Mark Twain Vacation Packages

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Top Holiday Package Deals in Mark Twain

Price found within the past 48 hours. Click for updated prices.

Hampton Inn & Suites Clayton/St. Louis-Galleria Area

Clayton

CA $1,042

per person

Oct 7 - Oct 9

found 7 hours ago

Roundtrip non-stop flight included

Winnipeg (YWG) to St. Louis (STL)

8.8/10 Excellent! (1,008 reviews)

Remodeled and Inviting Free EV

CA $1,566

per person

Oct 17 - Oct 24

found 1 day ago

Roundtrip flight included

Toronto (YYZ) to St. Louis (STL)

10/10 Exceptional! (1 review)

It was nice to stay for a weekend but the neighborhood was nice I like the location where it wasn't too far from grocery stores food areas the only thing I was saying is it's nothing for the kids to do but overall I like it

Reviewed on Aug 7, 2026

Courtyard St. Louis Airport/Earth City

CA $1,053

per person

Oct 7 - Oct 10

found 1 hour ago

Roundtrip non-stop flight included

Winnipeg (YWG) to St. Louis (STL)

8.4/10 Very good! (1,000 reviews)

Our first room’s floor was soaking wet from the A/C unit. Then they moved us to a room with a balcony door and the lock was broken. The third room was great, and the staff was helpful and friendly during this. But then our last night the power went out around 1:30 am and never came back on. Not related to a storm or any weather, and it wasn’t the power companies fault (it wasn’t on the outage map). Nothing was offered and they barely even acted sorry. Overall it was a decent hotel, but a bad experience.

Reviewed on Aug 25, 2026

Moonrise Hotel

Delmar Loop

CA $1,047

per person

Oct 7 - Oct 9

found 7 hours ago

Roundtrip non-stop flight included

Winnipeg (YWG) to St. Louis (STL)

9/10 Wonderful! (2,013 reviews)

The Knight Center at Washington University

CA $1,079

per person

Oct 7 - Oct 9

found 7 hours ago

Roundtrip non-stop flight included

Winnipeg (YWG) to St. Louis (STL)

9.4/10 Exceptional! (646 reviews)

Room was modern and clean. Gym was pretty small.

Reviewed on Aug 25, 2026

Where to stay in Mark Twain

Find the best Mark Twain areas and neighborhoods for the activities you enjoy most. Learn more about Mark Twain

A public park with a fountain featuring bronze sculptures of mythological figures, surrounded by trees and a large building in the background.

Downtown St. Louis

3 out of top 10 points of interest in this area

Ample dining options, fascinating museums, and great live music are just a few top things to explore in Downtown St. Louis. A visit to Gateway Arch or Busch Stadium might round out your trip, and you can jump aboard the metro at 8th and Pine Station or Stadium Station to get around town.

The illuminated Gateway Arch at night with a city skyline in the background.

Clayton

1 out of top 10 points of interest in this area

Visitors often come to Clayton for its abundant dining options, but many stay to explore sights like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. Getting around the area on the metro is easy if you catch a ride at Clayton Station.

A street with parked cars, a building with a sign reading "Brennan's", and a tree in front.

Central West End

Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.

An ornate hall with arched ceilings and intricate patterns.

Downtown West

2 out of top 10 points of interest in this area

If you're spending some time in Downtown West, St. Louis Union Station and St. Louis Aquarium at Union Station are top sights worth seeing.

A lake with a curved shoreline, a parking lot, and a forested area with autumn foliage.

Creve Coeur

Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.

Mark Twain Hotel Deals

Hyatt Regency St. Louis at The Arch

315 Chestnut St St. Louis MO

Fully refundableReserve now, pay when you stay

CA $185

CA $218 total

Aug 28 - Aug 29

includes taxes & fees

8.6/10 Excellent! (4,260 reviews)

"Great location steps from the arch. excellent service and varied dining options."

Reviewed on Aug 25, 2026

Clayton Plaza Hotel & Extended Stay

7750 Carondelet Avenue St. Louis MO

Fully refundableReserve now, pay when you stay

CA $128

CA $150 total

Sep 6 - Sep 7

includes taxes & fees

9/10 Wonderful! (3,380 reviews)

"This hotel is beautiful and the staff are very helpful! Breakfast is the best I've ever had at a hotel. Omelets and waffles made for you, or other choices if you prefer. The hotel is super clean. We enjoyed our stay. We will definitely come back."

Reviewed on Aug 24, 2026

Hollywood Casino & Hotel St. Louis

777 Casino Center Drive Maryland Heights MO

Fully refundableReserve now, pay when you stay

CA $137

CA $201 total

Aug 26 - Aug 27

includes taxes & fees

8.6/10 Excellent! (2,249 reviews)

"Stayed at the property for a concert. The shuttle service from the hotel to the venue was convenient. Casino was large and not very crowded for a Sunday night. Room was clean and functional. We would stay here for another concert/casino overnight."

Reviewed on Aug 24, 2026

See all 1,990 properties in Mark Twain

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.