Medical Center District Vacation Packages

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

    • payments icon

    Better together

    Save up to CA $1,096 when you book a flight and hotel together*
    lob hotels icon

    Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
    lob packages icon

    Rest easy

    Plan, book, and manage your trip all in one place

Top Holiday Package Deals in Medical Center District

Price found within the past 48 hours. Click for updated prices.
La Luz

La Luz

4.5 out of 5
Downtown San Antonio
per person
Oct 24 - Oct 28
found 1 day ago
Roundtrip non-stop flight included
Detroit (DTW) to San Antonio (SAT)
9.4/10 Exceptional! (38 reviews)
The place is beautiful on the inside. I loved everything about it. We enjoyed our stay. Only issue we had was in one bed there were ants in the bed the first few nights in which we got bitten a few times and woke up and killed them. Aside from that, our stay was very enjoyable and the condo is beautiful.

Reviewed on Jul. 30, 2025

Hotel Havana

Hotel Havana

3.5 out of 5
Downtown San Antonio
per person
Oct 9 - Oct 15
found 23 hours ago
Roundtrip non-stop flight included
Montreal (YUL) to San Antonio (SAT)
9/10 Wonderful! (1,007 reviews)
A great stay. Parking isn't included in some packages, as it states that it is on Expedia, but other than that a good experience.

Reviewed on Jul. 8, 2025

Canopy by Hilton San Antonio Riverwalk

Canopy by Hilton San Antonio Riverwalk

4 out of 5
Downtown San Antonio
per person
Oct 24 - Oct 28
found 1 day ago
Roundtrip non-stop flight included
Detroit (DTW) to San Antonio (SAT)
9.2/10 Wonderful! (1,499 reviews)
Our stay was good. Property was clean and modern. Staff was friendly and nice. Aubrey made our check in smooth. She went above and beyond to make sure I was a satisfied guest. I would come back just because of the empathy she showed me while checking in. First encounters do have a lasting impact.

Reviewed on Aug. 1, 2025

Hyatt Vacation Club at Wild Oak Ranch, San Antonio

Hyatt Vacation Club at Wild Oak Ranch, San Antonio

3.5 out of 5
Far West Side
per person
Oct 24 - Oct 28
found 1 day ago
Roundtrip non-stop flight included
Detroit (DTW) to San Antonio (SAT)
9/10 Wonderful! (1,000 reviews)
Really enjoyed our stay.

Reviewed on Aug. 2, 2025

Home2 Suites by Hilton San Antonio Riverwalk, TX

Home2 Suites by Hilton San Antonio Riverwalk, TX

3 out of 5
Downtown San Antonio
per person
Oct 24 - Oct 28
found 1 day ago
Roundtrip non-stop flight included
Detroit (DTW) to San Antonio (SAT)
8.8/10 Excellent! (1,187 reviews)
The front desk staff were extremely helpful. If they didn’t know the answer, they would find it. Our room was huge, clean and comfortable. We used all of the amenities that were offered. The breakfast was a little chaotic and could have a better layout to help cut down on congestion. Overall we loved this hotel and would stay here again in the future.

Reviewed on Aug. 2, 2025

Where to stay in Medical Center District

Find the best Medical Center District areas and neighborhoods for the activities you enjoy most. Learn more about Medical Center District
Downtown - Riverwalk showing heritage architecture, boating and a river or creek

Downtown San Antonio

4 out of top 10 points of interest in this area
4/5(209 area reviews)

Explore the heart of San Antonio with top attractions like the Alamo and River Walk, or enjoy kayaking and bicycling to the World Heritage Missions. Discover historic sites, theaters, and shopping at Rivercenter, all easily accessible by public transit.

Find hotels in Downtown San Antonio

Medical Center District Hotel Deals

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd, San Antonio, TX
Fully refundableReserve now, pay when you stay
The price is CA $122 per night from Aug 11 to Aug 12
CA $122
CA $144 total
Aug 11 - Aug 12
includes taxes & fees
8.4/10 Very Good! (2,822 reviews)
Great stay
"Staff was great and friendly , room was good and restrooms were 10/10 clean"

Reviewed on Aug. 2, 2025

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410, San Antonio, TX
Fully refundableReserve now, pay when you stay
The price is CA $120 per night from Aug 12 to Aug 13
CA $120
CA $143 total
Aug 12 - Aug 13
includes taxes & fees
8.4/10 Very Good! (1,000 reviews)
"staff was friendly and knowledgeable"

Reviewed on Jul. 30, 2025

San Antonio Marriott Northwest Medical Center
Fairfield Inn & Suites by Marriott San Antonio Medical Center

Fairfield Inn & Suites by Marriott San Antonio Medical Center

2.5 out of 5
7203 Wurzbach Road, San Antonio, TX
Fully refundableReserve now, pay when you stay
The price is CA $127 per night from Aug 10 to Aug 11
CA $127
CA $148 total
Aug 10 - Aug 11
includes taxes & fees
8.8/10 Excellent! (955 reviews)
"Breakfast was good"

Reviewed on Jul. 30, 2025

Fairfield Inn & Suites by Marriott San Antonio Medical Center
See all 4,533 properties in Medical Center District
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
All Inclusive Vacations
Beach Vacations
Beach Vacations
Family Vacations
Family Vacations

Frequently asked questions

How much does a Medical Center District vacation package cost?
Starting from just CA $630, a vacation package is your passport to low-priced travel. Create your own Medical Center District adventure by picking from our huge range of airfares, hotels and rental cars.
How do I get a cheap travel package to Medical Center District?
It's as simple as bundling. Hotels, rental cars and flights — combine whatever you need into a Medical Center District vacation package and save. Score even better deals when you include extras such as activities or tours to your booking. But that's not the only good part. You have the freedom to customize your vacation your own way. We offer over 550 airlines and 1,000,000 properties throughout the world, so that everyone has a chance to travel and fulfill those vacation dreams.
Where should I stay in Medical Center District?
Make a reservation just around the corner from Six Flags Fiesta Texas, one of this area's most well-known attractions. It's the ideal spot for serious sightseers.
What are the top hotels in Medical Center District?
Amazing, Contemporary, Beautiful and Fairfield Inn & Suites by Marriott San Antonio Medical Center are two of the most well-known hotels in Medical Center District. Why not take a look at the amenities and rates at each and then make up your mind?
How far in advance should I book my Medical Center District vacation?
It all depends on the airline, but it's usually possible to look up international fares on Expedia up to 12 months in advance. While it's generally recommended to book ahead of time, lucky customers will sometimes nab a cheaper ticket just weeks before the date of departure.
What does an Expedia Medical Center District travel package include?
Flights, car rentals and hotels — we connect you to the very best deals. All you'll have to do is figure out your ideal combination. Once you've made your booking, you can add on the fun stuff like activities and sightseeing tours. Our travel packages make it easy to customize an exciting Medical Center District vacation.
What should I know before booking a Medical Center District travel package?
You'll save plenty with an Expedia travel package. Combine your airfares, rental cars and hotels and land fantastic discounts. You're not limited to hotels, however. Book with us and select from island resorts, city apartments and just about everything in between!
Can I choose my airline with a Medical Center District Expedia vacation package?
Yes, you're in charge. We have access to over 550 partner airlines globally, so you can tailor your Medical Center District trip according to your budget and travel needs.
If I'm not able to travel, can I cancel my Medical Center District vacation package?
Whether it's your hotel or flight, you can cancel or change it. Booked your Medical Center District vacation package in the last 24 hours? You may be able to make any changes for free. For bookings made more than 24 hours ago, you may be charged a fee by your airline, hotel or car rental company. For more information, head to our Customer Service Portal. We're here to help you every step of the way.

Discover the most popular places to visit in Medical Center District

USAA Corporate Office Headquarters

USAA Corporate Office Headquarters is just one of the places to see in San Antonio, so why not enjoy the other things to explore during your travels? Stroll along the riverfront or attend a sporting event in this family-friendly area.

USAA Corporate Office Headquarters

Things to do

San Antonio: San Antonio Zoo Any Day Ticket

San Antonio: San Antonio Zoo Any Day Ticket

CA $41
per adult
94% of travellers recommend
San Antonio: San Antonio Zoo Any Day Ticket
SEA LIFE San Antonio

SEA LIFE San Antonio

CA $34
per adult
78% of travellers recommend
SEA LIFE San Antonio
See all activities in San Antonio
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.