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Find hotels in St. Charles, MN from CA $95

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    Check prices for these dates, December 14–15, 2026

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    Our top choices for St. Charles hotels

    1. Comfort Inn & Suites Rochester South Mayo Clinic

    A Comfort Inn & Suites hotel with a modern design, featuring a prominent signage and a parking lot.

    2. Spark by Hilton Rochester South

    A modern hotel lobby with a reception desk, seating area, and a large window providing natural light.

    3. Econo Lodge Mayo Clinic Area

    A hotel kitchen with a long counter, coffee machines, a bread display, and a fruit bowl.

    4. Holiday Inn Express Rochester South - Mayo Area by IHG

    A Holiday Inn Express building with a covered entrance, multiple floors, and a parking lot.

    5. Hampton Inn Rochester-South

    A reception area with a wooden reception desk, a "Welcome to the Bread & Butter State" sign, and a "Please Center" sign.

    6. Stone Mill Hotel & Suites

    A red building with a sign reading "FEED MILL Stone Mill Hotel & Suites" and a "VACANCY" sign.

    7. Quality Inn & Suites Mayo Clinic Area

    A modern living room with a sofa, coffee table, and a TV mounted on a stone wall.

    8. The Wen Inn formerly Andor Wenneson

    A covered porch with wicker furniture and a wooden deck.

    9. AmericInn by Wyndham Rochester Near Mayo Clinic

    A restaurant with wooden tables and bar stools, a bar area with a counter, and multiple televisions mounted on the walls.

    10. La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

    A La Quinta Inn & Suites hotel with a well-lit entrance, a parking area, and a clear view of the building's facade.

    11. Hyatt House Rochester/Mayo Clinic Area

    An outdoor seating area with a fire feature, blue cushioned chairs, and a modern building with large windows in the background.

    12. Sleep Inn & Suites West-Near Medical Center

    A Sleep Inn hotel with a covered entrance, stone pillars, and a clear blue sky.

    13. Comfort Inn & Suites West - Medical Center

    A Comfort Inn hotel with a stone facade, a covered entrance, and a parking area.

    14. Super 8 by Wyndham Rochester Mayo Clinic Area

    A hotel lobby with a reception desk, seating area, and a bar.

    15. Country Trails Inn & Suites

    A living room with a brick fireplace, two armchairs with decorative pillows, and a framed map on the wall.

    16. Hampton Inn & Suites Rochester-North

    A modern dining area with high tables, chairs, and pendant lighting.

    17. Hotel Indigo Rochester – Mayo Clinic Area by IHG

    A spacious outdoor dining area with multiple tables and chairs, large windows, and a wooden ceiling structure.

    18. MainStay Suites Rochester South Mayo Clinic

    Room

    19. Quality Inn near Medical Center

    Pool

    20. Days Inn by Wyndham Winona

    A hotel room with a large bed, a desk, a flat-screen TV, a painting on the wall, and a window with curtains.

    Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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    Compare top hotels in St. Charles

    A Comfort Inn & Suites hotel with a modern design, featuring a prominent signage and a parking lot.

    Comfort Inn & Suites Rochester South Mayo Clinic

    Rochester View

    A modern hotel lobby with a reception desk, seating area, and a large window providing natural light.

    Spark by Hilton Rochester South

    Rochester View

    A hotel kitchen with a long counter, coffee machines, a bread display, and a fruit bowl.

    Econo Lodge Mayo Clinic Area

    Rochester View

    A Holiday Inn Express building with a covered entrance, multiple floors, and a parking lot.

    Holiday Inn Express Rochester South - Mayo Area by IHG

    Rochester View

    A reception area with a wooden reception desk, a "Welcome to the Bread & Butter State" sign, and a "Please Center" sign.

    Hampton Inn Rochester-South

    Rochester View
    8.8Excellent1,000 reviews9.2Wonderful610 reviews9.0Wonderful1,000 reviews8.8Excellent1,003 reviews9.0Wonderful1,001 reviews
    CA $107 CA $123 totalincludes taxes & feesDec 11 - Dec 12 CA $96 CA $110 totalincludes taxes & feesNov 22 - Nov 23 CA $96 CA $110 totalincludes taxes & feesDec 12 - Dec 13 CA $123 CA $141 totalincludes taxes & feesDec 11 - Dec 12 CA $138 CA $159 totalincludes taxes & feesDec 12 - Dec 13
    • Breakfast included
    • Pool
    • Spa
    • Pet-friendly
    • WiFi included
    • Parking
    • Breakfast included
    • Pool
    • Spa
    • Pet-friendly
    • WiFi included
    • Parking
    • Breakfast included
    • Pool
    • Spa
    • Pet-friendly
    • WiFi included
    • Parking
    • Breakfast included
    • Pool
    • Spa
    • Pet-friendly
    • WiFi included
    • Parking
    • Breakfast included
    • Pool
    • Spa
    • Pet-friendly
    • WiFi included
    • Parking

    Learn more about St. Charles

    St. Charles awaits: its natural setting and more!

    See all hotels in St. Charles

    An aerial view of a town with industrial buildings, roads, and green areas.

    Top St. Charles Hotel Reviews

    Spark by Hilton Rochester South

    A modern hotel lobby with a reception desk, seating area, and a large window providing natural light.

    Holiday Inn Express Rochester South - Mayo Area by IHG

    A Holiday Inn Express building with a covered entrance, multiple floors, and a parking lot.

    Country Trails Inn & Suites

    A living room with a brick fireplace, two armchairs with decorative pillows, and a framed map on the wall.

    Quality Inn & Suites Mayo Clinic Area

    A modern living room with a sofa, coffee table, and a TV mounted on a stone wall.

    Hyatt House Rochester/Mayo Clinic Area

    An outdoor seating area with a fire feature, blue cushioned chairs, and a modern building with large windows in the background.

    Sleep Inn & Suites West-Near Medical Center

    A Sleep Inn hotel with a covered entrance, stone pillars, and a clear blue sky.

    Hampton Inn & Suites Rochester-North

    A modern dining area with high tables, chairs, and pendant lighting.

    Alexander Mansion Bed and Breakfast

    A grand staircase with a floral carpet, wooden balustrades, and a chandelier.

    Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

    A modern living room with a stone fireplace, a blue armchair, a round coffee table, and a large window offering a view of the outdoors.

    Comfort Inn & Suites West - Medical Center

    A Comfort Inn hotel with a stone facade, a covered entrance, and a parking area.

    EVEN Hotel Rochester - Mayo Clinic Area by IHG

    A modern outdoor seating area with a built-in fireplace, two wooden chairs, a table, and a sofa.

    TownePlace Suites by Marriott Rochester Mayo Clinic Area

    A coffee shop interior with a wooden counter, menu boards, and seating area.

    Frequently Asked Questions

    What are the best hotels in St Charles that travellers recommend?

    For a highly recommended hotel in St Charles, the White Valley Motel is an excellent option.

    Guests frequently mention that the rooms are comfortable and clean, and the staff are friendly. The motel offers air conditioning and free self-parking, adding to the convenience for travellers.

    What are the top pet-friendly hotels in St Charles?

    For a popular pet-friendly hotel in St Charles, the White Valley Motel is a great option.

    The White Valley Motel welcomes pets and offers convenient amenities such as free WiFi and complimentary toiletries. Guests often mention the comfortable and clean rooms, as well as the friendly staff. Free self-parking is also available, and the Whitewater River is approximately 9.6 kilometres away. See more pet-friendly hotels in St Charles

    What are the best budget hotels in St Charles?

    In St Charles, a top budget-friendly option is the White Valley Motel.

    This motel offers comfortable and clean rooms, as frequently mentioned by guests, along with friendly staff. Key amenities include free WiFi, complimentary toiletries, free self-parking, and air conditioning for a pleasant stay. It is also conveniently located just 9.6 km from the Whitewater River, making it an ideal base for exploring the area. View all budget hotels in St Charles

    When is the best time to go to St Charles?

    The best time to go to St. Charles, Minnesota, is during the summer months, from June to August, when the weather is warm and sunny, great for outdoor activities.

    During this period, the average daily temperatures range from 20°C to 28°C, making it comfortable for exploring the area's natural beauty. You'll find the Root River ideal for kayaking, canoeing, and fishing, with many local outfitters available for equipment hire. The numerous walking and cycling trails, such as the Root River State Trail, are also at their best, offering scenic views of the countryside.

    Couples looking for an active getaway will particularly enjoy the summer. The warm weather means you can spend your days cycling along the trails, perhaps stopping at small towns along the route, or enjoying a leisurely paddle on the river. Evenings can be spent at local restaurants, many of which offer outdoor seating to enjoy the pleasant temperatures.

    Families will also find summer an excellent time to visit. The mild weather allows for plenty of outdoor play, whether it's exploring Whitewater State Park, known for its trout fishing and hiking trails, or enjoying picnics by the river.

    Can I cancel my hotel reservation on Expedia?

    You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in St. Charles.

    How much is the nightly rate at a St. Charles hotel?

    Prices for hotels in St. Charles often vary, but you can find a great deal from CA $95 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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