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Your Santa Maria del Rio Vacation

With a Santa Maria del Rio vacation package, say goodbye to travel planning and hello to an effortless adventure. Every detail of your journey has been taken care of before you depart, so you can enjoy each moment experiencing this exciting city. A trip to Santa Maria del Rio wouldn't be complete without visiting its well-known attractions, starting with Sanctuary of Torrecitas. No matter your travel plans or the size of your budget, organizing a tailored Santa Maria del Rio vacation is a cinch with Expedia.

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Santa Maria del Rio Hotel Deals

Lourdes Hotel Campestre

Ex Hacienda la Labor del Rio Santa Maria del Rio SLP

CA $133

CA $202 total

Apr 23 - Apr 24

includes taxes & fees

8.2/10 Very Good! (67 reviews)

The staff was extremely helpful with directions and the security after hours were very professional in making sure “quiet hours” was met for all guests!

Reviewed on Dec 16, 2025

Hotel Guiant

374 Benito Juárez Benito Juárez Santa María del Río SLP

Fully refundableReserve now, pay when you stay

CA $109

CA $132 total

Apr 21 - Apr 22

includes taxes & fees

9.8/10 Exceptional! (9 reviews)

La limpieza y la amabilidad del personla

Reviewed on Feb 16, 2026

Rest in this Hacienda In the heart of México

El Fuerte, Santa María Del Río SLP

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See all 49 properties in Santa Maria del Rio

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.