10 Best Hotels in Uptown, Collinsville for 2026

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Where to stay in Uptown

Find the best Uptown areas and neighborhoods for the activities you enjoy most. Learn more about Uptown

An aerial view of a city with a prominent river, a large bridge, and surrounding buildings.

Eastport

If you're spending some time in Eastport, Gateway Conference Center and Splash City Family Waterpark are top sights worth seeing.

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Mulberry Hills

While Mulberry Hills isn't home to many top sights, World's Largest Catsup Bottle and Gateway Conference Center are some notable places to visit nearby.

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A large, historic building with arched windows and a prominent corner entrance.

Historic Downtown Collinsville

While Historic Downtown Collinsville isn't home to many top sights, World's Largest Catsup Bottle and Gateway Conference Center are some notable places to visit nearby.

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Top Uptown Hotel Reviews

Hyatt Regency St. Louis at The Arch

10/10 Excellent

"Check in was quick at 3pm and hotel in general was super clean!"

Hampton Inn St. Louis-Downtown (At the Gateway Arch)

8/10 Good

"Overall, I slept really well and the beds were very comfortable. The staff was welcoming. Breakfast was good - though the coffee was a little weak. The ice machines were not working on three of the floors, nor did the water cooler in the fitness room work. I would go there again."

Frequently asked questions

When is the best time to go to Uptown?

The best time to go to Uptown is from late spring (May) to early autumn (September), when the weather is most pleasant for exploring the area.

During these months, you'll find comfortable temperatures, typically ranging from 18°C to 28°C, which is ideal for walking around and enjoying outdoor attractions. The longer daylight hours also mean more time for sightseeing and relaxing by the lakefront. This period also sees various outdoor events and festivals, adding to the local experience.

Couples looking for a romantic getaway will appreciate the warmer months when they can take leisurely strolls along the lakefront or enjoy an evening meal at one of the many alfresco dining spots. The mild evenings are superb for catching a show at the historic venues in the district.

Solo travellers will find late spring and early autumn convenient for exploring Uptown's diverse offerings without the extreme heat or cold.

Can I cancel my hotel reservation on Expedia?

Many Expedia hotel reservations are refundable, provided that you cancel before the hotel's cancellation deadline – this is often within 24-48 hours of your scheduled arrival. If you have a non-refundable booking, it might still be possible to receive a refund if you cancel it within 24 hours of booking. Be sure to check your booking confirmation for the exact cancellation policy. For maximum flexibility, use our "Fully refundable property" filter during your search to find the right Uptown hotel for you.

How much is the nightly rate at a Uptown hotel?

Hotel prices in Uptown often vary, but you can find a great deal on Expedia. Different factors affect nightly hotel rates, such as the time of year or the days of the week you want to book. To find the best deals for your stay, be flexible with your dates, and sort search results by "Price: low to high" for our cheapest rates.

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Hotels in Uptown, Collinsville

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Our top choices for Uptown hotels

1. Drury Inn & Suites St. Louis Collinsville

2. La Quinta Inn & Suites by Wyndham Collinsville - St. Louis

3. Comfort Inn Collinsville near St. Louis

4. Days Inn by Wyndham Collinsville/St. Louis

5. Super 8 by Wyndham Collinsville St. Louis

6. Hampton Inn Collinsville

7. Americas Best Value Inn Collinsville St. Louis

8. Holiday Inn Express Troy by IHG

9. Best Western Troy Hotel

10. Holiday Inn St. Louis Fairview Heights by IHG

11. Drury Inn & Suites St. Louis Fairview Heights

12. Radisson Hotel Fairview Heights - St. Louis

13. Comfort Inn Edwardsville - St. Louis

14. Red Roof Inn St Louis - Troy, IL

15. Super 8 by Wyndham Troy IL/St. Louis Area

16. Hampton Inn O'Fallon

17. Quality Inn O'Fallon - St. Louis - Shiloh

18. Holiday Inn Express & Suites O'Fallon/Shiloh by IHG

19. Sleep Inn O'Fallon near I-64

20. Fairfield Inn & Suites St. Louis Pontoon Beach/Granite City

Where to stay in Uptown

Eastport

Mulberry Hills

Historic Downtown Collinsville

Top Uptown Hotel Reviews

Hyatt Regency St. Louis at The Arch

Frequently asked questions

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