Title: Book the Best Otay Mesa Hotels with Early Check-in in 2026 from CA $133 | Expedia.ca [Vacation Rentals in San Diego](https://expedia.ca/San-Diego-Vacation-Rentals.d3073.Travel-Guide-VacationRentals)[Flights to San Diego](https://expedia.ca/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.ca/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Otay Mesa Car Rentals](https://expedia.ca/Car-Rentals-In-Otay-Mesa.d6263723.Car-Rental-Guide)[Otay Mesa Vacations](https://expedia.ca/Otay-Mesa.d6263723.Destination-Travel-Guides) ![Tijuana Neighborhood Seen Over Border Fence](https://images.trvl-media.com/place/6263723/a421f2e3-03d1-46f6-89f3-1009103bee11.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6263723/a421f2e3-03d1-46f6-89f3-1009103bee11.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Otay Mesa Hotels with Early Check-in Tonight [Feb 6 - Feb 7](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2026-02-06&endDate=2026-02-07&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Feb 7 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2026-02-07&endDate=2026-02-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Feb 6 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2026-02-06&endDate=2026-02-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Feb 13 - Feb 15](https://www.expedia.ca/Hotel-Search?regionId=6263723&startDate=2026-02-13&endDate=2026-02-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Otay Mesa hotels with express check-in ![Free buffet breakfast](https://images.trvl-media.com/lodging/2000000/1640000/1632400/1632358/3f975189.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/2000000/1640000/1632400/1632358/1779e3cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/2000000/1640000/1632400/1632358/a1b42446.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1640000/1632400/1632358/e00d8cf9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG [](https://www.expedia.ca/San-Diego-Hotels-Holiday-Inn-Express-Hotel-Suites-San-Diego-Otay-Mesa.h1632358.Hotel-Information) Otay Mesa 8.0/10 Very good (1,631 reviews) "rooms clean and service great" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) patricia CA $176 CA $201 total includes taxes & fees Mar 8 - Mar 9 [](https://www.expedia.ca/San-Diego-Hotels-Holiday-Inn-Express-Hotel-Suites-San-Diego-Otay-Mesa.h1632358.Hotel-Information) ![Courtyard view](https://images.trvl-media.com/lodging/2000000/1930000/1925600/1925594/cfb92d1b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/2000000/1930000/1925600/1925594/261f9b70.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1930000/1925600/1925594/8c1d6307.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/2000000/1930000/1925600/1925594/a840fa64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard by Marriott San Diego Airport/Liberty Station [](https://www.expedia.ca/San-Diego-Hotels-Courtyard-By-Marriott-San-Diego-AirportLiberty-Station.h1925594.Hotel-Information) Point Loma 9.2/10 Wonderful (1,330 reviews) "Our room was clean, well stocked staff was great & very comfortable bed." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Benny CA $242 CA $278 total includes taxes & fees Feb 15 - Feb 16 [](https://www.expedia.ca/San-Diego-Hotels-Courtyard-By-Marriott-San-Diego-AirportLiberty-Station.h1925594.Hotel-Information) ![Suite, 1 King Bed with Sofa bed, Balcony | View from room](https://images.trvl-media.com/lodging/1000000/20000/11200/11109/w4000h2662x0y0-91d299a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![5 restaurants, breakfast, lunch, dinner served; Mexican cuisine](https://images.trvl-media.com/lodging/1000000/20000/11200/11109/252aa24a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down comforters, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/20000/11200/11109/f89e408d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/20000/11200/11109/14f99248.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sheraton San Diego Resort [](https://www.expedia.ca/San-Diego-Hotels-Sheraton-San-Diego-Resort.h11109.Hotel-Information) Harbor Island 8.4/10 Very good (3,311 reviews) "Beautiful views, outstanding location, clean room, and comfy beds" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Paris CA $232 CA $327 total includes taxes & fees Feb 7 - Feb 8 [](https://www.expedia.ca/San-Diego-Hotels-Sheraton-San-Diego-Resort.h11109.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/920000/919100/919096/ed62594a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/920000/919100/919096/28f6908f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/1000000/920000/919100/919096/afa7d184.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/920000/919100/919096/e6a3b291.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Garden Inn San Diego Old Town/SeaWorld Area [](https://www.expedia.ca/San-Diego-Hotels-Hilton-Garden-Inn-San-Diego-Old-TownSeaWorld-Area.h919096.Hotel-Information) Old Town San Diego 8.6/10 Excellent (1,332 reviews) "Great location, great price, nice hotel " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Estela CA $204 CA $234 total includes taxes & fees Feb 22 - Feb 23 [](https://www.expedia.ca/San-Diego-Hotels-Hilton-Garden-Inn-San-Diego-Old-TownSeaWorld-Area.h919096.Hotel-Information) ![Rooftop terrace](https://images.trvl-media.com/lodging/115000000/114120000/114116400/114116366/dd5fc603.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room](https://images.trvl-media.com/lodging/115000000/114120000/114116400/114116366/b4a5f1e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillowtop beds, desk, laptop workspace](https://images.trvl-media.com/lodging/115000000/114120000/114116400/114116366/6521c599.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Balcony Suite | Living area](https://images.trvl-media.com/lodging/115000000/114120000/114116400/114116366/4123f91e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sentral Gaslamp Quarter [](https://www.expedia.ca/San-Diego-Hotels-Sentral-Gaslamp-Quarter.h114116366.Hotel-Information) Downtown San Diego 9.4/10 Exceptional (665 reviews) "Great place to stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) KELLY CA $162 CA $228 total includes taxes & fees Feb 12 - Feb 13 [](https://www.expedia.ca/San-Diego-Hotels-Sentral-Gaslamp-Quarter.h114116366.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1480000/1475800/1475800/57e60275.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed](https://images.trvl-media.com/lodging/2000000/1480000/1475800/1475800/17909882.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/2000000/1480000/1475800/1475800/1c9bf72f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/2000000/1480000/1475800/1475800/fb95526d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hercor Hotel - Urban Boutique [](https://www.expedia.ca/Chula-Vista-Hotels-Hercor-Hotel-Urban-Boutique.h1475800.Hotel-Information) Chula Vista 8.6/10 Excellent (1,371 reviews) "Excellent service and spotless place. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ruslan CA $121 CA $133 total includes taxes & fees Feb 8 - Feb 9 [](https://www.expedia.ca/Chula-Vista-Hotels-Hercor-Hotel-Urban-Boutique.h1475800.Hotel-Information) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/2d829d4d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/9101297c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lounge](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/6e469c5b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/w5586h3835x5y5-2b129a15.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton San Diego Mission Valley [](https://www.expedia.ca/San-Diego-Hotels-Hilton-San-Diego-Mission-Valley.h16019.Hotel-Information) Mission Valley 8.0/10 Very good (2,325 reviews) "The cleanest room and nicest staff honestly would stay here again" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kevin CA $179 CA $206 total includes taxes & fees Mar 3 - Mar 4 [](https://www.expedia.ca/San-Diego-Hotels-Hilton-San-Diego-Mission-Valley.h16019.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/1500/1466/04fbf5a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bars/lounges](https://images.trvl-media.com/lodging/1000000/10000/1500/1466/febc70a4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bars/lounges](https://images.trvl-media.com/lodging/1000000/10000/1500/1466/a35bbd39.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 bars/lounges](https://images.trvl-media.com/lodging/1000000/10000/1500/1466/06935e98.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### San Diego Marriott Gaslamp Quarter [](https://www.expedia.ca/San-Diego-Hotels-San-Diego-Marriott-Gaslamp-Quarter.h1466.Hotel-Information) Downtown San Diego 8.8/10 Excellent (1,646 reviews) "Lovely hotel and perfect location near many amenities. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Johan CA $220 CA $255 total includes taxes & fees Feb 7 - Feb 8 [](https://www.expedia.ca/San-Diego-Hotels-San-Diego-Marriott-Gaslamp-Quarter.h1466.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/12100/12073/3bcd1d83.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 2 Double Beds, City View](https://images.trvl-media.com/lodging/1000000/20000/12100/12073/w5755h3835x5y5-b89c39e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![6 restaurants, breakfast, lunch, dinner served; seafood](https://images.trvl-media.com/lodging/1000000/20000/12100/12073/890e0549.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed, Corner](https://images.trvl-media.com/lodging/1000000/20000/12100/12073/w5755h3840x5y0-6bf272f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Manchester Grand Hyatt San Diego [](https://www.expedia.ca/San-Diego-Hotels-Manchester-Grand-Hyatt-San-Diego.h12073.Hotel-Information) Downtown San Diego 9.0/10 Wonderful (2,920 reviews) "Excellent stay...wonderful staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michelle CA $328 CA $455 total includes taxes & fees Feb 7 - Feb 8 [](https://www.expedia.ca/San-Diego-Hotels-Manchester-Grand-Hyatt-San-Diego.h12073.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/11800/11725/f387ad25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/11800/11725/88b059dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pure, Room, 1 King Bed](https://images.trvl-media.com/lodging/1000000/20000/11800/11725/3bae0140.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lounge](https://images.trvl-media.com/lodging/1000000/20000/11800/11725/ad966b3d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sheraton Mission Valley San Diego Hotel [](https://www.expedia.ca/San-Diego-Hotels-Sheraton-Mission-Valley-San-Diego-Hotel.h11725.Hotel-Information) Mission Valley 8.6/10 Excellent (1,723 reviews) "Great stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Linda CA $185 CA $212 total includes taxes & fees Mar 8 - Mar 9 [](https://www.expedia.ca/San-Diego-Hotels-Sheraton-Mission-Valley-San-Diego-Hotel.h11725.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-20&endDate=2026-02-21®ionId=6263723&adults=2&property_amenities_group_explore=express_checkin&sort=RECOMMENDED&openPlayBack=true) ## Top Otay Mesa Hotel Reviews ![Hard Rock Hotel San Diego](https://images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/fbbdfc57_y.jpg) ### Hard Rock Hotel San Diego 10/10 Excellent "Room was very clean and luxurious " [](https://expedia.ca/San-Diego-Hotels-Hard-Rock-Hotel-San-Diego.h1731557.Hotel-Information) ![Wyndham San Diego Bayside](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/c44ff51d_y.jpg) ### Wyndham San Diego Bayside 10/10 Excellent "Love the view to the bay. Room was clean and location had a lot of great restaurant options " [](https://expedia.ca/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) ![The Dana on Mission Bay](https://images.trvl-media.com/lodging/1000000/50000/41000/40953/08585098_y.jpg) ### The Dana on Mission Bay 10/10 Excellent "Fast Room Service " [](https://expedia.ca/San-Diego-Hotels-The-Dana-On-Mission-Bay.h40953.Hotel-Information) ![Bahia Resort Hotel](https://images.trvl-media.com/lodging/1000000/20000/18300/18241/86eea647_y.jpg) ### Bahia Resort Hotel 10/10 Excellent "All the staff goes out of their way, the resort is in the middle of everything. No need to drive out. So many delicious restaurants in and close. The rooms were perfect. We enjoyed every minute there " [](https://expedia.ca/San-Diego-Hotels-Bahia-Resort-Hotel.h18241.Hotel-Information) ![The Sofia Hotel](https://images.trvl-media.com/lodging/2000000/1580000/1573900/1573807/ba6cea84_y.jpg) ### The Sofia Hotel 10/10 Excellent "Rooms were clean, the beds were soo comfy, and staff was nice. " [](https://expedia.ca/San-Diego-Hotels-The-Sofia-Hotel.h1573807.Hotel-Information) ![Best Western Seven Seas](https://images.trvl-media.com/lodging/1000000/10000/1800/1734/w3837h2556x3y3-8b148daf_y.jpg) ### Best Western Seven Seas 10/10 Excellent "The Best Western than seven seas is special to me because I stayed there as a child with my parents and grandparents. It is old motor in style San Diego or best Western in its old form.. The staff is great and it has a nice pool and Jacuzzi.. It is very affordable.. " [](https://expedia.ca/San-Diego-Hotels-Best-Western-Seven-Seas.h1734.Hotel-Information) ![Sheraton San Diego Resort](https://images.trvl-media.com/lodging/1000000/20000/11200/11109/w4000h2662x0y0-91d299a1_y.jpg) ### Sheraton San Diego Resort 10/10 Excellent "I really enjoy staying here when in San Diego. What a relaxing place. I'm afforded the opportunity to contemplate and reflect when I'm here.. it's very rewarding and the accomodations are well above par. " [](https://expedia.ca/San-Diego-Hotels-Sheraton-San-Diego-Resort.h11109.Hotel-Information) ![Days Inn by Wyndham San Diego Hotel Circle](https://images.trvl-media.com/lodging/1000000/20000/19300/19220/3334d773_y.jpg) ### Days Inn by Wyndham San Diego Hotel Circle 10/10 Excellent "Great" [](https://expedia.ca/San-Diego-Hotels-Days-Inn-By-Wyndham-San-Diego-Hotel-Circle.h19220.Hotel-Information) ## Explore a world of travel with Expedia - Lodging - More ways to book - [Beach Hotel Hotels in Camp Pendleton Marine Corps Base ](https://www.expedia.ca/Camp-Pendleton-Marine-Corps-Base-Hotels-Beach-Hotel.0-0-d6068523-tBeachHotel.Travel-Guide-Filter-Hotels) - [Hotels with Early Check-in in Camp Pendleton Marine Corps Base ](https://www.expedia.ca/Camp-Pendleton-Marine-Corps-Base-Hotels-Hotel-With-Early-Check-In.0-0-d6068523-thotelwithearlycheckin.Travel-Guide-Filter-Hotels) - [Hotels with an Indoor Pool in Camp Pendleton Marine Corps Base ](https://www.expedia.ca/Camp-Pendleton-Marine-Corps-Base-Hotels-Hotels-With-Indoor-Pool.0-0-d6068523-tHotelswithIndoorPool.Travel-Guide-Filter-Hotels) - 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