Title: Book the Best Sanderson SPA Resorts - Spa Hotels in Sanderson, FL | Expedia.ca [Hotels in Sanderson](https://expedia.ca/Sanderson-Hotels.d6185900.Travel-Guide-Hotels)[Vacation Rentals in Sanderson](https://expedia.ca/Sanderson-Vacation-Rentals.d6185900.Travel-Guide-VacationRentals)[Sanderson Car Rentals](https://expedia.ca/Car-Rentals-In-Sanderson.d6185900.Car-Rental-Guide)[Sanderson Vacation Packages](https://expedia.ca/Sanderson.d6185900.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/bex-affinities/pool.jpeg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Spa Hotels in Sanderson, FL ![calendar shield illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Sanderson Spa Hotels Tonight [Sep 17 - Sep 18](https://www.expedia.ca/Hotel-Search?regionId=6185900&startDate=2025-09-17&endDate=2025-09-18&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Sep 18 - Sep 19](https://www.expedia.ca/Hotel-Search?regionId=6185900&startDate=2025-09-18&endDate=2025-09-19&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Sep 19 - Sep 21](https://www.expedia.ca/Hotel-Search?regionId=6185900&startDate=2025-09-19&endDate=2025-09-21&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Sep 26 - Sep 28](https://www.expedia.ca/Hotel-Search?regionId=6185900&startDate=2025-09-26&endDate=2025-09-28&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Sanderson Spa Hotels ## Top Sanderson Hotel Reviews ![Best Western Plus Lake City](//images.trvl-media.com/lodging/1000000/910000/901400/901396/a415bbca_y.jpg) ### Best Western Plus Lake City 10/10 Excellent "We arrived by Rv pulling a vehicle on a late Saturday night. Parking was full but front desk and security found us parking and it was immediate and very personal. Room was clean and roomy. Breakfast was delicious, lots of choices and staff was very helpful and very hard working." [](https://expedia.ca/Lake-City-Hotels-Best-Western-Plus-Lake-City.h901396.Hotel-Information) ![Red Roof Inn MacClenny](//images.trvl-media.com/lodging/1000000/10000/6500/6410/d2d37fb1_y.jpg) ### Red Roof Inn MacClenny 10/10 Excellent "Yeah" [](https://expedia.ca/Jacksonville-Hotels-Red-Roof-Inn-MacClenny.h6410.Hotel-Information) ![Baymont by Wyndham Lake City](//images.trvl-media.com/lodging/1000000/20000/15800/15747/590bae4a_y.jpg) ### Baymont by Wyndham Lake City 10/10 Excellent "Room was clean. Bed was comfy. Folks up front were super nice. " [](https://expedia.ca/Lake-City-Hotels-Baymont-By-Wyndham-Lake-City.h15747.Hotel-Information) ![Hampton Inn & Suites Lake City](//images.trvl-media.com/lodging/2000000/1510000/1505900/1505814/1d104673_y.jpg) ### Hampton Inn & Suites Lake City 10/10 Excellent "Just want to give a shout out to the manager that helped my daughter after she was in an accident on the interstate. I truly appreciate the staff that helped her out while I traveled to pick her up. We have no family around the area and don’t what we would have done without your help. " [](https://expedia.ca/Lake-City-Hotels-Hampton-Inn-Suites-Lake-City.h1505814.Hotel-Information) ![Holiday Inn & Suites Lake City by IHG](//images.trvl-media.com/lodging/2000000/1120000/1115400/1115327/5d9b579a_y.jpg) ### Holiday Inn & Suites Lake City by IHG 10/10 Excellent "We needed a convenient place to rest overnight and they are pet friendly. It worked out to my expectations. Very friendly staff." [](https://expedia.ca/Lake-City-Hotels-Holiday-Inn-Suites-Lake-City.h1115327.Hotel-Information) ![Fairfield Inn & Suites Lake City](//images.trvl-media.com/lodging/3000000/2080000/2076600/2076513/9a0ddc50_y.jpg) ### Fairfield Inn & Suites Lake City 10/10 Excellent "Found it to be clean!" [](https://expedia.ca/Lake-City-Hotels-Fairfield-Inn-Suites-Lake-City.h2076513.Hotel-Information) ![Comfort Suites Lake City](//images.trvl-media.com/lodging/3000000/2480000/2479600/2479520/6850b4f8_y.jpg) ### Comfort Suites Lake City 10/10 Excellent "Loved it nice friendly staff Meridith and the security guard were amazing" [](https://expedia.ca/Lake-City-Hotels-Comfort-Suites-Lake-City.h2479520.Hotel-Information) ## Frequently asked questions ### Looking to vacation at a spa hotel in Sanderson? > Treat yourself to some time in a luxurious spa hotel and you won't regret it. Check out the historical sites and restaurants in Sanderson—your day trip starts here. Enjoy the natural parks during your vacation. Spa hotels are a great way to break away from your routine and add a layer of luxury to your vacation. ### What's there to see and do in Sanderson? > Enjoy all that Sanderson has to offer when you visit Okefenokee National Wildlife Refuge, Olustee Battlefield Historic State Park, and Osceola National Forest. If you have a little extra time during your trip, you might want to make a stop at Heritage Park Village and Macclenny Park. ### What is a Sanderson spa hotel? > Spa hotels in Sanderson provide lodging and have a full on-site spa offering services like massages and beauty treatments. Some also offer in-room treatments. 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