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Southern Illinois Vacation Rentals

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Check prices for these dates

In two weeks
Nov 20 - Nov 22
In two months
Jan 1 - Jan 3
In three months
Jan 29 - Jan 31
In four months
Feb 26 - Feb 28

Our top choices for Southern Illinois vacation rentals

A large outdoor area with a pond, several wooden cabins, and a road.

1. Pet Friendly! Couples Retreat in Southern Illinois

Pet Friendly! Couples Retreat in Southern Illinois
3.0 star property
Murphysboro
The price is CA $168
CA $329 total
includes taxes & fees
Nov 8 - Nov 9
Pet Friendly! Couples Retreat in Southern Illinois
A cabin with a porch, two chairs, and a covered grill area.

2. Whispering Oaks - Cozy cabin in the woods

Whispering Oaks - Cozy cabin in the woods
Bluford
9.6 out of 10, Exceptional, (43 reviews)
"We had a great time ,very quiet and serene."
United States
Richard H.
The price is CA $170
CA $263 total
includes taxes & fees
Nov 24 - Nov 25
Whispering Oaks - Cozy cabin in the woods
A modern living room with a sectional sofa, a coffee table, a TV mounted on the wall, and a window with blinds.

3. The Lab! Come stay in our brand new space.

The Lab! Come stay in our brand new space.
Murphysboro
9.6 out of 10, Exceptional, (35 reviews)
"We enjoyed our visit"
United States
Tim P.
The price is CA $170
CA $276 total
includes taxes & fees
Nov 10 - Nov 11
The Lab! Come stay in our brand new space.
A rustic log cabin with a green roof, surrounded by dense greenery and a calm pond.

4. A Little Slice Of Heaven

A Little Slice Of Heaven
Marion
10.0 out of 10, Exceptional, (85 reviews)
"Loved our stay! "
United States
Michael
The price is CA $196
CA $277 total
includes taxes & fees
Nov 8 - Nov 9
A Little Slice Of Heaven
A wooden cabin with a green door, a number '2' sign, a small porch with a wooden railing, and a wall-mounted lantern.

5. 3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!

3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!
Makanda
9.8 out of 10, Exceptional, (80 reviews)
"Very clean and comfortable stay"
United States
Alison K.
The price is CA $144
CA $255 total
includes taxes & fees
Dec 7 - Dec 8
3 Minutes to Giant City - 6 Minutes to SIU - 4 Minutes to Shawnee Winetrail!
A kitchen with wooden cabinets, a refrigerator, a microwave, a stove, a sink, and a dining table with chairs.

6. Charming 2-bedroom apartment with AC, WiFi in tranquil Benton

Charming 2-bedroom apartment with AC, WiFi in tranquil Benton
Benton
10.0 out of 10, Exceptional, (22 reviews)
"Perfect"
United States
Lane
The price is CA $140
CA $174 total
includes taxes & fees
Nov 15 - Nov 16
Charming 2-bedroom apartment with AC, WiFi in tranquil Benton
An open-plan office with exposed brick walls, wooden floors, and large windows.

7. The Exchange. Cozy Studio., XCHNG Studio

The Exchange. Cozy Studio., XCHNG Studio
Effingham
10.0 out of 10, Exceptional, (36 reviews)
"Wonderful place, love the location. "
United States
Dawn K.
The price is CA $149
CA $246 total
includes taxes & fees
Nov 8 - Nov 9
The Exchange. Cozy Studio., XCHNG Studio
A cozy living room with a dark green wall, a wooden chair with a white macrame throw, a potted plant, and a framed picture.

8. Luxury 1BR/BA Loft in the Heart of Downtown Marshall

Luxury 1BR/BA Loft in the Heart of Downtown Marshall
Marshall
9.8 out of 10, Exceptional, (17 reviews)
"It was beautifully decorated and had everything that you would need for a stay away from home. "
United States
Anonymous traveller
The price is CA $196
CA $293 total
includes taxes & fees
Nov 9 - Nov 10
Luxury 1BR/BA Loft in the Heart of Downtown Marshall
A cozy cabin interior with a stone fireplace, wooden walls, and various framed pictures.

9. Pine Cabin #3 on 30 Acres! 1 mi. from Carbondale, IL & SIUC Campus

Pine Cabin #3 on 30 Acres! 1 mi. from Carbondale, IL & SIUC Campus
Carbondale
9.2 out of 10, Wonderful, (156 reviews)
"Great place to get away while still being close enough to town"
United States
Travis S.
Pine Cabin #3 on 30 Acres! 1 mi. from Carbondale, IL & SIUC Campus
A wooden cabin entrance with a welcome sign, a small table with a lamp and flowers, and a woven mat on the floor.

10. Vintage Charmer on Main Street

Vintage Charmer on Main Street
Greenup
10.0 out of 10, Exceptional, (79 reviews)
"Great stay !"
United States
chris H.
The price is CA $124
CA $186 total
includes taxes & fees
Nov 17 - Nov 18
Vintage Charmer on Main Street
A rustic wooden console table with a mirror, a small plant, and a bird figurine.

11. The Tinley House. Close to hiking, hunting. Bike trail and hospital, shopping

The Tinley House. Close to hiking, hunting. Bike trail and hospital, shopping
Harrisburg
10.0 out of 10, Exceptional, (33 reviews)
"It was convenient having a garage for our car and luckily our car is small, because it barely fit. Nonetheless, a great feature. The place was clean, quaint, and adequate for the two of us. It was decorated to feel very homey. I recommend this as an option to stay if you are in the Harrisburg, Shawnee National Forest area."
United States
Shirley
The price is CA $126
CA $215 total
includes taxes & fees
Nov 9 - Nov 10
The Tinley House. Close to hiking, hunting. Bike trail and hospital, shopping
A modern kitchen with granite countertops, stainless steel appliances, and decorative wall shelves.

12. Tiny Cabin in the Woods - Firepit - just off I-70 - Pets Welcome!

Tiny Cabin in the Woods - Firepit - just off I-70 - Pets Welcome!
Mulberry Grove
9.8 out of 10, Exceptional, (37 reviews)
"Went to visit kids who live in the area. Normally we get a hotel but decided to try doing something different. This was so much better than hotels and plan to go back next time we are down."
United States
Julie
The price is CA $176
CA $305 total
includes taxes & fees
Dec 7 - Dec 8
Tiny Cabin in the Woods - Firepit - just off I-70 - Pets Welcome!
A two-story wooden house with a porch, a welcome sign, and a sliding glass door.

13. Hunter's Retreat

Hunter's Retreat
Christopher
9.6 out of 10, Exceptional, (21 reviews)
"We had a great stay, thank you!"
United States
Meg H.
The price is CA $175
CA $296 total
includes taxes & fees
Nov 14 - Nov 15
Hunter's Retreat
A rustic cabin with a wooden staircase leading to a deck, surrounded by greenery.

14. Treehouse w/ Hot Tub near Shawnee National Forest

Treehouse w/ Hot Tub near Shawnee National Forest
Marion
9.8 out of 10, Exceptional, (30 reviews)
"The Blonde is very well kept, the host is very communacative, friendly, and helpful. We enjoyed our stay!"
United States
Elizabeth M.
The price is CA $210
CA $354 total
includes taxes & fees
Dec 2 - Dec 3
Treehouse w/ Hot Tub near Shawnee National Forest
A wooden deck with a railing overlooking a lake, surrounded by trees and grassy areas.

15. Lake & Oaks Hideaway- Hidden Cabin on Private Lake

Lake & Oaks Hideaway- Hidden Cabin on Private Lake
Waltonville
10.0 out of 10, Exceptional, (64 reviews)
"Beautiful all the way around!"
United States
Colleen G.
The price is CA $161
CA $315 total
includes taxes & fees
Nov 16 - Nov 17
Lake & Oaks Hideaway- Hidden Cabin on Private Lake
A room with a wooden barn door, a dining area with blue chairs, and a washing machine in the background.

16. The Clark: Where Superheroes Sleep!

The Clark: Where Superheroes Sleep!
Metropolis
9.8 out of 10, Exceptional, (18 reviews)
"This property is amazing and the attention to detail is fantastic. We had a super stay and hope to come back soon!"
United States
Mallory H.
The price is CA $149
CA $213 total
includes taxes & fees
Nov 8 - Nov 9
The Clark: Where Superheroes Sleep!
A brick house with a white door, a mailbox, and a wooden porch.

17. Brickway Retreat

Brickway Retreat
Mattoon
9.8 out of 10, Exceptional, (53 reviews)
"Great place for a stay. Nice amenities and very clean. Would absolutely stay again"
United States
Kevin F.
The price is CA $154
CA $241 total
includes taxes & fees
Nov 8 - Nov 9
Brickway Retreat
A spacious room with a brick wall, a large bed, a ceiling fan, and two wicker lamps.

18. Unique loft in historic downtown

Unique loft in historic downtown
Vandalia
9.8 out of 10, Exceptional, (29 reviews)
"Beautiful loft, great place to stay!!"
United States
Sara
The price is CA $108
CA $177 total
includes taxes & fees
Nov 8 - Nov 9
Unique loft in historic downtown
A living room with a black leather sofa, a coffee table, and a floor lamp. There is a kitchen visible through an open doorway.

19. Next door to Wildlife Mgmt Area. Full kitchen, washer/dryer.

Next door to Wildlife Mgmt Area. Full kitchen, washer/dryer.
Kevil
9.8 out of 10, Exceptional, (83 reviews)
"Very nice and quiet place to stay while we went to the AQS quilt show in Paducah. "
United States
Curt K.
The price is CA $164
CA $205 total
includes taxes & fees
Nov 8 - Nov 9
Next door to Wildlife Mgmt Area. Full kitchen, washer/dryer.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Southern Illinois Hotel Reviews

A hotel lobby with a Kitchen+Bar area, seating arrangements, and a view to the outside.
Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon

Drury Plaza Hotel Mt. Vernon
Mount Vernon

10/10 Excellent

Excellent hotel. Both breakfast and the free supper were great. Friendly staff. Clean, well maintained property. The pool is a bit boring, especially if the divider is closed. Pool is 3 ft deep on both ends, and 5 ft in the middle.
Canada
Christina
Reviewed September 29, 2026
Drury Plaza Hotel Mt. Vernon

Find out more about Southern Illinois

Everything you need to know about Southern Illinois vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Southern Illinois vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, cottages, cabins, villas... The list goes on, and on… and on!

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Southern Illinois vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Southern Illinois vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Southern Illinois. If you’re looking for a little peace, consider booking during the quieter months, such as . For more hustle and bustle, you may prefer to visit in .

Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Southern Illinois vacation rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in.  The selection of Southern Illinois vacation rentals we have selected for you start as low as CA $108 per night. Entering your travel dates in the search wizard you might find even better deals!

How to find incredible deals on Southern Illinois rentals

At Expedia, we put the best Southern Illinois vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Southern Illinois rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Southern Illinois vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Southern Illinois. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

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