The best area to stay in Des Peres is along Manchester Road, particularly around West County Center, as it offers the most convenient access to amenities and attractions.This area is the commercial heart of Des Peres, featuring a large shopping centre, numerous restaurants, and various services. Manchester Road (Route 100) is the main thoroughfare, making it easy to navigate the city and access nearby highways for trips further afield. You'll find a good selection of modern hotels here, often with ample parking.For families, this area is particularly suitable due to the sheer convenience. You're footsteps away from West County Center, which provides a wide range of shopping and dining options, from casual eateries to sit-down restaurants. Additionally, the proximity to various family-friendly activities like parks and entertainment venues makes planning days out straightforward.Couples looking for a comfortable and convenient base will also appreciate this location. The hotels in this area generally offer good quality accommodation, often with amenities such as indoor pools and high-end fitness equipment.