A red train on tracks, palm trees, and modern buildings.

Central San Diego Vacation Rentals

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
In two months
In three months
In four months

Our top choices for Central San Diego vacation rentals

1. City24 Hotel Little Italy Mission Hills

City24 Hotel Little Italy Mission Hills
4.5 star property
Middletown
9.6 out of 10, Exceptional, (242 reviews)
"Location is great because it is so close to the airport and you won’t even be able to hear the planes. The room is so roomy and has every utility you need !"
United States
Stephanie
The price is CA $164
CA $233 total
includes taxes & fees
Dec 2 - Dec 3
City24 Hotel Little Italy Mission Hills

2. Uptown Inn by Vantaggio - Limited Service Apart-Hotel

Uptown Inn by Vantaggio - Limited Service Apart-Hotel
2.5 star property
Hillcrest
8.4 out of 10, Very good, (514 reviews)
"Front desk service was amazing and love the central location to all the LGBTQ bars and restaurants."
United States
Victor
The price is CA $132
CA $149 total
includes taxes & fees
Nov 9 - Nov 10
Uptown Inn by Vantaggio - Limited Service Apart-Hotel

3. San Diego Centralized Retreat

San Diego Centralized Retreat
Birdland
10.0 out of 10, Exceptional, (2 reviews)
"A beautiful apartment! Definitely going to reserve that location for more days next time. Kitchen is great and loved having upstairs-downstairs for separate spaces when one of us was working"
United States
Margaret C.
The price is CA $97
CA $266 total
includes taxes & fees
Nov 18 - Nov 19
San Diego Centralized Retreat

4. Private 1-bedroom suite close to it all in San Diego

Private 1-bedroom suite close to it all in San Diego
Middletown
The price is CA $141
CA $176 total
includes taxes & fees
Nov 8 - Nov 9
Private 1-bedroom suite close to it all in San Diego

5. Modern Hideaway in North Park - 3941

Modern Hideaway in North Park - 3941
North Park
10.0 out of 10, Exceptional, (3 reviews)
"Such a great experience here! The host was very communicative and attentive. Spot was clean and perfect for our weekend getaway. There are plenty of bars and cool shops within walking distance. We will definitely be booking the same spot on our next trip!"
United States
Madison S.
The price is CA $114
CA $329 total
includes taxes & fees
Nov 16 - Nov 17
Modern Hideaway in North Park - 3941

6. Modern 1BR/1BA Getaway in Central San Diego – Walk to Zoo, Balboa Park & Dining

Modern 1BR/1BA Getaway in Central San Diego – Walk to Zoo, Balboa Park & Dining
University City
10.0 out of 10, Exceptional, (1 review)
"Nice spacious 1 bed room apartment in very nice area "
United States
ILL W.
The price is CA $252
CA $423 total
includes taxes & fees
Dec 2 - Dec 3
Modern 1BR/1BA Getaway in Central San Diego – Walk to Zoo, Balboa Park & Dining

7. Adorable 1 bedroom house 8 min from La Jolla!

Adorable 1 bedroom house 8 min from La Jolla!
Bay Ho
10.0 out of 10, Exceptional, (65 reviews)
"Clean well equipped place. Great communication and flexible hosts. Would stay again when back in town."
United States
Keith L.
The price is CA $282
CA $442 total
includes taxes & fees
Nov 13 - Nov 14
Adorable 1 bedroom house 8 min from La Jolla!

8. Cozy 2-Bedroom Cottage Near Balboa Park

Cozy 2-Bedroom Cottage Near Balboa Park
Mid-City
8.8 out of 10, Excellent, (13 reviews)
"Overall it was a great place to stay."
United States
Cristal M.
The price is CA $181
CA $404 total
includes taxes & fees
Dec 2 - Dec 3
Cozy 2-Bedroom Cottage Near Balboa Park

9. Secluded, Charming and Unique! Spacious Apartment EXCELLENT Central Location

Secluded, Charming and Unique! Spacious Apartment EXCELLENT Central Location
Mission Valley
9.0 out of 10, Wonderful, (67 reviews)
"Very big and nice place. We really enjoyed it"
United States
Jose U.
The price is CA $167
CA $439 total
includes taxes & fees
Nov 9 - Nov 10
Secluded, Charming and Unique! Spacious Apartment EXCELLENT Central Location

10. 1BR King Bed Apartment with AC in sunny San Diego

1BR King Bed Apartment with AC in sunny San Diego
Mid-City
The price is CA $144
CA $377 total
includes taxes & fees
Nov 30 - Dec 1
1BR King Bed Apartment with AC in sunny San Diego

11. Luxury San Diego 1BR with Premium Conveniences

Luxury San Diego 1BR with Premium Conveniences
Mid-City
The price is CA $165
CA $387 total
includes taxes & fees
Nov 17 - Nov 18
Luxury San Diego 1BR with Premium Conveniences

12. Charming 1-bedroom house in Beautiful San Diego with WiFi, AC

Charming 1-bedroom house in Beautiful San Diego with WiFi, AC
Mid-City
10.0 out of 10, Exceptional, (2 reviews)
"Our stay was excellent. We enjoyed the space. Used TV, sofa and bed… nothing else. Quiet and easy access to property. "
United States
Socorro C.
The price is CA $198
CA $409 total
includes taxes & fees
Nov 9 - Nov 10
Charming 1-bedroom house in Beautiful San Diego with WiFi, AC

13. Close to Airport | Walk to Restaurants

Close to Airport | Walk to Restaurants
Middletown
8.8 out of 10, Excellent, (3 reviews)
"Exactly as advertised. Door to bathroom being shutters was an interesting decision but apart from that it was clean and in good condition and generally a good place to stay. Great location, close to a row of restaurants and can see the taxiways for San Diego international."
United States
Yan W.
The price is CA $124
CA $452 total
includes taxes & fees
Nov 25 - Nov 26
Close to Airport | Walk to Restaurants

14. Prime North Park Stay: Walkable 95/100 + Parking!

Prime North Park Stay: Walkable 95/100 + Parking!
North Park
9.6 out of 10, Exceptional, (10 reviews)
"Great value and location for our short stay in San diego. Only 10 minutes from the zoo, and plenty of food options nearby! Would definitely stay here again!"
United States
Jon G.
The price is CA $130
CA $411 total
includes taxes & fees
Nov 11 - Nov 12
Prime North Park Stay: Walkable 95/100 + Parking!

15. Relaxing Retreat in North Park – 3943

Relaxing Retreat in North Park – 3943
North Park
8.0 out of 10, Very good, (3 reviews)
"Host is very responsive which I always appreciate. The place is very practical and the location is great."
United States
Andrea S.
The price is CA $114
CA $329 total
includes taxes & fees
Nov 19 - Nov 20
Relaxing Retreat in North Park – 3943

16. Cozy caravan in San Diego with AC & Wifi

Cozy caravan in San Diego with AC & Wifi
Miramar
2.0 out of 10, (1 review)
The price is CA $157
CA $253 total
includes taxes & fees
Nov 8 - Nov 9
Cozy caravan in San Diego with AC & Wifi

17. Stylish & Comfy Gem: Walk To Everything ~ Parking!

Stylish & Comfy Gem: Walk To Everything ~ Parking!
North Park
9.4 out of 10, Exceptional, (3 reviews)
"Absolutely wonderful first experience with Vrbo. Rebecca was always available & is definitely a top notch host!Lovely home & hope to be back on San Diego soon &!would definitely recommend those property to everyone."
United States
Martha M.
The price is CA $137
CA $418 total
includes taxes & fees
Nov 8 - Nov 9
Stylish & Comfy Gem: Walk To Everything ~ Parking!

18. Adorable 1 bd cottage, heart of Old Town-- WE LOVE PETS! Insta @oldtownvacay

Adorable 1 bd cottage, heart of Old Town-- WE LOVE PETS! Insta @oldtownvacay
Old Town San Diego
10.0 out of 10, Exceptional, (309 reviews)
"Very clean place, the host Joan was amazing. Very kind to give a little tour of the place and let me know where to park. Easy to communicate with. Place was very quiet and I appreciated that and the location was great. Right in Old Town pretty much which was fun to experience! I definitely recommend this place to anyone who is looking to stay in SD!"
United States
Paulina
The price is CA $223
CA $279 total
includes taxes & fees
Nov 9 - Nov 10
Adorable 1 bd cottage, heart of Old Town-- WE LOVE PETS! Insta @oldtownvacay

19. 2 bd w/ yard in heart of Old Town-- WE LOVE PETS! Check our Insta @oldtownvacay

2 bd w/ yard in heart of Old Town-- WE LOVE PETS! Check our Insta @oldtownvacay
Old Town San Diego
10.0 out of 10, Exceptional, (238 reviews)
"We loved being within walking distance of historic Old Town. The safe parking gave us total peace of mind, and having so many restaurants right around the corner was so convenient. Great place for a family of 5!"
Australia
Young ran
The price is CA $234
CA $295 total
includes taxes & fees
Nov 17 - Nov 18
2 bd w/ yard in heart of Old Town-- WE LOVE PETS! Check our Insta @oldtownvacay

20. New Modern Condo in The Hills! Sleeps 2-4 - Only 5 min to Little Italy

New Modern Condo in The Hills! Sleeps 2-4 - Only 5 min to Little Italy
Middletown
6.2 out of 10, (20 reviews)
"Perfect location if you are traveling and wanting to see San Diego!"
United States
Jeanette P.
The price is CA $108
CA $218 total
includes taxes & fees
Nov 9 - Nov 10
New Modern Condo in The Hills! Sleeps 2-4 - Only 5 min to Little Italy
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Top Central San Diego Hotel Reviews

Find out more about Central San Diego

You always said you would go on a dream vacation someday. Now, someday is here. But you don’t just want to dip your toe into the trip of a lifetime, you want to cannon ball into the deep end. Go ahead, unplug and unwind in style. When you book one of our vacation rentals, the ordinary is in the rearview. Instead of sharing your vacation with hundreds of hotel guests, you get to take advantage of all the space at your private apartment or room. You also get to enjoy all the amenities of a private residence for a truly unique and memorable stay. Why don’t you take off your shoes and settle in for a while? Your vacation just got upgraded.

As much as you love your short-term rental, it’s always good to get out and explore to soak up . Live like a local: Eat regional food, cheer on the home team, and visit the best cultural attractions in town. No matter the season, there is always something going on in . Seeing all the best attractions is bound to make you fall in love with Central San Diego. Who knows, you may even be tempted to extend your vacation rental stay. There’s a reason home rentals are so popular here—after a long day of exploration, going back to your very own living room to stretch out is a dream come true.

It’s your escape so why share it? You deserve your own slice of paradise. Booking your vacation rental on Expedia is simple and safe. Just pick your dates to search for the perfect property and book securely. We let you contact the property owner directly to make any special arrangements. All that’s left to do is show up with bells on and have a memorable vacation. With all the amenities available in short-term rentals, that won’t be hard to do.

Explore a world of travel with Expedia