Title: Book The Best Hotels in La Mesilla, NM for 2026 from CA $85 - Fully Refundable Options - Expedia.ca [Vacation Rentals in La Mesilla](https://expedia.ca/La-Mesilla-Vacation-Rentals.d553248635975872198.Travel-Guide-VacationRentals)[La Mesilla Car Rentals](https://expedia.ca/Car-Rentals-In-La-Mesilla.d553248635975872198.Car-Rental-Guide)[La Mesilla Vacation Packages](https://expedia.ca/La-Mesilla.d553248635975872198.Destination-Travel-Guides) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Go beyond your typical stay in La Mesilla Family friendly [](https://www.expedia.ca/Hotel-Search?destination=La+Mesilla%2C+New+Mexico%2C+United+States+of+America®ionId=553248635975872198&latLong=35.948358%2C-106.070579&adults=2&startDate=2026-02-14&d1=2026-02-14&endDate=2026-02-16&d2=2026-02-16&travelerType=family_friendly) Pet friendly [](https://www.expedia.ca/Hotel-Search?destination=La+Mesilla%2C+New+Mexico%2C+United+States+of+America®ionId=553248635975872198&latLong=35.948358%2C-106.070579&adults=2&startDate=2026-02-14&d1=2026-02-14&endDate=2026-02-16&d2=2026-02-16&amenities=PETS) Hot tub [](https://www.expedia.ca/Hotel-Search?destination=La+Mesilla%2C+New+Mexico%2C+United+States+of+America®ionId=553248635975872198&latLong=35.948358%2C-106.070579&adults=2&startDate=2026-02-14&d1=2026-02-14&endDate=2026-02-16&d2=2026-02-16&amenities=HOT_TUB) Condo [](https://www.expedia.ca/Hotel-Search?destination=La+Mesilla%2C+New+Mexico%2C+United+States+of+America®ionId=553248635975872198&latLong=35.948358%2C-106.070579&adults=2&startDate=2026-02-14&d1=2026-02-14&endDate=2026-02-16&d2=2026-02-16&lodging=CONDO) Cottage [](https://www.expedia.ca/Hotel-Search?destination=La+Mesilla%2C+New+Mexico%2C+United+States+of+America®ionId=553248635975872198&latLong=35.948358%2C-106.070579&adults=2&startDate=2026-02-14&d1=2026-02-14&endDate=2026-02-16&d2=2026-02-16&lodging=COTTAGE) ## Check prices for these dates Tonight [Jan 31 - Feb 1](https://www.expedia.ca/Hotel-Search?regionId=553248635975872198&startDate=2026-01-31&endDate=2026-02-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Feb 1 - Feb 2](https://www.expedia.ca/Hotel-Search?regionId=553248635975872198&startDate=2026-02-01&endDate=2026-02-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Feb 6 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=553248635975872198&startDate=2026-02-06&endDate=2026-02-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Feb 13 - Feb 15](https://www.expedia.ca/Hotel-Search?regionId=553248635975872198&startDate=2026-02-13&endDate=2026-02-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for La Mesilla hotels ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/460000/458100/458023/5368dc35.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Flat-screen TV](https://images.trvl-media.com/lodging/1000000/460000/458100/458023/5b9132ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/460000/458100/458023/98987c70.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/460000/458100/458023/08aa50f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Ohkay Casino Resort Hotel [](https://www.expedia.ca/Santa-Fe-Hotels-Ohkay-Casino-Resort-Hotel.h458023.Hotel-Information) Ohkay Owingeh 8.0/10 Very good (798 reviews) "Great front desk! They were so friendly " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) sarah [](https://www.expedia.ca/Santa-Fe-Hotels-Ohkay-Casino-Resort-Hotel.h458023.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/2000000/1590000/1581300/1581298/7e65bc33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/2000000/1590000/1581300/1581298/e9bf53df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![32-inch flat-screen TV with cable channels, TV, fireplace](https://images.trvl-media.com/lodging/2000000/1590000/1581300/1581298/6861e853.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1590000/1581300/1581298/af39f9b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Inn at the Delta [](https://www.expedia.ca/Santa-Fe-Hotels-The-Inn-At-The-Delta.h1581298.Hotel-Information) Espanola 9.4/10 Exceptional (1,000 reviews) "Staff friendly and helpful." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Joan [](https://www.expedia.ca/Santa-Fe-Hotels-The-Inn-At-The-Delta.h1581298.Hotel-Information) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/130000/120800/120761/4dd42a18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed | View from room](https://images.trvl-media.com/lodging/1000000/130000/120800/120761/26a45628.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/130000/120800/120761/112d7b19.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bathroom sink](https://images.trvl-media.com/lodging/1000000/130000/120800/120761/a406f7fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Cities Of Gold Casino [](https://www.expedia.ca/Santa-Fe-Hotels-Cities-Of-Gold-Casino.h120761.Hotel-Information) Santa Fe 8.0/10 Very good (1,079 reviews) "Very clean rooms, convenient, friendly staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dawn CA $74 CA $85 total includes taxes & fees Feb 1 - Feb 2 [](https://www.expedia.ca/Santa-Fe-Hotels-Cities-Of-Gold-Casino.h120761.Hotel-Information) ![Porch](https://images.trvl-media.com/lodging/1000000/530000/521400/521375/6ea44016.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/530000/521400/521375/71fb0337.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Kiva Room](https://images.trvl-media.com/lodging/1000000/530000/521400/521375/f8395467.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/530000/521400/521375/w797h532x3y3-17b34bb2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Casa Escondida Bed & Breakfast [](https://www.expedia.ca/Santa-Fe-Hotels-Casa-Escondida-Bed-Breakfast.h521375.Hotel-Information) Chimayo 9.4/10 Exceptional (263 reviews) "Beautiful historic property. Great staff and excellent breakfast. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Julie CA $160 CA $179 total includes taxes & fees Feb 1 - Feb 2 [](https://www.expedia.ca/Santa-Fe-Hotels-Casa-Escondida-Bed-Breakfast.h521375.Hotel-Information) ![Indoor pool, seasonal outdoor pool, cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/3000000/2060000/2059000/2058957/8424680e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/3000000/2060000/2059000/2058957/866cf9af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/3000000/2060000/2059000/2058957/a175ea0e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed](https://images.trvl-media.com/lodging/3000000/2060000/2059000/2058957/2bd32ee5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Santa Fe Buffalo Thunder [](https://www.expedia.ca/Santa-Fe-Hotels-Hilton-Santa-Fe-Buffalo-Thunder.h2058957.Hotel-Information) Santa Fe 8.8/10 Excellent (1,007 reviews) "It was clean and during the time we stayed it was really affordable. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sabrina CA $147 CA $168 total includes taxes & fees Feb 17 - Feb 18 [](https://www.expedia.ca/Santa-Fe-Hotels-Hilton-Santa-Fe-Buffalo-Thunder.h2058957.Hotel-Information) ![View from room](https://images.trvl-media.com/lodging/1000000/20000/19700/19678/c2604840.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/19700/19678/ecbc45c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/19700/19678/90618c21.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bathtub, free toiletries, hair dryer, towels](https://images.trvl-media.com/lodging/1000000/20000/19700/19678/59a04f5f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn by Wyndham Espanola [](https://www.expedia.ca/Santa-Fe-Hotels-Days-Inn-By-Wyndham-Espanola.h19678.Hotel-Information) Espanola 5.8/10 (591 reviews) "Everything was fine." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Thomas CA $116 CA $132 total includes taxes & fees Feb 26 - Feb 27 [](https://www.expedia.ca/Santa-Fe-Hotels-Days-Inn-By-Wyndham-Espanola.h19678.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/40800/40737/4b0bf4d8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/1000000/50000/40800/40737/ebb137d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room (Bunkhouse)](https://images.trvl-media.com/lodging/1000000/50000/40800/40737/ff2c1212.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/40800/40737/dc73db0b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Bishop's Lodge, Auberge Collection [](https://www.expedia.ca/Santa-Fe-Hotels-Bishops-Lodge.h40737.Hotel-Information) Tesuque 9.4/10 Exceptional (97 reviews) "Everyone was so kind and attentive and the rooms and grounds were so beautiful and clean." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Liza [](https://www.expedia.ca/Santa-Fe-Hotels-Bishops-Lodge.h40737.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/50000/40800/40731/31eee379.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/1000000/50000/40800/40731/06dccf6c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 9:00 AM to 9:00 PM, pool umbrellas, sun loungers](https://images.trvl-media.com/lodging/1000000/50000/40800/40731/7f6e9855.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Couples treatment rooms, body treatments, hot stone massages](https://images.trvl-media.com/lodging/1000000/50000/40800/40731/459f0ba7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Four Seasons Resort Rancho Encantado Santa Fe [](https://www.expedia.ca/Santa-Fe-Hotels-Four-Seasons-Resort-Rancho-Encantado-Santa-Fe.h40731.Hotel-Information) Santa Fe 9.4/10 Exceptional (269 reviews) "Great service and property " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sharmin CA $661 CA $826 total includes taxes & fees Mar 3 - Mar 4 [](https://www.expedia.ca/Santa-Fe-Hotels-Four-Seasons-Resort-Rancho-Encantado-Santa-Fe.h40731.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/3200/3139/ca9f58d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/10000/3200/3139/b8126edd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/10000/3200/3139/e3129a4d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/3200/3139/11393c3b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Glorieta [](https://www.expedia.ca/Santa-Fe-Hotels-Hotel-Glorieta.h3139.Hotel-Information) Santa Fe 8.4/10 Very good (83 reviews) "Great quiet place to stay, beautiful setting and great location." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Shirley CA $127 CA $186 total includes taxes & fees Mar 2 - Mar 3 [](https://www.expedia.ca/Santa-Fe-Hotels-Hotel-Glorieta.h3139.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1190000/1184600/1184592/w3248h2773x0y32-e87fb9ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Executive Room, 1 King Bed, Non Smoking (Multi-level)](https://images.trvl-media.com/lodging/2000000/1190000/1184600/1184592/8cabce0c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/2000000/1190000/1184600/1184592/fa5fca8a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout drapes, iron/ironing board, bed sheets](https://images.trvl-media.com/lodging/2000000/1190000/1184600/1184592/ad784a28.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Homewood Suites by Hilton Santa Fe-North [](https://www.expedia.ca/Santa-Fe-Hotels-Homewood-Suites-By-Hilton-Santa-Fe-North.h1184592.Hotel-Information) Santa Fe 9.2/10 Wonderful (1,001 reviews) "Beautiful room" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mark CA $178 CA $204 total includes taxes & fees Mar 2 - Mar 3 [](https://www.expedia.ca/Santa-Fe-Hotels-Homewood-Suites-By-Hilton-Santa-Fe-North.h1184592.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/16200/16124/ff6e8279.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds, Non Smoking](https://images.trvl-media.com/lodging/1000000/20000/16200/16124/81762e6e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/16200/16124/2aaff96a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/20000/16200/16124/3a9dbc27.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Rodeway Inn Española [](https://www.expedia.ca/Santa-Fe-Hotels-Rodeway-Inn.h16124.Hotel-Information) Espanola 6.2/10 (468 reviews) "Nice staff. Clean room. Good location. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) James CA $91 CA $103 total includes taxes & fees Mar 2 - Mar 3 [](https://www.expedia.ca/Santa-Fe-Hotels-Rodeway-Inn.h16124.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/1000000/910000/908700/908632/188d3975.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/910000/908700/908632/b013eb88.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/910000/908700/908632/8c161554.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/910000/908700/908632/4901e7b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Los Alamos White Rock [](https://www.expedia.ca/Santa-Fe-Hotels-Hampton-Inn-Suites-Los-Alamos-White-Rock.h908632.Hotel-Information) Los Alamos 9.0/10 Wonderful (688 reviews) "Very friendly staff, nice room, convenient breakfast." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jenna CA $154 CA $172 total includes taxes & fees Feb 27 - Feb 28 [](https://www.expedia.ca/Santa-Fe-Hotels-Hampton-Inn-Suites-Los-Alamos-White-Rock.h908632.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/460000/459600/459557/8ddd7ae1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Vending machine](https://images.trvl-media.com/lodging/1000000/460000/459600/459557/cead4504.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/460000/459600/459557/f940fb2b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/1000000/460000/459600/459557/c4231c19.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 Espanola, NM [](https://www.expedia.ca/Santa-Fe-Hotels-Motel-6-Espanola.h459557.Hotel-Information) Espanola 6.4/10 (520 reviews) "One of the better hotels I have stayed in." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) james CA $120 CA $136 total includes taxes & fees Feb 2 - Feb 3 [](https://www.expedia.ca/Santa-Fe-Hotels-Motel-6-Espanola.h459557.Hotel-Information) ![Front of property - evening/night](https://images.trvl-media.com/lodging/3000000/2980000/2976500/2976403/1e1b9063.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/3000000/2980000/2976500/2976403/4c9d463d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/3000000/2980000/2976500/2976403/08467533.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast](https://images.trvl-media.com/lodging/3000000/2980000/2976500/2976403/65b278ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Los Alamos Entrada Park by IHG [](https://www.expedia.ca/Santa-Fe-Hotels-Holiday-Inn-Express-Hotel-Suites-Los-Alamos.h2976403.Hotel-Information) Los Alamos 8.8/10 Excellent (754 reviews) "Friendly staff, wicked clean and comfy room" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Daisy CA $173 CA $194 total includes taxes & fees Feb 8 - Feb 9 [](https://www.expedia.ca/Santa-Fe-Hotels-Holiday-Inn-Express-Hotel-Suites-Los-Alamos.h2976403.Hotel-Information) ![Suite, 1 Queen Bed with Sofa bed, Hearing Accessible, Non Smoking (Mobility, Roll-In Shower)](https://images.trvl-media.com/lodging/1000000/80000/74700/74653/d168a9eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/80000/74700/74653/4c8e5531.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/80000/74700/74653/e5b066f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Vending machine](https://images.trvl-media.com/lodging/1000000/80000/74700/74653/1d1fd205.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Wingate by Wyndham Los Alamos [](https://www.expedia.ca/Santa-Fe-Hotels-Comfort-Inn-Suites-Los-Alamos.h74653.Hotel-Information) Los Alamos 8.0/10 Very good (583 reviews) "Solid hotel with very friendly and supportive staff. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Markus CA $164 CA $184 total includes taxes & fees Feb 8 - Feb 9 [](https://www.expedia.ca/Santa-Fe-Hotels-Comfort-Inn-Suites-Los-Alamos.h74653.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.ca/Hotel-Search?startDate=2026-02-14&endDate=2026-02-15®ionId=553248635975872198&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FLa-Mesilla-Hotels.d553248635975872198.Travel-Guide-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FLa-Mesilla-Hotels.d553248635975872198.Travel-Guide-Hotels) ## Top La Mesilla Hotel Reviews ![Hilton Santa Fe Buffalo Thunder](https://images.trvl-media.com/lodging/3000000/2060000/2059000/2058957/c6ba74ab_y.jpg) ### Hilton Santa Fe Buffalo Thunder 10/10 Excellent "Great Hotel!" [](https://expedia.ca/Santa-Fe-Hotels-Hilton-Santa-Fe-Buffalo-Thunder.h2058957.Hotel-Information) ![Casa Escondida Bed & Breakfast](https://images.trvl-media.com/lodging/1000000/530000/521400/521375/a25f16f6_y.jpg) ### Casa Escondida Bed & Breakfast 10/10 Excellent "Great location, friendly staff. Breakfast was delicious." [](https://expedia.ca/Santa-Fe-Hotels-Casa-Escondida-Bed-Breakfast.h521375.Hotel-Information) ![Holiday Inn Express & Suites Los Alamos Entrada Park by IHG](https://images.trvl-media.com/lodging/3000000/2980000/2976500/2976403/65b278ef_y.jpg) ### Holiday Inn Express & Suites Los Alamos Entrada Park by IHG 10/10 Excellent "Friendly staff, wicked clean and comfy room" [](https://expedia.ca/Santa-Fe-Hotels-Holiday-Inn-Express-Hotel-Suites-Los-Alamos.h2976403.Hotel-Information) ![Hampton Inn & Suites Los Alamos White Rock](https://images.trvl-media.com/lodging/1000000/910000/908700/908632/4901e7b8_y.jpg) ### Hampton Inn & Suites Los Alamos White Rock 10/10 Excellent "Yes" [](https://expedia.ca/Santa-Fe-Hotels-Hampton-Inn-Suites-Los-Alamos-White-Rock.h908632.Hotel-Information) ![Ohkay Casino Resort Hotel](https://images.trvl-media.com/lodging/1000000/460000/458100/458023/5368dc35_y.jpg) ### Ohkay Casino Resort Hotel 10/10 Excellent "Great front desk! They were so friendly " [](https://expedia.ca/Santa-Fe-Hotels-Ohkay-Casino-Resort-Hotel.h458023.Hotel-Information) ![The Inn at the Delta](https://images.trvl-media.com/lodging/2000000/1590000/1581300/1581298/a0789287_y.jpg) ### The Inn at the Delta 10/10 Excellent "Staff friendly and helpful." [](https://expedia.ca/Santa-Fe-Hotels-The-Inn-At-The-Delta.h1581298.Hotel-Information) ![Homewood Suites by Hilton Santa Fe-North](https://images.trvl-media.com/lodging/2000000/1190000/1184600/1184592/97badd85_y.jpg) ### Homewood Suites by Hilton Santa Fe-North 10/10 Excellent "Beautiful room" [](https://expedia.ca/Santa-Fe-Hotels-Homewood-Suites-By-Hilton-Santa-Fe-North.h1184592.Hotel-Information) ![Cities Of Gold Casino](https://images.trvl-media.com/lodging/1000000/130000/120800/120761/4dd42a18_y.jpg) ### Cities Of Gold Casino 10/10 Excellent "Room was comfortable. No noises. Will stay here again " [](https://expedia.ca/Santa-Fe-Hotels-Cities-Of-Gold-Casino.h120761.Hotel-Information) ![Visitors Love the Location, I Love the View!](https://images.trvl-media.com/lodging/28000000/27490000/27489100/27489064/83009d59_y.jpg) ### Visitors Love the Location, I Love the View! 10/10 Excellent "Exceeded my expectations! " [](https://expedia.ca/Santa-Fe-Hotels-Mountain-View-Plus-A-Perfect-Location.h27489064.Hotel-Information) ## More cheap stays in La Mesilla ![Days Inn by Wyndham Espanola](https://images.trvl-media.com/lodging/1000000/20000/19700/19678/c2604840_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Days Inn by Wyndham Espanola 807 S Riverside Dr Espanola NM CA $116 CA $132 total Feb 26 - Feb 27 includes taxes & fees 5.6/10 (588 reviews) [](https://expedia.ca/Santa-Fe-Hotels-Days-Inn-By-Wyndham-Espanola.h19678.Hotel-Information) ![Motel 6 Espanola, NM](https://images.trvl-media.com/lodging/1000000/460000/459600/459557/96f30ddd_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Motel 6 Espanola, NM 811 S Riverside Drive Espanola NM CA $120 CA $136 total Feb 2 - Feb 3 includes taxes & fees 6.4/10 (520 reviews) [](https://expedia.ca/Santa-Fe-Hotels-Motel-6-Espanola.h459557.Hotel-Information) ![Hampton Inn & Suites Los Alamos White Rock](https://images.trvl-media.com/lodging/1000000/910000/908700/908632/4901e7b8_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hampton Inn & Suites Los Alamos White Rock 124 State Hwy 4 Los Alamos NM CA $154 CA $172 total Feb 27 - Feb 28 includes taxes & fees 9/10 Wonderful! (687 reviews) [](https://expedia.ca/Santa-Fe-Hotels-Hampton-Inn-Suites-Los-Alamos-White-Rock.h908632.Hotel-Information) ![Wingate by Wyndham Los Alamos](https://images.trvl-media.com/lodging/1000000/80000/74700/74653/e5b066f8_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Wingate by Wyndham Los Alamos 2455 Trinity Dr Los Alamos NM CA $164 CA $184 total Feb 8 - Feb 9 includes taxes & fees 8/10 Very Good! (583 reviews) [](https://expedia.ca/Santa-Fe-Hotels-Comfort-Inn-Suites-Los-Alamos.h74653.Hotel-Information) ![Holiday Inn Express & Suites Los Alamos Entrada Park by IHG](https://images.trvl-media.com/lodging/3000000/2980000/2976500/2976403/65b278ef_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Holiday Inn Express & Suites Los Alamos Entrada Park by IHG 60 Entrada Dr Los Alamos NM CA $173 CA $194 total Feb 8 - Feb 9 includes taxes & fees 8.8/10 Excellent! (752 reviews) [](https://expedia.ca/Santa-Fe-Hotels-Holiday-Inn-Express-Hotel-Suites-Los-Alamos.h2976403.Hotel-Information) ![Ohkay Casino Resort Hotel](https://images.trvl-media.com/lodging/1000000/460000/458100/458023/5368dc35_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Ohkay Casino Resort Hotel Highway 68 Ohkay Owingeh NM [Get rates](https://expedia.ca/Hotel-Search?startDate=14%2F02%2F2026&endDate=15%2F02%2F2026&selected=458023&PinnedHotelID=458023&HadPinnedHotel=true®ionId=553248635975872198) 7.8/10 Good! (798 reviews) [](https://expedia.ca/Santa-Fe-Hotels-Ohkay-Casino-Resort-Hotel.h458023.Hotel-Information) ## Hotels in La Mesilla with star rating ![5 Star Hotels](https://images.trvl-media.com/lodging/1000000/30000/25600/25559/c6e0103a_z.jpg) 5 Star Hotels 2 properties [](https://expedia.ca/5Star-La-Mesilla-Hotels.s50-0-d553248635975872198.Travel-Guide-Filter-Hotels) ![4 Star Hotels](https://images.trvl-media.com/lodging/1000000/30000/23700/23677/6ae928dd_z.jpg) 4 Star Hotels 8 properties [](https://expedia.ca/4Star-La-Mesilla-Hotels.s40-0-d553248635975872198.Travel-Guide-Filter-Hotels) ![3 Star Hotels](https://images.trvl-media.com/lodging/20000000/19690000/19681400/19681371/84fffc75_z.jpg) 3 Star Hotels 25 properties [](https://expedia.ca/3Star-La-Mesilla-Hotels.s30-0-d553248635975872198.Travel-Guide-Filter-Hotels) ![2 Star Hotels](https://images.trvl-media.com/lodging/92000000/91830000/91828000/91827910/6717a2ac_z.jpg) 2 Star Hotels 30 properties [](https://expedia.ca/2Star-La-Mesilla-Hotels.s20-0-d553248635975872198.Travel-Guide-Filter-Hotels) ## Frequently asked questions ### What is the best area to stay in La Mesilla? > This area is the main draw for visitors and is incredibly walkable. The Historic Plaza is surrounded by adobe buildings housing art galleries, unique shops, and restaurants, all within a short stroll of each other. The Basilica of San Albino, a prominent landmark, is also located on the Plaza. > > > Couples looking for a relaxing and culturally rich getaway will find this area particularly appealing. The evenings around the Plaza can be quite pleasant, with opportunities for dining and enjoying the local atmosphere. Many of the accommodations here are boutique hotels or guesthouses, often with a distinctive Southwestern character. ### When is the best time to go to La Mesilla? > During these periods, the weather is pleasantly mild, with warm days and cooler evenings, making it ideal for exploring the historic town and enjoying outdoor activities. The average daytime temperatures are comfortable, generally ranging from 20°C to 28°C. This avoids the intense heat of summer and the chill of winter. > > > For those interested in local culture and events, autumn is particularly appealing. La Mesilla hosts various festivals and celebrations during this time, often coinciding with the harvest season, which adds a special touch to your visit. The mild weather makes walking around the historic plaza and visiting local shops and restaurants a truly enjoyable experience. ### Can I cancel my hotel reservation on Expedia? ### How can I save on a La Mesilla hotel booking with Expedia? ### How much is the nightly rate at a La Mesilla hotel? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - Vacation Rental - More ways to book - [5 Star Hotels in El Valle de Arroyo Seco ](https://www.expedia.ca/5Star-El-Valle-De-Arroyo-Seco-Hotels.s50-0-d553248634983124254.Travel-Guide-Filter-Hotels) - [Alcalde Hotels ](https://www.expedia.ca/Alcalde-Hotels.d3000421609.Travel-Guide-Hotels) - [Aldea de Santa Fe Hotels ](https://www.expedia.ca/Aldea-De-Santa-Fe-Santa-Fe-Hotels.0-n553248635976480919-0.Travel-Guide-Filter-Hotels) - [Hotels near Bandelier National Monument ](https://www.expedia.ca/Bandelier-National-Monument-Hotels.0-l6093677-0.Travel-Guide-Filter-Hotels) - [Casas de San Juan Hotels ](https://www.expedia.ca/Casas-De-San-Juan-Santa-Fe-Hotels.0-n553248635976481286-0.Travel-Guide-Filter-Hotels) - 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