-tCheapHotels.Travel-Guide-Filter-Hotels)
-   [Paynesville Hotels](https://www.expedia.ca/Paynesville-Hotels.d553248634983404502.Travel-Guide-Hotels)
-   [Golf Hotels in Perry](https://www.expedia.ca/Perry-Hotels-Golf-Hotel.0-0-d6288740-tGolfHotel.Travel-Guide-Filter-Hotels)
-   [Luxury Hotels in Perry](https://www.expedia.ca/Perry-Hotels-Luxury-Hotel.0-0-d6288740-tLuxuryHotel.Travel-Guide-Filter-Hotels)
-   [Apartments in Rensselaer](https://www.expedia.ca/Rensselaer-Apartments.d553248634983403977-aaApartments.Travel-Guide-Accommodation)
-   [Hotels near Rockcliffe Mansion](https://www.expedia.ca/Rockcliffe-Mansion-Hotels.0-l553248621532649035-0.Travel-Guide-Filter-Hotels)
-   [Farmstay in Saverton](https://www.expedia.ca/Saverton-Agritourism.d3000349535-aaAgritourism.Travel-Guide-Accommodation)
-   [Cottages in Saverton](https://www.expedia.ca/Saverton-Cottages.d3000349535-aaCottages.Travel-Guide-Accommodation)
-   [Saverton Hotels](https://www.expedia.ca/Saverton-Hotels.d3000349535.Travel-Guide-Hotels)
-   [Honeymoon Resorts and in St. Louis](https://www.expedia.ca/St-Louis-Hotels-Honeymoon-Hotels.0-0-d178309-tHoneymoonHotels.Travel-Guide-Filter-Hotels)
-   [Hotels with Childcare in St. Louis](https://www.expedia.ca/St-Louis-Hotels-Hotels-With-Childcare.0-0-d178309-tHotelswithChildcare.Travel-Guide-Filter-Hotels)
-   [Hotels with smoking rooms in St. Louis](https://www.expedia.ca/St-Louis-Hotels-Hotels-With-Smoking-Rooms.0-0-d178309-tHotelswithsmokingrooms.Travel-Guide-Filter-Hotels)
-   [Oceanfront Hotels in St. Louis](https://www.expedia.ca/St-Louis-Hotels-Oceanfront-Hotels.0-0-d178309-tOceanfrontHotels.Travel-Guide-Filter-Hotels)
-   [Winery Hotels in St. Louis](https://www.expedia.ca/St-Louis-Hotels-Winery-Hotel.0-0-d178309-tWineryHotel.Travel-Guide-Filter-Hotels)
-   [Tarrants Hotels](https://www.expedia.ca/Tarrants-Hotels.d553248634983265749.Travel-Guide-Hotels)
-   [Cheap Hotels in Taylor](https://www.expedia.ca/Taylor-Hotels-Cheap-Hotels.0-0-d3000445518-tCheapHotels.Travel-Guide-Filter-Hotels)
-   [Farmstay in Troy](https://www.expedia.ca/Troy-Agritourism.d180952-aaAgritourism.Travel-Guide-Accommodation)
-   [B&B in Troy](https://www.expedia.ca/Troy-Bed-And-Breakfast.d180952-aaBedAndBreakfast.Travel-Guide-Accommodation)
-   [Family Hotels in Troy](https://www.expedia.ca/Troy-Hotels-Family-Hotel.0-0-d180952-tFamilyHotel.Travel-Guide-Filter-Hotels)
-   [Hotels with Hot Tubs in Troy](https://www.expedia.ca/Troy-Hotels-Hotels-With-Hot-Tubs.0-0-d180952-tHotelsWithHotTubs.Travel-Guide-Filter-Hotels)
-   [Pet-Friendly Hotels in Troy](https://www.expedia.ca/Troy-Hotels-Pet-Friendly-Hotel.0-0-d180952-tPetfriendlyHotel.Travel-Guide-Filter-Hotels)
-   [Romantic Hotels in Troy](https://www.expedia.ca/Troy-Hotels-Romantic-Hotel.0-0-d180952-tRomanticHotel.Travel-Guide-Filter-Hotels)
-   [Spa Hotels in Troy](https://www.expedia.ca/Troy-Hotels-Spa-Hotel.0-0-d180952-tSpaHotel.Travel-Guide-Filter-Hotels)
-   [Troy Hotels](https://www.expedia.ca/Troy-Hotels.d180952.Travel-Guide-Hotels)
-   [Lodges in Troy](https://www.expedia.ca/Troy-Lodges.d180952-aaLodges.Travel-Guide-Accommodation)
-   [Resorts in Troy](https://www.expedia.ca/Troy-Resort-Hotels.d180952-aaResortHotels.Travel-Guide-Accommodation)
-   [Treehouses in Troy](https://www.expedia.ca/Troy-Treehouses.d180952-aaTreehouses.Travel-Guide-Accommodation)
-   [Lodges in Truxton](https://www.expedia.ca/Truxton-Lodges.d553248634983496300-aaLodges.Travel-Guide-Accommodation)
-   [Apartments in Vandalia](https://www.expedia.ca/Vandalia-Apartments.d3000445553-aaApartments.Travel-Guide-Accommodation)
-   [Cheap Hotels in Vandalia](https://www.expedia.ca/Vandalia-Hotels-Cheap-Hotels.0-0-d3000445553-tCheapHotels.Travel-Guide-Filter-Hotels)
-   [Vandalia Hotels](https://www.expedia.ca/Vandalia-Hotels.d3000445553.Travel-Guide-Hotels)
-   [Cheap Hotels in Winfield](https://www.expedia.ca/Winfield-Hotels-Cheap-Hotels.0-0-d3000445646-tCheapHotels.Travel-Guide-Filter-Hotels)

-   [Flights to Troy](https://www.expedia.ca/Cheap-Flights-To-Troy.d180952.Travel-Guide-Flights)
-   [Flights from Silex](https://www.expedia.ca/lp/flights/3000349540/flights-from-silex)
-   [Flights from Vandalia](https://www.expedia.ca/lp/flights/3000445553/flights-from-vandalia)
-   [Flights from Hannibal](https://www.expedia.ca/lp/flights/6068/flights-from-hannibal)

-   [Visit Bowling Green](https://www.expedia.ca/Bowling-Green.dx602836)
-   [Clarksville State Game Refuge](https://www.expedia.ca/Clarksville-State-Game-Refuge-United-States-of-America.d553248621586065652.Vacation-Attraction)
-   [Mark Twain Boyhood Home and Museum](https://www.expedia.ca/Mark-Twain-Boyhood-Home-And-Museum-Hannibal.d6092645.Vacation-Attraction)
-   [Troy Vacations](https://www.expedia.ca/Troy.d180952.Destination-Travel-Guides)

-   [Car rental Hannibal](https://www.expedia.ca/Car-Rentals-In-Hannibal.d6068.Car-Rental-Guide)

-   [Hannibal Vacation Rentals](https://www.expedia.ca/Hannibal-Vacation-Rentals.d6068.Travel-Guide-VacationRentals)
-   [Perry Vacation Rentals](https://www.expedia.ca/Perry-Vacation-Rentals.d6288740.Travel-Guide-VacationRentals)

-   [Book Spa Hotels in Louisiana on Expedia.com](https://www.expedia.com/Louisiana-Hotels-Spa-Hotel.0-0-d127811-tSpaHotel.Travel-Guide-Filter-Hotels)