Name: 21C Museum Hotel St Louis
Price range: CA $231
Rating: 9

Your Edwardsville Vacation

When you reserve a vacation package to Edwardsville, all the planning is done before you leave. This means you'll have more time to uncover some of the things that characterize this picturesque city, such as its lively atmosphere, rich history and spectacular views. Make your trip to Edwardsville even more fun by including some sightseeing. Edwardsville Arts Center, Villa Marie Winery & Banquet Center and St. Andrews Episcopal Church are among the most popular attractions you'll want to explore. No matter your travel plans or the size of your budget, organizing your ultimate tailored Edwardsville vacation is a walk in the park with Expedia.

Top Edwardsville Vacation Deals

Price found within the past 48 hours. Click for updated prices.

The Wildwood Hotel

CA $914

per person

Jul 24 - Jul 27

found 1 day ago

Roundtrip flight included

Toronto (YTO) to St. Louis (STL)

9.2/10 Wonderful! (1,627 reviews)

The entire stay was incredible

Reviewed on May 7, 2026

The Cheshire

CA $1,082

per person

Jul 24 - Jul 27

found 1 day ago

Roundtrip flight included

Toronto (YTO) to St. Louis (STL)

8.6/10 Excellent! (1,007 reviews)

The overall upkeep and cleanliness is not great. The breakfast bar was ok but not as well stocked or organized as it used to be and the eggs were always cold. I stayed 4 nights.

Reviewed on May 10, 2026

21C Museum Hotel St Louis

Downtown West

CA $1,330

per person

Jul 24 - Jul 27

found 1 day ago

Roundtrip flight included

Toronto (YTO) to St. Louis (STL)

9/10 Wonderful! (1,797 reviews)

Loved the look of the building and where it was located but the one thing I didn't like was there was no stairs. Everyone had to use the elevator.

Reviewed on May 9, 2026

Osceola

Mount Pleasant

CA $4,639

per person

Jul 24 - Jul 27

found 1 day ago

Roundtrip flight included

Toronto (YTO) to St. Louis (STL)

No reviews

Ameristar Casino Resort and Spa

CA $1,089

per person

Jul 24 - Jul 27

found 1 day ago

Roundtrip flight included

Toronto (YTO) to St. Louis (STL)

8.6/10 Excellent! (1,005 reviews)

The room was very nice and one of the cleanest hotel rooms I’ve stayed in. Very friendly staff and beautiful grounds

Reviewed on May 6, 2026

Ready to book your vacation to Edwardsville?

Choose your dates

Edwardsville Hotel Deals

Hyatt Regency St. Louis at The Arch

315 Chestnut St St. Louis MO

Fully refundableReserve now, pay when you stay

CA $173

CA $204 total

May 25 - May 26

includes taxes & fees

8.6/10 Excellent! (4,068 reviews)

I did not have breakfast

Reviewed on May 10, 2026

Clayton Plaza Hotel & Extended Stay

7750 Carondelet Avenue St. Louis MO

Fully refundableReserve now, pay when you stay

CA $138

CA $161 total

May 17 - May 18

includes taxes & fees

8.8/10 Excellent! (3,203 reviews)

It wasn’t a bad stay it is right next to the jail which is a little sketchy. The room was clean! The AC was super loud when it would turn on and off.

Reviewed on May 10, 2026

21C Museum Hotel St Louis

1528 Locust street St. Louis MO

Fully refundableReserve now, pay when you stay

CA $231

CA $277 total

May 17 - May 18

includes taxes & fees

9/10 Wonderful! (1,825 reviews)

Loved the look of the building and where it was located but the one thing I didn't like was there was no stairs. Everyone had to use the elevator.

Reviewed on May 9, 2026

See all 1,580 properties in Edwardsville

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.