Isla Grande Vacation Rentals

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
Nov 27 - Nov 29
In two months
Jan 8 - Jan 10
In three months
Feb 5 - Feb 7
In four months
Mar 5 - Mar 7

Our top choices for Isla Grande vacation rentals

A modern house with a covered patio, a lawn, and a view of the surrounding landscape.

1. Lovely Caribbean Apartment with AC + Wifi + BBQ + Beach + Kitchen + Parking

Lovely Caribbean Apartment with AC + Wifi + BBQ + Beach + Kitchen + Parking
Puerto Lindo
The price is CA $318
CA $346 total
includes taxes & fees
Nov 10 - Nov 11
Lovely Caribbean Apartment with AC + Wifi + BBQ + Beach + Kitchen + Parking
A hotel room with a large bed, a second smaller bed, a view of a beach and pool, and a wooden ceiling.

2. Casa frente al mar - turtle cay marina

Casa frente al mar - turtle cay marina
2.5 star property
Nombre de Dios
The price is CA $839
CA $980 total
includes taxes & fees
Nov 15 - Nov 16
Casa frente al mar - turtle cay marina
A covered outdoor dining area with a view of the beach and palm trees.

3. Caribbean getaway: beach cottage just on the sand

Caribbean getaway: beach cottage just on the sand
Palenque
9.2 out of 10, Wonderful, (5 reviews)
"the view is beautiful! We were taken care of well."
United States
Mirelys
The price is CA $342
CA $425 total
includes taxes & fees
Nov 10 - Nov 11
Caribbean getaway: beach cottage just on the sand
A balcony with a hammock, a table, and chairs overlooking a body of water and a distant island.

4. BEAUTIFUL APARTMENT RIGHT BY THE OCEAN

BEAUTIFUL APARTMENT RIGHT BY THE OCEAN
Portobelo
7.0 out of 10, Good, (4 reviews)
"All of it! Gabriel is a marvelous host; absolutely above and beyond. The house is lovely, very unique, and the location, right on the water, superb. We'll be back!"
United States
Rosa M.
The price is CA $221
CA $238 total
includes taxes & fees
Nov 10 - Nov 11
BEAUTIFUL APARTMENT RIGHT BY THE OCEAN
A modern hotel room with a balcony overlooking a pool and the ocean.

5. Bala Bliss Charming 2-bedroom apartment with WiFi, AC in Maria Chiquita

Bala Bliss Charming 2-bedroom apartment with WiFi, AC in Maria Chiquita
Maria Chiquita
6.6 out of 10, (4 reviews)
"Well-appointed apartment, view of the ocean, big pool, fast Internet, attentive security. We had a great time here, thanks!"
United States
Will
The price is CA $151
CA $208 total
includes taxes & fees
Nov 10 - Nov 11
Bala Bliss Charming 2-bedroom apartment with WiFi, AC in Maria Chiquita
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Find vacation rentals that suit your style

Apartment image
Apartments
Apartments
villa image
Villas
Villas

Top Isla Grande Hotel Reviews

A coastal resort with overwater bungalows, a beach, and a pier.
Ordovician Beach Resort

Ordovician Beach Resort

Ordovician Beach Resort
Isla Grande

10/10 Excellent

The resort was outstanding. It exceeded expectations in every way. The service was the best we had in Panama. The cocktails were fun and the food was delicious and they have a vegan menu. We stayed in a king room and it was very private, pristine and well appointed.
Canada
Janet
Reviewed February 21, 2026
Ordovician Beach Resort

Find out more about Isla Grande

Everything you need to know about Isla Grande vacation rentals

Whether you’re excited for the perfect family vacation, a romantic getaway for two, or the ultimate city break, we’ve got the Isla Grande vacation rental for you. At Expedia, you can take your pick from private vacation homes, apartments, cottages, cabins, villas... The list goes on, and on… and on!

There’s just as wide a choice of amenities, too. Maybe you’re dreaming of your own pool, long evenings in a hot tub, or watching the kids laugh through the day at a waterpark. Maybe you just want a quiet retreat in a pet-friendly apartment. Well, we can help you find it. Hunt out the perfect Isla Grande vacation rental for you by simply entering your desired dates. Then check your favorite filters to narrow down your search.

Isla Grande vacation rentals: An excellent choice for every season

Whenever you want to travel, a warm welcome awaits you in Isla Grande. If you’re looking for a little peace, consider booking during the quieter months, such as . For more hustle and bustle, you may prefer to visit in .

Prices vary throughout the year and depends on the property type. Your chosen location and amenities will impact the cost of your trip, too. A Isla Grande vacation rental often works out to be a fantastic, cost-effective option for groups and families visiting for a few nights or longer. And if a hotel room is just too small, get a vacation rental with multiple bedrooms and shared living spaces to kick back in.  The selection of Isla Grande vacation rentals we have selected for you start as low as CA $151 per night. Entering your travel dates in the search wizard you might find even better deals!

How to find incredible deals on Isla Grande rentals

At Expedia, we put the best Isla Grande vacation rentals in one place. All you need to do is take your pick. And as we offer book now, pay later options, as well as free cancellation on some properties, you can plan your trip with total peace of mind. You’ll always find a great deal with Expedia.

To find some top Isla Grande rental deals, enter your travel dates, and sort your search results by price. You can also filter by budget, so you only see accommodation in your ballpark. Next, add any filters you want—and just like that, you’ve built your dream Isla Grande vacation.

If you’re looking for a little inspiration, browse our latest incredible offers, or use the map to view all accommodation in and around Isla Grande. And to unlock even more fantastic deals, bundle your accommodation, flights, and car rental together to save and book with Expedia in complete confidence.

Frequently Asked Questions

Can I find vacation rentals in Isla Grande?

Yes, we have vacation rentals near top sights in Isla Grande, or you can select a more secluded option if you'd like a relaxing place to stay. Isla Grande is known for its parks.

What are some of the best vacation home rentals in Isla Grande?

Caribbean Haven Of Nature 'Preci Beach': You might want to consider this vacation home rental near Isla Grande, which is located on the beach and has an outdoor pool, a fireplace, and a barbecue grill to put you at ease in your new surroundings. It has 4 bedrooms as well as a kitchen with a fridge, a stovetop, and a microwave, so you can cook with friends or family. It offers a balcony, a garden, and a selection of games so you can immerse yourself in your vacation.

How many vacation rentals will I find in Isla Grande?

With 3 Expedia vacation rentals, you're sure to find just the right place for your Isla Grande stay.

What can I see and do in Isla Grande?

While you're exploring the area, Isla Mamey and Blanca Beach are a couple of picturesque spots to get outside and enjoy nature. In the larger area, you’ll find Playa La Angosta and Portobelo National Park.

What are vacation rentals like in Isla Grande?

Vacation rentals are private properties you can stay in for several days or more in Isla Grande. Vacation rentals offer extras such as laundry facilities and kitchens so you'll have everything you need. If you're concerned about a sanitized environment, vacation rentals can provide a sense of seclusion away from shared hotel elevators and busy concierge desks while still allowing you the excitement and enjoyment of travel. You'll also have more space in a vacation rental than in a standard hotel, which makes a vacation rental an attractive choice for family gatherings.