Find Spa Hotels in Sanderson, FL from CA $85

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Check prices for these dates

Tonight
Nov 10 - Nov 11
Tomorrow
Nov 11 - Nov 12
This weekend
Nov 13 - Nov 15
Next weekend
Nov 20 - Nov 22
No exact matches found, but these alternatives could be just right

Recommended hotels in Sanderson

A Hampton Inn & Suites with a covered outdoor area, stone pillars, and a well-lit entrance.

1. Hampton Inn & Suites MacClenny I-10

Hampton Inn & Suites MacClenny I-10
2.5 star property
MacClenny
9.4 out of 10, Exceptional, (946 reviews)
The price is CA $143
CA $157 total
includes taxes & fees
Nov 24 - Nov 25
Hampton Inn & Suites MacClenny I-10
A modern hotel with a covered entrance, multiple floors, and a landscaped front yard.

2. Holiday Inn Express & Suites Macclenny by IHG

Holiday Inn Express & Suites Macclenny by IHG
2.5 star property
MacClenny
9.2 out of 10, Wonderful, (387 reviews)
The price is CA $131
CA $145 total
includes taxes & fees
Dec 11 - Dec 12
Holiday Inn Express & Suites Macclenny by IHG
A modern kitchen with a central island, a dining area with a sofa, and a staircase leading to an upper level.

3. Island Oaks RV Resort

Island Oaks RV Resort
4.0 star property
Glen St. Mary
9.0 out of 10, Wonderful, (55 reviews)
The price is CA $213
CA $265 total
includes taxes & fees
Nov 23 - Nov 24
Island Oaks RV Resort
A hotel room with a bed, bedside tables, a desk, a chair, a television, and a bathroom visible through an open door.

4. Red Roof Inn MacClenny

Red Roof Inn MacClenny
2.0 star property
MacClenny
7.6 out of 10, Good, (727 reviews)
The price is CA $86
CA $95 total
includes taxes & fees
Nov 17 - Nov 18
Red Roof Inn MacClenny
An indoor swimming pool with clear water, surrounded by glass doors and windows, and a wooden deck area.

5. Fairfield Inn & Suites Lake City

Fairfield Inn & Suites Lake City
3.0 star property
Lake City
9.0 out of 10, Wonderful, (300 reviews)
The price is CA $133
CA $149 total
includes taxes & fees
Dec 11 - Dec 12
Fairfield Inn & Suites Lake City
A La Quinta hotel with a modern facade, multiple windows, and a well-lit entrance.

6. La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City
3.0 star property
Lake City
8.8 out of 10, Excellent, (1,208 reviews)
The price is CA $132
CA $149 total
includes taxes & fees
Dec 2 - Dec 3
La Quinta Inn & Suite by Wyndham Lake City
A hotel room with two beds, a desk, a microwave, a refrigerator, and a TV.

7. Homestay Inn & Suites

Homestay Inn & Suites
2.5 star property
MacClenny
6.6 out of 10, (61 reviews)
The price is CA $86
CA $94 total
includes taxes & fees
Dec 3 - Dec 4
Homestay Inn & Suites
A spacious living area with a grey sofa, a coffee table, and a TV stand.

8. Best Western Plus Lake City

Best Western Plus Lake City
2.5 star property
Lake City
9.0 out of 10, Wonderful, (1,134 reviews)
The price is CA $113
CA $127 total
includes taxes & fees
Dec 8 - Dec 9
Best Western Plus Lake City
A hotel room with two beds, a desk, a lamp, a heater, and a door.

9. Motel 6 Macclenny, FL

Motel 6 Macclenny, FL
2.0 star property
MacClenny
7.4 out of 10, Good, (513 reviews)
The price is CA $89
CA $97 total
includes taxes & fees
Nov 12 - Nov 13
Motel 6 Macclenny, FL
A hotel room with a gray sofa, a bed with white linens, a desk with a chair, and a window with blinds.

10. Comfort Suites Lake City

Comfort Suites Lake City
2.5 star property
Lake City
9.4 out of 10, Exceptional, (1,002 reviews)
The price is CA $134
CA $150 total
includes taxes & fees
Dec 6 - Dec 7
Comfort Suites Lake City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Choose what matters most at spa hotels in Sanderson

Pool
Breakfast included

Top Sanderson Hotel Reviews

A modern hotel with a covered entrance, multiple floors, and a landscaped front yard.
Holiday Inn Express & Suites Macclenny by IHG

Holiday Inn Express & Suites Macclenny by IHG

Holiday Inn Express & Suites Macclenny by IHG
MacClenny

10/10 Excellent

a
Canada
Adam
Reviewed October 27, 2026
Holiday Inn Express & Suites Macclenny by IHG

Frequently Asked Questions

Looking to vacation at a spa hotel in Sanderson?

Treat yourself to some time in a luxurious spa hotel and you won't regret it. Check out the historical sites and restaurants in Sanderson—your day trip starts here. Enjoy the natural parks during your vacation. Spa hotels are a great way to break away from your routine and add a layer of luxury to your vacation.

What's there to see and do in Sanderson?

Enjoy all that Sanderson has to offer when you visit Okefenokee National Wildlife Refuge, Olustee Battlefield Historic State Park, and Osceola National Forest. If you have a little extra time during your trip, you might want to make a stop at Heritage Park Village and Macclenny Park.

What is a Sanderson spa hotel?

Spa hotels in Sanderson provide lodging and have a full on-site spa offering services like massages and beauty treatments. Some also offer in-room treatments. Spa hotels are ideal if you are looking for some R&R during your vacation.

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