Title: South Carolina Midlands Vacation Rentals from CA $153: Short-Term Rentals for 2025 | Expedia.ca [South Carolina Midlands Travel Guide](https://expedia.ca/South-Carolina-Midlands.dx6057938)[Hotels in South Carolina Midlands](https://expedia.ca/South-Carolina-Midlands-Hotels.d6057938.Travel-Guide-Hotels)[Flights to South Carolina Midlands](https://expedia.ca/Cheap-Flights-To-South-Carolina-Midlands.d6057938.Travel-Guide-Flights)[Things to do in South Carolina Midlands](https://expedia.ca/Things-To-Do-In-South-Carolina-Midlands.d6057938.Travel-Guide-Activities)[South Carolina Midlands Car Rentals](https://expedia.ca/Car-Rentals-In-South-Carolina-Midlands.d6057938.Car-Rental-Guide)[South Carolina Midlands Vacation Packages](https://expedia.ca/South-Carolina-Midlands.d6057938.Destination-Travel-Guides) ![South Carolina State House](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/183000/183997-State-House.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # South Carolina Midlands Vacation Rentals ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Oct 10 - Oct 11](https://www.expedia.ca/Hotel-Search?regionId=6057938&startDate=2025-10-10&endDate=2025-10-11&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 11 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=6057938&startDate=2025-10-11&endDate=2025-10-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 10 - Oct 12](https://www.expedia.ca/Hotel-Search?regionId=6057938&startDate=2025-10-10&endDate=2025-10-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=6057938&startDate=2025-10-17&endDate=2025-10-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Vacation Rentals in South Carolina Midlands ![Terrace/patio](https://images.trvl-media.com/lodging/72000000/71950000/71943400/71943321/b733a543.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Full-size fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/72000000/71950000/71943400/71943321/cfa3fc89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/72000000/71950000/71943400/71943321/e9758649.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/72000000/71950000/71943400/71943321/be58ae40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### stayAPT Suites Columbia-Irmo Harbison Irmo 8.6/10 Excellent (314) "This property was a great stay with our fur babies. I love the spacious room and of course being a pet friendly property. " CA $163 CA $177 total includes taxes & fees Oct 11 - Oct 12 [](https://www.expedia.ca/Irmo-Hotels-StayAPT-Suites-Columbia-Irmo-Harbison.h71943321.Hotel-Information) ![Interior detail](https://images.trvl-media.com/lodging/46000000/45150000/45148000/45147909/afc287a0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Full-size fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/46000000/45150000/45148000/45147909/3b341f15.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Loft 007 Ft. on HGTV | Terrace/patio](https://images.trvl-media.com/lodging/46000000/45150000/45148000/45147909/0841e785.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Loft 007 Ft. on HGTV](https://images.trvl-media.com/lodging/46000000/45150000/45148000/45147909/91af7762.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Hangar Lofts Hotel Rosewood 8.6/10 Excellent (65) "Property was a very pleasant surprise. Only thing I wish I we had was a secondary safety look on the door. " CA $206 CA $231 total includes taxes & fees Oct 12 - Oct 13 [](https://www.expedia.ca/Columbia-Hotels-The-Hangar-Lofts-Hotel.h45147909.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/72000000/71950000/71945700/71945688/w7294h4496x8y0-e7e0c635.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/72000000/71950000/71945700/71945688/5ac04ce0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Full-size fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/72000000/71950000/71945700/71945688/d6e5ecdd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/72000000/71950000/71945700/71945688/2b2bb3f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### stayAPT Suites Rock Hill Rock Hill 8.4/10 Very good (186) "This was such an amazing stay ! Very peaceful atmosphere and great employees!" CA $138 CA $153 total includes taxes & fees Oct 19 - Oct 20 [](https://www.expedia.ca/Rock-Hill-Hotels-StayAPT-Suites-Rock-Hill.h71945688.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/64000000/63170000/63163900/63163810/aa493255.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/64000000/63170000/63163900/63163810/b5f90dbf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/64000000/63170000/63163900/63163810/850d0032.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/64000000/63170000/63163900/63163810/86594ed3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sunset Gem private dock & boat ramp on Lake Murray Prosperity 9.6/10 Exceptional (94) "Great place to stay" [](https://www.expedia.ca/Prosperity-Hotels-Sunset-Gem-Private-Dock-Boat-Ramp-On-Lake-Murray.h63163810.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/25000000/24260000/24257000/24256959/d11c2084.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/25000000/24260000/24257000/24256959/ce07daaf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/25000000/24260000/24257000/24256959/8cdaa2d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/25000000/24260000/24257000/24256959/d8d48774.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Replica home from Jack Nicholson movie - 'Something's Gotta Give' Chapin 9.8/10 Exceptional (139) "We had a relaxing wonderful time..the owner was very nice and helpful ..always responded promptly." [](https://www.expedia.ca/Chapin-Hotels-Replica-Home-From-Jack-Nicholson-Movie-Somethings-Gotta-Give.h24256959.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/101000000/100710000/100706200/100706194/87150793.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, iron/ironing board, travel crib, WiFi](https://images.trvl-media.com/lodging/101000000/100710000/100706200/100706194/8e7a6fa8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV](https://images.trvl-media.com/lodging/101000000/100710000/100706200/100706194/81ecd585.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/101000000/100710000/100706200/100706194/6f910332.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 2 Bdrm Condo w/in 10 min from USC, Downtown Columbia, Ft Jackson, VA hospital Rosewood 9.4/10 Exceptional (46) "It was cozy apartment great for a weekend getaway. My daughter loved the rooms and said the beds were super comfy." [](https://www.expedia.ca/Columbia-Hotels-2-Bdrm-Condo-Win-10-Min-From-USC.h100706194.Hotel-Information) ![Beach nearby, sun loungers, beach towels](https://images.trvl-media.com/lodging/77000000/76320000/76317400/76317327/3fe1338e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/77000000/76320000/76317400/76317327/01ea4499.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![7 bedrooms, desk, iron/ironing board, travel crib](https://images.trvl-media.com/lodging/77000000/76320000/76317400/76317327/a1639ff4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/77000000/76320000/76317400/76317327/09ba0e05.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Exclusive Peninsula Retreat on Lake Murray – Beach, Fire Pit & Stunning Sunsets Chapin 10/10 Exceptional (56) "We had a wonderful time. We definitely recommend this lake house. Absolutely beautiful " [](https://www.expedia.ca/Chapin-Hotels-Mind-Blowing-Sunsets-On-A-Gated-Peninsula-Property-With-A-White-Sand-Beach.h76317327.Hotel-Information) ![Smart TV](https://images.trvl-media.com/lodging/92000000/91040000/91039900/91039871/w1024h680x0y3-9269f16b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, cookware/dishes/utensils](https://images.trvl-media.com/lodging/92000000/91040000/91039900/91039871/50215f8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/92000000/91040000/91039900/91039871/b59bdaca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, cookware/dishes/utensils](https://images.trvl-media.com/lodging/92000000/91040000/91039900/91039871/eac9cc87.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### NoMa Green House Columbia 9.8/10 Exceptional (67) "Suited our needs with 3 adults in the party. Quite neighborhood. Lovely front porch.Comfortable beds and large rooms." CA $211 CA $450 total includes taxes & fees Oct 23 - Oct 24 [](https://www.expedia.ca/Columbia-Hotels-NoMa-Green-House.h91039871.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/113000000/112570000/112562700/112562606/56893853.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/113000000/112570000/112562700/112562606/d02f516e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/113000000/112570000/112562700/112562606/78bc4929.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/113000000/112570000/112562700/112562606/4a367a68.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Romantic bungalow on Lake Murray w/cold plunge/hot tub/sauna, gym & dock gazebo Lexington 10/10 Exceptional (12) "Took the Mrs fishing for a weekend away. Kent was very professional and made all accommodations perfect. Would definitely recommend and look forward to coming back. " [](https://www.expedia.ca/Lexington-Hotels-Romantic-Bungalow-On-Lake-Murray-Wcold-Plungehot-Tubsauna.h112562606.Hotel-Information) ![Outdoor spa tub](https://images.trvl-media.com/lodging/27000000/26930000/26925700/26925650/b1fcd805.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/27000000/26930000/26925700/26925650/7ecb4f61.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Marina](https://images.trvl-media.com/lodging/27000000/26930000/26925700/26925650/2df875b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/27000000/26930000/26925700/26925650/1c0b7271.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Beautiful & Spacious with Hot Tub, Game Room & More. Large Yard Near the Dam! Lexington 9.8/10 Exceptional (134) "Great stay, every thing was easy, clean and as advertised! We would stay here again!" CA $283 CA $510 total includes taxes & fees Oct 13 - Oct 14 [](https://www.expedia.ca/Columbia-Hotels-Lake-Murray-Paradise-Lake-Front-Upstairs-Home-W-Peninsula-Lake-Views.h26925650.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/104000000/103460000/103459000/103458981/54575a7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/104000000/103460000/103459000/103458981/2ab091e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/104000000/103460000/103459000/103458981/bb62c643.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Microwave, oven, stovetop, dishwasher](https://images.trvl-media.com/lodging/104000000/103460000/103459000/103458981/9c00edd0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quant Downtown Columbia Apartment Downtown Columbia 10/10 Exceptional (2) "Nice stay in center of five points close yo everything " CA $163 CA $339 total includes taxes & fees Oct 16 - Oct 17 [](https://www.expedia.ca/Columbia-Hotels-Quant-Downtown-Columbia-Apartment.h103458981.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/95000000/94790000/94783400/94783316/9046973f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/95000000/94790000/94783400/94783316/75879089.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Smart TV, books](https://images.trvl-media.com/lodging/95000000/94790000/94783400/94783316/e4df59bc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/95000000/94790000/94783400/94783316/05a68624.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Stylish suite DOWNTOWN with FREE parking and a GYM Downtown Columbia 9.6/10 Exceptional (34) "Good location, excellent communication with our host and met or exceeded expectations " CA $101 CA $239 total includes taxes & fees Oct 21 - Oct 22 [](https://www.expedia.ca/Columbia-Hotels-Stylish-Suite-DOWNTOWN-With-FREE-Parking-And-A-GYM.h94783316.Hotel-Information) ![Exterior detail](https://images.trvl-media.com/lodging/93000000/92180000/92179900/92179823/0cf39ca3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/93000000/92180000/92179900/92179823/344f2c74.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/93000000/92180000/92179900/92179823/35b785f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/93000000/92180000/92179900/92179823/00193b79.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### This Old House By The Park Columbia 10/10 Exceptional (4) "Nice spacious home, very comfortable furniture and the host was very accommodating. We will stay again if ever in the area. " [](https://www.expedia.ca/Columbia-Hotels-This-Old-House-By-The-Park.h92179823.Hotel-Information) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/104000000/103650000/103645300/103645220/e62938f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, WiFi, bed sheets](https://images.trvl-media.com/lodging/104000000/103650000/103645300/103645220/w1194h809x0y0-6a70d0c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/104000000/103650000/103645300/103645220/c590a240.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/104000000/103650000/103645300/103645220/w1192h808x0y5-23b83bf6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cozy 3 Bedroom Townhome West Columbia 9.2/10 Wonderful (11) "We enjoyed our stay! Easy to navigate to and from restaurants and I-26! Very safe feeling little neighborhood too!" [](https://www.expedia.ca/West-Columbia-Hotels-Cozy-Townhome.h103645220.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/84000000/83260000/83256600/83256529/b5bbad4a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/84000000/83260000/83256600/83256529/c3f4c891.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/84000000/83260000/83256600/83256529/df7cfe08.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, WiFi](https://images.trvl-media.com/lodging/84000000/83260000/83256600/83256529/e32159d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Home away from home Rock Hill 9.8/10 Exceptional (104) "Stay was wonderful we really enjoy it. " [](https://www.expedia.ca/Rock-Hill-Hotels-Home-Away-From-Home.h83256529.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/98000000/97410000/97408700/97408699/96d90c64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/98000000/97410000/97408700/97408699/5f066aad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/98000000/97410000/97408700/97408699/2b257aba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, WiFi, bed sheets](https://images.trvl-media.com/lodging/98000000/97410000/97408700/97408699/38b3a2ca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Rustic Country Cottage Near Lake Murray -Just 1 hour from The Masters! Columbia 10/10 Exceptional (25) "We enjoyed having games to play as a family in our down time. " [](https://www.expedia.ca/Columbia-Hotels-Country-Cottage-Near-Lake-Murray-On-2-Acres-With-Firepit-And-Chicken-Coop.h97408699.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/44000000/44000000/43992600/43992569/bfd80ad8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/44000000/44000000/43992600/43992569/cf50a6e8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/44000000/44000000/43992600/43992569/3622349b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Balcony](https://images.trvl-media.com/lodging/44000000/44000000/43992600/43992569/17d2f4e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Wyndham Vacation Resorts Lake Marion Santee 9.2/10 Wonderful (20) "Friendly staff. Excellent accomodations. Peaceful and beautiful vacation." [](https://www.expedia.ca/Orangeburg-Hotels-Wyndham-Vacation-Resorts-Lake-Marion.h43992569.Hotel-Information) ![Living area](https://images.trvl-media.com/lodging/109000000/108480000/108475900/108475851/9ca22f7d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/109000000/108480000/108475900/108475851/fd14fd8b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Private kitchen](https://images.trvl-media.com/lodging/109000000/108480000/108475900/108475851/3e745e7a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bedrooms, WiFi, bed sheets](https://images.trvl-media.com/lodging/109000000/108480000/108475900/108475851/3fb8a374.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quintessential 2-bedroom bungalow in the heart of Shandon in Columbia, SC. Downtown Columbia 10/10 Exceptional (34) "Cozy, clean, cute, beautiful property, comfy beds, excellent AC, and comfortable beds, the owners have thought of every amenity you might need! " [](https://www.expedia.ca/Columbia-Hotels-Quintessential-2-Bedroom-Bungalow-In-The-Heart-Of-Shandon-In-Columbia.h108475851.Hotel-Information) ![Smart TV, offices](https://images.trvl-media.com/lodging/92000000/91790000/91788500/91788460/dc99579a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/92000000/91790000/91788500/91788460/79beb629.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/92000000/91790000/91788500/91788460/10896652.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/92000000/91790000/91788500/91788460/339c1207.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Kindred Spirits Retreat at Lake Marion - Pet Friendly Getaway Minutes from I-95! Santee 10/10 Exceptional (36) "Me and my husband had a great stay. Our 2 4 legged furry boys loved the yard so much. Would definitely stay again. " CA $140 CA $456 total includes taxes & fees Oct 16 - Oct 17 [](https://www.expedia.ca/Santee-Hotels-This-House-Is-A-3-Bedroom.h91788460.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/101000000/100340000/100331800/100331731/c0dd0c9c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/101000000/100340000/100331800/100331731/6b36aec6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/101000000/100340000/100331800/100331731/334558e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/101000000/100340000/100331800/100331731/85927cae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Charleston Home-Walk to 5pts/USC Downtown Columbia 10/10 Exceptional (22) "We enjoyed everything about our stay. The home was well appointed and perfectly suited for our family. Great location, and excellent communication with the host. Thanks!" CA $350 CA $1,008 total includes taxes & fees Oct 20 - Oct 21 [](https://www.expedia.ca/Columbia-Hotels-Charleston-Home-Walk-To-5ptsUSC.h100331731.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-10-24&endDate=2025-10-25®ionId=6057938&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSouth-Carolina-Midlands-Vacation-Rentals.d6057938.Travel-Guide-VacationRentals)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSouth-Carolina-Midlands-Vacation-Rentals.d6057938.Travel-Guide-VacationRentals) ## Top South Carolina Midlands Hotel Reviews ![La Quinta Inn by Wyndham Columbia SE / Fort Jackson](//images.trvl-media.com/lodging/1000000/10000/5100/5038/e9b1ea9e_y.jpg) ### La Quinta Inn by Wyndham Columbia SE / Fort Jackson 10/10 Excellent "Room was clean and it was perfect for a nights sleep while traveling. " [](https://expedia.ca/Columbia-Hotels-La-Quinta-Inn-By-Wyndham-Columbia-SE-Fort-Jackson.h5038.Hotel-Information) ![Courtyard by Marriott Columbia Downtown at USC](//images.trvl-media.com/lodging/1000000/10000/2300/2289/w3996h2667x0y0-8dd1e3e0_y.jpg) ### Courtyard by Marriott Columbia Downtown at USC 10/10 Excellent "Clean room. Good fitness center great staff!" [](https://expedia.ca/Columbia-Hotels-Courtyard-By-Marriott-Columbia-Downtown-At-USC.h2289.Hotel-Information) ![Marriott Columbia](//images.trvl-media.com/lodging/1000000/20000/17400/17353/4bcf0c43_y.jpg) ### Marriott Columbia 10/10 Excellent "I enjoy your everything " [](https://expedia.ca/Columbia-Hotels-Marriott-Columbia.h17353.Hotel-Information) ![Graduate by Hilton Columbia SC](//images.trvl-media.com/lodging/3000000/2520000/2515100/2515057/22f12a1f_y.jpg) ### Graduate by Hilton Columbia SC 10/10 Excellent "Nice" [](https://expedia.ca/Columbia-Hotels-Graduate-Columbia.h2515057.Hotel-Information) ![Clarion Pointe Near University](//images.trvl-media.com/lodging/1000000/30000/22100/22006/69d65d2e_y.jpg) ### Clarion Pointe Near University 10/10 Excellent "The room was very clean and nice We parked right at our room" [](https://expedia.ca/Rock-Hill-Hotels-Clarion-Pointe-Rock-Hill-Near-Training-Camp.h22006.Hotel-Information) ![Hilton Garden Inn Columbia/Harbison](//images.trvl-media.com/lodging/2000000/1520000/1513800/1513707/f8933df9_y.jpg) ### Hilton Garden Inn Columbia/Harbison 10/10 Excellent "Staff was nice, room was a great size, clean hotel. Many food places and shops nearby. " [](https://expedia.ca/Columbia-Hotels-Hilton-Garden-Inn-ColumbiaHarbison.h1513707.Hotel-Information) ![Baymont by Wyndham Columbia Fort Jackson](//images.trvl-media.com/lodging/1000000/580000/574500/574461/c68af965_y.jpg) ### Baymont by Wyndham Columbia Fort Jackson 10/10 Excellent "The bed was comfortable and firm" [](https://expedia.ca/Columbia-Hotels-Baymont-By-Wyndham-Columbia-Fort-Jackson.h574461.Hotel-Information) ![ La Quinta Inn by Wyndham Columbia NE/Fort Jackson](//images.trvl-media.com/lodging/1000000/50000/43600/43541/ebebcc50_y.jpg) ### La Quinta Inn by Wyndham Columbia NE/Fort Jackson 10/10 Excellent "Very nice staff" [](https://expedia.ca/Columbia-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Columbia-NE-Fort-Jackson.h43541.Hotel-Information) ![Sleep Inn Columbia](//images.trvl-media.com/lodging/1000000/130000/127000/126908/de238acf_y.jpg) ### Sleep Inn Columbia 10/10 Excellent "Definitely business-friendly. Check-in easy and friendly, kudos to Beth for her performance at the front desk." [](https://expedia.ca/Columbia-Hotels-Sleep-Inn-At-Bush-River-Road.h126908.Hotel-Information) ## Find out more about South Carolina Midlands **Everything you need to know about** **South Carolina Midlands** **vacation rentals** Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the South Carolina Midlands vacation rental for you. At Expedia, you can take your pick from [private vacation homes](https://www.expedia.ca/aa/PrivateVacationHomes), [apartments](https://www.expedia.ca/aa/Apartments), cottages, [cabins](https://www.expedia.ca/aa/Cabins), villas... The list goes on, and on… and on! There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect South Carolina Midlands vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.  **South Carolina Midlands vacation rentals: An excellent choice for every season** Whenever you want to travel, a warm welcome awaits you in South Carolina Midlands. If you’re looking for a little peace, consider booking during the quieter months, such as  . For more hustle and bustle, you may prefer to visit in .  Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A South Carolina Midlands vacation rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in.  The selection of South Carolina Midlands vacation rentals we have selected for you start as low as CA $153 per night. Entering your travel dates in the search wizard you might find even better deals! **How to find incredible deals on South Carolina Midlands rentals** At Expedia, we put the best South Carolina Midlands vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.  To find some top South Carolina Midlands rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream South Carolina Midlands vacation. If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around South Carolina Midlands. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.  ## Explore a world of travel with Expedia - Trending destinations on Expedia.ca - All accommodation types in South Carolina Midlands ### Trending destinations on Expedia.ca - [Canmore Vacation Rentals](https://www.expedia.ca/Canmore-Vacation-Rentals.d10131.Travel-Guide-VacationRentals) - [Maui Vacation Rentals](https://www.expedia.ca/Maui-Vacation-Rentals.d180073.Travel-Guide-VacationRentals) - [Kelowna Vacation Rentals](https://www.expedia.ca/Kelowna-Vacation-Rentals.d3997.Travel-Guide-VacationRentals) - [Whistler Vacation Rentals](https://www.expedia.ca/Whistler-Vacation-Rentals.d4115.Travel-Guide-VacationRentals) - [Florida Vacation Rentals](https://www.expedia.ca/Destinations-In-Florida.d211.Vacation-Rental-Destinations) - [Victoria Vacation Rentals](https://www.expedia.ca/Victoria-Vacation-Rentals.d4138.Travel-Guide-VacationRentals) - 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Scan the QR code with your device camera and download our app ![QR code to download the app](data:image/png;base64,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)