
Hotels in South Main, Houston
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Our top choices for South Main hotels

Wingate Houston near NRG Park/Medical Center
Wingate Houston near NRG Park/Medical CenterSouth Main
6.6 out of 10, (1,010 reviews)
The price is CA $99
CA $116 total
includes taxes & fees
Jul 12 - Jul 13

Wyndham Houston near NRG Park/Medical Center
Wyndham Houston near NRG Park/Medical CenterSouth Main
7.2 out of 10, Good, (1,297 reviews)
The price is CA $138
CA $162 total
includes taxes & fees
Jul 12 - Jul 13

Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical CenterSouth Main
6.6 out of 10, (1,005 reviews)
The price is CA $87
CA $102 total
includes taxes & fees
Jul 12 - Jul 13

Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG StadiumSouth Main
8.6 out of 10, Excellent, (1,011 reviews)
The price is CA $148
CA $173 total
includes taxes & fees
Jul 10 - Jul 11

Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHGSouth Main
7.4 out of 10, Good, (869 reviews)
The price is CA $104
CA $121 total
includes taxes & fees
Jul 12 - Jul 13

Studio 6 Houston, TX – Pearland/Medical Center
Studio 6 Houston, TX – Pearland/Medical CenterSoutheast Houston, 12.9 km from South Main
9.4 out of 10, Exceptional, (113 reviews)
The price is CA $93
CA $109 total
includes taxes & fees
Jul 13 - Jul 14

La Quinta Inn & Suites by Wyndham Houston Bush IAH South
La Quinta Inn & Suites by Wyndham Houston Bush IAH South31.2 km from South Main
8.0 out of 10, Very good, (2,128 reviews)
The price is CA $118
CA $139 total
includes taxes & fees
Jul 7 - Jul 8

GreenTree Inn Houston IAH Airport
GreenTree Inn Houston IAH Airport31.4 km from South Main
6.8 out of 10, (1,194 reviews)
The price is CA $68
CA $80 total
includes taxes & fees
Jul 15 - Jul 16

Best Western Plus Pearland/Houston Medical Center Hotel
Best Western Plus Pearland/Houston Medical Center HotelSoutheast Houston, 10.2 km from South Main
9.4 out of 10, Exceptional, (288 reviews)
The price is CA $111
CA $130 total
includes taxes & fees
Jul 12 - Jul 13

Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham
Heritage Inn Suites Houston/Sugar Land, Trademark by Wyndham18.5 km from South Main
8.8 out of 10, Excellent, (1,228 reviews)
The price is CA $118
CA $135 total
includes taxes & fees
Jul 5 - Jul 6

Hampton Inn & Suites Houston-Bush Intercontinental Aprt
Hampton Inn & Suites Houston-Bush Intercontinental Aprt31.8 km from South Main
8.8 out of 10, Excellent, (1,917 reviews)
The price is CA $127
CA $149 total
includes taxes & fees
Jun 19 - Jun 20

Platinum Inn & Suites Webster
Platinum Inn & Suites Webster30.8 km from South Main
7.8 out of 10, Good, (1,013 reviews)
The price is CA $107
CA $126 total
includes taxes & fees
Jun 18 - Jun 19

GreenTree Hotel & Extended Stay I-10 FWY Houston, Channelview, Baytown
GreenTree Hotel & Extended Stay I-10 FWY Houston, Channelview, Baytown28.8 km from South Main
8.6 out of 10, Excellent, (724 reviews)
The price is CA $68
CA $78 total
includes taxes & fees
Jun 25 - Jun 26

Heritage Place Houston Brookhollow
Heritage Place Houston Brookhollow15.4 km from South Main
8.6 out of 10, Excellent, (1,042 reviews)
The price is CA $153
CA $180 total
includes taxes & fees
Jun 26 - Jun 27

Tru by Hilton Houston Webster NASA
Tru by Hilton Houston Webster NASA30.7 km from South Main
9.0 out of 10, Wonderful, (1,012 reviews)
The price is CA $120
CA $141 total
includes taxes & fees
Jul 6 - Jul 7

Hotel Royale
Hotel Royale20.9 km from South Main
9.0 out of 10, Wonderful, (42 reviews)
The price is CA $99
CA $115 total
includes taxes & fees
Jul 7 - Jul 8

SpringHill Suites by Marriott Houston Intercontinental Arprt
SpringHill Suites by Marriott Houston Intercontinental Arprt31.8 km from South Main
9.0 out of 10, Wonderful, (1,819 reviews)
The price is CA $177
CA $207 total
includes taxes & fees
Jul 10 - Jul 11

Hyatt Place Houston/Sugar Land
Hyatt Place Houston/Sugar Land21.4 km from South Main
8.8 out of 10, Excellent, (1,926 reviews)
The price is CA $197
CA $227 total
includes taxes & fees
Jul 7 - Jul 8

Hilton Garden Inn Houston/Bush Intercontinental Airport
Hilton Garden Inn Houston/Bush Intercontinental Airport31.1 km from South Main
8.4 out of 10, Very good, (1,014 reviews)
The price is CA $142
CA $167 total
includes taxes & fees
Jul 10 - Jul 11

Holiday Inn Express Hotel & Suites - Houston Space Center by IHG
Holiday Inn Express Hotel & Suites - Houston Space Center by IHG30.8 km from South Main
9.0 out of 10, Wonderful, (1,021 reviews)
The price is CA $122
CA $142 total
includes taxes & fees
Jul 6 - Jul 7
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Compare popular hotels in South Main
Property | Star rating | Guest rating | Breakfast included | Pool | Spa | Pet-friendly | WiFi included | |
|---|---|---|---|---|---|---|---|---|
![]() Comfort Suites Houston near Medical Center- NRG Stadium | 8.6 Excellent 1,011 reviews | View | ||||||
![]() Wyndham Houston near NRG Park/Medical Center | 7.2 Good 1,297 reviews | View | ||||||
![]() Candlewood Suites Houston Medical Center by IHG | 7.4 Good 869 reviews | View | ||||||
![]() Wingate Houston near NRG Park/Medical Center | 6.6 1,010 reviews | View | ||||||
![]() Quality Inn & Suites NRG Park - Medical Center | 6.6 1,005 reviews | View |
Where to stay in South Main
Find the best South Main areas and neighborhoods for the activities you enjoy most.

Downtown Houston
Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

The Galleria
Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

Texas Medical Center
Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

Montrose
Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

Photo by George Zimzores
Open Photo by George Zimzores
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.
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