Title: Top 10 4 Star Hotels in Santee : Find a Four Star Hotel in Santee | Expedia.ca [Santee Travel Guide](https://expedia.ca/Santee.dx9953)[Hotels in Santee](https://expedia.ca/Santee-Hotels.d9953.Travel-Guide-Hotels)[Vacation Rentals in Santee](https://expedia.ca/Santee-Vacation-Rentals.d9953.Travel-Guide-VacationRentals)[Flights to Santee](https://expedia.ca/Cheap-Flights-To-Santee.d9953.Travel-Guide-Flights)[Santee Car Rentals](https://expedia.ca/Car-Rentals-In-Santee.d9953.Car-Rental-Guide)[Santee Vacation Packages](https://expedia.ca/Santee.d9953.Destination-Travel-Guides) ![](https://mediaim.expedia.com/destination/1/271db9a9db85f6f3488271b71d2f238f.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # 4 Star Hotels in Santee ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__calendar_shield.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Sign in to save 10% or more on thousands of hotels [Sign in](https://www.expedia.ca/login) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Santee 4 Star Hotels Tonight [Oct 12 - Oct 13](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2025-10-12&endDate=2025-10-13&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [Oct 13 - Oct 14](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2025-10-13&endDate=2025-10-14&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [Oct 17 - Oct 19](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2025-10-17&endDate=2025-10-19&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [Oct 24 - Oct 26](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2025-10-24&endDate=2025-10-26&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Santee 4 Star Hotels ![Exterior](https://images.trvl-media.com/lodging/44000000/44000000/43992600/43992569/bfd80ad8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Balcony](https://images.trvl-media.com/lodging/44000000/44000000/43992600/43992569/17d2f4e1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/44000000/44000000/43992600/43992569/cf50a6e8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Flat-screen TV, DVD player](https://images.trvl-media.com/lodging/44000000/44000000/43992600/43992569/d97d64ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Wyndham Vacation Resorts Lake Marion Santee 9.2/10 Wonderful (20) "Friendly staff. Excellent accomodations. Peaceful and beautiful vacation." [](https://www.expedia.ca/Orangeburg-Hotels-Wyndham-Vacation-Resorts-Lake-Marion.h43992569.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.ca/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F4Star-Santee-Hotels.s40-0-d9953.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.ca/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F4Star-Santee-Hotels.s40-0-d9953.Travel-Guide-Filter-Hotels) ## Learn more about Santee Nestled along Lake Marion, this charming town offers prime fishing and boating opportunities for outdoor enthusiasts. Visitors can tee off at Santee National Golf Club or explore nearby Santee State Park's hiking trails and campgrounds. [See all hotels in Santee](https://www.expedia.ca/Hotel-Search?startDate=2025-10-26&endDate=2025-10-27&adults=2®ionId=9953) ![](https://mediaim.expedia.com/destination/1/271db9a9db85f6f3488271b71d2f238f.jpg?impolicy=fcrop&w=900&h=280&p=1&q=high) ## Top Santee Hotel Reviews ![Wyndham Vacation Resorts Lake Marion](//images.trvl-media.com/lodging/44000000/44000000/43992600/43992569/bfd80ad8_y.jpg) ### Wyndham Vacation Resorts Lake Marion 10/10 Excellent "Friendly staff. Excellent accomodations. Peaceful and beautiful vacation." [](https://expedia.ca/Orangeburg-Hotels-Wyndham-Vacation-Resorts-Lake-Marion.h43992569.Hotel-Information) ## Find out more about Santee If you’re looking for a spot with great rates, just-for-you amenities, and a world of luxurious little perks, the best 4 Stars hotels in Santee are calling your name. Known for providing first-rate service in amazing locations, each of the Santee 4 Stars hotels lets discerning travelers bask in an unforgettable experience. Kick back in your spacious room. Relax in the lobby’s sumptuous surroundings. Start the day with delicious room service, and then use the complimentary body care items to freshen up before you head out for the day. It’s all waiting for you at the top four star hotels in Santee. Plus, when you book with Expedia.ca, you might find a cheap deal on a 4 Stars hotel in Santee, South Carolina, neighbourhoods near the most popular attractions, so you can see the sights and bask in the discounts all in one trip. Whether you’re planning a romantic retreat or simply want to experience everything the area has to offer, the top Santee hotels with 4 Stars provide everything you need to unwind in style. ## Frequently asked questions ### How much does it cost to stay in a 4-star hotel in Santee? > With Expedia's filter tool, bagging a fabulous deal on a 4-star hotel in Santee just got simpler. Start by keying in your chosen arrival date and length of your break. Then list the results by price and pick the option that best fits your style and budget. > > > > - Search for the lowest price ### What's the difference between 5-star and 4-star hotels in Santee? > If you choose to vacation at a 4-star hotel in Santee, you'll usually find loads of conveniences to keep you comfortable, such as a restaurant, pool and gym. You can experience high-quality service and upscale accommodations. Choose a 5-star hotel and you'll get a few more perks — think around-the-clock concierge, on-site spas and opulent turndown services. You'll most likely get extra amenities and exclusive services at a 5-star stay, but both are superb options for luxury guests. ### Does Santee have any 4-star all-inclusive resorts? > Use our "All inclusive" filter to search for your next dream escape in Santee where everything is taken care of, from your accommodations to your food, activities and entertainment. 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