Clayton Vacation Packages

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Your Clayton Vacation

Lock in a Clayton vacation package and prepare to experience all this lively city has to offer. Consider staying in the neighborhood of Soulard, which is good for distilleries and craft breweries, bars and pubs and markets. Fill your spare time with tours of St. Louis Zoo, St. Louis Art Museum and Cathedral Basilica of St. Louis, some of the attractions you just have to see during a trip to Clayton. A couple of clicks is all it takes to put together the perfect Clayton vacation on Expedia.

Top Holiday Package Deals in Clayton

Price found within the past 48 hours. Click for updated prices.
The Wildwood Hotel

The Wildwood Hotel

CA $1,296
per person
Dec 15 - Dec 19
found 1 day ago
Roundtrip flight included
Edmonton (YEG) to St. Louis (STL)
9.2/10 Wonderful! (1,679 reviews)
Clean, quiet, great continental breakfast, and close to several places to eat.

Reviewed on Oct 14, 2026

Residence Inn by Marriott St Louis Downtown

Residence Inn by Marriott St Louis Downtown

Midtown
CA $1,536
per person
Nov 25 - Dec 2
found 4 hours ago
Roundtrip non-stop flight included
Edmonton (YEG) to St. Louis (STL)
7.6/10 Good! (1,000 reviews)
Crowne Plaza St. Louis Airport by IHG

Crowne Plaza St. Louis Airport by IHG

CA $1,437
per person
Nov 25 - Dec 2
found 4 hours ago
Roundtrip non-stop flight included
Edmonton (YEG) to St. Louis (STL)
8/10 Very good! (1,001 reviews)
The Cheshire

The Cheshire

CA $1,502
per person
Dec 15 - Dec 19
found 1 day ago
Roundtrip flight included
Edmonton (YEG) to St. Louis (STL)
8.8/10 Excellent! (1,011 reviews)
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

CA $1,573
per person
Dec 15 - Dec 19
found 1 day ago
Roundtrip flight included
Edmonton (YEG) to St. Louis (STL)
8.6/10 Excellent! (1,062 reviews)
Need a Microwave in Room More Lighting in Room Breakfast Option

Reviewed on Oct 14, 2026

Where to stay in Clayton

Find the best Clayton areas and neighborhoods for the activities you enjoy most. Learn more about Clayton
A public park with a fountain featuring bronze sculptures of mythological figures, surrounded by trees and a large building in the background.

Downtown St. Louis

4 out of top 10 points of interest in this area

Ample dining options, fascinating museums, and great live music are just a few top things to explore in Downtown St. Louis. A visit to Old Courthouse or Gateway Arch National Park might round out your trip, and you can jump aboard the metro at 8th and Pine Station or Stadium Station to get around town.

Find hotels in Downtown St. Louis
A street with parked cars, a building with a sign reading "Brennan's", and a tree in front.

Central West End

Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.

Find hotels in Central West End
A wooden bridge with metal trusses, surrounded by trees.

St. Charles Historic District

Discover a national historic district featuring over 100 buildings, including the First Missouri State Capitol and St. Charles Odd Fellows Hall, showcasing architectural styles like Greek Revival and Italianate.

Find hotels in St. Charles Historic District
A lake with a curved shoreline, a parking lot, and a forested area with autumn foliage.

Creve Coeur

Creve Coeur is known for its abundant dining options, and you can plan a trip to Creve Coeur Golf Club and Skip Viragh Center for the Arts while you're in town.

Find hotels in Creve Coeur
An ornate hall with arched ceilings and intricate patterns.

Downtown West

2 out of top 10 points of interest in this area

If you're spending some time in Downtown West, St. Louis Union Station and St. Louis Aquarium at Union Station are top sights worth seeing.

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Clayton Hotel Deals

Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

7750 Carondelet Avenue St. Louis MO
Fully refundableReserve now, pay when you stay
CA $127
CA $148 total
Oct 25 - Oct 26
includes taxes & fees
8.8/10 Excellent! (3,476 reviews)
"Great location and place to stay"

Reviewed on Oct 15, 2026

Clayton Plaza Hotel & Extended Stay
Le Méridien St. Louis Clayton

Le Méridien St. Louis Clayton

7730 Bonhomme Ave St. Louis MO
Fully refundableReserve now, pay when you stay
CA $216
CA $255 total
Oct 25 - Oct 26
includes taxes & fees
Le Méridien St. Louis Clayton
AC Hotel St. Louis Clayton

AC Hotel St. Louis Clayton

227 South Central Ave St. Louis MO
Fully refundableReserve now, pay when you stay
CA $183
CA $213 total
Oct 18 - Oct 19
includes taxes & fees
AC Hotel St. Louis Clayton
See all 1,984 properties in Clayton
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Vacations
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Frequently asked questions

How much does a Clayton vacation package cost?
From as little as CA $1,296, you can tailor make your Clayton vacation package. Simply combine hotels, flights and rental cars and be rewarded with discounts.
How do I get a cheap travel package to Clayton?
By bundling. Flights, hotels and rental cars — combine whatever you need into a Clayton vacation package to save a pile of cash. Score even more discounts when you include extras such as tours or experiences to your booking. But that's not the only good part. You have the freedom to customize your trip your own way. We offer over 550 air carriers and 1,000,000 properties across the globe, so that everyone has a chance to travel and fulfill those vacation dreams.
Where should I stay in Clayton?
With so much to discover in Clayton, it'd be convenient for you to secure a room in a hotel close to its attractions. St. Louis Zoo, Washington University in St. Louis and Forest Park are some good ones to put on your must-see list.
What are the top hotels in Clayton?
If it's your first time staying in Clayton, secure a room at King Bed, Comfy Environment, Cozy Space or Homewood Suites by Hilton St Louis - Galleria. Both hotels offer friendly service and are top options with many savvy travelers.
How far in advance should I book my Clayton vacation?
It's difficult to pick the ideal time for airfares, but we usually say the earlier, the better. Most international flights on Expedia become available to compare up to 12 months in advance. If you're unable to do so, don't despair. Low prices appear from time to time just weeks before departure dates.
What does an Expedia Clayton travel package include?
With Expedia, you can select any combination of flights, hotels and car rentals to build your perfect Clayton package. Once you've made your booking, you can add on the fun things like sightseeing tours and activities. Remember, the more you bundle, the more dollars you'll save!
What should I know before booking a Clayton travel package?
Whether it's relaxation or adventure you're seeking, a Clayton vacation package lets you organize your escape your way. Plus, you'll get access to great discounts when you combine your hotel with your flights and rental car. The more you bundle, the more you'll save!
Can I choose my airline with a Clayton Expedia vacation package?
You sure can. We have more than 550 partner airlines worldwide, so fly with the carrier that's a good fit for your needs.
If I'm not able to travel, can I cancel my Clayton vacation package?
We get that the universe can throw the odd curveball. If you've booked a Clayton vacation package and need to amend or cancel it, we can help. We suggest looking up our Customer Service Portal first for information. But generally, if you've booked your package in the last 24 hours, you may be able to amend or cancel your itinerary for free. If it's been more than 24 hours, your hotel, airline or car rental company may charge a fee.

Stay near popular Clayton attractions

Chapel of St. Timothy And St. Titus, Concordia Seminary

Find out about the history of St. Louis when you take a trip to Chapel of St. Timothy And St. Titus, Concordia Seminary. Experience the area's great live music or attend a sporting event.
See properties

Shaw Park Tennis Center

Catch an event at Shaw Park Tennis Center during your trip to St. Louis. Check out the shops and top-notch restaurants in this family-friendly area.
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Things to do

St. Louis: Gateway Ghouls and Hauntings Walking Tour

St. Louis Ghost Tour: Sinister Sins & Shadows

CA $34
per adult
100% of travellers recommend
St. Louis Ghost Tour: Sinister Sins & Shadows
The Gateway Arch National Park & Museum

StL's Signature "Sights and Bites" - Private Tour in St. Louis

CA $245
per adult
StL's Signature "Sights and Bites" - Private Tour in St. Louis
Lemp Haunted Neighborhood Walking Tour

Lemp Haunted Neighborhood Walking Tour

CA $35
per adult
84% of travellers recommend
Lemp Haunted Neighborhood Walking Tour
See all activities in St. Louis
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.