Southeast Jacksonville Adventure Vacations

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to CA $4,200 when you book a flight and hotel together*
  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
  • Rest easy

    Plan, book, and manage your trip all in one place

Adventure Hotels in Southeast Jacksonville

Delta Hotels by Marriott™ Jacksonville Deerwood

Delta Hotels by Marriott™ Jacksonville Deerwood

4700 Salisbury Rd Jacksonville FL
  • 10 min drive from Mayo Clinic Florida
Book a stay at this business-friendly hotel in Jacksonville. Enjoy breakfast (surcharge), a free area shuttle, and room service. Our guests praise the helpful ...
8.4/10 Very good! (729 reviews)
"Great stay! We will be happy to stay again😄"

Reviewed on Sep 20, 2026

Delta Hotels by Marriott™ Jacksonville Deerwood
Residence Inn by Marriott Jacksonville Butler Boulevard

Residence Inn by Marriott Jacksonville Butler Boulevard

10551 Deerwood Park Blvd Jacksonville FL
  • 7 min drive from Mayo Clinic Florida
Book a stay at this business-friendly hotel in Jacksonville. Enjoy free breakfast, free WiFi, and a fitness center. Our guests praise the helpful staff and the ...
Residence Inn by Marriott Jacksonville Butler Boulevard
Marriott Jacksonville

Marriott Jacksonville

4670 Salisbury Rd Jacksonville FL
  • 10 min drive from Mayo Clinic Florida
Book a stay at this business-friendly hotel in Jacksonville. Enjoy free parking, breakfast (surcharge), and room service. Our guests praise the helpful staff ...
Marriott Jacksonville
See all 605 properties in Southeast Jacksonville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Things to do

St. Augustine: St. Johns River Airboat Safari with a Guide

St. Augustine: St. Johns River Airboat Safari with a Guide

CA $72
per adult
100% of travellers recommend
St. Augustine: St. Johns River Airboat Safari with a Guide
Half-Day City Tour in Downtown Jacksonville

Half-Day City Tour in Downtown Jacksonville

CA $158
per adult
100% of travellers recommend
Half-Day City Tour in Downtown Jacksonville
The Escape Game at St. John's Town Center in Jacksonville

The Escape Game at St. John's Town Center in Jacksonville

CA $58
per adult
100% of travellers recommend
The Escape Game at St. John's Town Center in Jacksonville
See all activities in Southeast Jacksonville

More vacations you might like

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.