Default HTG hotel image

Hotels in Mark Twain, St. Louis

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Oct 16 - Oct 18
Next weekend
Oct 23 - Oct 25

Filter by

Star rating

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Mark Twain hotels

A snack kiosk with a variety of packaged foods and beverages, a cash register, and a sign reading 'The Shop.'

1. Hilton Garden Inn St. Louis Airport

Hilton Garden Inn St. Louis Airport
3.0 star property
7.8 km from Mark Twain
8.4 out of 10, Very good, (1,000 reviews)
"Staff were super friendly and helpful. Room was spotless clean. My only gripe is that the hallways and rooms are dark, and my room was very dank. Bedside lamp was broken and just overall the room was sorta depressing. The rooms are in need of a facelift. Location was great. Ultimately will stay somewhere newer and brighter next time though for the same price."
United States
Lauren
The price is CA $190
CA $222 total
includes taxes & fees
Oct 18 - Oct 19
Hilton Garden Inn St. Louis Airport
The Clayton Plaza Hotel sign with a stone wall and plants in front.

2. Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay
3.5 star property
9.4 km from Mark Twain
8.8 out of 10, Excellent, (3,474 reviews)
"Great location, lots of things to do in the area and the staff was amazing!"
United States
Daniele
The price is CA $127
CA $148 total
includes taxes & fees
Oct 25 - Oct 26
Clayton Plaza Hotel & Extended Stay
An indoor swimming pool with a hot tub, lounge chairs, and a brick wall with artwork.

3. Pear Tree Inn St. Louis Near Union Station

Pear Tree Inn St. Louis Near Union Station
3.0 star property
Downtown West, 7 km from Mark Twain
8.8 out of 10, Excellent, (2,236 reviews)
"friendly staff, great for kids"
United States
Samantha
The price is CA $148
CA $173 total
includes taxes & fees
Oct 25 - Oct 26
Pear Tree Inn St. Louis Near Union Station
A hot tub with a wooden deck, surrounded by a bamboo fence, and string lights.

4. The West End

The West End
2.0 star property
Central West End, 5.4 km from Mark Twain
8.6 out of 10, Excellent, (680 reviews)
"Very clean room and really good customer service"
United States
Sergio
The price is CA $140
CA $192 total
includes taxes & fees
Oct 19 - Oct 20
The West End
An indoor pool area with a hot tub, seating, and a stone wall.

5. Drury Plaza Hotel St. Louis Union Station

Drury Plaza Hotel St. Louis Union Station
3.0 star property
Downtown West, 7.3 km from Mark Twain
9.4 out of 10, Exceptional, (1,603 reviews)
"Very nice hotel!"
United States
James A.
The price is CA $161
CA $191 total
includes taxes & fees
Nov 1 - Nov 2
Drury Plaza Hotel St. Louis Union Station
An outdoor dining area with multiple wooden tables and benches, surrounded by wicker chairs.

6. Hotel Indigo St Louis - Central West End by IHG

Hotel Indigo St Louis - Central West End by IHG
3.5 star property
Central West End, 5.4 km from Mark Twain
8.8 out of 10, Excellent, (1,001 reviews)
"Room was clean and staff were friendly!"
United States
Lydia
The price is CA $199
CA $250 total
includes taxes & fees
Oct 18 - Oct 19
Hotel Indigo St Louis - Central West End by IHG
An outdoor seating area with a fire pit, cushioned benches, and a covered patio with string lights.

7. Home2 Suites by Hilton St. Louis/Forest Park

Home2 Suites by Hilton St. Louis/Forest Park
3.0 star property
The Grove, 6.6 km from Mark Twain
8.6 out of 10, Excellent, (1,002 reviews)
"Staff was nice and helpful food was great and room was amazing!!! "
United States
paullita jeanne
The price is CA $221
CA $259 total
includes taxes & fees
Oct 18 - Oct 19
Home2 Suites by Hilton St. Louis/Forest Park
A rooftop restaurant with round tables, chairs, and a view of the city.

8. Moonrise Hotel

Moonrise Hotel
4.0 star property
6.3 km from Mark Twain
9.0 out of 10, Wonderful, (2,035 reviews)
"Such a cute place to stay, and convenient to a music venue and restaurants."
United States
Jessie
The price is CA $213
CA $254 total
includes taxes & fees
Oct 18 - Oct 19
Moonrise Hotel
An indoor swimming pool with lounge chairs and a pool table, surrounded by large windows.

9. Hampton Inn & Suites St. Louis at Forest Park

Hampton Inn & Suites St. Louis at Forest Park
3.5 star property
Dogtown, 7.4 km from Mark Twain
9.4 out of 10, Exceptional, (1,000 reviews)
"Great location clean room"
United States
Melissa
The price is CA $197
CA $233 total
includes taxes & fees
Nov 10 - Nov 11
Hampton Inn & Suites St. Louis at Forest Park
A hotel room with two beds, a chair, a desk, and a large window.

10. Forest Park Hotel by MDR

Forest Park Hotel by MDR
3.0 star property
The Hill, 8.8 km from Mark Twain
7.4 out of 10, Good, (1,661 reviews)
"The rooms were spacious and beds so comfortable."
United States
Kevan
The price is CA $114
CA $140 total
includes taxes & fees
Oct 27 - Oct 28
Forest Park Hotel by MDR
A Comfort Inn & Suites hotel with a modern design, featuring a covered entrance and a brick facade.

11. Comfort Inn & Suites Saint Louis Lafayette Square

Comfort Inn & Suites Saint Louis Lafayette Square
2.5 star property
The Gate, 8.4 km from Mark Twain
8.2 out of 10, Very good, (421 reviews)
"Great breakfeast and the room was clean. Also lot of room to park!"
United States
greg
The price is CA $156
CA $182 total
includes taxes & fees
Oct 29 - Oct 30
Comfort Inn & Suites Saint Louis Lafayette Square
A modern bar area with a wooden bar counter, black bar stools, and a large wall with city names.

12. Fairfield Inn & Suites by Marriott St. Louis Downtown

Fairfield Inn & Suites by Marriott St. Louis Downtown
3.0 star property
Downtown West, 7.1 km from Mark Twain
9.2 out of 10, Wonderful, (1,008 reviews)
"Great central location for our desired attractions"
United States
Vicky
The price is CA $165
CA $197 total
includes taxes & fees
Nov 1 - Nov 2
Fairfield Inn & Suites by Marriott St. Louis Downtown
An outdoor patio with a fire pit, seating, and a building in the background.

13. Courtyard by Marriott St. Louis Brentwood

Courtyard by Marriott St. Louis Brentwood
3.0 star property
10.4 km from Mark Twain
9.4 out of 10, Exceptional, (910 reviews)
"Beautiful accommodations! Helpful staff😊"
United States
Anna
The price is CA $168
CA $205 total
includes taxes & fees
Nov 1 - Nov 2
Courtyard by Marriott St. Louis Brentwood
A spacious lobby with modern seating, a reception desk, and large windows offering views of the parking area.

14. Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport
2.5 star property
12.6 km from Mark Twain
9.2 out of 10, Wonderful, (3,291 reviews)
"Excellent stay"
United States
Murphy
The price is CA $126
CA $149 total
includes taxes & fees
Oct 27 - Oct 28
Pear Tree Inn St. Louis Airport
A swimming pool with a 40 ft depth marker, lounge chairs, and a brick wall.

15. Drury Inn & Suites St. Louis Forest Park

Drury Inn & Suites St. Louis Forest Park
3.0 star property
9 km from Mark Twain
9.4 out of 10, Exceptional, (1,023 reviews)
"Loved staying there!"
United States
Tammy
The price is CA $192
CA $224 total
includes taxes & fees
Nov 1 - Nov 2
Drury Inn & Suites St. Louis Forest Park
A pool area with clear water, red lounge chairs, and a view of the outside through large windows.

16. Aloft by Marriott St Louis Central West End

Aloft by Marriott St Louis Central West End
3.0 star property
Central West End, 6 km from Mark Twain
8.6 out of 10, Excellent, (1,004 reviews)
"Very nice staff and helped us with all our needs and was close to the event we were going to and loved the pool table and pool they had there"
United States
Brittany
The price is CA $162
CA $189 total
includes taxes & fees
Oct 25 - Oct 26
Aloft by Marriott St Louis Central West End
A rooftop terrace with outdoor seating, string lights, and a city skyline view.

17. Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
4.0 star property
5.6 km from Mark Twain
8.8 out of 10, Excellent, (1,169 reviews)
"Always our top pick to stay when in town for travel. Great people, Great vibes and a Great distance from alot of downtown hot spots ☺️"
United States
Skylee
The price is CA $180
CA $212 total
includes taxes & fees
Oct 18 - Oct 19
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
A modern living room with a built-in fireplace, a large flat-screen TV, a unique hexagonal pendant light, and a patterned rug.

18. Hyatt Select St. Louis Airport

Hyatt Select St. Louis Airport
2.5 star property
11.2 km from Mark Twain
9.2 out of 10, Wonderful, (1,006 reviews)
"This is a great place to stay at !"
United States
Daisy
The price is CA $156
CA $194 total
includes taxes & fees
Oct 25 - Oct 26
Hyatt Select St. Louis Airport
A modern hotel room with a dining area, wooden cabinets, a checkered floor, and a flat-screen TV.

19. Wingate by Wyndham St. Louis Airport

Wingate by Wyndham St. Louis Airport
3.0 star property
12.6 km from Mark Twain
9.2 out of 10, Wonderful, (1,697 reviews)
"Staff was wonderful..great location with BBQ restaurant next door"
United States
Mary
The price is CA $138
CA $163 total
includes taxes & fees
Oct 21 - Oct 22
Wingate by Wyndham St. Louis Airport
A lobby with a sofa, two armchairs, a coffee table, and a staircase.

20. Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch
4.0 star property
Downtown St. Louis, 8.4 km from Mark Twain
8.6 out of 10, Excellent, (4,349 reviews)
"Great stay"
United States
Johnny
The price is CA $191
CA $225 total
includes taxes & fees
Oct 30 - Oct 31
Hyatt Regency St. Louis at The Arch
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Mark Twain

Find the best Mark Twain areas and neighborhoods for the activities you enjoy most. Learn more about Mark Twain
Learn more about Mark Twain
The Gateway Arch in St. Louis, Missouri, with a well-maintained lawn and trees in the foreground.

Downtown St. Louis

Ample dining options, fascinating museums, and great live music are just a few top things to explore in Downtown St. Louis. A visit to Old Courthouse or Gateway Arch National Park might round out your trip, and you can jump aboard the metro at 8th and Pine Station or Stadium Station to get around town.
A gazebo by a calm pond with autumn foliage and clear skies.

Clayton

Visitors often come to Clayton for its abundant dining options, but many stay to explore sights like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. Getting around the area on the metro is easy if you catch a ride at Clayton Station.
A historic building with a green dome and adjacent modern high-rise buildings.

Central West End

Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.
A wooden bridge with metal trusses, surrounded by trees.

St. Charles Historic District

Discover a national historic district featuring over 100 buildings, including the First Missouri State Capitol and St. Charles Odd Fellows Hall, showcasing architectural styles like Greek Revival and Italianate.
A lake with a curved shoreline, a parking lot, and a forested area with autumn foliage.

Creve Coeur

Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.

Top Mark Twain Hotel Reviews

Pear Tree Inn St. Louis Near Union Station

Pear Tree Inn St. Louis Near Union Station

8/10 Good
"Check in was easy and staff was very nice. Room was hot and AC was not working well. 2 elevators to accommodate lots of people. Lots of wait time. Amenities were very nice. Hotel overall was very nice but could use a good scrubbing."
Patricia 1-night trip
Posted 5 hours ago
Pear Tree Inn St. Louis Near Union Station

Frequently asked questions

What's it like in Mark Twain?
Travelers will be sure to find plenty to entertain them in St. Louis's Mark Twain neighborhood.
If I need to cancel my hotel reservation in Mark Twain, will I receive a refund?
Yes, you'll find most room reservations are fully refundable provided that you cancel before the hotel's cancellation deadline, which is usually within 24-48 hours of your scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of booking. Add your dates and click on "Search", then use the filter option "fully refundable" to get the best deals available in Mark Twain.
What is there to do around this St. Louis neighborhood?
Bellefontaine Cemetery, Calvary Cemetery, and Julia Davis Branch Library are just a few of the places to visit in and around Mark Twain. Shelley House and The Ville Monument are also worth a visit when you're out sightseeing in St. Louis.