The illuminated Gateway Arch at night with a city skyline in the background.

5 Stars Hotels in Clayton, St. Louis from CA $197

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Check availability on Clayton 5 Star Hotels

This weekend
Oct 2 - Oct 4
Next weekend
Oct 9 - Oct 11

Our top choices for Clayton 5-star hotels

A modern hotel lobby with a glass facade, seating area, and a staircase.

1. Four Seasons Hotel St Louis

Four Seasons Hotel St Louis
5.0 star property
Downtown St. Louis
9.4 out of 10, Exceptional, (1,000 reviews)
"Exceptional, from check-in to check-out!"
United States
Nicole
The price is CA $532
CA $622 total
includes taxes & fees
Oct 7 - Oct 8
Four Seasons Hotel St Louis
An indoor dining area with a long table, chairs, hanging plants, and a view of a brick building through large windows.

2. The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis
5.0 star property
Clayton
9.2 out of 10, Wonderful, (586 reviews)
"Incredible stay! Loved the room, the staff were great, and the amenities were amazing! Definitely recommend staying here!"
United States
Kennedy
The price is CA $824
CA $962 total
includes taxes & fees
Nov 1 - Nov 2
The Ritz-Carlton, St. Louis
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Clayton.
Renaissance St. Louis Airport Hotel

Renaissance St. Louis Airport Hotel

9801 Natural Bridge Road St. Louis MO
The price is CA $168 per night from Oct 15 to Oct 16
CA $168
CA $197 total
Oct 15 - Oct 16
includes taxes & fees
8.4/10 Very good! (1,173 reviews)
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Clayton Hotel Reviews

Frequently asked questions

What are the best 5-star hotels in Clayton?
Offering first-rate amenities and guest services, Expedia travellers rate The Ritz-Carlton, St. Louis as one of the best 5-star hotels in Clayton. You'll be in the lap of luxury from the minute you arrive.
How much does it cost to stay in a 5-star hotel in Clayton?
There are a variety of pricing options for 5-star hotels in Clayton on Expedia. How much you'll pay will depend on your travel dates, length of your trip and other factors. Compare all of the available accommodations for your desired dates and make use of our pricing and other filters to land the perfect luxury stay.

  • Search for the lowest price per night from CA $197

What makes a hotel 5 stars in Clayton?
In Clayton, a hotel must provide a certain number of top-notch amenities to be designated 5 stars. These may include gourmet restaurants, saunas and spas, on-site gyms, luxury toiletries, premium bedding and more. What also sets 5-star hotels apart is their guest-centric service. You can look forward to things like nightly turn-down services, in-room massages and concierge services. Some may also offer thoughtful touches like welcome gifts.

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