Beginning of main content
Trip Type
Flight 1
Flight 2
Flight 3
Flight 4
Flight 5

Search 321,000 hotels worldwide.

Get the price guarantee available for your trip.

No Expedia cancellation fee to change or cancel almost any hotel reservation.


Featured St. Louis 4 stars Hotels

See all 265 Hotels in St. Louis
Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

315 Chestnut St, St. Louis
4.0 out of 5.0
4.3 out of 5 (1,640 reviews)
ComfortableVery much enjoyed my stay at this hotel. The staff was welcoming and helpful. The room was extremely comfortable with a lovely bathroom. Got hooked up with a view of the city. Woke up to a great sunrise.
  23 Sep 2017

C$170

C$170
HoteLumiere at the Arch

HoteLumiere at the Arch

999 N. 2nd St., St. Louis
4.0 out of 5.0
2.8 out of 5 (95 reviews)
Had never stayed here before - Got a good deal on a room - was nice to be so close to the casino - would definitely stay here again!
  20 Sep 2017

C$148

C$148
The Hotel Majestic St. Louis

The Hotel Majestic St. Louis

1019 Pine St, St. Louis
4.0 out of 5.0
3.9 out of 5 (475 reviews)
Great Place to Stay! This hotel is true to it's name; very majestic! The decor is beautiful and most important of all I found it to be very clean. The staff was very attentive, the breakfast was very good. One day they made a breakfast potato casserole: it had onions, red & green bell peppers with cheese! Absolutely ...
  25 Sep 2017

C$137

C$137
The Westin St. Louis

The Westin St. Louis

811 Spruce St, St. Louis
4.5 out of 5.0
4.6 out of 5 (910 reviews)
Westin I liked the location and how clean the room was.
  22 Sep 2017

C$230

C$230
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

1 Ameristar Blvd, St. Charles
4.5 out of 5.0
4.5 out of 5 (303 reviews)
Nice hotel with easy access.Hotel stay was great, check in took a little longer than I wanted but it was ok. The rooms could use some softer pillows. Nice and clean rooms.
  25 Sep 2017

C$163

C$163
Moonrise Hotel

Moonrise Hotel

6177 Delmar Blvd, St. Louis
4.0 out of 5.0
4.7 out of 5 (540 reviews)
Superior experience . Everyone from the Valet to the front desk were over the top nice and helpful. Don't usually see 24 hour room service and a full service gym with iced towels along with a roof top club open till 2am even on week nights .My new place to stay in St Louis!
  23 Sep 2017

C$210

C$210
Marriott St. Louis Grand

Marriott St. Louis Grand

800 Washington Ave, St. Louis
4.0 out of 5.0
4.0 out of 5 (91 reviews)
Great LocationWe were there for a convention ... the location is great!! Right across the street from the convention center, lots of great restaurants, shopping and easy on/off rides to see the sites. During our stay there was a lot of protesting causing most of the restaurants to close ... the hotel staff did ...
  22 Sep 2017

C$149

C$149
River City Casino & Hotel

River City Casino & Hotel

777 River City Casino Blvd, St. Louis
4.0 out of 5.0
4.5 out of 5 (253 reviews)
The staff is what impressed me the most. They were extremely friendly in every area from check-in, gift shop, valet, casino, resturaunts and check out.
  25 Sep 2017

C$154

C$154
Hilton St. Louis Downtown at the Arch

Hilton St. Louis Downtown at the Arch

400 Olive St, St. Louis
4.0 out of 5.0
4.3 out of 5 (308 reviews)
Nice hotel. Close to dome of the americas. Friendly staff. Nice rooms. Comfortable beds. The good was also hood in the hotel. Not many restaurants downtown to choose from.
  25 Sep 2017

C$184

C$184
The Chase Park Plaza Royal Sonesta St. Louis

The Chase Park Plaza Royal Sonesta St. Louis

212 N Kingshighway, St. Louis
4.5 out of 5.0
4.4 out of 5 (619 reviews)
Central LocationGreeted with kindness from the moment we arrived. The valet staff remembered us from our last stay and immediately accommodated our TEXAS sized vehicle. Check in staff were warm and friendly; bellman attentive. Visited two of the restaurants - easy to adjust menu to fit requests. Excellent food & ...
  11 Sep 2017

C$243

C$243
Map

If you’re looking for a spot with great rates, just-for-you amenities, and a world of luxurious little perks, the best 4 stars hotels in St. Louis are calling your name. Known for providing first-rate service in amazing locations, each of the St. Louis 4 stars hotels lets discerning travelers bask in an unforgettable experience.

Kick back in your spacious room. Relax in the lobby’s sumptuous surroundings. Start the day with delicious room service, and then use the complimentary body care items to freshen up before you head out for the day.

It’s all waiting for you at the top four star hotels in St. Louis. Plus, when you book with Expedia.ca, you might find a cheap deal on a 4 stars hotel in St. Louis, Missouri, neighbourhoods near the most popular attractions, so you can see the sights and bask in the discounts all in one trip. Whether you’re planning a romantic retreat or simply want to experience everything the area has to offer, the top St. Louis hotels with 4 stars provide everything you need to unwind in style.

Recently booked St. Louis hotels

Hyatt Regency St. Louis at The Arch
4.0 out of 5.0
Last booking: 12 minutes ago
The Chase Park Plaza
4.5 out of 5.0
Last booking: 30 minutes ago