A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

5 Stars Hotels in Defiance, St. Louis from CA $203

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Defiance 5 Star Hotels

Next weekend
Aug 7 - Aug 9
In two weeks
Aug 14 - Aug 16
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Defiance.
Hilton St. Louis Frontenac

Hilton St. Louis Frontenac

1335 S Lindbergh Blvd Frontenac MO
The price is CA $206 per night from Aug 16 to Aug 17
CA $206
CA $240 total
Aug 16 - Aug 17
includes taxes & fees
Still don't see what you're looking for?
See all properties in Defiance.
You can also use these popular filters to refine your search.
PoolSpaHot tubBreakfast includedWaterpark
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighbouring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

See all hotels in Defiance
A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

Top Defiance Hotel Reviews

Find out more about Defiance

Five Star Hotels in Defiance

There's nothing wrong with enjoying the finer things in life. Indulge yourself on your next leisure time. After all, this is one of the Top 10 locations in Expedia's portfolio. You'll join the multitudes of vacationers who have made Defiance so fashionable in the last year. We should also mention, the hotels in this area receive outstanding marks for guest services, so you know you'll be looked after during your getaway. You deserve the great vacation you're dreaming about. Book one of Expedia's luxurious 5-star hotels in Defiance and get ready to be pampered like never before.

Get a Great Deal on 5-Star Hotels in Defiance

Don't be afraid to live the high life while you're on vacation, along with pristine rooms. Excellent customer care, spacious rooms, and fabulous spa offerings are all on offer. We have a huge number of hotels in the region, and all of them offer outstanding amenities. Besides that, you'll find that these hotels are kept in fantastic condition and provide a fine place to kick back after your daily adventures. What kind of amenities will make your stay a wonderful one? A concierge to help you plan every detail of your day? A Swedish massage to help your cares fall away? Fluffy down pillows, piping hot coffees, and even space for your family pet in some cases...these hotels have it all. Want to see for yourself? Then explore the 31,943 reviews various guests have left on Expedia and get to know these places.

Can't wait to get outside? We've got you covered. You'll find lots of attractions to see in a sprawling city like this one, like visiting art galleries and taking in live performances. Say hi to the locals—they're sure to have advice on what kind of excitement you can find in town.

Make Your Escape to Defiance

The results are in, and Defiance 5-star hotels are the place to be when you book your next vacation. Many visitors recommend a trip to this location, so don't wait any longer. This is a great time to find 5-star hotel deals in Defiance! Don't put off your dream vacation any longer. Choose one of the 5-star hotels in Defiance today and settle down in the lap of luxury tomorrow.

Frequently asked questions

How much does it cost to stay in a 5-star hotel in Defiance?
You'll find a range of pricing options for 5-star hotels in Defiance on Expedia. How much you'll pay will depend on when you travel, trip length and other factors. Compare available accommodations for your chosen dates and make use of our pricing and other filters to discover the perfect high-end stay.

  • Search for the lowest price per night from CA $203

What makes a hotel 5 stars in Defiance?
In Defiance, a hotel is required to offer a certain amount of upscale conveniences to be designated 5 stars. These can include saunas and spas, on-site gyms, gourmet restaurants, luxury bathroom products, premium bedding and more. What also sets 5-star hotels apart is their guest-centric standard of service. You can look forward to things like concierge services, in-room massages and nightly turn-down services. Some may even offer thoughtful touches like welcome gifts.
Are there any 5-star all-inclusive resorts in Defiance?
Our filter tool is the easiest way to find exactly what you want. Select "5-star" and "All inclusive" to see the most upscale resorts in Defiance where your meals, lodging, entertainment and activities are included in the price. At these retreats, your trip is absolute indulgence from the moment you arrive.

Explore a world of travel with Expedia