A city square with a fountain, modern buildings, and a historic tower.

Luxury Hotels & Resorts in Missouri

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Top Cities in Missouri

A wide river with a person walking along the shore, boats on the water, and a forested hill in the background.
HotelsHotels

Osage Beach

Osage Beach

Check availability on Missouri Luxury Hotels

This weekend
Oct 2 - Oct 4
Next weekend
Oct 9 - Oct 11

Our top choices for Missouri luxury hotels

A hotel with a swimming pool, lounge chairs, and a courtyard with palm trees.

1. The Royal Sonesta Chase Park Plaza St. Louis

The Royal Sonesta Chase Park Plaza St. Louis
4.5 star property
Central West End
9.2 out of 10, Wonderful, (1,013 reviews)
  • cleanliness
    Indulge in historic elegance at this St. Louis gem featuring 3 restaurants, a spectacular pool area, and luxurious rooms near Forest Park.
The price is CA $211
CA $290 total
includes taxes & fees
Oct 4 - Oct 5
The Royal Sonesta Chase Park Plaza St. Louis
An indoor swimming pool with clear glass walls, metal railings, and a tiled floor.

2. Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa
4.5 star property
St. Charles
8.6 out of 10, Excellent, (1,062 reviews)
  • cleanliness
    Indulge in lavish comfort at this St. Charles retreat featuring a full-service spa, seasonal pool, and 6 exceptional restaurants.
The price is CA $211
CA $270 total
includes taxes & fees
Oct 12 - Oct 13
Ameristar Casino Resort and Spa
An indoor dining area with a long table, chairs, hanging plants, and a view of a brick building through large windows.

3. The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis
5.0 star property
Clayton
9.2 out of 10, Wonderful, (586 reviews)
  • cleanliness
    Ritz-Carlton elegance defines this St. Louis retreat with indulgent spa services and dining excellence.
The price is CA $875
CA $1,022 total
includes taxes & fees
Oct 18 - Oct 19
The Ritz-Carlton, St. Louis
A modern hotel lobby with a glass facade, seating area, and a staircase.

4. Four Seasons Hotel St Louis

Four Seasons Hotel St Louis
5.0 star property
Downtown St. Louis
9.4 out of 10, Exceptional, (1,002 reviews)
  • cleanliness
    Lavish riverside luxury awaits at the Four Seasons St. Louis with spa indulgences and poolside bliss.
The price is CA $530
CA $620 total
includes taxes & fees
Oct 4 - Oct 5
Four Seasons Hotel St Louis

5. Moberly Inn and Suites

Moberly Inn and Suites
2.5 star property
Moberly
5.0 out of 10, (172 reviews)
Moberly Inn and Suites
The Clayton Plaza Hotel sign with a stone wall and plants in front.

6. Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay
3.5 star property
Clayton
8.8 out of 10, Excellent, (3,442 reviews)
  • cleanliness
    Luxurious getaway near St. Louis features pillowtop beds, tranquil sauna, and heated indoor pool.
The price is CA $131
CA $153 total
includes taxes & fees
Oct 11 - Oct 12
Clayton Plaza Hotel & Extended Stay
A modern hotel room with a large bed, a nightstand, a mirror, and a view of the city through arched windows.

7. The Westin St. Louis

The Westin St. Louis
4.5 star property
Downtown St. Louis
8.6 out of 10, Excellent, (1,011 reviews)
  • cleanliness
    Opulent downtown retreat with pillowtop beds, soaking tubs, and Italian dining moments from Busch Stadium.
The price is CA $185
CA $217 total
includes taxes & fees
Oct 18 - Oct 19
The Westin St. Louis

8. Cliffs Resort Table Rock Lake

Cliffs Resort Table Rock Lake
4.0 star property
Branson
9.2 out of 10, Wonderful, (967 reviews)
  • cleanliness
    Lakeside luxury resort offers private balconies, seasonal outdoor pool, and hot tub near Silver Dollar City.
Cliffs Resort Table Rock Lake
A modern hotel with a prominent 'ARGOSY' sign, featuring a glass facade and classical architectural elements like columns and arches.

9. Argosy Casino & Hotel

Argosy Casino & Hotel
4.0 star property
Riverside
8.4 out of 10, Very good, (1,576 reviews)
  • cleanliness
    Plush pillowtop beds and premium amenities await at this riverside retreat with 6 restaurants and casino.
The price is CA $138
CA $170 total
includes taxes & fees
Oct 25 - Oct 26
Argosy Casino & Hotel
A rooftop terrace with wicker furniture, offering a city view.

10. Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch
3.0 star property
Downtown St. Louis
9.6 out of 10, Exceptional, (3,780 reviews)
  • cleanliness
    Enjoy downtown St. Louis luxury with rooftop views, steakhouse dining, and hot tub relaxation.
The price is CA $191
CA $223 total
includes taxes & fees
Oct 3 - Oct 4
Drury Plaza Hotel St. Louis at the Arch
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Missouri Hotel Reviews

Thousand Hills Resort Hotel

Thousand Hills Resort Hotel

10/10 Excellent
"Love this place!!"
Dawn 1-night trip
Posted less than an hour ago
Thousand Hills Resort Hotel

Explore a world of travel with Expedia