Photo by Southernmost Illinois Tourism Bureau

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Pet-friendly Hotels in Southwest Illinois

La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis

136 Regency Park O'Fallon IL

3 hours drive from Southern Illinois University

Book a stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the clean rooms in our reviews. ...

6/10 (1,000 reviews)

Nice for price

Reviewed on Feb 4, 2026

Drury Inn & Suites St. Louis Fairview Heights

12 Ludwig Dr Fairview Heights IL

3 hours drive from Southern Illinois University

Book a stay at this business-friendly hotel in Fairview Heights. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...

9.2/10 Wonderful! (1,004 reviews)

Guest services, it was quiet and the food was great.

Reviewed on Feb 15, 2026

Drury Inn & Suites St. Louis O'Fallon, IL

1118 Central Park Drive O'Fallon IL

3 hours drive from Southern Illinois University

Book a stay at this business-friendly hotel in O'Fallon. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...

9.6/10 Exceptional! (1,001 reviews)

Cleanliness. Just wish a microwave was in room

Reviewed on Feb 16, 2026

See all 744 properties in Southwest Illinois

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.