A cityscape with a park, a river, and a large building with a red roof.

4 Stars Hotels in Texas Medical Center, Houston from CA $177

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Check availability on Texas Medical Center 4 Star Hotels

Our top choices for Texas Medical Center 4-star hotels

A spacious living area with a dining table, chairs, and a chandelier.

1. Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District
4.5 star property
South Central Houston
9.2 out of 10, Wonderful, (1,007 reviews)
"Great place!"
United States
Madiha
The price is CA $321
CA $441 total
includes taxes & fees
Oct 18 - Oct 19
Hotel Zaza Houston Museum District
A dining table with white tablecloth, two plates of food, two wine glasses, and a vase with white flowers.

2. Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston
4.0 star property
Downtown Houston
8.6 out of 10, Excellent, (4,529 reviews)
"Great stay"
Australia
Jonathon
The price is CA $151
CA $177 total
includes taxes & fees
Oct 19 - Oct 20
Club Quarters Hotel Downtown, Houston
A rooftop patio with outdoor seating, fire pits, and a view of the cityscape.

3. Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
4.5 star property
Texas Medical Center
8.4 out of 10, Very good, (2,193 reviews)
"Room was great, staff was helpful"
United States
Marvin
The price is CA $156
CA $185 total
includes taxes & fees
Oct 18 - Oct 19
Hilton Houston Plaza/Medical Center
A high-rise hotel with a modern design, featuring a central courtyard with palm trees and a swimming pool.

4. DoubleTree by Hilton Hotel & Suites Houston by the Galleria

DoubleTree by Hilton Hotel & Suites Houston by the Galleria
4.0 star property
Greater Uptown
8.4 out of 10, Very good, (4,567 reviews)
"The staff was very friendly and accommodating."
United States
Gena
The price is CA $180
CA $212 total
includes taxes & fees
Oct 22 - Oct 23
DoubleTree by Hilton Hotel & Suites Houston by the Galleria
A modern hotel interior with a central spiral staircase, large glass windows, and a buffet area with various food items.

5. The Royal Sonesta Houston Galleria

The Royal Sonesta Houston Galleria
4.0 star property
The Galleria
8.8 out of 10, Excellent, (2,300 reviews)
"Enjoyed our stay"
United States
Thomas
The price is CA $183
CA $214 total
includes taxes & fees
Oct 15 - Oct 16
The Royal Sonesta Houston Galleria
A modern cityscape with high-rise buildings, including a curved skyscraper with illuminated windows and a rectangular building with a grid-like facade.

6. The Whitehall Houston

The Whitehall Houston
4.0 star property
Downtown Houston
8.6 out of 10, Excellent, (2,451 reviews)
"Great staff, great hotel"
United States
Abraham
The price is CA $188
CA $220 total
includes taxes & fees
Oct 22 - Oct 23
The Whitehall Houston
A spacious lobby with plush seating, a marble coffee table, and a grand chandelier.

7. Blossom Hotel Houston, Curio Collection by Hilton

Blossom Hotel Houston, Curio Collection by Hilton
4.0 star property
Texas Medical Center
9.0 out of 10, Wonderful, (3,834 reviews)
"Excellent service and beautiful hotel"
United States
Jennifer
The price is CA $221
CA $259 total
includes taxes & fees
Oct 25 - Oct 26
Blossom Hotel Houston, Curio Collection by Hilton
A modern bar area with multiple shelves of liquor bottles, a central bar counter, and seating with tables and chairs.

8. The Chifley Houston, Tapestry Collection by Hilton

The Chifley Houston, Tapestry Collection by Hilton
4.0 star property
The Galleria
9.2 out of 10, Wonderful, (1,392 reviews)
"Everything was great. I’ll definitely be staying here again"
United States
Silas
The price is CA $198
CA $231 total
includes taxes & fees
Oct 24 - Oct 25
The Chifley Houston, Tapestry Collection by Hilton
A modern hotel with a prominent 'DoubleTree by Hilton' sign, surrounded by well-maintained greenery and a busy road with traffic.

9. DoubleTree by Hilton Hotel Houston - Greenway Plaza

DoubleTree by Hilton Hotel Houston - Greenway Plaza
4.0 star property
Greenway Plaza-Upper Kirby
8.4 out of 10, Very good, (1,925 reviews)
"The staff was very courteous and made our stay very welcoming ."
United States
Yvonne
The price is CA $156
CA $183 total
includes taxes & fees
Oct 17 - Oct 18
DoubleTree by Hilton Hotel Houston - Greenway Plaza
A modern high-rise building with a glass facade, multiple floors, and a rooftop parking area.

10. The Laura Hotel, Houston Downtown, Autograph Collection

The Laura Hotel, Houston Downtown, Autograph Collection
4.5 star property
Downtown Houston
9.2 out of 10, Wonderful, (1,258 reviews)
"Great hotel"
United States
Charles
The price is CA $284
CA $378 total
includes taxes & fees
Oct 23 - Oct 24
The Laura Hotel, Houston Downtown, Autograph Collection
A hotel entrance with a sign reading "MORAN" and a neon sign for "radiom ilano".

11. The Moran CITYCENTRE

The Moran CITYCENTRE
4.0 star property
Memorial
9.2 out of 10, Wonderful, (1,206 reviews)
"Great property and location"
United States
sophia
The price is CA $283
CA $374 total
includes taxes & fees
Oct 17 - Oct 18
The Moran CITYCENTRE
A modern living room with a grey sofa, white cushions, a marble coffee table, a vase with white flowers, and a hanging light fixture.

12. Rusk House Serviced Apartments

Rusk House Serviced Apartments
4.5 star property
Downtown Houston
9.2 out of 10, Wonderful, (537 reviews)
"Love this hotel!"
United States
Lee
The price is CA $221
CA $259 total
includes taxes & fees
Oct 19 - Oct 20
Rusk House Serviced Apartments
A rooftop pool area with lounge chairs and a view of a tall building at night.

13. The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District
4.0 star property
Texas Medical Center
9.2 out of 10, Wonderful, (1,238 reviews)
"Great place"
United States
Matthew
The price is CA $229
CA $285 total
includes taxes & fees
Oct 25 - Oct 26
The Westin Houston Medical Center/Museum District
An aerial view of a hotel with a distinctive pool area featuring a unique wavy design.

14. Marriott Marquis Houston

Marriott Marquis Houston
4.0 star property
Downtown Houston
9.0 out of 10, Wonderful, (1,323 reviews)
"Place was awesome"
United States
Krissy
The price is CA $405
CA $521 total
includes taxes & fees
Oct 30 - Oct 31
Marriott Marquis Houston
A modern living room with a large flat-screen TV, comfortable seating, and a city view through large windows.

15. The Westin Galleria Houston

The Westin Galleria Houston
4.5 star property
The Galleria
9.2 out of 10, Wonderful, (1,005 reviews)
"The spot for restful accommodations, great shopping & good eating!!"
United States
Sara
The price is CA $295
CA $392 total
includes taxes & fees
Oct 16 - Oct 17
The Westin Galleria Houston
A modern bar area with a central island, bar stools, and a glass display case filled with bottles.

16. Omni Houston Hotel

Omni Houston Hotel
4.0 star property
Greater Uptown
9.2 out of 10, Wonderful, (1,003 reviews)
"Great location"
United States
Thomas
The price is CA $193
CA $229 total
includes taxes & fees
Oct 29 - Oct 30
Omni Houston Hotel
A rooftop pool area with lounge chairs, a fire feature, and a neon sign for "RANCH WATER".

17. Hyatt Regency Houston/Galleria

Hyatt Regency Houston/Galleria
4.0 star property
Greater Uptown
9.2 out of 10, Wonderful, (1,541 reviews)
"Super clean spacious rooms. Friendly staff, great beds!"
United States
Diego
The price is CA $222
CA $262 total
includes taxes & fees
Nov 7 - Nov 8
Hyatt Regency Houston/Galleria
A swimming pool with a sunlit water surface and a cityscape in the background.

18. Hilton Americas-Houston

Hilton Americas-Houston
4.0 star property
Downtown Houston
9.4 out of 10, Exceptional, (1,872 reviews)
"Delicious breakfast and very clean hotel."
United States
Kalynn
The price is CA $268
CA $316 total
includes taxes & fees
Oct 31 - Nov 1
Hilton Americas-Houston
An indoor swimming pool with a glass-domed structure, surrounded by blue-tinted walls and a stone-tiled floor.

19. Grand Tuscany Hotel

Grand Tuscany Hotel
4.0 star property
Fairbanks
8.4 out of 10, Very good, (370 reviews)
"I truly enjoyed my stay can’t wait to come back"
United States
Jazmyne Nicole
The price is CA $159
CA $186 total
includes taxes & fees
Oct 18 - Oct 19
Grand Tuscany Hotel
A grand staircase with multiple steps, black railings, and lit candles on each step.

20. Magnolia Hotel Houston, A Tribute Portfolio Hotel

Magnolia Hotel Houston, A Tribute Portfolio Hotel
4.0 star property
Downtown Houston
9.2 out of 10, Wonderful, (1,684 reviews)
"Location and friendly staff."
United States
Hans
The price is CA $191
CA $228 total
includes taxes & fees
Oct 25 - Oct 26
Magnolia Hotel Houston, A Tribute Portfolio Hotel
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Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Texas Medical Center.
The Post Oak Hotel at Uptown Houston

The Post Oak Hotel at Uptown Houston

1600 West Loop South Houston TX
The price is CA $798 per night from Nov 5 to Nov 6
CA $798
CA $934 total
Nov 5 - Nov 6
includes taxes & fees
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Texas Medical Center Hotel Reviews

Club Quarters Hotel Downtown, Houston

Club Quarters Hotel Downtown, Houston

10/10 Excellent
"We went for a last minute trip. We have stayed at this hotel a few times and absolutely love it. The front staff is helpful. The rooms are clean and comfortable. They have a place for you to fill your water bottles and get delicious coffee. There are plenty of places near the hotel to eat. There is a restaurant in the hotel, but I don’t prefer it. The service is sub par and the meal is not as exquisite as what you can find around the hotel. There is valet parking and the team out there has always been amazing.All in all, great place to stay. Oh, and your fur baby is welcome."
Angela 1-night trip
Posted 1 hour ago
Club Quarters Hotel Downtown, Houston

Frequently asked questions

What are the best 4-star hotels in Texas Medical Centre?
Blossom Hotel Houston and DoubleTree by Hilton Houston Medical Centre Hotel & Suites are two highly recommended picks situated around Texas Medical Centre. Both have a 4-star rating and promise luxury comfort alongside an unbeatable guest experience. Check in to the first and enjoy access to a rooftop terrace and designer toiletries. The second comes with a swimming pool and pool sun loungers, among other conveniences.
How much does it cost to stay in a 4-star hotel in Texas Medical Centre?
With Expedia's filter tool, scoring a fabulous deal on a 4-star hotel in Texas Medical Centre just got simpler. Start by keying in your chosen arrival date and length of your trip. Then sort the results by price and choose a hotel that best suits your style and budget.

  • Search for the lowest price from CA $406

What's the difference between 5-star and 4-star hotels in Texas Medical Centre?
If you choose to vacation at a 4-star hotel in Texas Medical Centre, you'll usually find plenty of conveniences to keep you comfortable, such as a pool, restaurant and gym. You can experience excellent service and upmarket accommodations. Choose a 5-star hotel and you'll get a few extra bells and whistles — think concierge assistance, on-site spas and indulgent turndown services. You'll most likely get extra amenities and premium services at a 5-star getaway, but both are fabulous options for luxury travellers.

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