Hotels in Mark Twain, St. Louis

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Our top choices for Mark Twain hotels

Hyatt Select St. Louis Airport

Hyatt Select St. Louis Airport
2.5 star property
11.2 km from Mark Twain
9.2 out of 10, Wonderful, (1,005 reviews)
"Great stay."
United States
Marty
The price is CA $151
CA $186 total
includes taxes & fees
Jun 14 - Jun 15
Hyatt Select St. Louis Airport

Holiday Inn Express Troy by IHG

Holiday Inn Express Troy by IHG
2.5 star property
28.8 km from Mark Twain
9.2 out of 10, Wonderful, (772 reviews)
"Great place to stay and get good sleep and an excellent breakfast."
United States
debbie
The price is CA $168
CA $186 total
includes taxes & fees
May 24 - May 25
Holiday Inn Express Troy by IHG

Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch
3.0 star property
Downtown St. Louis, 8.5 km from Mark Twain
9.6 out of 10, Exceptional, (3,421 reviews)
"Nice hotel, helpful staff, and excellent location."
United States
JEFF
The price is CA $210
CA $246 total
includes taxes & fees
Jun 14 - Jun 15
Drury Plaza Hotel St. Louis at the Arch

Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport
2.5 star property
12.6 km from Mark Twain
9.4 out of 10, Exceptional, (2,999 reviews)
"Great room, staff, breakfast and location. "
United States
Elesia
The price is CA $136
CA $160 total
includes taxes & fees
Jun 17 - Jun 18
Pear Tree Inn St. Louis Airport

Super 8 by Wyndham Troy IL/St. Louis Area

Super 8 by Wyndham Troy IL/St. Louis Area
2.0 star property
28.6 km from Mark Twain
8.0 out of 10, Very good, (1,004 reviews)
"Everything was great. We actually came here from walking out at a different hotel. This was a great place to stay with the family. "
United States
Virgil
The price is CA $99
CA $110 total
includes taxes & fees
May 26 - May 27
Super 8 by Wyndham Troy IL/St. Louis Area

The Principal Hotel

The Principal Hotel
3.5 star property
27.7 km from Mark Twain
9.8 out of 10, Exceptional, (267 reviews)
"Highly recommend will stay again!"
United States
Mark
The price is CA $140
CA $155 total
includes taxes & fees
May 19 - May 20
The Principal Hotel

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
3.0 star property
25.5 km from Mark Twain
8.0 out of 10, Very good, (1,281 reviews)
"Would stay here again."
United States
Randy
The price is CA $123
CA $142 total
includes taxes & fees
May 24 - May 25
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Wingate by Wyndham St. Louis Airport

Wingate by Wyndham St. Louis Airport
3.0 star property
12.6 km from Mark Twain
9.2 out of 10, Wonderful, (1,601 reviews)
"Great room, breakfast, and staff. Would stay again! "
United States
Lilia
The price is CA $151
CA $178 total
includes taxes & fees
May 25 - May 26
Wingate by Wyndham St. Louis Airport

Comfort Inn Edwardsville - St. Louis

Comfort Inn Edwardsville - St. Louis
2.5 star property
22.1 km from Mark Twain
8.4 out of 10, Very good, (849 reviews)
"Enjoyed my stay! Hotel was nice and convenient"
United States
Renita M.
The price is CA $145
CA $167 total
includes taxes & fees
May 25 - May 26
Comfort Inn Edwardsville - St. Louis

Drury Inn & Suites St. Louis Airport

Drury Inn & Suites St. Louis Airport
3.0 star property
11.9 km from Mark Twain
9.2 out of 10, Wonderful, (1,240 reviews)
"Clean room staff was great and the food was actually good."
United States
Benjamin
The price is CA $181
CA $213 total
includes taxes & fees
Jun 16 - Jun 17
Drury Inn & Suites St. Louis Airport

River City Casino & Hotel

River City Casino & Hotel
4.0 star property
17.8 km from Mark Twain
9.0 out of 10, Wonderful, (1,557 reviews)
"Great place to stay!"
United States
Cassady
The price is CA $107
CA $145 total
includes taxes & fees
Jun 3 - Jun 4
River City Casino & Hotel

Drury Inn & Suites St. Louis O'Fallon, IL

Drury Inn & Suites St. Louis O'Fallon, IL
3.0 star property
29.9 km from Mark Twain
9.6 out of 10, Exceptional, (1,007 reviews)
"Rooms are clean and the staff is helpful and efficient."
United States
Mary
The price is CA $169
CA $196 total
includes taxes & fees
May 26 - May 27
Drury Inn & Suites St. Louis O'Fallon, IL

Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters
2.5 star property
29.8 km from Mark Twain
8.0 out of 10, Very good, (1,006 reviews)
"Friendly staff. Comfy bed. Good breakfast. "
United States
Melanie
The price is CA $145
CA $167 total
includes taxes & fees
May 25 - May 26
Hampton Inn St. Charles St. Peters

Pear Tree Inn St. Louis Near Union Station

Pear Tree Inn St. Louis Near Union Station
3.0 star property
Downtown West, 7 km from Mark Twain
8.8 out of 10, Excellent, (1,967 reviews)
"Stay here often always great "
United States
Laurie
The price is CA $168
CA $196 total
includes taxes & fees
Jun 8 - Jun 9
Pear Tree Inn St. Louis Near Union Station

Super 8 by Wyndham St Charles

Super 8 by Wyndham St Charles
2.0 star property
27.8 km from Mark Twain
8.0 out of 10, Very good, (1,015 reviews)
"Great staff and great coffee."
United States
Kim
The price is CA $104
CA $120 total
includes taxes & fees
May 25 - May 26
Super 8 by Wyndham St Charles

Holiday Inn Express & Suites Edwardsville by IHG

Holiday Inn Express & Suites Edwardsville by IHG
2.5 star property
25.5 km from Mark Twain
9.2 out of 10, Wonderful, (869 reviews)
"Clean and very nice staff"
United States
Khanh
The price is CA $205
CA $236 total
includes taxes & fees
Jun 14 - Jun 15
Holiday Inn Express & Suites Edwardsville by IHG

Hilton St. Louis Airport

Hilton St. Louis Airport
3.5 star property
11.5 km from Mark Twain
7.6 out of 10, Good, (1,008 reviews)
"Great stay "
United States
Austin
The price is CA $198
CA $236 total
includes taxes & fees
Jun 5 - Jun 6
Hilton St. Louis Airport

Wingate by Wyndham St. Louis/Fenton Route 66

Wingate by Wyndham St. Louis/Fenton Route 66
3.0 star property
25.7 km from Mark Twain
7.8 out of 10, Good, (1,218 reviews)
"Lots of food choices and gas stations near by also very easy highway access"
United States
Daquana
The price is CA $117
CA $135 total
includes taxes & fees
May 19 - May 20
Wingate by Wyndham St. Louis/Fenton Route 66

Best Western St. Louis Inn

Best Western St. Louis Inn
2.5 star property
27.6 km from Mark Twain
8.2 out of 10, Very good, (1,009 reviews)
"Nice clean economical place to stay with a very good breakfast "
United States
Henry
The price is CA $112
CA $128 total
includes taxes & fees
Jun 1 - Jun 2
Best Western St. Louis Inn

Drury Inn & Suites St. Louis Collinsville

Drury Inn & Suites St. Louis Collinsville
3.0 star property
20 km from Mark Twain
9.6 out of 10, Exceptional, (1,004 reviews)
"Hotel was welcoming, pool was nice for kids, meals were provided and access to highway was very good. Staff was excellent and helpful"
United States
Rick
The price is CA $153
CA $175 total
includes taxes & fees
May 25 - May 26
Drury Inn & Suites St. Louis Collinsville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Mark Twain

Find the best Mark Twain areas and neighborhoods for the activities you enjoy most. Learn more about Mark Twain
Learn more about Mark Twain

Downtown St. Louis

Ample dining options, fascinating museums, and great live music are just a few top things to explore in Downtown St. Louis. A visit to Gateway Arch or Busch Stadium might round out your trip, and you can jump aboard the metro at 8th and Pine Station or Stadium Station to get around town.

Clayton

Visitors often come to Clayton for its abundant dining options, but many stay to explore sights like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. Getting around the area on the metro is easy if you catch a ride at Clayton Station.

Creve Coeur

Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.

Central West End

Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.

Downtown West

If you're spending some time in Downtown West, St. Louis Union Station and St. Louis Aquarium at Union Station are top sights worth seeing.

Top Mark Twain Hotel Reviews

Frequently asked questions

What's it like in Mark Twain?
Travelers will be sure to find plenty to entertain them in St. Louis's Mark Twain neighborhood.
If I need to cancel my hotel reservation in Mark Twain, will I receive a refund?
Yes, you'll find most room reservations are fully refundable provided that you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of your scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of booking. Add your dates and click on "Search", then use the filter option "fully refundable" to get the best deals available in Mark Twain.
What is there to do around this St. Louis neighborhood?
Bellefontaine Cemetery, Calvary Cemetery, and Julia Davis Branch Library are just a few of the places to visit in and around Mark Twain. Shelley House and The Ville Monument are also worth a visit when you're out sightseeing in St. Louis.