Photo by Southernmost Illinois Tourism Bureau

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Your Murphysboro Vacation

Amazing adventures await when you reserve a Murphysboro vacation package. Whether you're a foodie, art buff or just a traveler who loves to see new places, there's something for everyone in this vibrant city. Lake Murphysboro State Park, Hickory Ridge Public Golf Center and General John A. Logan Museum are just a few of the many sights you'll want to explore during your trip to Murphysboro. A couple of quick clicks is all it takes to craft the perfect Murphysboro vacation on Expedia.

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Murphysboro Hotel Deals

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

120 MUDDY MONSTER ROAD Murphysboro IL

Fully refundable

CA $168

CA $186 total

Jun 14 - Jun 15

includes taxes & fees

9.4/10 Exceptional! (542 reviews)

"Room was very clean even when we had to switch rooms because we clogged the toilet oops. The breakfast might not have been the freshest but otherwise everyone was super friendly!"

Reviewed on Apr 28, 2026

Pet Friendly! Couples Retreat in Southern Illinois

Murphysboro IL

CA $120

CA $320 total

May 24 - May 25

includes taxes & fees

5 Star Cabin LUXURY AMMENITIES W/POOL HTUB close to WINE TRAIL, HIKING, FISHING

Murphysboro IL

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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.