Southern Illinois Vacation Packages
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Your Southern Illinois Vacation
When adventure is calling, answer it with a vacation package to Southern Illinois. Well known for its culture and history, this is one destination you'll never forget. Start your trip to Southern Illinois with a few nights in O'Fallon visiting popular sights like O'Fallon Family Sports Park and FanDuel Sportsbook and Horse Racing. Effingham is another city that draws travellers from far and wide. Lake Sara and Effingham Performance Centre are two of the leading places to see in this destination. Quit dreaming and get packing, because your Southern Illinois vacation is just clicks away with Expedia.
Top Southern Illinois Vacation Deals
Price found within the past 48 hours. Click for updated prices.
The Westin St. Louis
Downtown St. Louis
CA $2,339
per person
Nov 8 - Nov 13
found 17 hours ago
Roundtrip non-stop flight included
Edmonton (YEG) to St. Louis (STL)
8.6/10 Excellent! (1,007 reviews)
Top notch property from super clean and comfortable room to great breakfast. Staff excelled at enjoying their jobs and being friendly and personable. Cant rate them higher! Thank you.
Reviewed on Sep 7, 2026
Where to stay in Southern Illinois
Find the best Southern Illinois areas and neighborhoods for the activities you enjoy most. Learn more about Southern Illinois
Eastport
If you're spending some time in Eastport, Gateway Conference Center and Splash City Family Waterpark are top sights worth seeing.
Uptown
If you're spending some time in Uptown, Kruta Bakery and World's Largest Catsup Bottle are top sights worth seeing.
Alorton
Alorton is well-liked for its restaurants. If you'd like to do some sightseeing in the greater East St. Louis area, you might plan a trip to Arsenal BG Ballpark or Gateway Arch.
Mulberry Hills
While Mulberry Hills isn't home to many top sights, Gateway Conference Center and FanDuel Sportsbook and Horse Racing are some notable places to visit nearby.
Historic Downtown Collinsville
While Historic Downtown Collinsville isn't home to many top sights, Gateway Conference Center and Splash City Family Waterpark are some notable places to visit nearby.
Ready to book your vacation to Southern Illinois?
Southern Illinois Hotel Deals
Drury Inn & Suites St. Louis Fairview Heights
12 Ludwig Dr Fairview Heights IL
Fully refundableReserve now, pay when you stay
CA $124
CA $140 total
Sep 14 - Sep 15
includes taxes & fees
9.2/10 Wonderful! (1,022 reviews)
"My son and I stayed here for a couple of days while I was in town visiting family over Labor Day weekend. The front desk person, Romello (sorry if I spelled your name wrong), was super nice and welcoming. All of the other staff we encountered throughout our stay were great as well. My son especially ..."
Reviewed on Sep 7, 2026
Drury Plaza Hotel Mt. Vernon
145 North 44th Street Mount Vernon IL
Fully refundableReserve now, pay when you stay
CA $153
CA $173 total
Sep 13 - Sep 14
includes taxes & fees
9.8/10 Exceptional! (1,807 reviews)
"Room was clean and comfortable. Staff were friendly and helpful. Area was convenient to shopping and restaurants. 10 out of 10."
Reviewed on Sep 8, 2026
Quality Inn O'Fallon - St. Louis - Shiloh
1409 W US 50 O'Fallon IL
Fully refundable
CA $93
CA $106 total
Sep 17 - Sep 18
includes taxes & fees
7.4/10 Good! (1,008 reviews)
"Location great"
Reviewed on Sep 4, 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Stay near popular Southern Illinois attractions
Garden of the Gods Recreation Area
9.8/10 (63 reviews)
See for yourself why Harrisburg’s unearthly sandstone formations, tucked within lush Shawnee National Forest, earn their ethereal name.
World Wide Technology Raceway
9.0/10 (2 reviews)
Catch an event at World Wide Technology Raceway during your trip to St. Louis. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.
O'Fallon Family Sports Park
8.6/10 (137 reviews)
Explore the great outdoors at O'Fallon Family Sports Park, a lovely green space in O'Fallon. Check out the shops and top-notch restaurants in this family-friendly area.
DuQuoin State Fairgrounds
8.2/10 (95 reviews)
Catch an event at DuQuoin State Fairgrounds during your trip to Du Quoin. Experience the area's festivals and live music.
Frequently asked questions
How much does a Southern Illinois vacation package cost?
From just CA $1,989, you can tailor make your Southern Illinois vacation package. Simply bundle hotels, flights and car rentals and be rewarded with discounts.
How do I get a cheap travel package to Southern Illinois?
Bundle your flights and hotels with Expedia to save big on your next big adventure. With over 550 airlines and 1,000,000 hotels globally, your Southern Illinois vacation package can be tailored exactly to suit your budget. With all that extra money, why not throw in one or more awesome activities and tours? It's an easy way to unlock even more discounts. Your dream getaway to Southern Illinois is much closer than you thought!
What are the top hotels in Southern Illinois?
Take a look at Super 8 by Wyndham Carbondale and Best Western Saluki Inn. They're top picks for lots of travelers to Carbondale. If Marion is on your travel itinerary, Super 8 by Wyndham Marion and Quality Inn And Suites are a couple of popular options.
How far in advance should I book my Southern Illinois vacation?
Reward yourself with the widest variety at the lowest prices by booking your vacation to Southern Illinois early. Air carriers usually sell flight tickets around 12 months before departure, so reserve your spot ASAP. That said, Expedia is dedicated to giving you the best bargains around, so it's never a bad time to book your dream vacation!
What does an Expedia Southern Illinois travel package include?
That depends on what sort of trip you're contemplating. Southern Illinois vacation deals can include flights, hotels and car rentals. You can mix and match to create the travel package that suits you. You can also add on experiences and activities after you've booked to get even bigger discounts.
What should I know before booking a Southern Illinois travel package?
You'll score excellent savings when you combine your flights, hotels and rental cars into a package. Not only that, booking everything in one spot will make your trip planning easier. So why waste your money or time? Whether you're organizing a ritzy city getaway or a low-cost family road trip, explore our vacation packages today.
Can I choose my airline with a Southern Illinois Expedia vacation package?
You can, and with more than 550 airlines to pick from across the globe, you're not short on choice. Browse the available options and see which airline fits your needs and budget.
If I'm not able to travel, can I cancel my Southern Illinois vacation package?
You can cancel your Southern Illinois booking if your plans have changed. Whether you'll be charged a fee or not depends on your airline, hotel or car rental company. It may be possible to cancel or change for free if you booked in the last 24 hours. Visit our Customer Service Portal to learn more.
Explore a world of travel with Expedia
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- Best location on Lake of Egypt by land and by water!
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- Super 8 by Wyndham Salem
- Belle Prairie City Hotels
- Farmstay in Sunfield
- Hotels with smoking rooms in Marion
- Carmi Hotels
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- Hotels with an Indoor Pool in Harrisburg
- Keenes Hotels
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- Thompsonville Hotels
- Villas in Benton
- Apartments in Cisne
- Harrisburg Hotels
- Quality Inn & Suites Marion
- Villas in Buckner
- 3 Star Hotels in Keenes
- Cabin Rentals in Carlyle
- Best Western Plus Centralia Hotel & Suites
- Mount Vernon Hotels
- Treehouse w/ Hot Tub near Shawnee National Forest
- Apartments in Fairfield
- Flights from Toronto (YYZ) to Carbondale (MDH)
- Flights from Vancouver (YVR) to Mount Vernon (MVN)
- Flights to Ina
- Flights from Benton
- Flights to Fairfield
- Flights from Waltonville
- Flights from Carterville
- Flights from Mount Vernon
- Flights from Belle Rive
- Flights to Marion
- Flights to Centralia
- Flights to Southern Illinois
- Flights from Cutler
- Flights from Cisne
- Flights from Macedonia
- Flights to Benton
- Flights from Elkville
- Flights from Christopher
- Flights from Phoenix (PHX) to Carbondale (MDH)
- Flights to Du Quoin
- Flights from Cleveland (CLE) to Carbondale (MDH)
- Flights to Patoka
- Flights to Mount Vernon
- Flights to Flora
- Flights from Ewing
- Flights from Columbus (CMH) to Carbondale (MDH)
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
