Clayton Vacation Packages

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Your Clayton Vacation

Lock in a Clayton vacation package and prepare to experience all this lively city has to offer. Consider staying in the neighborhood of Soulard, which is good for distilleries and craft breweries, bars and pubs and markets. Fill your spare time with tours of St. Louis Zoo, St. Louis Art Museum and Cathedral Basilica of St. Louis, some of the attractions you just have to see during a trip to Clayton. A couple of clicks is all it takes to put together the perfect Clayton vacation on Expedia.

Where to stay in Clayton

Find the best Clayton areas and neighborhoods for the activities you enjoy most. Learn more about Clayton
A public park with a fountain featuring bronze sculptures of mythological figures, surrounded by trees and a large building in the background.

Downtown St. Louis

3 out of top 10 points of interest in this area

Ample dining options, fascinating museums, and great live music are just a few top things to explore in Downtown St. Louis. A visit to Gateway Arch or Busch Stadium might round out your trip, and you can jump aboard the metro at 8th and Pine Station or Stadium Station to get around town.

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A street with parked cars, a building with a sign reading "Brennan's", and a tree in front.

Central West End

Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.

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An ornate hall with arched ceilings and intricate patterns.

Downtown West

2 out of top 10 points of interest in this area

If you're spending some time in Downtown West, St. Louis Union Station and St. Louis Aquarium at Union Station are top sights worth seeing.

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A lake with a curved shoreline, a parking lot, and a forested area with autumn foliage.

Creve Coeur

Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.

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A wooden bridge with metal trusses, surrounded by trees.

St. Charles Historic District

Discover a national historic district featuring over 100 buildings, including the First Missouri State Capitol and St. Charles Odd Fellows Hall, showcasing architectural styles like Greek Revival and Italianate.

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Clayton Hotel Deals

Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

7750 Carondelet Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
CA $128
CA $150 total
Sep 6 - Sep 7
includes taxes & fees
8.8/10 Excellent! (3,375 reviews)
"Always clean, staff friendly, breakfast is good."

Reviewed on Aug 24, 2026

Clayton Plaza Hotel & Extended Stay
Le Méridien St. Louis Clayton

Le Méridien St. Louis Clayton

7730 Bonhomme Ave St. Louis MO
Fully refundableReserve now, pay when you stay
CA $209
CA $246 total
Aug 28 - Aug 29
includes taxes & fees
Le Méridien St. Louis Clayton
AC Hotel St. Louis Clayton

AC Hotel St. Louis Clayton

227 South Central Ave St. Louis MO
Fully refundableReserve now, pay when you stay
CA $167
CA $195 total
Sep 13 - Sep 14
includes taxes & fees
9.2/10 Wonderful! (375 reviews)
"The property was clean and staff was courteous and the location was great"

Reviewed on Aug 24, 2026

AC Hotel St. Louis Clayton
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

How much does a Clayton vacation package cost?
From as little as , you can tailor make your Clayton vacation package. Simply combine hotels, flights and rental cars and be rewarded with discounts.
How do I get a cheap travel package to Clayton?
By bundling. Flights, hotels and rental cars — combine whatever you need into a Clayton vacation package to save a pile of cash. Score even more discounts when you include extras such as tours or experiences to your booking. But that's not the only good part. You have the freedom to customize your trip your own way. We offer over 550 air carriers and 1,000,000 properties across the globe, so that everyone has a chance to travel and fulfill those vacation dreams.
Where should I stay in Clayton?
With so much to discover in Clayton, it'd be convenient for you to secure a room in a hotel close to its attractions. St. Louis Zoo, Washington University in St. Louis and Forest Park are some good ones to put on your must-see list.
What are the top hotels in Clayton?
If it's your first time staying in Clayton, secure a room at King Bed, Comfy Environment, Cozy Space or Homewood Suites by Hilton St Louis - Galleria. Both hotels offer friendly service and are top options with many savvy travelers.
How far in advance should I book my Clayton vacation?
It's difficult to pick the ideal time for airfares, but we usually say the earlier, the better. Most international flights on Expedia become available to compare up to 12 months in advance. If you're unable to do so, don't despair. Low prices appear from time to time just weeks before departure dates.
What does an Expedia Clayton travel package include?
With Expedia, you can select any combination of flights, hotels and car rentals to build your perfect Clayton package. Once you've made your booking, you can add on the fun things like sightseeing tours and activities. Remember, the more you bundle, the more dollars you'll save!
What should I know before booking a Clayton travel package?
Whether it's relaxation or adventure you're seeking, a Clayton vacation package lets you organize your escape your way. Plus, you'll get access to great discounts when you combine your hotel with your flights and rental car. The more you bundle, the more you'll save!
Can I choose my airline with a Clayton Expedia vacation package?
You sure can. We have more than 550 partner airlines worldwide, so fly with the carrier that's a good fit for your needs.
If I'm not able to travel, can I cancel my Clayton vacation package?
We get that the universe can throw the odd curveball. If you've booked a Clayton vacation package and need to amend or cancel it, we can help. We suggest looking up our Customer Service Portal first for information. But generally, if you've booked your package in the last 24 hours, you may be able to amend or cancel your itinerary for free. If it's been more than 24 hours, your hotel, airline or car rental company may charge a fee.

Stay near popular Clayton attractions

Chapel of St. Timothy And St. Titus, Concordia Seminary

Find out about the history of St. Louis when you take a trip to Chapel of St. Timothy And St. Titus, Concordia Seminary. Experience the area's acclaimed art scene or attend a sporting event.
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Shaw Park Tennis Center

Catch an event at Shaw Park Tennis Center during your trip to St. Louis. Check out the shops and top-notch restaurants in this family-friendly area.
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Things to do

St. Louis: Gateway Ghouls and Hauntings Walking Tour

St. Louis Ghost Tour: Sinister Sins & Shadows

CA $34
per adult
100% of travellers recommend
St. Louis Ghost Tour: Sinister Sins & Shadows
The Gateway Arch National Park & Museum

StL's Signature "Sights and Bites" - Private Tour in St. Louis

CA $246
per adult
StL's Signature "Sights and Bites" - Private Tour in St. Louis
Lemp Haunted Neighborhood Walking Tour

Lemp Haunted Neighborhood Walking Tour

CA $35
per adult
84% of travellers recommend
Lemp Haunted Neighborhood Walking Tour
See all activities in St. Louis
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.