Depew Vacation Packages

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Your Depew Vacation

A great way to experience this interesting city is with a customized Depew vacation package. Base yourself in the neighborhood of Downtown Buffalo, which is great for nightlife, shopping and bars and pubs or choose someplace else — our packages are all about you. Make your trip to Depew even more fulfilling by going sightseeing. Walden Galleria Mall, Holiday Twin Rinks and Eastern Hills Mall are some of the popular attractions you'll want to explore. Whoever you're taking time off with and whatever your bank balance, your ultimate Depew vacation is just clicks away with Expedia.

Top Depew Vacation Deals

Price found within the past 48 hours. Click for updated prices.
Holiday Inn Express Grand Island - Niagara Falls by IHG

Holiday Inn Express Grand Island - Niagara Falls by IHG

2.5 out of 5
Price was CA $822, price is now CA $579 per person
CA $579
per person
Jun 8 - Jun 12
found 1 day ago
Roundtrip flight included
Edmonton (YEG) to Buffalo (BUF)
9/10 Wonderful! (1,737 reviews)
Location was a little out of the way, so nice if you want quiet. Good distance to easily get to the falls and Canadian border. The property could use some updating but it was clean and staff was friendly.

Reviewed on Apr 12, 2026

Niagara Crossing Hotel & Spa

Niagara Crossing Hotel & Spa

3.5 out of 5
Price was CA $858, price is now CA $680 per person
CA $680
per person
Jun 8 - Jun 12
found 1 day ago
Roundtrip flight included
Edmonton (YEG) to Buffalo (BUF)
9/10 Wonderful! (1,618 reviews)
Not every room has hot tub

Reviewed on Apr 16, 2026

La Quinta Inn by Wyndham Buffalo Airport

La Quinta Inn by Wyndham Buffalo Airport

3 out of 5
Price was CA $1,250, price is now CA $1,007 per person
CA $1,007
per person
Jun 24 - Jun 28
found 14 hours ago
Roundtrip non-stop flight included
Montreal (YUL) to Buffalo (BUF)
8/10 Very Good! (1,491 reviews)
The breakfast was bad....not what is expected. The guy said they had had a problem with the food supplier for about a week and it showed. Orange juice was basically water. The warming trays were there but no food in them?? No packaged muffins, English muffins, just bagels. Also, no yogurt.

Reviewed on Apr 17, 2026

Courtyard by Marriott Buffalo Amherst/University

Courtyard by Marriott Buffalo Amherst/University

3 out of 5
Price was CA $788, price is now CA $643 per person
CA $643
per person
Jun 8 - Jun 12
found 1 day ago
Roundtrip flight included
Edmonton (YEG) to Buffalo (BUF)
8.2/10 Very Good! (1,004 reviews)
Close to highway but the property is very quiet

Reviewed on Apr 13, 2026

Buffalo Airport Hotel

Buffalo Airport Hotel

3 out of 5
Price was CA $1,185, price is now CA $967 per person
CA $967
per person
Jun 24 - Jun 28
found 14 hours ago
Roundtrip non-stop flight included
Montreal (YUL) to Buffalo (BUF)
8/10 Very Good! (2,928 reviews)
Best staff I’ve came across and the rooms were clean.

Reviewed on Apr 17, 2026

Ready to book your vacation to Depew?

 

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Depew Hotel Deals

Buffalo Airport Hotel

Buffalo Airport Hotel

3 out of 5
4600 Genesee St Buffalo NY
Fully refundableReserve now, pay when you stay
The price is CA $86 per night from Apr 26 to Apr 27
CA $86
CA $98 total
Apr 26 - Apr 27
includes taxes & fees
8/10 Very Good! (2,944 reviews)
Best staff I’ve came across and the rooms were clean.

Reviewed on Apr 17, 2026

Buffalo Airport Hotel
Sleep Inn & Suites Buffalo Airport

Sleep Inn & Suites Buffalo Airport

2.5 out of 5
100 Holtz Dr Buffalo NY
Fully refundableReserve now, pay when you stay
The price is CA $94 per night from Apr 26 to Apr 27
CA $94
CA $107 total
Apr 26 - Apr 27
includes taxes & fees
8/10 Very Good! (2,062 reviews)
Stay was ok. Rooms were not fully clean.

Reviewed on Apr 16, 2026

Sleep Inn & Suites Buffalo Airport
Holiday Inn Express Grand Island - Niagara Falls by IHG

Holiday Inn Express Grand Island - Niagara Falls by IHG

2.5 out of 5
2761 Long Road Grand Island NY
Fully refundable
The price is CA $156 per night from Apr 26 to Apr 27
CA $156
CA $178 total
Apr 26 - Apr 27
includes taxes & fees
9/10 Wonderful! (1,757 reviews)
The breakfast that I ate was great coffee juice fruit was fresh the staffs was approachable great environment Keep up the good work management team once the head is on properly the whole body will run smoothly

Reviewed on Apr 13, 2026

Holiday Inn Express Grand Island - Niagara Falls by IHG
See all 879 properties in Depew
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
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Discover the most popular places to visit in Depew

University At Buffalo - North Campus

University At Buffalo - North Campus

Enjoy the collegiate vibe when you visit University At Buffalo - North Campus, during your trip to Amherst. Experience the area's great live music and acclaimed theater scene.

University At Buffalo - North Campus
Highmark Stadium

Highmark Stadium

Catch an event at Highmark Stadium during your trip to Orchard Park. Experience the area's entertainment choices and great live music.

Highmark Stadium
Downtown Buffalo NY

KeyBank Center

Catch an event at KeyBank Center during your trip to Buffalo. Experience the area's entertainment choices and great live music.

KeyBank Center

What to do in Depew

Theodore Roosevelt Inaugural National Historic Site Admission and Guided Tour

Theodore Roosevelt Inaugural National Historic Site Admission and Guided Tour

CA $18
per adult
100% of travellers recommend
Theodore Roosevelt Inaugural National Historic Site Admission and Guided Tour
Niagara Falls Day Tour from Toronto

Niagara Falls Day Tour from Toronto

CA $71
per adult
96% of travellers recommend
Niagara Falls Day Tour from Toronto
Niagara Falls Self-Guided Driving Audio Tour from Toronto

Niagara Falls Self-Guided Driving Audio Tour from Toronto

CA $23
per traveller
Niagara Falls Self-Guided Driving Audio Tour from Toronto
See all activities in Depew

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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.