A coastal landscape with rocky cliffs, green hills, and a clear blue sea.

4 Stars Hotels in Mediterranean Region, from CA $101

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Check availability on Mediterranean Region 4 Star Hotels

Tonight
Sep 5 - Sep 6
Tomorrow
Sep 6 - Sep 7
Next weekend
Sep 11 - Sep 13
In two weeks
Sep 18 - Sep 20

Our top choices for Mediterranean Region 4-star hotels

A spacious lobby with modern seating arrangements, a large digital screen displaying a scenic view, and a high ceiling with natural light.
A modern hotel room with a bed, bedside table, lamp, and a bathroom visible through a glass partition.
A buffet with various food items and dishes.
A modern bar area with wooden paneling, bar stools, and a long counter.

1. Barcelona Airport Hotel

Barcelona Airport Hotel
El Prat de Llobregat
United States
Taylor
CA $236
CA $266 total
includes taxes & fees
Sep 28 - Sep 29
Barcelona Airport Hotel
A modern hotel interior with a central hallway, multiple balconies, and a sign reading 'HOTEL 101 MADRID'.
A gym with treadmills, elliptical machines, and weight benches.
A modern restaurant interior with long tables, black chairs, and a wooden bench seating area.
A modern indoor pool with lounge chairs, a tiled floor, and a building with balconies.

2. Hotel101- Madrid

Hotel101- Madrid
Barajas
United States
Rodner
CA $91
CA $101 total
includes taxes & fees
Sep 6 - Sep 7
Hotel101- Madrid
The exterior of a building with a prominent "BARCELONA" sign.
A buffet with various food items and condiments, a red vase, and two monitors on the wall.
A reception area with a granite counter, a clock, and a reception desk.
A hotel room with a bed, a desk, a chair, and a desk lamp.

3. Hotel 3K Barcelona

Hotel 3K Barcelona
Lisbon City Center
United States
Ana
CA $157
CA $179 total
includes taxes & fees
Sep 13 - Sep 14
Hotel 3K Barcelona
A rooftop pool area with modern loungers and a city view.
A modern restaurant with wooden tables and chairs, a bar area, and large windows offering a view of the outdoors.
A modern indoor seating area with sofas and tables, large windows, and indoor plants.
A table with a glass of wine, a plate of food, and a lamp on a balcony overlooking a cityscape at night.

4. The Stanley

The Stanley
Athens City Centre
United States
shreeya
CA $200
CA $244 total
includes taxes & fees
Sep 29 - Sep 30
The Stanley
A modern living room with a sofa, a coffee table, and a bookshelf.
A modern bathroom with a large mirror, a robe hanging on a rack, and a towel shelf.
A modern hotel room with a sofa, a bed, a coffee table, and a framed artwork on the wall.
A balcony with breakfast items, two glasses of juice, and a view of a statue and building facade.

5. Hotel Regina

Hotel Regina
Madrid Centro
United States
ALEJANDRO
CA $306
CA $337 total
includes taxes & fees
Sep 7 - Sep 8
Hotel Regina
A spacious hotel lobby with a checkered floor, multiple dining tables, and a central reception area.
A spacious lobby with a high ceiling, a central seating area with sofas, and a reception desk.
A modern living room with a sofa, a coffee table, a TV, and a side table with a candle.
A modern hotel room with a large bed, a TV mounted on a wooden panel wall, a seating area with a small table and chair, and a view of the city through large windows.

6. Hilton Rome Airport

Hilton Rome Airport
Fiumicino
United States
Cristian
CA $409
CA $466 total
includes taxes & fees
Sep 6 - Sep 7
Hilton Rome Airport
A Radisson hotel with a modern design, featuring a prominent sign and multiple floors.
A modern lobby with marble walls, a large abstract mural, and a staircase.
A modern hotel lobby with a buffet area, marble flooring, and large mirrors.
A modern hotel lobby with marble flooring, a central staircase, and a reception area.

7. Radisson Blu Hotel

Radisson Blu Hotel
Lisbon City Center
United States
Luis
CA $182
CA $206 total
includes taxes & fees
Sep 6 - Sep 7
Radisson Blu Hotel
A modern kitchen with wooden cabinetry, a built-in coffee machine, and a seating area with tables and chairs.
A large, multi-story hotel with a prominent sign reading "Hilton Garden Inn." The building features a symmetrical facade with evenly spaced windows and a central entrance.
A modern bar area with multiple seating options, including bar stools and tables, and a counter with a variety of beverages.
A hotel room with two beds, a desk with a computer, a chair, and a TV.

8. Hilton Garden Inn Rome Airport

Hilton Garden Inn Rome Airport
Fiumicino
Canada
Sheena
CA $309
CA $355 total
includes taxes & fees
Sep 8 - Sep 9
Hilton Garden Inn Rome Airport
A modern breakfast bar with a variety of food options, a seating area with tables and chairs, and a view of the cityscape through large windows.
A modern lobby with seating areas, a coffee bar, and a large abstract painting on the wall.
A modern hotel lobby with wooden flooring, blue seating, and various plants.
An outdoor deck with white tables and chairs, a bar area with chalkboard menu, and a view of the sea.

9. Holiday Inn Lisbon by IHG

Holiday Inn Lisbon by IHG
Lisbon City Center
United Kingdom
Aguinalda Joana
CA $168
CA $215 total
includes taxes & fees
Sep 13 - Sep 14
Holiday Inn Lisbon by IHG
A hotel entrance with a modern sign, traditional brick buildings, and a covered walkway.
A hotel room with a large bed, two bedside tables, a nightstand, and a window with curtains.
A modern interior with a long reception area, bar seating, and a staircase leading to an upper level.
A modern lobby with a central bookshelf, seating area, and a staircase.

10. Hotel Gran Versalles

Hotel Gran Versalles
Chamberí
United States
German
CA $161
CA $177 total
includes taxes & fees
Sep 6 - Sep 7
Hotel Gran Versalles
A swimming pool with lounge chairs and umbrellas, surrounded by greenery and a building in the background.
A modern, well-lit hallway with a wooden floor, white walls, and potted plants.
A spacious, modern hotel lobby with a high ceiling, large windows, and a mix of seating areas including a sofa and chairs.
A modern outdoor dining area with white furniture and a pool in the background.

11. Italiana Hotels Florence

Italiana Hotels Florence
Florence
Canada
Daniela
CA $124
CA $159 total
includes taxes & fees
Sep 7 - Sep 8
Italiana Hotels Florence
A swimming pool with blue and white stripes, a large building with a dome, and a cityscape in the background.
A buffet with various pastries and desserts.
A spacious lobby with seating areas, a reception desk, and a modern ceiling design.
A balcony with wicker chairs and a small table, overlooking a cityscape with historic buildings and a dome structure.

12. Urban Hive Madrid

Urban Hive Madrid
Madrid Centro
United Kingdom
Demi
CA $270
CA $297 total
includes taxes & fees
Sep 6 - Sep 7
Urban Hive Madrid
A restaurant with wooden tables and chairs, string lights, and large windows with a view of greenery.
A pool area with lounge chairs and a hot tub.
An outdoor dining area with bamboo walls, wooden tables, and chairs.
A hotel with a curved facade, palm trees, and a sign reading 'ISOLA SACRA.'

13. Hotel Isola Sacra Rome Airport

Hotel Isola Sacra Rome Airport
Isola Sacra
Canada
Giuseppe
CA $223
CA $261 total
includes taxes & fees
Sep 9 - Sep 10
Hotel Isola Sacra Rome Airport
A modern restaurant with a variety of seating options, including tables and chairs, and a central display case with food items.
A modern indoor swimming pool with a wooden floor, tiled walls, and a glass barrier.
A modern building with a pool area, lounge chairs, and a sign indicating amenities like 'chegadas arrivals' and 'parque parking'.
A spacious lobby with a high ceiling, large windows, and modern seating arrangements.

14. Meliá Lisboa Aeroporto

Meliá Lisboa Aeroporto
Lisbon
United States
Lucy
CA $339
CA $372 total
includes taxes & fees
Sep 20 - Sep 21
Meliá Lisboa Aeroporto
A bar area with chairs and a table, overlooking a cityscape with buildings and a dome structure.
A hotel lobby with a circular ceiling light, a reception desk, and a seating area with sofas.
A pool area with multiple white umbrellas and a clear view of the city skyline.
A breakfast table with a variety of food items, a glass of orange juice, and a cup of coffee.

15. Hotel Riu Plaza España

Hotel Riu Plaza España
Madrid Centro
Canada
daryl
CA $242
CA $266 total
includes taxes & fees
Sep 6 - Sep 7
Hotel Riu Plaza España
A modern hotel room with a large bed, a bathtub, and a seating area with a view of the city.
A swimming pool with two people floating on inflatable rings.
A modern hotel with a glass facade, illuminated by blue lights, and a visible 'HOTEL' sign.
A modern outdoor seating area with a glass balustrade, potted plants, and a view of the cityscape.

16. Hard Rock Hotel Madrid

Hard Rock Hotel Madrid
Arganzuela
United States
Jon
CA $224
CA $246 total
includes taxes & fees
Sep 6 - Sep 7
Hard Rock Hotel Madrid
A spacious living area with a large window overlooking a pool and garden. There are multiple seating options including sofas and chairs.
A hotel with multiple floors, a rooftop pool, and outdoor seating areas.
A modern restaurant with booths, tables, and a decorative wall with arches.
A modern lobby with a central seating area, a large bookshelf, and a decorative column.

17. Cardo Roma, Autograph Hotel

Cardo Roma, Autograph Hotel
Ostiense
Canada
Nicole
CA $350
CA $409 total
includes taxes & fees
Sep 6 - Sep 7
Cardo Roma, Autograph Hotel

18. Locke de Santa Joana

Locke de Santa Joana
Lisbon City Center
United States
Mateusz
CA $180
CA $204 total
includes taxes & fees
Sep 22 - Sep 23
Locke de Santa Joana
A rooftop terrace with wicker chairs and a table set for dining, overlooking a cityscape with buildings and a hill in the background.
A modern lounge area with a sectional sofa, bean bags, and a small coffee table.
A modern cafe with a bar area, seating, and a 'HOLA' sign.

19. Moxy Barcelona

Moxy Barcelona
Sants-Montjuïc
United Kingdom
Robert
CA $230
CA $282 total
includes taxes & fees
Sep 13 - Sep 14
Moxy Barcelona
A rooftop bar with outdoor seating, overlooking a historic building with a dome.
A room with a patterned floor, a bench, and a ceiling light fixture.
A large, white, multi-story building with a classic architectural style, featuring a central entrance with a green awning and multiple balconies.
A rooftop infinity pool with a city view.

20. Pestana CR7 Gran Vía Madrid

Pestana CR7 Gran Vía Madrid
Madrid Centro
United States
K
CA $356
CA $392 total
includes taxes & fees
Sep 6 - Sep 7
Pestana CR7 Gran Vía Madrid
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Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Mediterranean Region.
Grand Hyatt Athens

Grand Hyatt Athens

115, Syngrou Avenue Athens Attica
CA $265
CA $326 total
Sep 7 - Sep 8
includes taxes & fees
Grand Hyatt Athens
Corinthia Lisbon

Corinthia Lisbon

Avenida Columbano Bordalo Pinheiro, 105 Lisbon
CA $383
CA $419 total
Sep 13 - Sep 14
includes taxes & fees
9.6/10 Exceptional! (1,264 reviews)
Corinthia Lisbon
Grand Hyatt Barcelona

Grand Hyatt Barcelona

Plaza de Pio XII, 4 Barcelona
CA $326
CA $401 total
Sep 20 - Sep 21
includes taxes & fees
9.2/10 Wonderful! (1,599 reviews)
Grand Hyatt Barcelona
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Learn more about Mediterranean Region

During your stay in Mediterranean Region, you can discover things to see and do in the local area.

See all hotels in Mediterranean Region
A winding road through a mountainous landscape with the sun setting behind the hills.

Top Mediterranean Region Hotel Reviews

Hilton Rome Airport

Hilton Rome Airport

8/10 Good
"Excellent staff. Food was expensive but at least breakfast was included."
Robert 1-night trip
Posted 2 hours ago
Hilton Rome Airport
Hilton Garden Inn Rome Airport

Hilton Garden Inn Rome Airport

10/10 Excellent
"Very nice hotel, airport shuttle runs every 10-15 minutes, so convenient"
Gregorio 1-night trip
Posted 3 hours ago
Hilton Garden Inn Rome Airport
Hotel Regina

Hotel Regina

10/10 Excellent
"One of the most welcoming and accommodating hotels I’ve ever stayed in. The location is perfect and the hotel is beautiful. Definitely coming back!"
Melissa 2-night trip
Posted 12 hours ago
Hotel Regina
Hotel 3K Barcelona

Hotel 3K Barcelona

10/10 Excellent
"This was one of the best experiences we’ve ever had! The staff were amazing from the start. They let us keep our luggage at the hotel, the check-in was super smooth and easy and the room was exactly as pictured—great space, comfort and cleanliness. They also helped us out when we made a small mistake during check-out, and they provided an amazing solution. A huge shout-out to all the staff, especially the lady who was with us during our stay."
Carlos 2-night trip
Posted 13 hours ago
Hotel 3K Barcelona
Hotel Riu Plaza España

Hotel Riu Plaza España

10/10 Excellent
"Hotel is very clean. Breakfast was amazing and staffs are very helpful. Highly recommend"
Paresh 3-night trip
Posted 16 hours ago
Hotel Riu Plaza España
Barcelona Airport Hotel

Barcelona Airport Hotel

10/10 Excellent
"Hotel was a really nice surprise! We ate dinner at the restaurant. Food we had was very good. I have dietary issues. There is no deviations on their menu. Shuttle pickup and drop was a great relief. I would highly recommend BAH."
Jo 1-night trip
Posted 18 hours ago
Barcelona Airport Hotel
Hotel101- Madrid

Hotel101- Madrid

10/10 Excellent
"Location was great, rooms clean and staff helpful and friendly."
Kaneez 3-night trip
Posted 19 hours ago
Hotel101- Madrid
Hotel Isola Sacra Rome Airport

Hotel Isola Sacra Rome Airport

10/10 Excellent
"This hotel is a gem. Very nice staff and the food is incredible."
BELKYS 1-night trip
Posted 2 days ago
Hotel Isola Sacra Rome Airport
Moxy Barcelona

Moxy Barcelona

10/10 Excellent
"Boutique hotel great rooftop bar and pool"
Robert 4-night trip
Posted 4 days ago
Moxy Barcelona

Find out more about Mediterranean Region

If you’re looking for a spot with great rates, just-for-you amenities, and a world of luxurious little perks, the best 4 Stars hotels in Mediterranean Region are calling your name. Known for providing first-rate service in amazing locations, each of the Mediterranean Region 4 Stars hotels lets discerning travelers bask in an unforgettable experience.

Kick back in your spacious room. Relax in the lobby’s sumptuous surroundings. Start the day with delicious room service, and then use the complimentary body care items to freshen up before you head out for the day.

It’s all waiting for you at the top four star hotels in Mediterranean Region. Plus, when you book with Expedia.ca, you might find a cheap deal on a 4 Stars hotel in Mediterranean Region, , neighbourhoods near the most popular attractions, so you can see the sights and bask in the discounts all in one trip. Whether you’re planning a romantic retreat or simply want to experience everything the area has to offer, the top Mediterranean Region hotels with 4 Stars provide everything you need to unwind in style.