Title: Top 10 4 Star Hotels in Santee : Find a Four Star Hotel in Santee | Expedia.ca

[Santee Travel Guide](https://expedia.ca/Santee.dx9953)[Hotels in Santee](https://expedia.ca/Santee-Hotels.d9953.Travel-Guide-Hotels)[Vacation Rentals in Santee](https://expedia.ca/Santee-Vacation-Rentals.d9953.Travel-Guide-VacationRentals)[Flights to Santee](https://expedia.ca/Cheap-Flights-To-Santee.d9953.Travel-Guide-Flights)[Santee Car Rentals](https://expedia.ca/Car-Rentals-In-Santee.d9953.Car-Rental-Guide)[Santee Vacation Packages](https://expedia.ca/Santee.d9953.Destination-Travel-Guides)

![Cypress Trees with Spanish Moss growing on them. In Lake Marion at Santee State Park, Santee, Orangeburg County, South Carolina](https://images.trvl-media.com/place/9953/cd2a687d-b68e-41e2-9556-82dcf249bc2d.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

![](https://images.trvl-media.com/place/9953/cd2a687d-b68e-41e2-9556-82dcf249bc2d.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

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## Check availability on Santee 4 Star Hotels

Tonight

[Jan 31 - Feb 1](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2026-01-31&endDate=2026-02-01&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[Feb 1 - Feb 2](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2026-02-01&endDate=2026-02-02&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[Feb 6 - Feb 8](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2026-02-06&endDate=2026-02-08&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two weeks

[Feb 13 - Feb 15](https://www.expedia.ca/Hotel-Search?regionId=9953&startDate=2026-02-13&endDate=2026-02-15&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Santee 4-star hotels

![Exterior](https://images.trvl-media.com/lodging/44000000/44000000/43992600/43992569/bfd80ad8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Flat-screen TV, DVD player](https://images.trvl-media.com/lodging/44000000/44000000/43992600/43992569/d97d64ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool](https://images.trvl-media.com/lodging/44000000/44000000/43992600/43992569/cf50a6e8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/44000000/44000000/43992600/43992569/3622349b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Wyndham Vacation Resorts Lake Marion

[](https://www.expedia.ca/Orangeburg-Hotels-Wyndham-Vacation-Resorts-Lake-Marion.h43992569.Hotel-Information)

Santee

9.4/10

Exceptional

(23 reviews)

"Excellent "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

John

[](https://www.expedia.ca/Orangeburg-Hotels-Wyndham-Vacation-Resorts-Lake-Marion.h43992569.Hotel-Information)

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## Learn more about Santee

Nestled along Lake Marion, this charming town offers prime fishing and boating opportunities for outdoor enthusiasts. Visitors can tee off at Santee National Golf Club or explore nearby Santee State Park's hiking trails and campgrounds.

[See all hotels in Santee](https://www.expedia.ca/Hotel-Search?startDate=2026-02-14&endDate=2026-02-15&adults=2&regionId=9953)

![Cypress Trees with Spanish Moss growing on them. In Lake Marion at Santee State Park, Santee, Orangeburg County, South Carolina](https://images.trvl-media.com/place/9953/cd2a687d-b68e-41e2-9556-82dcf249bc2d.jpg?impolicy=fcrop&w=899&h=634&p=1&q=high)

## Top Santee Hotel Reviews

![Wyndham Vacation Resorts Lake Marion](https://images.trvl-media.com/lodging/44000000/44000000/43992600/43992569/bfd80ad8_y.jpg)

### Wyndham Vacation Resorts Lake Marion

10/10 Excellent

"The room was spacious and very clean. The front desk person was friendly and they did try to sell my fiance some things, but he wasn't interested. Once we kindly said no they understood and wasn't being pushy which we greatly appreciated. My family and I will stay here each time. My fiance and I dropped my niece off to college which is about 30 min away. She was able to have her own room and bathroom in addition to us. It was very safe and comfortable around the resort."

[](https://expedia.ca/Orangeburg-Hotels-Wyndham-Vacation-Resorts-Lake-Marion.h43992569.Hotel-Information)

## Find out more about Santee

If you’re looking for a spot with great rates, just-for-you amenities, and a world of luxurious little perks, the best 4 Stars hotels in Santee are calling your name. Known for providing first-rate service in amazing locations, each of the Santee 4 Stars hotels lets discerning travelers bask in an unforgettable experience.

Kick back in your spacious room. Relax in the lobby’s sumptuous surroundings. Start the day with delicious room service, and then use the complimentary body care items to freshen up before you head out for the day.

It’s all waiting for you at the top four star hotels in Santee. Plus, when you book with Expedia.ca, you might find a cheap deal on a 4 Stars hotel in Santee, South Carolina, neighbourhoods near the most popular attractions, so you can see the sights and bask in the discounts all in one trip. Whether you’re planning a romantic retreat or simply want to experience everything the area has to offer, the top Santee hotels with 4 Stars provide everything you need to unwind in style.

## Frequently asked questions

### How much does it cost to stay in a 4-star hotel in Santee?

> - Search for the lowest price

### What's the difference between 5-star and 4-star hotels in Santee?

### Does Santee have any 4-star all-inclusive resorts?

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