Photo by RVOutlawz

4 Stars Hotels in Lignumvitae Key Botanical State Park, Islamorada from CA $218

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Nov 10 - Nov 11
Tomorrow
Nov 11 - Nov 12
This weekend
Nov 13 - Nov 15
Next weekend
Nov 20 - Nov 22

Our top choices for Lignumvitae Key Botanical State Park 4-star hotels

A pool area with lounge chairs and umbrellas, surrounded by palm trees.

1. Hawks Cay Resort

Hawks Cay Resort
4.0 star property
Marathon
8.2 out of 10, Very good, (1,004 reviews)
"Lots of amenities and great staff will be coming back to this location"
United States
Holly
The price is CA $308
CA $475 total
includes taxes & fees
Nov 16 - Nov 17
Hawks Cay Resort
A beach with lounge chairs and a pier extending into the water.

2. Baker's Cay Resort Key Largo, Curio Collection by Hilton

Baker's Cay Resort Key Largo, Curio Collection by Hilton
4.0 star property
Key Largo
8.8 out of 10, Excellent, (1,202 reviews)
"Very relaxing the beach was nice and pretty from that side of the property clean rooms staff was nice and helpful they made the stay enjoyable"
United States
Damion
The price is CA $372
CA $496 total
includes taxes & fees
Nov 30 - Dec 1
Baker's Cay Resort Key Largo, Curio Collection by Hilton
An aerial view of a resort with two swimming pools surrounded by palm trees and sun loungers.

3. Islander Resort

Islander Resort
4.0 star property
Matecumbe
9.4 out of 10, Exceptional, (1,163 reviews)
"The entire resort was clean, staff very friendly, bar and restaurant and pools were fabulous! Would definitely stay there again!"
United States
DEBORAH
The price is CA $253
CA $388 total
includes taxes & fees
Nov 15 - Nov 16
Islander Resort
A wooden deck with two lounge chairs, a table with two glasses of champagne and red roses, and a view of the beach and ocean.

4. Amara Cay Resort

Amara Cay Resort
4.0 star property
Matecumbe
8.8 out of 10, Excellent, (1,337 reviews)
"Great location as well."
United States
Amir
The price is CA $233
CA $365 total
includes taxes & fees
Nov 17 - Nov 18
Amara Cay Resort
A balcony with wicker chairs, a small table with drinks, and a view of the beach and ocean.

5. Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort

Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort
4.0 star property
Islamorada
9.0 out of 10, Wonderful, (311 reviews)
"Great place to stay!"
United States
Liosbel
The price is CA $293
CA $432 total
includes taxes & fees
Nov 30 - Dec 1
Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort
An aerial view of a resort with a large pool, palm trees, and a beach.

6. Playa Largo Resort & Spa, Autograph Collection

Playa Largo Resort & Spa, Autograph Collection
4.5 star property
Rock Harbor
9.0 out of 10, Wonderful, (1,004 reviews)
"Everything was amazing!!! Beautiful hotel and great location."
United States
Jorge
The price is CA $371
CA $496 total
includes taxes & fees
Nov 30 - Dec 1
Playa Largo Resort & Spa, Autograph Collection
A row of beachside cottages with colorful exteriors, each with a beach chair and umbrella.

7. La Siesta Resort & Villas

La Siesta Resort & Villas
4.0 star property
Matecumbe
8.6 out of 10, Excellent, (1,000 reviews)
"Great place to stay!"
United States
Brianne
The price is CA $218
CA $349 total
includes taxes & fees
Nov 16 - Nov 17
La Siesta Resort & Villas
A wooden deck with a pool and chairs overlooking a beach with palm trees.

8. Grassy Flats Resort & Beach Club

Grassy Flats Resort & Beach Club
4.0 star property
Marathon
9.4 out of 10, Exceptional, (505 reviews)
"Loved everything about this place!"
United States
Amanda
The price is CA $260
CA $360 total
includes taxes & fees
Dec 9 - Dec 10
Grassy Flats Resort & Beach Club
A resort pool with palm trees and lounge chairs, surrounded by a beachfront.

9. Villas At Hawks Cay Resort

Villas At Hawks Cay Resort
4.0 star property
Marathon
8.0 out of 10, Very good, (234 reviews)
"Na"
United States
Kushla
The price is CA $648
CA $816 total
includes taxes & fees
Nov 16 - Nov 17
Villas At Hawks Cay Resort
A beach with palm trees, lounge chairs, and a thatched-roof structure.

10. Condo in the Keys

Condo in the Keys
4.0 star property
Tavernier
8.2 out of 10, Very good, (17 reviews)
"Love the location "
United States
Angela
Condo in the Keys
A dining area with a glass table, chairs, and a vase with decorative flowers. There is a sofa and a television in the background.

11. Oceanfront Duck Key Villa: 2 Marinas Steps Away!

Oceanfront Duck Key Villa: 2 Marinas Steps Away!
4.0 star property
Marathon
Oceanfront Duck Key Villa: 2 Marinas Steps Away!
Interior

12. Florida Keys Getaway w/ Stunning Ocean Views

Florida Keys Getaway w/ Stunning Ocean Views
4.0 star property
Long Key
Florida Keys Getaway w/ Stunning Ocean Views

Top Lignumvitae Key Botanical State Park Hotel Reviews

An aerial view of a resort with two swimming pools surrounded by palm trees and sun loungers.
Islander Resort

Islander Resort

Islander Resort
Matecumbe

10/10 Excellent

This resort was absolutely amazing and exceeded all of my expectations. We originally booked just one night on our way to Key West, but after experiencing everything the property had to offer, we wished we had stayed much longer. If we have the opportunity to make this trip again, we would choose to stay here for our entire vacation and simply take a day trip or two to Key West. The resort offers everything you need for a relaxing and enjoyable stay, with beautiful surroundings, excellent...
Canada
Amanda
Reviewed June 9, 2026
Islander Resort

Find out more about Lignumvitae Key Botanical State Park

If you’re looking for a spot with great rates, just-for-you amenities, and a world of luxurious little perks, the best 4 Stars hotels in Lignumvitae Key Botanical State Park are calling your name. Known for providing first-rate service in amazing locations, each of the Lignumvitae Key Botanical State Park 4 Stars hotels lets discerning travelers bask in an unforgettable experience.

Kick back in your spacious room. Relax in the lobby’s sumptuous surroundings. Start the day with delicious room service, and then use the complimentary body care items to freshen up before you head out for the day.

It’s all waiting for you at the top four star hotels in Lignumvitae Key Botanical State Park. Plus, when you book with Expedia.ca, you might find a cheap deal on a 4 Stars hotel in Lignumvitae Key Botanical State Park, Islamorada, neighbourhoods near the most popular attractions, so you can see the sights and bask in the discounts all in one trip. Whether you’re planning a romantic retreat or simply want to experience everything the area has to offer, the top Lignumvitae Key Botanical State Park hotels with 4 Stars provide everything you need to unwind in style.

Frequently Asked Questions

How much does it cost to stay in a 4-star hotel in Lignumvitae Key Botanical State Park?

With Expedia's search and sort filters, scoring a top deal on a 4-star hotel in Lignumvitae Key Botanical State Park just got simpler. Start by keying in your chosen travel dates and length of your break. Then list the results by price and pick the option that best matches your style and budget.

  • Search for the lowest price from CA $218

What's the difference between 5-star and 4-star hotels in Lignumvitae Key Botanical State Park?

Offering a welcoming traveller experience and upscale surroundings, 4-star hotels are a fabulous option for your Lignumvitae Key Botanical State Park getaway. These kinds of stays generally come with loads of useful amenities that make it a breeze to unpack and relax — think 24-hour room service, pools and gyms. Or enjoy even more lavishness at a 5-star hotel designed to indulge you in luxury perks and amenities. On-site health clubs, oversized bathrooms and world-class dining are typically featured at these plush properties.

Does Lignumvitae Key Botanical State Park have any 4-star all-inclusive resorts?

Use our "All inclusive" filter to search for your next escape in Lignumvitae Key Botanical State Park where just about everything is taken care of, from your meals to your accommodations, entertainment and activities. We can also help you find standard 4-star stays in and around this sought-after destination.

Are there any 4-star casino hotels in Lignumvitae Key Botanical State Park?

Shuffle between your room and the poker table with ease by using our filter tool to find 4-star casino hotels in and around Lignumvitae Key Botanical State Park. Celebrating a special occasion? Narrow your search further by selecting amenities with that extra wow-factor, like a pool or hot tub.

Explore a world of travel with Expedia