Title: South Carolina Midlands Inns from CA $102 | Expedia.ca [South Carolina Midlands Travel Guide](https://expedia.ca/South-Carolina-Midlands.dx6057938)[Hotels in South Carolina Midlands](https://expedia.ca/South-Carolina-Midlands-Hotels.d6057938.Travel-Guide-Hotels)[Vacation Rentals in South Carolina Midlands](https://expedia.ca/South-Carolina-Midlands-Vacation-Rentals.d6057938.Travel-Guide-VacationRentals)[Flights to South Carolina Midlands](https://expedia.ca/Cheap-Flights-To-South-Carolina-Midlands.d6057938.Travel-Guide-Flights)[Things to do in South Carolina Midlands](https://expedia.ca/Things-To-Do-In-South-Carolina-Midlands.d6057938.Travel-Guide-Activities)[South Carolina Midlands Car Rentals](https://expedia.ca/Car-Rentals-In-South-Carolina-Midlands.d6057938.Car-Rental-Guide)[South Carolina Midlands Vacation Packages](https://expedia.ca/South-Carolina-Midlands.d6057938.Destination-Travel-Guides) ![South Carolina State House](https://images.trvl-media.com/place/6082681/1934af6a-1aa9-4e01-8cd3-8eb8fe4af18f.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6082681/1934af6a-1aa9-4e01-8cd3-8eb8fe4af18f.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Next weekend [Mar 6 - Mar 8](https://www.expedia.ca/Hotel-Search?regionId=6057938&startDate=2026-03-06&endDate=2026-03-08&adults=2&lodging=INN&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Mar 13 - Mar 15](https://www.expedia.ca/Hotel-Search?regionId=6057938&startDate=2026-03-13&endDate=2026-03-15&adults=2&lodging=INN&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In one month [Mar 27 - Mar 29](https://www.expedia.ca/Hotel-Search?regionId=6057938&startDate=2026-03-27&endDate=2026-03-29&adults=2&lodging=INN&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two months [Apr 24 - Apr 26](https://www.expedia.ca/Hotel-Search?regionId=6057938&startDate=2026-04-24&endDate=2026-04-26&adults=2&lodging=INN&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) No exact matches found, but these alternatives could be just right ## Recommended hotels in South Carolina Midlands ![Exterior](https://images.trvl-media.com/lodging/1000000/970000/970000/969975/ffaddd2a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/970000/970000/969975/689a1cfa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free buffet breakfast](https://images.trvl-media.com/lodging/1000000/970000/970000/969975/83cb7582.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/970000/970000/969975/9f09eded.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG [](https://www.expedia.ca/Florence-Hotels-Holiday-Inn-Express-Hotel-Suites-Florence-I-95-At-Hwy-327.h969975.Hotel-Information) Florence 8.6/10 Excellent (1,014 reviews) "Friendly staff, quick check in, nice lobby" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jennifer CA $147 CA $164 total includes taxes & fees Mar 15 - Mar 16 [](https://www.expedia.ca/Florence-Hotels-Holiday-Inn-Express-Hotel-Suites-Florence-I-95-At-Hwy-327.h969975.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/4b412627.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/cce2b53c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/11da224f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/40f69ad1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru By Hilton Santee [](https://www.expedia.ca/Santee-Hotels-Tru-By-Hilton-Santee.h92600969.Hotel-Information) Santee 9.2/10 Wonderful (731 reviews) "Large, clean room, friendly staff, nice breakfast. Would stay again. Also a nice Mexican restaurant nearby for dinner. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Susan CA $140 CA $155 total includes taxes & fees Mar 4 - Mar 5 [](https://www.expedia.ca/Santee-Hotels-Tru-By-Hilton-Santee.h92600969.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/93ba5eb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/044c704d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/67da47be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds, Non Smoking, Jetted Tub](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/ec6d0d77.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Santee Inn [](https://www.expedia.ca/Orangeburg-Hotels-Best-Western-Plus-Santee-Inn.h21863.Hotel-Information) Santee 8.8/10 Excellent (1,007 reviews) "Courteous reception,clean rooms and great breakfast! Have been there many times in the last 15 years and I will return.!" ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Roger CA $153 CA $170 total includes taxes & fees Feb 25 - Feb 26 [](https://www.expedia.ca/Orangeburg-Hotels-Best-Western-Plus-Santee-Inn.h21863.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1830000/1823700/1823665/a1a27db5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, desk, blackout drapes](https://images.trvl-media.com/lodging/2000000/1830000/1823700/1823665/e94102a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Seasonal outdoor pool](https://images.trvl-media.com/lodging/2000000/1830000/1823700/1823665/abbeba1a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily self-serve breakfast](https://images.trvl-media.com/lodging/2000000/1830000/1823700/1823665/16d0ef5b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lexington Expo Hotel by IHG [](https://www.expedia.ca/Lexington-Hotels-Lexington-Expo-Hotel-By-IHG.h1823665.Hotel-Information) Lexington 9.2/10 Wonderful (1,002 reviews) "Great location " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Konrad CA $147 CA $163 total includes taxes & fees Feb 27 - Feb 28 [](https://www.expedia.ca/Lexington-Hotels-Lexington-Expo-Hotel-By-IHG.h1823665.Hotel-Information) ![Free daily full breakfast](https://images.trvl-media.com/lodging/1000000/10000/5100/5038/e9b1ea9e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed, Non Smoking](https://images.trvl-media.com/lodging/1000000/10000/5100/5038/3fbd24c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/5100/5038/470d616b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/5100/5038/b50995e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn by Wyndham Columbia SE / Fort Jackson [](https://www.expedia.ca/Columbia-Hotels-La-Quinta-Inn-By-Wyndham-Columbia-SE-Fort-Jackson.h5038.Hotel-Information) Columbia 7.8/10 Good (1,016 reviews) "I really enjoyed our stay , beds were very comfortable we slept like babies. Very quiet place , staff was very helpful and kind. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ranetta Whitton CA $109 CA $125 total includes taxes & fees Mar 15 - Mar 16 [](https://www.expedia.ca/Columbia-Hotels-La-Quinta-Inn-By-Wyndham-Columbia-SE-Fort-Jackson.h5038.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/dfe24eeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/d654e116.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/e78e5670.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/3029fb89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Santee [](https://www.expedia.ca/Orangeburg-Hotels-Fairfield-Inn-Suites-By-Marriott-Santee.h26116.Hotel-Information) Santee 9.8/10 Exceptional (1,006 reviews) "Room had everything we wanted... very clean & fresh, microwave, fridge, comfy beds. Hotel was very nice and close to everything needed." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Marcia CA $171 CA $190 total includes taxes & fees Mar 2 - Mar 3 [](https://www.expedia.ca/Orangeburg-Hotels-Fairfield-Inn-Suites-By-Marriott-Santee.h26116.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/64840011.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/fefdad76.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillowtop beds, desk, blackout drapes, iron/ironing board](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/6df606aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/a63ff680.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Florence Center Area [](https://www.expedia.ca/Florence-Hotels-Comfort-Inn-Suites.h38336321.Hotel-Information) Florence 9.2/10 Wonderful (1,239 reviews) "The staff was friendly and the room was clean. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Camila CA $132 CA $148 total includes taxes & fees Feb 25 - Feb 26 [](https://www.expedia.ca/Florence-Hotels-Comfort-Inn-Suites.h38336321.Hotel-Information) ![Outdoor banquet area](https://images.trvl-media.com/lodging/30000000/29860000/29853300/29853240/2fa2ba7c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/30000000/29860000/29853300/29853240/22dee554.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/30000000/29860000/29853300/29853240/1403ad34.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/30000000/29860000/29853300/29853240/2a082860.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Crowne Plaza North Augusta by IHG [](https://www.expedia.ca/Aiken-Hotels-Crowne-Plaza-North-Augusta.h29853240.Hotel-Information) North Augusta 8.8/10 Excellent (868 reviews) "Great room and great staff. My favorite staycation spot." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) cedric CA $159 CA $192 total includes taxes & fees Mar 1 - Mar 2 [](https://www.expedia.ca/Aiken-Hotels-Crowne-Plaza-North-Augusta.h29853240.Hotel-Information) ![Desk, blackout drapes, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/d2da67e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/1c5cc7ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/320acff9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/25ebdfeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Santee [](https://www.expedia.ca/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information) Santee 8.0/10 Very good (1,437 reviews) "Room were very clean and staff was very helpful. I would stay there again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Charolette CA $109 CA $121 total includes taxes & fees Feb 25 - Feb 26 [](https://www.expedia.ca/Orangeburg-Hotels-Baymont-By-Wyndham-Santee.h15379.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/1000000/30000/22000/21992/2f1f8cba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/22000/21992/1aef51e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![LCD TV](https://images.trvl-media.com/lodging/1000000/30000/22000/21992/bea66887.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard king non smoking](https://images.trvl-media.com/lodging/1000000/30000/22000/21992/b241d6b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Rock Hill [](https://www.expedia.ca/Rock-Hill-Hotels-Hampton-Inn-Rock-Hill.h21992.Hotel-Information) Rock Hill 9.2/10 Wonderful (1,004 reviews) "We have stayed here several times and it never disappoints! Room is clean, staff very friendly, and they provide a great breakfast!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Erma CA $122 CA $136 total includes taxes & fees Mar 1 - Mar 2 [](https://www.expedia.ca/Rock-Hill-Hotels-Hampton-Inn-Rock-Hill.h21992.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/59000000/58990000/58985600/58985556/2544034c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/59000000/58990000/58985600/58985556/5cc0357e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/59000000/58990000/58985600/58985556/2a6d6c86.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily full breakfast](https://images.trvl-media.com/lodging/59000000/58990000/58985600/58985556/fcf4fdd5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Latta by IHG [](https://www.expedia.ca/Florence-Hotels-Holiday-Inn-Express-Suites-Latta.h58985556.Hotel-Information) Latta 9.4/10 Exceptional (559 reviews) "Front desk is amazing! Rooms are clean and quiet. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kimberly CA $141 CA $154 total includes taxes & fees Mar 9 - Mar 10 [](https://www.expedia.ca/Florence-Hotels-Holiday-Inn-Express-Suites-Latta.h58985556.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/4000000/3030000/3026100/3026100/c68ab7f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/4000000/3030000/3026100/3026100/434898b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![BBQ/picnic area](https://images.trvl-media.com/lodging/4000000/3030000/3026100/3026100/5054dc3e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/4000000/3030000/3026100/3026100/d963a865.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Suites Florence I-95 [](https://www.expedia.ca/Florence-Hotels-Comfort-Suites-Florence-I-95.h3026100.Hotel-Information) Florence 8.4/10 Very good (1,001 reviews) "Great accommodations and courteous staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Leslie CA $138 CA $160 total includes taxes & fees Feb 25 - Feb 26 [](https://www.expedia.ca/Florence-Hotels-Comfort-Suites-Florence-I-95.h3026100.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/92000000/91270000/91267900/91267861/713b3c0a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/92000000/91270000/91267900/91267861/55a9de69.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/92000000/91270000/91267900/91267861/df416cc1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio Suite, Multiple Beds](https://images.trvl-media.com/lodging/92000000/91270000/91267900/91267861/cff7c686.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Springhill Suites by Marriott Columbia near Fort Jackson [](https://www.expedia.ca/Columbia-Hotels-Springhill-Suites-By-Marriott-Columbia-Southeast.h91267861.Hotel-Information) Columbia 9.4/10 Exceptional (620 reviews) "Great place to stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Howard CA $134 CA $150 total includes taxes & fees Mar 1 - Mar 2 [](https://www.expedia.ca/Columbia-Hotels-Springhill-Suites-By-Marriott-Columbia-Southeast.h91267861.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/c8bc9166.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Serves lunch and dinner](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/e2ea309a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property - evening/night](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/c29c3321.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/a93e569b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Place Florence Downtown [](https://www.expedia.ca/Florence-Hotels-Hyatt-Place-Florence-Downtown.h32772870.Hotel-Information) Florence 9.0/10 Wonderful (1,006 reviews) "Great location and well maintained property. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Karen CA $150 CA $169 total includes taxes & fees Mar 2 - Mar 3 [](https://www.expedia.ca/Florence-Hotels-Hyatt-Place-Florence-Downtown.h32772870.Hotel-Information) ![Free daily full breakfast](https://images.trvl-media.com/lodging/1000000/260000/250900/250862/w3837h2560x3y0-51e671c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed with Sofa bed, Non Smoking, Refrigerator & Microwave (with Sofabed)](https://images.trvl-media.com/lodging/1000000/260000/250900/250862/w3837h2560x3y0-92efb678.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/260000/250900/250862/w3837h2557x3y3-458537c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/260000/250900/250862/w3837h2560x3y0-d38b71cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Plus Lexington Inn [](https://www.expedia.ca/Columbia-Hotels-Best-Western-Plus-Lexington-Inn.h250862.Hotel-Information) Downtown Lexington 9.2/10 Wonderful (1,004 reviews) "Great stay good price" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jeff CA $137 CA $152 total includes taxes & fees Feb 25 - Feb 26 [](https://www.expedia.ca/Columbia-Hotels-Best-Western-Plus-Lexington-Inn.h250862.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/32fd6fc1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee service](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/e7174d53.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/7b1066c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Double Beds, Non Smoking (1st Floor) | Room amenity](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/f9691b25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Howard Johnson by Wyndham Florence [](https://www.expedia.ca/Florence-Hotels-Howard-Johnson-By-Wyndham-Florence.h11037.Hotel-Information) Florence 8.6/10 Excellent (2,578 reviews) "I nice place to stay, very quiet, good breakfast, nice staff, spotless room. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Timothy CA $91 CA $102 total includes taxes & fees Feb 25 - Feb 26 [](https://www.expedia.ca/Florence-Hotels-Howard-Johnson-By-Wyndham-Florence.h11037.Hotel-Information) ![Premium bedding, pillowtop beds, laptop workspace, soundproofing](https://images.trvl-media.com/lodging/1000000/10000/500/455/ef1db617.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/10000/500/455/be7cdd34.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/10000/500/455/344e3fdf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/500/455/af3985b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Inn [](https://www.expedia.ca/Florence-Hotels-Best-Western-Inn.h455.Hotel-Information) Florence 7.8/10 Good (1,006 reviews) "Front desk staff was great and very friendly! Made for a smooth check-in!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Patric CA $122 CA $137 total includes taxes & fees Feb 25 - Feb 26 [](https://www.expedia.ca/Florence-Hotels-Best-Western-Inn.h455.Hotel-Information) ![Frette Italian sheets, premium bedding, pillowtop beds, blackout drapes](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/fc94b516.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/2824d996.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 Queen Bed with Sofa bed, Non Smoking (Non Smoking/Interior Hall)](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/91286f8a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free buffet breakfast](https://images.trvl-media.com/lodging/1000000/520000/518500/518401/0b55a618.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Santee [](https://www.expedia.ca/Orangeburg-Hotels-Comfort-Inn-Suites-Santee.h518401.Hotel-Information) Santee 8.0/10 Very good (1,010 reviews) "Clean rooms, nice staff, decent breakfast " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dale CA $150 CA $167 total includes taxes & fees Mar 2 - Mar 3 [](https://www.expedia.ca/Orangeburg-Hotels-Comfort-Inn-Suites-Santee.h518401.Hotel-Information) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/99c8fb35.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/f2adc30e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/c836e9b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/c5155ebb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru by Hilton Orangeburg [](https://www.expedia.ca/Orangeburg-Hotels-Tru-By-Hilton-Orangeburg.h34323336.Hotel-Information) Orangeburg 9.2/10 Wonderful (1,007 reviews) "Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Thomas CA $156 CA $173 total includes taxes & fees Mar 12 - Mar 13 [](https://www.expedia.ca/Orangeburg-Hotels-Tru-By-Hilton-Orangeburg.h34323336.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1170000/1160800/1160796/7d6c02d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, sun loungers](https://images.trvl-media.com/lodging/2000000/1170000/1160800/1160796/7cb8c23e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Accessible, Non Smoking](https://images.trvl-media.com/lodging/2000000/1170000/1160800/1160796/12c9570f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1170000/1160800/1160796/bcb0f0ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Country Inn & Suites by Radisson, Columbia Airport, SC [](https://www.expedia.ca/Columbia-Hotels-Country-Inn-Suites-By-Radisson.h1160796.Hotel-Information) Cayce 8.4/10 Very good (1,008 reviews) "Breakfast was great " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mayah CA $127 CA $141 total includes taxes & fees Mar 22 - Mar 23 [](https://www.expedia.ca/Columbia-Hotels-Country-Inn-Suites-By-Radisson.h1160796.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-03-10&endDate=2026-03-11®ionId=6057938&adults=2&lodging=INN&sort=RECOMMENDED&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-us-ca.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Vacation Sale Members save up to 40% on hotels and homes. Plan this year’s big trip and save. [Book now](https://expedia.ca/deals?rfrr=AA_SPRING_PROMO_6057938) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSouth-Carolina-Midlands-Inns.d6057938-aaInns.Travel-Guide-Accommodation)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSouth-Carolina-Midlands-Inns.d6057938-aaInns.Travel-Guide-Accommodation) ## Top South Carolina Midlands Hotel Reviews ![Hilton Garden Inn Columbia/Harbison](https://images.trvl-media.com/lodging/2000000/1520000/1513800/1513707/f8933df9_y.jpg) ### Hilton Garden Inn Columbia/Harbison 10/10 Excellent "Older hotel, but it was very clean and priced affordably. Would definitely stay here again!" [](https://expedia.ca/Columbia-Hotels-Hilton-Garden-Inn-ColumbiaHarbison.h1513707.Hotel-Information) ![Sleep Inn Columbia](https://images.trvl-media.com/lodging/1000000/130000/127000/126908/de238acf_y.jpg) ### Sleep Inn Columbia 10/10 Excellent "Good" [](https://expedia.ca/Columbia-Hotels-Sleep-Inn-At-Bush-River-Road.h126908.Hotel-Information) ![Tru By Hilton Columbia Downtown](https://images.trvl-media.com/lodging/111000000/110650000/110648500/110648494/w3840h2557x0y3-1e9d91e1_y.jpg) ### Tru By Hilton Columbia Downtown 10/10 Excellent "Everything was really nice. Wednesday's happy hr was great and food was very good " [](https://expedia.ca/Columbia-Hotels-Tru-By-Hilton-Columbia-Downtown.h110648494.Hotel-Information) ![Howard Johnson by Wyndham Florence](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/32fd6fc1_y.jpg) ### Howard Johnson by Wyndham Florence 10/10 Excellent "Friendly staff. Room clean and comfortable." [](https://expedia.ca/Florence-Hotels-Howard-Johnson-By-Wyndham-Florence.h11037.Hotel-Information) ![Holiday Inn Express & Suites Columbia-I-26 @ Harbison Blvd by IHG](https://images.trvl-media.com/lodging/1000000/690000/688700/688607/805d082b_y.jpg) ### Holiday Inn Express & Suites Columbia-I-26 @ Harbison Blvd by IHG 10/10 Excellent "Staff was friendly; room was clean and quiet for the night; breakfast was good." [](https://expedia.ca/Columbia-Hotels-Holiday-Inn-Express-Suites-Columbia-I-26-Harbison-Blvd.h688607.Hotel-Information) ![Comfort Inn & Suites Florence Center Area](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/a0861bce_y.jpg) ### Comfort Inn & Suites Florence Center Area 10/10 Excellent "Everyone was friendly, they had the place decorated for Valentine's day, it smelled nice in there as soon as you walked in " [](https://expedia.ca/Florence-Hotels-Comfort-Inn-Suites.h38336321.Hotel-Information) ![Wyndham Garden Columbia/Ft. Jackson](https://images.trvl-media.com/lodging/78000000/77820000/77814700/77814689/e6cbdb45_y.jpg) ### Wyndham Garden Columbia/Ft. Jackson 10/10 Excellent "Our stay was amazing." [](https://expedia.ca/Columbia-Hotels-Hotel-Columbia-Inn-Suites.h77814689.Hotel-Information) ![La Quinta Inn by Wyndham Columbia SE / Fort Jackson](https://images.trvl-media.com/lodging/1000000/10000/5100/5038/e9b1ea9e_y.jpg) ### La Quinta Inn by Wyndham Columbia SE / Fort Jackson 10/10 Excellent "Ok" [](https://expedia.ca/Columbia-Hotels-La-Quinta-Inn-By-Wyndham-Columbia-SE-Fort-Jackson.h5038.Hotel-Information) ![ La Quinta Inn by Wyndham Columbia NE/Fort Jackson](https://images.trvl-media.com/lodging/1000000/50000/43600/43541/ebebcc50_y.jpg) ### La Quinta Inn by Wyndham Columbia NE/Fort Jackson 10/10 Excellent "This is the nicest mid level inn we have ever enjoyed. Clean, comfortable, close to restaurants and shops, fine breakfast. We come here again!" [](https://expedia.ca/Columbia-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Columbia-NE-Fort-Jackson.h43541.Hotel-Information) ## Find out more about South Carolina Midlands ## South Carolina Midlands Inns information | Number of reviews | 21,123 | | ----------------- | ------- | | Accommodation | 1 Inns | | Lowest Price | CA $102 | | Highest Price | CA $192 | ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [Hotels near Allen University ](https://www.expedia.ca/Allen-University-Hotels.0-l6245638-0.Travel-Guide-Filter-Hotels) - [B&B in Arcadia Lakes ](https://www.expedia.ca/Arcadia-Lakes-Bed-And-Breakfast.d553248634998974994-aaBedAndBreakfast.Travel-Guide-Accommodation) - [Guest Houses in Arcadia Lakes ](https://www.expedia.ca/Arcadia-Lakes-Guest-Houses.d553248634998974994-aaGuestHouses.Travel-Guide-Accommodation) - [Arcadia Lakes Hotels ](https://www.expedia.ca/Arcadia-Lakes-Hotels.d553248634998974994.Travel-Guide-Hotels) - 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