Title: Hotels by Marriott Hotels & Resorts in St. Charles from CA $272 | Expedia.ca [St. Charles Travel Guide](https://expedia.ca/St-Charles.dx183431)[Hotels in St. Charles](https://expedia.ca/St-Charles-Hotels.d183431.Travel-Guide-Hotels)[Vacation Rentals in St. Charles](https://expedia.ca/St-Charles-Vacation-Rentals.d183431.Travel-Guide-VacationRentals)[Flights to St. Charles](https://expedia.ca/Cheap-Flights-To-St-Charles.d183431.Travel-Guide-Flights)[St. Charles Car Rentals](https://expedia.ca/Car-Rentals-In-St-Charles.d183431.Car-Rental-Guide)[St. Charles Vacation Packages](https://expedia.ca/St-Charles.d183431.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Hotels by Marriott Hotels & Resorts in St. Charles from CA $272 ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [Oct 24 - Oct 25](https://www.expedia.ca/Hotel-Search?regionId=183431&startDate=2025-10-24&endDate=2025-10-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 25 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=183431&startDate=2025-10-25&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=183431&startDate=2025-10-24&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 31 - Nov 2](https://www.expedia.ca/Hotel-Search?regionId=183431&startDate=2025-10-31&endDate=2025-11-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top St. Charles Marriott Hotels & Resorts Hotels ![View from property](https://images.trvl-media.com/lodging/1000000/10000/4000/3948/ae2efa7d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/4000/3948/c64e8429.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/4000/3948/0e013528.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed, Non Smoking | Interior entrance](https://images.trvl-media.com/lodging/1000000/10000/4000/3948/967fe3e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Marriott Rochester Mayo Clinic Downtown Rochester 8.2/10 Very good (517) "It was fine " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jill CA $236 CA $272 total includes taxes & fees Oct 25 - Oct 26 [](https://www.expedia.ca/Rochester-Hotels-Marriott-Rochester-Mayo-Clinic.h3948.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2025-11-07&endDate=2025-11-08®ionId=183431&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FSt-Charles-Hotels-Marriott-Hotels-Resorts.0-0-d183431--bMarriottHotelsResorts.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FSt-Charles-Hotels-Marriott-Hotels-Resorts.0-0-d183431--bMarriottHotelsResorts.Travel-Guide-Filter-Hotels) ## Top St. Charles Hotel Reviews ![Kahler Inn and Suites - Mayo Clinic Area](//images.trvl-media.com/lodging/1000000/180000/171600/171566/e56e7dae_y.jpg) ### Kahler Inn and Suites - Mayo Clinic Area 10/10 Excellent "Our room was very nice. It did accumulate dust from the construction across the street. Everyone was ver hospitable, even when our dogs were batking" [](https://expedia.ca/Rochester-Hotels-Kahler-Inn-And-Suites-Mayo-Clinic-Area.h171566.Hotel-Information) ![AmericInn by Wyndham Rochester Near Mayo Clinic](//images.trvl-media.com/lodging/1000000/10000/8100/8008/71b6fb30_y.jpg) ### AmericInn by Wyndham Rochester Near Mayo Clinic 10/10 Excellent "Clean room but lots of permanent stains on walls. Yet by far the best 2 star hotel I’ve stayed at. Need a place to crash and not worry about bugs? This is it! Look no further. " [](https://expedia.ca/Rochester-Hotels-Ramada-By-Wyndham-Rochester-Mayo-Clinic-Area.h8008.Hotel-Information) ![Spark by Hilton Rochester South](//images.trvl-media.com/lodging/12000000/11680000/11673200/11673145/w3837h2557x3y3-c2ce9db3_y.jpg) ### Spark by Hilton Rochester South 10/10 Excellent "The room and hotel were very clean and nice. The staff was so friendly and accommodating. My daughter had appointments at mayo and the drive was 10 minutes away. Super easy to get there. They do have a shuttle service to Mayo, but we just drove. I wish that there were more breakfast options. The bed was extremely comfortable and sheets were so soft. I would definitely stay here again when my daughter has her next appointments at mayo. " [](https://expedia.ca/Rochester-Hotels-Spark-By-Hilton-Rochester-South.h11673145.Hotel-Information) ![Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area](//images.trvl-media.com/lodging/1000000/10000/3600/3556/b33056f7_y.jpg) ### Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area 10/10 Excellent "For the price, Centerstone is hard to beat. All the other spots downtown are more expensive and additional charges for parking. Here, parking is free, it's right by People's Food Co-op, and just a stone's throw from all the fun things to do in Rochester's historic district. Check out Tessa's Office for libations and Thai Pop for incredible Thai cuisine. " [](https://expedia.ca/Rochester-Hotels-Centerstone-Plaza-Hotel-Soldiers-FieldMayo-Clinic-Area.h3556.Hotel-Information) ![Kahler Grand Hotel](//images.trvl-media.com/lodging/1000000/30000/25600/25516/a12994da_y.jpg) ### Kahler Grand Hotel 10/10 Excellent "Clean, comfortable room. Meeting space was very nice for our event. Excellent restaurant. " [](https://expedia.ca/Rochester-Hotels-Kahler-Grand-Hotel.h25516.Hotel-Information) ![Hampton Inn Rochester-South](//images.trvl-media.com/lodging/1000000/20000/16600/16522/f90bd051_y.jpg) ### Hampton Inn Rochester-South 10/10 Excellent "Gentleman at desk was very nice. Good dining options " [](https://expedia.ca/Rochester-Hotels-Hampton-Inn-Rochester.h16522.Hotel-Information) ![Express Suites Riverport Inn & Suites](//images.trvl-media.com/lodging/1000000/20000/11700/11603/dccd832e_y.jpg) ### Express Suites Riverport Inn & Suites 10/10 Excellent "Great additional breakfast. Quick check in. Clean and easy." [](https://expedia.ca/Winona-Hotels-Express-Suites-Riverport-Inn-Suites.h11603.Hotel-Information) ![La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S](//images.trvl-media.com/lodging/8000000/7780000/7772100/7772018/569eb353_y.jpg) ### La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S 10/10 Excellent "Everything good overall" [](https://expedia.ca/Rochester-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Rochester-Mayo-Clinic-S.h7772018.Hotel-Information) ![Best Western Rochester Hotel Mayo Clinic Area/St. Mary's](//images.trvl-media.com/lodging/1000000/10000/3700/3682/w3836h2559x4y0-f5ee734c_y.jpg) ### Best Western Rochester Hotel Mayo Clinic Area/St. Mary's 10/10 Excellent "The property employees are nice and room was nice. Easy parking and a great bar and grill. I would stay here again. 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