Title: 4 Stars Hotels in Adrian, Texas - Find Cheap Adrian Hotels With 4 Stars | Expedia.ca [Adrian Travel Guide](https://expedia.ca/Adrian.dx3000422512)[Hotels in Adrian](https://expedia.ca/Adrian-Hotels.d3000422512.Travel-Guide-Hotels)[Vacation Rentals in Adrian](https://expedia.ca/Adrian-Vacation-Rentals.d3000422512.Travel-Guide-VacationRentals)[Flights to Adrian](https://expedia.ca/Cheap-Flights-To-Adrian.d3000422512.Travel-Guide-Flights)[Adrian Car Rentals](https://expedia.ca/Car-Rentals-In-Adrian.d3000422512.Car-Rental-Guide)[Adrian Vacation Packages](https://expedia.ca/Adrian.d3000422512.Destination-Travel-Guides) ![Adrian is just off Interstate 40. It is also the midpoint of the historic Route 66. From here it is 1139 miles East to Chicago and 1139 miles West to Los Angeles. There is also Midpoint Cafe, a 50's style diner with a great burger and fries. However, if you stop you have to ask about their "Ugly Pie."](https://images.trvl-media.com/place/3000422512/a77a6e86-60b8-4227-9215-9b9641bf45f7.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Jeff White # 4 Stars Hotels in Adrian, Texas - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Adrian 4 Star Hotels Tonight [Jan 3 - Jan 4](https://www.expedia.ca/Hotel-Search?regionId=3000422512&startDate=2026-01-03&endDate=2026-01-04&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Jan 4 - Jan 5](https://www.expedia.ca/Hotel-Search?regionId=3000422512&startDate=2026-01-04&endDate=2026-01-05&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Jan 9 - Jan 11](https://www.expedia.ca/Hotel-Search?regionId=3000422512&startDate=2026-01-09&endDate=2026-01-11&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Jan 16 - Jan 18](https://www.expedia.ca/Hotel-Search?regionId=3000422512&startDate=2026-01-16&endDate=2026-01-18&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F4Star-Adrian-Hotels.s40-0-d3000422512.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F4Star-Adrian-Hotels.s40-0-d3000422512.Travel-Guide-Filter-Hotels) ## Learn more about Adrian At the midpoint of Route 66, stop at the Midpoint Café for their famous 'ugly crust' pies and Route 66 memorabilia. Snap a photo with the town's midway marker, then chat with locals who'll share stories about this tiny highway community. [See all hotels in Adrian](https://www.expedia.ca/Hotel-Search?startDate=2026-01-17&endDate=2026-01-18&adults=2®ionId=3000422512) ![Route 66 midpoint sign](https://images.trvl-media.com/place/3000422512/2d6ba6c5-60b8-4e08-9416-59acd9115cc9.jpg?impolicy=fcrop&w=900&h=506&p=1&q=high) ## Top Adrian Hotel Reviews ## Find out more about Adrian If you’re looking for a spot with great rates, just-for-you amenities, and a world of luxurious little perks, the best 4 Stars hotels in Adrian are calling your name. Known for providing first-rate service in amazing locations, each of the Adrian 4 Stars hotels lets discerning travelers bask in an unforgettable experience. Kick back in your spacious room. Relax in the lobby’s sumptuous surroundings. Start the day with delicious room service, and then use the complimentary body care items to freshen up before you head out for the day. It’s all waiting for you at the top four star hotels in Adrian. Plus, when you book with Expedia.ca, you might find a cheap deal on a 4 Stars hotel in Adrian, Texas, neighbourhoods near the most popular attractions, so you can see the sights and bask in the discounts all in one trip. Whether you’re planning a romantic retreat or simply want to experience everything the area has to offer, the top Adrian hotels with 4 Stars provide everything you need to unwind in style. ## Frequently asked questions ### How much does it cost to stay in a 4-star hotel in Adrian? > - Search for the lowest price ### What's the difference between 5-star and 4-star hotels in Adrian? ### Does Adrian have any 4-star all-inclusive resorts? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Other - More ways to book - [2 Star Hotels in Dumas ](https://www.expedia.ca/2Star-Dumas-Hotels.s20-0-d7920.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Amarillo ](https://www.expedia.ca/5Star-Amarillo-Hotels.s50-0-d371.Travel-Guide-Filter-Hotels) - [Apartments in Amarillo ](https://www.expedia.ca/Amarillo-Apartments.d371-aaApartments.Travel-Guide-Accommodation) - [B&B in Amarillo ](https://www.expedia.ca/Amarillo-Bed-And-Breakfast.d371-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Cottages in Amarillo ](https://www.expedia.ca/Amarillo-Cottages.d371-aaCottages.Travel-Guide-Accommodation) - [Guest Houses in Amarillo ](https://www.expedia.ca/Amarillo-Guest-Houses.d371-aaGuestHouses.Travel-Guide-Accommodation) - [Adults Only Resorts & in Amarillo ](https://www.expedia.ca/Amarillo-Hotels-Adults-Only-Resorts.0-0-d371-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels) - [Beach Hotel Hotels in Amarillo ](https://www.expedia.ca/Amarillo-Hotels-Beach-Hotel.0-0-d371-tBeachHotel.Travel-Guide-Filter-Hotels) - [Boutique Hotels in Amarillo ](https://www.expedia.ca/Amarillo-Hotels-Boutique-Hotel.0-0-d371-tBoutiqueHotel.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Amarillo ](https://www.expedia.ca/Amarillo-Hotels-Cheap-Hotels.0-0-d371-tCheapHotels.Travel-Guide-Filter-Hotels) - [Historic Hotels in Amarillo ](https://www.expedia.ca/Amarillo-Hotels-Historic-Hotel.0-0-d371-tHistoricHotel.Travel-Guide-Filter-Hotels) - [Hotels with a Pool in Amarillo ](https://www.expedia.ca/Amarillo-Hotels-Hotel-With-Pool.0-0-d371-tHotelwithPool.Travel-Guide-Filter-Hotels) - [Hotels with Balconies in Amarillo ](https://www.expedia.ca/Amarillo-Hotels-Hotels-With-Balconies.0-0-d371-tHotelswithBalconies.Travel-Guide-Filter-Hotels) - [Hotels with Bar in Amarillo ](https://www.expedia.ca/Amarillo-Hotels-Hotels-With-Bar.0-0-d371-tHotelswithBar.Travel-Guide-Filter-Hotels) - [Hotels with Free Airport Shuttle in Amarillo ](https://www.expedia.ca/Amarillo-Hotels-Hotels-With-Free-Airport-Shuttle.0-0-d371-tHotelswithFreeAirportShuttle.Travel-Guide-Filter-Hotels) - [Hotels with Free Parking in Amarillo ](https://www.expedia.ca/Amarillo-Hotels-Hotels-With-Free-Parking.0-0-d371-tHotelswithFreeParking.Travel-Guide-Filter-Hotels) - [Hotels with an Indoor Pool in Amarillo ](https://www.expedia.ca/Amarillo-Hotels-Hotels-With-Indoor-Pool.0-0-d371-tHotelswithIndoorPool.Travel-Guide-Filter-Hotels) - [Hotels with Kitchenettes in Amarillo ](https://www.expedia.ca/Amarillo-Hotels-Hotels-With-Kitchenettes.0-0-d371-tHotelswithKitchenettes.Travel-Guide-Filter-Hotels) - [Hotels with Waterslides in Amarillo ](https://www.expedia.ca/Amarillo-Hotels-Hotels-With-Waterslides.0-0-d371-tHotelswithWaterslides.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Amarillo ](https://www.expedia.ca/Amarillo-Hotels-Luxury-Hotel.0-0-d371-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Amarillo ](https://www.expedia.ca/Amarillo-Hotels-Pet-Friendly-Hotel.0-0-d371-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Romantic Hotels in Amarillo ](https://www.expedia.ca/Amarillo-Hotels-Romantic-Hotel.0-0-d371-tRomanticHotel.Travel-Guide-Filter-Hotels) - [Spa Hotels in Amarillo ](https://www.expedia.ca/Amarillo-Hotels-Spa-Hotel.0-0-d371-tSpaHotel.Travel-Guide-Filter-Hotels) - [Amarillo Hotels ](https://www.expedia.ca/Amarillo-Hotels.d371.Travel-Guide-Hotels) - [Hotels near Amarillo Museum of Art ](https://www.expedia.ca/Amarillo-Museum-Of-Art-Hotels.0-l6080841-0.Travel-Guide-Filter-Hotels) - [Vacation Homes in Amarillo ](https://www.expedia.ca/Amarillo-Private-Vacation-Homes.d371-aaPrivateVacationHomes.Travel-Guide-Accommodation) - [Ranches in Amarillo ](https://www.expedia.ca/Amarillo-Ranches.d371-aaRanches.Travel-Guide-Accommodation) - [Hotels near Amarillo Zoo ](https://www.expedia.ca/Amarillo-Zoo-Hotels.0-l6080847-0.Travel-Guide-Filter-Hotels) - [Business Hotels in Bishop Hills ](https://www.expedia.ca/Bishop-Hills-Amarillo-Hotels-Business-Hotel.0-n553248634998737595-0-tBusinessHotel.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Bishop Hills ](https://www.expedia.ca/Bishop-Hills-Amarillo-Hotels-Pet-Friendly-Hotel.0-n553248634998737595-0-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Bishop Hills Hotels ](https://www.expedia.ca/Bishop-Hills-Amarillo-Hotels.0-n553248634998737595-0.Travel-Guide-Filter-Hotels) - [Boys Ranch Hotels ](https://www.expedia.ca/Boys-Ranch-Hotels.d553248635974901102.Travel-Guide-Hotels) - [Cheap Hotels in Bushland ](https://www.expedia.ca/Bushland-Amarillo-Hotels-Cheap-Hotels.0-n3000354152-0-tCheapHotels.Travel-Guide-Filter-Hotels) - [Historic Hotels in Bushland ](https://www.expedia.ca/Bushland-Amarillo-Hotels-Historic-Hotel.0-n3000354152-0-tHistoricHotel.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Bushland ](https://www.expedia.ca/Bushland-Amarillo-Hotels-Luxury-Hotel.0-n3000354152-0-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Bushland ](https://www.expedia.ca/Bushland-Amarillo-Hotels-Pet-Friendly-Hotel.0-n3000354152-0-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Bushland Hotels ](https://www.expedia.ca/Bushland-Amarillo-Hotels.0-n3000354152-0.Travel-Guide-Filter-Hotels) - [Hotels near Cadillac Ranch ](https://www.expedia.ca/Cadillac-Ranch-Hotels.0-l6080853-0.Travel-Guide-Filter-Hotels) - [Farmstay in Canyon ](https://www.expedia.ca/Canyon-Agritourism.d7244-aaAgritourism.Travel-Guide-Accommodation) - [B&B in Canyon ](https://www.expedia.ca/Canyon-Bed-And-Breakfast.d7244-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Guest Houses in Canyon ](https://www.expedia.ca/Canyon-Guest-Houses.d7244-aaGuestHouses.Travel-Guide-Accommodation) - [Boutique Hotels in Canyon ](https://www.expedia.ca/Canyon-Hotels-Boutique-Hotel.0-0-d7244-tBoutiqueHotel.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Canyon ](https://www.expedia.ca/Canyon-Hotels-Cheap-Hotels.0-0-d7244-tCheapHotels.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Canyon ](https://www.expedia.ca/Canyon-Hotels-Pet-Friendly-Hotel.0-0-d7244-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Ski Hotels in Canyon ](https://www.expedia.ca/Canyon-Hotels-Ski-Hotel.0-0-d7244-tSkiHotel.Travel-Guide-Filter-Hotels) - [Spa Hotels in Canyon ](https://www.expedia.ca/Canyon-Hotels-Spa-Hotel.0-0-d7244-tSpaHotel.Travel-Guide-Filter-Hotels) - [Canyon Hotels ](https://www.expedia.ca/Canyon-Hotels.d7244.Travel-Guide-Hotels) - [Inns in Canyon ](https://www.expedia.ca/Canyon-Inns.d7244-aaInns.Travel-Guide-Accommodation) - [Lodges in Canyon ](https://www.expedia.ca/Canyon-Lodges.d7244-aaLodges.Travel-Guide-Accommodation) - [Motels in Canyon ](https://www.expedia.ca/Canyon-Motels.d7244-aaMotels.Travel-Guide-Accommodation) - [Ranches in Canyon ](https://www.expedia.ca/Canyon-Ranches.d7244-aaRanches.Travel-Guide-Accommodation) - [Resorts in Canyon ](https://www.expedia.ca/Canyon-Resort-Hotels.d7244-aaResortHotels.Travel-Guide-Accommodation) - [La Quinta Inn & Suites Hotels in Channing ](https://www.expedia.ca/Channing-Hotels-La-Quinta-Inn-Suites.0-0-d553248634998593849--bLaQuintaInnSuites.Travel-Guide-Filter-Hotels) - [Channing Hotels ](https://www.expedia.ca/Channing-Hotels.d553248634998593849.Travel-Guide-Hotels) - [Hartley County Hotels ](https://www.expedia.ca/Destinations-In-Hartley-County.d553248635976433674.Hotel-Destinations) - [Casino Hotels in Downtown Amarillo ](https://www.expedia.ca/Downtown-Amarillo-Amarillo-Hotels-Casino-Hotel.0-n897247168017158144-0-tCasinoHotel.Travel-Guide-Filter-Hotels) - [Cheap Hotels in Downtown Amarillo ](https://www.expedia.ca/Downtown-Amarillo-Amarillo-Hotels-Cheap-Hotels.0-n897247168017158144-0-tCheapHotels.Travel-Guide-Filter-Hotels) - [Hotels with an Indoor Pool in Downtown Amarillo ](https://www.expedia.ca/Downtown-Amarillo-Amarillo-Hotels-Hotels-With-Indoor-Pool.0-n897247168017158144-0-tHotelswithIndoorPool.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Downtown Amarillo ](https://www.expedia.ca/Downtown-Amarillo-Amarillo-Hotels-Luxury-Hotel.0-n897247168017158144-0-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Downtown Amarillo Hotels ](https://www.expedia.ca/Downtown-Amarillo-Amarillo-Hotels.0-n897247168017158144-0.Travel-Guide-Filter-Hotels) - [La Quinta Inn & Suites Hotels in Friona ](https://www.expedia.ca/Friona-Hotels-La-Quinta-Inn-Suites.0-0-d55115--bLaQuintaInnSuites.Travel-Guide-Filter-Hotels) - [Spa Hotels in Friona ](https://www.expedia.ca/Friona-Hotels-Spa-Hotel.0-0-d55115-tSpaHotel.Travel-Guide-Filter-Hotels) - [Friona Hotels ](https://www.expedia.ca/Friona-Hotels.d55115.Travel-Guide-Hotels) - [B&B in Hereford ](https://www.expedia.ca/Hereford-Bed-And-Breakfast.d8336-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Cheap Hotels in Hereford ](https://www.expedia.ca/Hereford-Hotels-Cheap-Hotels.0-0-d8336-tCheapHotels.Travel-Guide-Filter-Hotels) - [Family Hotels in Hereford ](https://www.expedia.ca/Hereford-Hotels-Family-Hotel.0-0-d8336-tFamilyHotel.Travel-Guide-Filter-Hotels) - [Hotels with Free Breakfast in Hereford ](https://www.expedia.ca/Hereford-Hotels-Hotels-With-Free-Breakfast.0-0-d8336-tHotelswithFreeBreakfast.Travel-Guide-Filter-Hotels) - [Hereford Hotels ](https://www.expedia.ca/Hereford-Hotels.d8336.Travel-Guide-Hotels) - [Masterson Hotels ](https://www.expedia.ca/Masterson-Hotels.d3000354351.Travel-Guide-Hotels) - [Inns in Masterson ](https://www.expedia.ca/Masterson-Inns.d3000354351-aaInns.Travel-Guide-Accommodation) - [Hotels near Northwest Texas Hospitals ](https://www.expedia.ca/Northwest-Texas-Hospitals-Hotels.0-l6080875-0.Travel-Guide-Filter-Hotels) - [Beach Hotel Hotels in San Jacinto ](https://www.expedia.ca/San-Jacinto-Amarillo-Hotels-Beach-Hotel.0-n897260423896846336-0-tBeachHotel.Travel-Guide-Filter-Hotels) - [Luxury Hotels in San Jacinto ](https://www.expedia.ca/San-Jacinto-Amarillo-Hotels-Luxury-Hotel.0-n897260423896846336-0-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Soncy ](https://www.expedia.ca/Soncy-Amarillo-Hotels-Luxury-Hotel.0-n3000007996-0-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Pet-Friendly Hotels in Soncy ](https://www.expedia.ca/Soncy-Amarillo-Hotels-Pet-Friendly-Hotel.0-n3000007996-0-tPetfriendlyHotel.Travel-Guide-Filter-Hotels) - [Soncy Hotels ](https://www.expedia.ca/Soncy-Amarillo-Hotels.0-n3000007996-0.Travel-Guide-Filter-Hotels) - [Hotels with a Pool in Vega ](https://www.expedia.ca/Vega-Hotels-Hotel-With-Pool.0-0-d10261-tHotelwithPool.Travel-Guide-Filter-Hotels) - [Hotels with an Indoor Pool in Vega ](https://www.expedia.ca/Vega-Hotels-Hotels-With-Indoor-Pool.0-0-d10261-tHotelswithIndoorPool.Travel-Guide-Filter-Hotels) - [Vega Hotels ](https://www.expedia.ca/Vega-Hotels.d10261.Travel-Guide-Hotels) - [Hotels near Westgate Mall ](https://www.expedia.ca/Westgate-Mall-Hotels.0-l6080887-0.Travel-Guide-Filter-Hotels) - [Wildorado Hotels ](https://www.expedia.ca/Wildorado-Hotels.d3000459391.Travel-Guide-Hotels) - [Flights to Amarillo ](https://www.expedia.ca/Cheap-Flights-To-Amarillo.d371.Travel-Guide-Flights) - [Flights to Canyon ](https://www.expedia.ca/Cheap-Flights-To-Canyon.d7244.Travel-Guide-Flights) - [Flights from Vega ](https://www.expedia.ca/lp/flights/10261/flights-from-vega) - [Flights from Amarillo ](https://www.expedia.ca/lp/flights/371/flights-from-amarillo) - [Flights from Channing ](https://www.expedia.ca/lp/flights/553248634998593849/flights-from-channing) - [Flights from Canyon ](https://www.expedia.ca/lp/flights/7244/flights-from-canyon) - [Amarillo Vacations ](https://www.expedia.ca/Amarillo.d371.Destination-Travel-Guides) - [Cadillac Ranch ](https://www.expedia.ca/Cadillac-Ranch-Amarillo.d6080853.Vacation-Attraction) - [John Stiff Memorial Dog Park ](https://www.expedia.ca/John-Stiff-Memorial-Dog-Park-Amarillo.d553248621561866764.Vacation-Attraction) - [Vega Vacations ](https://www.expedia.ca/Vega.d10261.Destination-Travel-Guides) - [Avis Rental Cars in Amarillo ](https://www.expedia.ca/Avis-Car-Rentals-In-Amarillo.d371-c41.Car-Rental-Guide-Suppliers) - [Avis Rental Cars in Hereford ](https://www.expedia.ca/Avis-Car-Rentals-In-Hereford.d8336-c41.Car-Rental-Guide-Suppliers) - [Car rentals in Budget 405 S Citrus Ave ](https://www.expedia.ca/Budget-at-405-S-Citrus-Ave-Covina-California-USA.v7244.Car-Rental-Guide-Location) - [Car rentals near Amarillo ](https://www.expedia.ca/Car-Rentals-In-Amarillo.d371.Car-Rental-Guide) - [Car rental Canyon ](https://www.expedia.ca/Car-Rentals-In-Canyon.d7244.Car-Rental-Guide) - [Car rental Hereford ](https://www.expedia.ca/Car-Rentals-In-Hereford.d8336.Car-Rental-Guide) - [Car rental Vega ](https://www.expedia.ca/Car-Rentals-In-Vega.d10261.Car-Rental-Guide) - [Pickup Car Rentals near Don and Sybil Harrington Cancer Center ](https://www.expedia.ca/Pickup-Car-Rentals-In-Don-And-Sybil-Harrington-Cancer-Center.d6080861-tPickup.Car-Rental-Guide-Class) - [Things to do in Amarillo ](https://www.expedia.ca/Things-To-Do-In-Amarillo.d371.Travel-Guide-Activities) - [Book 4 Star Hotels in Adrian on Expedia.com ](https://www.expedia.com/4Star-Adrian-Hotels.s40-0-d3000422512.Travel-Guide-Filter-Hotels)