Title: 5 Stars Hotels in Defiance, St. Louis from CA $175 - Find Cheap Defiance Hotels With 5 Stars | Expedia.ca [Defiance Travel Guide](https://expedia.ca/Defiance.dx6353634)[Hotels in Defiance](https://expedia.ca/Defiance-Hotels.d6353634.Travel-Guide-Hotels)[Vacation Rentals in Defiance](https://expedia.ca/Defiance-Vacation-Rentals.d6353634.Travel-Guide-VacationRentals)[Flights to Defiance](https://expedia.ca/Cheap-Flights-To-Defiance.d6353634.Travel-Guide-Flights)[Defiance Car Rentals](https://expedia.ca/Car-Rentals-In-Defiance.d6353634.Car-Rental-Guide)[Defiance Vacation Packages](https://expedia.ca/Defiance.d6353634.Destination-Travel-Guides) ![A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri](https://images.trvl-media.com/place/6353634/33b2b915-0d1b-4946-ae10-3b89e88434a7.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # 5 Stars Hotels in Defiance, St. Louis from CA $175 - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Defiance 5 Star Hotels Tonight [Dec 18 - Dec 19](https://www.expedia.ca/Hotel-Search?regionId=6353634&startDate=2025-12-18&endDate=2025-12-19&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Dec 19 - Dec 20](https://www.expedia.ca/Hotel-Search?regionId=6353634&startDate=2025-12-19&endDate=2025-12-20&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [Dec 19 - Dec 21](https://www.expedia.ca/Hotel-Search?regionId=6353634&startDate=2025-12-19&endDate=2025-12-21&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Dec 26 - Dec 28](https://www.expedia.ca/Hotel-Search?regionId=6353634&startDate=2025-12-26&endDate=2025-12-28&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Defiance-Hotels.s50-0-d6353634.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Defiance-Hotels.s50-0-d6353634.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Defiance. ![Hilton St. Louis Frontenac](https://images.trvl-media.com/lodging/1000000/10000/2100/2054/68baaab6_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hilton St. Louis Frontenac 1335 S Lindbergh Blvd Frontenac MO CA $179 CA $209 total Jan 4 - Jan 5, 2026 includes taxes & fees 8.6/10 Excellent! (1,000 reviews) [](https://expedia.ca/St-Louis-Hotels-Hilton-St-Louis-Frontenac.h2054.Hotel-Information) ![Ameristar Casino Resort and Spa](https://images.trvl-media.com/lodging/2000000/1880000/1873300/1873292/c42cf5fe_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Ameristar Casino Resort and Spa 1 Ameristar Blvd St. Charles MO [Get rates](https://expedia.ca/Hotel-Search?startDate=01%2F01%2F2026&endDate=02%2F01%2F2026&selected=1873292&PinnedHotelID=1873292&HadPinnedHotel=true®ionId=6353634) 8.4/10 Very Good! (1,004 reviews) [](https://expedia.ca/St-Louis-Hotels-Ameristar-Casino-Resort-And-Spa.h1873292.Hotel-Information) ![DoubleTree by Hilton St. Louis - Westport](https://images.trvl-media.com/lodging/1000000/20000/19400/19336/67aabb2b_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### DoubleTree by Hilton St. Louis - Westport 1973 Craigshire Rd Maryland Heights MO CA $151 CA $175 total Dec 28 - Dec 29 includes taxes & fees 8/10 Very Good! (1,005 reviews) [](https://expedia.ca/St-Louis-Hotels-DoubleTree-By-Hilton-Hotel-St-Louis-Westport.h19336.Hotel-Information) Still don't see what you're looking for? [See all properties in Defiance.](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=19%2F12%2F2025&endDate=20%2F12%2F2025®ionId=6353634&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=19%2F12%2F2025&endDate=20%2F12%2F2025®ionId=6353634&star=50&star=50&amenities=POOL)[Spa](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=19%2F12%2F2025&endDate=20%2F12%2F2025®ionId=6353634&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=19%2F12%2F2025&endDate=20%2F12%2F2025®ionId=6353634&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=19%2F12%2F2025&endDate=20%2F12%2F2025®ionId=6353634&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.ca/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=19%2F12%2F2025&endDate=20%2F12%2F2025®ionId=6353634&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Learn more about Defiance Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside. [See all hotels in Defiance](https://www.expedia.ca/Hotel-Search?startDate=2026-01-01&endDate=2026-01-02&adults=2®ionId=6353634) ![A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri](https://images.trvl-media.com/place/6353634/33b2b915-0d1b-4946-ae10-3b89e88434a7.jpg?impolicy=fcrop&w=900&h=600&p=1&q=high) ## Top Defiance Hotel Reviews ## Find out more about Defiance ## Five Star Hotels in Defiance There's nothing wrong with enjoying the finer things in life. Indulge yourself on your next leisure time. After all, this is one of the Top 10 locations in Expedia's portfolio. You'll join the multitudes of vacationers who have made Defiance so fashionable in the last year. We should also mention, the hotels in this area receive outstanding marks for guest services, so you know you'll be looked after during your getaway. You deserve the great vacation you're dreaming about. Book one of Expedia's luxurious 5-star hotels in Defiance and get ready to be pampered like never before. #### Get a Great Deal on 5-Star Hotels in Defiance Don't be afraid to live the high life while you're on vacation, along with pristine rooms. Excellent customer care, spacious rooms, and fabulous spa offerings are all on offer. We have a huge number of hotels in the region, and all of them offer outstanding amenities. Besides that, you'll find that these hotels are kept in fantastic condition and provide a fine place to kick back after your daily adventures. What kind of amenities will make your stay a wonderful one? A concierge to help you plan every detail of your day? A Swedish massage to help your cares fall away? Fluffy down pillows, piping hot coffees, and even space for your family pet in some cases...these hotels have it all. Want to see for yourself? Then explore the 31,943 reviews various guests have left on Expedia and get to know these places. Can't wait to get outside? We've got you covered. You'll find lots of attractions to see in a sprawling city like this one, like visiting art galleries and taking in live performances. Say hi to the locals—they're sure to have advice on what kind of excitement you can find in town. #### Make Your Escape to Defiance The results are in, and Defiance 5-star hotels are the place to be when you book your next vacation. Many visitors recommend a trip to this location, so don't wait any longer. This is a great time to find 5-star hotel deals in Defiance! Don't put off your dream vacation any longer. Choose one of the 5-star hotels in Defiance today and settle down in the lap of luxury tomorrow. ## Frequently asked questions ### How much does it cost to stay in a 5-star hotel in Defiance? > - Search for the lowest price per night from CA $175 ### What makes a hotel 5 stars in Defiance? ### Are there any 5-star all-inclusive resorts in Defiance? ## Explore a world of travel with Expedia - Lodging - Flights - Packages - Cars - More ways to book - [1 Star Hotels in Cuba ](https://www.expedia.ca/1Star-Cuba-Hotels.s10-0-d6499.Travel-Guide-Filter-Hotels) - [1 Star Hotels in Mackenzie ](https://www.expedia.ca/1Star-Mackenzie-St-Louis-Hotels.s10-n553248634983448776-0.Travel-Guide-Filter-Hotels) - [1 Star Hotels in Maryland Heights ](https://www.expedia.ca/1Star-Maryland-Heights-Hotels.s10-0-d7347.Travel-Guide-Filter-Hotels) - [2 Star Hotels in Ladue ](https://www.expedia.ca/2Star-Ladue-St-Louis-Hotels.s20-n3000445131-0.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Cuba ](https://www.expedia.ca/3Star-Cuba-Hotels.s30-0-d6499.Travel-Guide-Filter-Hotels) - 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